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5-HT4 receptor
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<h2 id="function">Function</h2> <p>This gene is a member of the family of human <a href="/facts/Serotonin/EzY58q4a">serotonin</a> receptors, which are <a href="/facts/G_protein-coupled_receptors/0arUMkQc">G protein-coupled receptors</a> that stimulate <a href="/facts/Cyclic_adenosine_monophosphate/flK2vwUe">cAMP</a> production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various <a href="/facts/Neurotransmitters/LlpYFSU3">neurotransmitters</a>. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p> <h2 id="location">Location</h2> <p>The receptor is located in the <a href="/facts/Alimentary_tract/nK2zwqBS">alimentary tract</a>, <a href="/facts/Urinary_bladder/g8Khaf7A">urinary bladder</a>, <a href="/facts/Heart/fF4KSGdk">heart</a> and <a href="/facts/Adrenal_gland/3f8jV5aJ">adrenal gland</a> as well as the <a href="/facts/Central_nervous_system/k8I6To97">central nervous system</a> (CNS).<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> In the CNS the receptor appears in the <a href="/facts/Putamen/nIPFAP17">putamen</a>, <a href="/facts/Caudate_nucleus/tAkRY4c0">caudate nucleus</a>, <a href="/facts/Nucleus_accumbens/2M43u5X4">nucleus accumbens</a>, <a href="/facts/Globus_pallidus/QSGvBlAh">globus pallidus</a>, and <a href="/facts/Substantia_nigra/qDpsqpcJ">substantia nigra</a>, and to a lesser extent in the <a href="/facts/Neocortex/YEVjPgGK">neocortex</a>, <a href="/facts/Raphe_nuclei/DCmphm59">raphe</a>, <a href="/facts/Pontine_nuclei/bjn9GPru">pontine nuclei</a>, and some areas of the <a href="/facts/Thalamus/UHDtUStc">thalamus</a>. It has not been found in the cerebellum.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h2 id="isoforms">Isoforms</h2> <p>Internalization is isoform-specific.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="ligands">Ligands</h2> <p>Several drugs that act as 5-HT4 selective agonists have recently been introduced into use in both scientific research and clinical medicine. Some drugs that act as 5-HT4 agonists are also active as 5-HT3 antagonists, such as mosapride, metoclopramide, renzapride, and zacopride, and so these compounds cannot be considered highly selective. Research in this area is ongoing.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> Amongst these agonists <a href="/facts/Prucalopride/oNfjK7RV">prucalopride</a> has >150-fold higher affinity for 5-HT4 receptors than for other receptors. </p><p>SB-207,145 radiolabeled with <a href="/facts/Carbon-11/K1LfqDNj">carbon-11</a> is used as a <a href="/facts/Radioligand/BD7LXsdM">radioligand</a> for 5-HT4 in <a href="/facts/Positron_emission_tomography/5SmcW6qz">positron emission tomography</a> pig<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> and human<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> studies. </p> <h3>Agonists</h3> <ul><li><a href="/facts/Tropisetron/tv9CTt86">Tropisetron</a><a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> – partial agonist</li> <li><a href="/facts/BIMU-8/JtA2haTz">BIMU-8</a></li> <li><a href="/facts/Cisapride/9JMdgmW8">Cisapride</a></li> <li><a href="/facts/CJ-033%2c466/CHaXfzJJ">CJ-033,466</a> – partial agonist</li> <li>Felcisetrag</li> <li>ML-10302<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a></li> <li><a href="/facts/Mosapride/WNBkaNBd">Mosapride</a></li> <li><a href="/facts/Prucalopride/oNfjK7RV">Prucalopride</a></li> <li><a href="/facts/Renzapride/ngFW4R09">Renzapride</a></li> <li>RS-67506</li> <li><a href="/facts/RS-67333/dUV2zDPM">RS-67333</a> – partial agonist</li> <li><a href="/facts/SL65.0155/MIqElyq6">SL65.0155</a> – partial agonist</li> <li><a href="/facts/Tegaserod/DaUMlpRh">Tegaserod</a></li> <li><a href="/facts/Zacopride/Rl8UAagG">Zacopride</a></li> <li><a href="/facts/Metoclopramide/3Gadd8hg">Metoclopramide</a></li> <li><a href="/facts/Sulpiride/DlW0tpnR">Sulpiride</a></li> <li>Naronapride</li> <li>Usmarapride</li></ul> <h3>Antagonists</h3> <ul><li><a href="/facts/Lysine/CEetgA9L">L-lysine</a></li> <li><a href="/facts/Piboserod/tQRGE2nW">Piboserod</a></li> <li><a href="/facts/GR-113%2c808/07k1Y0GT">GR-113,808</a> (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a></li> <li>GR-125,487</li> <li>RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)</li> <li>SB-203,186</li> <li><a href="/facts/SB-204%2c070/ENYg9MHz">SB-204,070</a></li> <li>([Methoxy-11C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a></li> <li>Chamomile (ethanol extract)<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a></li></ul> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/5-HT_receptor/D6656QzQ">5-HT receptor</a></li> <li><a href="/facts/5-HT1_receptor/c2tVGHCw">5-HT1 receptor</a></li> <li><a href="/facts/5-HT2_receptor/83TWw6EC">5-HT2 receptor</a></li> <li><a href="/facts/5-HT3_receptor/7Qa2T8v3">5-HT3 receptor</a></li> <li><a href="/facts/5-HT5_receptor/Iclxf8po">5-HT5 receptor</a></li> <li><a href="/facts/5-HT6_receptor/2QQJ7upp">5-HT6 receptor</a></li> <li><a href="/facts/5-HT7_receptor/rcpLc6FL">5-HT7 receptor</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Licht CL, 2009, <i>Changes in the 5-HT4 receptor in <a href="/facts/Animal_models_of_depression/BY8mQuvh">animal models of depression</a> and antidepressant treatment</i>, PhD thesis, <a href="/facts/University_of_Copenhagen/GdnhESXv">University of Copenhagen</a>.</li> <li>Ullmer C, Schmuck K, Kalkman HO, Lübbert H (August 1995). <a href="https://doi.org/10.1016%2F0014-5793%2895%2900828-W">"Expression of serotonin receptor mRNAs in blood vessels"</a>. <i>FEBS Letters</i>. 370 (3): 215–21. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1995FEBSL.370..215U">1995FEBSL.370..215U</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0014-5793%2895%2900828-W">10.1016/0014-5793(95)00828-W</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7656980">7656980</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:9015835">9015835</a>.</li> <li>Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R (August 1997). <a href="https://doi.org/10.1016%2FS0014-5793%2897%2900820-X">"Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium"</a>. <i>FEBS Letters</i>. 412 (3): 465–74. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1997FEBSL.412..465B">1997FEBSL.412..465B</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2897%2900820-X">10.1016/S0014-5793(97)00820-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9276448">9276448</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23714426">23714426</a>.</li> <li>Van den Wyngaert I, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W, Bender E (November 1997). <a href="https://doi.org/10.1046%2Fj.1471-4159.1997.69051810.x">"Cloning and expression of a human serotonin 5-HT4 receptor cDNA"</a>. <i>Journal of Neurochemistry</i>. 69 (5): 1810–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1471-4159.1997.69051810.x">10.1046/j.1471-4159.1997.69051810.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9349523">9349523</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:25269904">25269904</a>.</li> <li>Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A (October 1997). <a href="https://hal.archives-ouvertes.fr/hal-02491123/file/1997%20Neuroreport%20Claeysen.pdf">"Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase"</a> (PDF). <i>NeuroReport</i>. 8 (15): 3189–96. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2F00001756-199710200-00002">10.1097/00001756-199710200-00002</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9351641">9351641</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:20624532">20624532</a>.</li> <li>Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R (June 1998). <a href="https://web.archive.org/web/20230610072158/https://hal-universite-paris-saclay.archives-ouvertes.fr/hal-03617007/file/Version%20HAL.pdf">"Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus"</a> (PDF). <i>Journal of Neurochemistry</i>. 70 (6): 2252–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1471-4159.1998.70062252.x">10.1046/j.1471-4159.1998.70062252.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9603189">9603189</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:24203530">24203530</a>. Archived from <a href="https://hal-universite-paris-saclay.archives-ouvertes.fr/hal-03617007/file/Version%20HAL.pdf">the original</a> (PDF) on 10 June 2023. Retrieved 8 April 2022.</li> <li>Cichon S, Kesper K, Propping P, Nöthen MM (1998). "Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31-q33)". <i>Molecular Membrane Biology</i>. 15 (2): 75–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.3109%2F09687689809027521">10.3109/09687689809027521</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9724925">9724925</a>.</li> <li>Claeysen S, Sebben M, Becamel C, Bockaert J, Dumuis A (May 1999). <a href="https://hal.archives-ouvertes.fr/hal-02487737/file/1999%20MolPharm%20Claeysen.pdf">"Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain"</a> (PDF). <i>Molecular Pharmacology</i>. 55 (5): 910–20. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0026-895X%2824%2923188-6">10.1016/S0026-895X(24)23188-6</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10220570">10220570</a>.</li> <li>Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W (February 2000). "Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant". <i>Journal of Neurochemistry</i>. 74 (2): 478–89. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1471-4159.2000.740478.x">10.1046/j.1471-4159.2000.740478.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10646498">10646498</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:33817190">33817190</a>.</li> <li>Mialet J, Berque-Bestel I, Eftekhari P, Gastineau M, Giner M, Dahmoune Y, Donzeau-Gouge P, Hoebeke J, Langlois M, Sicsic S, Fischmeister R, Lezoualc'h F (February 2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571890">"Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines"</a>. <i>British Journal of Pharmacology</i>. 129 (4): 771–81. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.bjp.0703101">10.1038/sj.bjp.0703101</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571890">1571890</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10683202">10683202</a>.</li> <li>Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO (February 2001). "5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle". <i>Naunyn-Schmiedeberg's Archives of Pharmacology</i>. 363 (2): 146–60. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs002100000299">10.1007/s002100000299</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11218067">11218067</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:27504006">27504006</a>.</li> <li>Medhurst AD, Lezoualc'h F, Fischmeister R, Middlemiss DN, Sanger GJ (June 2001). "Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR". <i>Brain Research. Molecular Brain Research</i>. 90 (2): 125–34. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0169-328X%2801%2900095-X">10.1016/S0169-328X(01)00095-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11406291">11406291</a>.</li> <li>Hiroi T, Hayashi-Kobayashi N, Nagumo S, Ino M, Okawa Y, Aoba A, Matsui H (November 2001). "Identification and characterization of the human serotonin-4 receptor gene promoter". <i>Biochemical and Biophysical Research Communications</i>. 289 (2): 337–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.2001.5979">10.1006/bbrc.2001.5979</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11716477">11716477</a>.</li> <li>Vilaró MT, Doménech T, Palacios JM, Mengod G (January 2002). "Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants". <i>Neuropharmacology</i>. 42 (1): 60–73. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0028-3908%2801%2900154-X">10.1016/S0028-3908(01)00154-X</a>. <a href="/facts/Hdl_(identifier)/rdebSxmC">hdl</a>:<a href="https://hdl.handle.net/10261%2F112650">10261/112650</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11750916">11750916</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23722311">23722311</a>.</li> <li>López-Rodríguez ML, Murcia M, Benhamú B, Olivella M, Campillo M, Pardo L (November 2001). "Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin". <i>Journal of Computer-Aided Molecular Design</i>. 15 (11): 1025–33. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2001JCAMD..15.1025L">2001JCAMD..15.1025L</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1023%2FA%3A1014895611874">10.1023/A:1014895611874</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11989623">11989623</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23478175">23478175</a>.</li> <li>Ohtsuki T, Ishiguro H, Detera-Wadleigh SD, Toyota T, Shimizu H, Yamada K, Yoshitsugu K, Hattori E, Yoshikawa T, Arinami T (2003). "Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees". <i>Molecular Psychiatry</i>. 7 (9): 954–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.mp.4001133">10.1038/sj.mp.4001133</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12399948">12399948</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:21064320">21064320</a>.</li> <li>Norum JH, Hart K, Levy FO (January 2003). <a href="https://doi.org/10.1074%2Fjbc.M206237200">"Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a)"</a>. <i>The Journal of Biological Chemistry</i>. 278 (5): 3098–104. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M206237200">10.1074/jbc.M206237200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12446729">12446729</a>.</li> <li>Cartier D, Lihrmann I, Parmentier F, Bastard C, Bertherat J, Caron P, Kuhn JM, Lacroix A, Tabarin A, Young J, Vaudry H, Lefebvre H (January 2003). <a href="https://doi.org/10.1210%2Fjc.2002-021107">"Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome"</a>. <i>The Journal of Clinical Endocrinology and Metabolism</i>. 88 (1): 248–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1210%2Fjc.2002-021107">10.1210/jc.2002-021107</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12519861">12519861</a>.</li> <li>Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW (July 2003). "5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia". <i>Science</i>. 301 (5630): 226–9. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2003Sci...301..226M">2003Sci...301..226M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1084674">10.1126/science.1084674</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12855812">12855812</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:13641423">13641423</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://web.archive.org/web/20160605115442/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2329">"5-HT4"</a>. <i>IUPHAR Database of Receptors and Ion Channels</i>. International Union of Basic and Clinical Pharmacology. Archived from <a href="http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2329">the original</a> on 5 June 2016. Retrieved 25 November 2008.</li> <li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=HTR4"><i>HTR4</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=HTR4"><i>HTR4</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S (December 1997). "Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31→q33 by in situ hybridization" (PDF). Cytogenetics and Cell Genetics. 78 (2): 133–4. doi:10.1159/000134646. PMID 9371406. <a href="https://hal.archives-ouvertes.fr/hal-02491196/file/1997%20CytoCellGen%20Claeysen.pdf" target="_blank">https://hal.archives-ouvertes.fr/hal-02491196/file/1997%20CytoCellGen%20Claeysen.pdf</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R (August 1997). "Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium". FEBS Letters. 412 (3): 465–74. Bibcode:1997FEBSL.412..465B. doi:10.1016/S0014-5793(97)00820-X. PMID 9276448. S2CID 23714426. <a href="https://doi.org/10.1016%2FS0014-5793%2897%2900820-X" target="_blank">https://doi.org/10.1016%2FS0014-5793%2897%2900820-X</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: HTR4 5-hydroxytryptamine (serotonin) receptor 4". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3360" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3360</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Hegde SS, Eglen RM (October 1996). "Peripheral 5-HT4 receptors". FASEB Journal. 10 (12): 1398–407. doi:10.1096/fasebj.10.12.8903510. PMID 8903510. S2CID 21596751. <a href="https://doi.org/10.1096%2Ffasebj.10.12.8903510" target="_blank">https://doi.org/10.1096%2Ffasebj.10.12.8903510</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Varnäs K, Halldin C, Pike VW, Hall H (August 2003). "Distribution of 5-HT4 receptors in the postmortem human brain--an autoradiographic study using [125I]SB 207710". European Neuropsychopharmacology. 13 (4): 228–34. doi:10.1016/S0924-977X(03)00009-9. PMID 12888181. S2CID 27945284. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Mnie-Filali O, Amraei MG, Benmbarek S, Archer-Lahlou E, Peñas-Cazorla R, Vilaró MT, Boye SM, Piñeyro G (March 2010). "Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: effects of 5-HT and RS67333 on isoforms A and B". Cellular Signalling. 22 (3): 501–9. doi:10.1016/j.cellsig.2009.11.004. PMID 19922792. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L (April 2009). "Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors" (PDF). Molecular Pharmacology. 75 (4): 982–90. doi:10.1124/mol.108.053686. PMID 19168624. S2CID 17957338. <a href="https://hal.archives-ouvertes.fr/hal-02483472/file/2009%20MolPharm%20Pellissier.pdf" target="_blank">https://hal.archives-ouvertes.fr/hal-02483472/file/2009%20MolPharm%20Pellissier.pdf</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knudsen GM (January 2009). "Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig". Journal of Cerebral Blood Flow and Metabolism. 29 (1): 186–96. doi:10.1038/jcbfm.2008.110. PMID 18797470. <a href="https://doi.org/10.1038%2Fjcbfm.2008.110" target="_blank">https://doi.org/10.1038%2Fjcbfm.2008.110</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Marner L, Gillings N, Comley RA, Baaré WF, Rabiner EA, Wilson AA, Houle S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM (June 2009). "Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo". Journal of Nuclear Medicine. 50 (6): 900–8. doi:10.2967/jnumed.108.058552. PMID 19470850. <a href="https://doi.org/10.2967%2Fjnumed.108.058552" target="_blank">https://doi.org/10.2967%2Fjnumed.108.058552</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Costall B, Naylor RJ (November 1993). "The pharmacology of the 5-HT4 receptor". International Clinical Psychopharmacology. 8 Suppl 2 (Suppl 2): 11–18. doi:10.1097/00004850-199311002-00002. PMID 8201242. S2CID 36692776. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V (March 2011). "Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia". Pain. 152 (3): 687–97. doi:10.1016/j.pain.2010.12.020. PMID 21239110. S2CID 140204185. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP (January 1994). "GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor". British Journal of Pharmacology. 111 (1): 332–8. doi:10.1111/j.1476-5381.1994.tb14064.x. PMC 1910004. PMID 8012715. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1910004" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1910004</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Xu R, Hong J, Morse CL, Pike VW (October 2010). "Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography". Journal of Medicinal Chemistry. 53 (19): 7035–47. doi:10.1021/jm100668r. PMC 2951497. PMID 20812727. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951497" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951497</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D (2006). "Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors". Phytomedicine. 13 (Suppl 5): 51–5. doi:10.1016/j.phymed.2006.03.012. PMID 16973340. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> </ol>