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Cyclazodone
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<h2 id="safety">Safety</h2> <p>Cyclazodone has not been evaluated by the United States Food and Drug Administration for use in humans as a nootropic, anorectic, or stimulant and thus safety information is lacking. However, in studies relating to the therapeutic uses of cyclazodone, it was noted that it exhibited less cardiotoxic and hepatotoxic effects than D-amphetamine in studies on mice.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="synthesis">Synthesis</h2> <p>α-Chlorophenylacetyl chloride (1) and 1-cyclopropylurea (2) react to give the <a href="/facts/Amide/C6kCzYEA">amide</a> (3). The <a href="/facts/Heterocycle/8oYSjJxY">heterocycle</a> cyclazodone is formed on threatment of this with <a href="/facts/Sodium_ethoxide/3vrWu24b">sodium ethoxide</a>.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a><a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Fenozolone/vUEE2Lqa">Fenozolone</a></li> <li><a href="/facts/Amiphenazole/zdgQCjYT">Amiphenazole</a></li> <li><a href="/facts/List_of_aminorex_analogues/ps61PoJu">List of aminorex analogues</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>US 3321470, Howell Jr CF, Hardy RA, Quinones N, "5-Arylidene-2-Amino-2-Oxazolin-4-Ones", issued 23 May 1967, assigned to American Cyanamid <a href="https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3321470" target="_blank">https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3321470</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>US 3609159, De Marne V, Pierre D, Guidicelli RL, Najer H, "5-Phenyl-2-Cyclopropylamino-4-Oxazolinone", issued 28 September 1971, assigned to Les Laboratoires Dausse <a href="https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3609159" target="_blank">https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3609159</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>GB 1005738, De Marne V, Pierre D, Guidicelli RL, Najer H, "5-Phenyl-2-Cyclopropylamino-4-Oxazolinone", issued 29 September 1965, assigned to Les Laboratoires Dausse <a href="https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=GB1005738" target="_blank">https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=GB1005738</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology. 7 (4): 566–78. doi:10.1016/0041-008x(65)90042-6. PMID 4378772. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>"World Anti-Doping Agency 2008 Prohibited List" (PDF). World Anti-Doping Agency. 22 September 2007. <a href="https://www.wada-ama.org/sites/default/files/resources/files/WADA_Prohibited_List_2008_EN.pdf" target="_blank">https://www.wada-ama.org/sites/default/files/resources/files/WADA_Prohibited_List_2008_EN.pdf</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>US 3609159, De Marne V, Pierre D, Guidicelli RL, Najer H, "5-Phenyl-2-Cyclopropylamino-4-Oxazolinone", issued 28 September 1971, assigned to Les Laboratoires Dausse <a href="https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3609159" target="_blank">https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3609159</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>US 3609159, De Marne V, Pierre D, Guidicelli RL, Najer H, "5-Phenyl-2-Cyclopropylamino-4-Oxazolinone", issued 28 September 1971, assigned to Les Laboratoires Dausse <a href="https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3609159" target="_blank">https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3609159</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Najer, H. et al, Bull. Soc. Chim. Fr., 1963, 1810. <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> </ol>