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Caldesmon
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<h2 id="immunochemistry">Immunochemistry</h2> <p>In diagnostic <a href="/facts/Immunochemistry/foDc3y5z">immunochemistry</a>, caldesmon is a marker for <a href="/facts/Smooth_muscle/mpcpTsHp">smooth muscle</a> differentiation. </p> <h2 id="further-reading">Further reading</h2> <ul><li>Huber PA (1998). "Caldesmon". <i>Int. J. Biochem. Cell Biol</i>. 29 (8–9): 1047–51. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS1357-2725%2897%2900004-6">10.1016/S1357-2725(97)00004-6</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9415999">9415999</a>.</li> <li>Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation". <i>Biochemistry Mosc</i>. 66 (10): 1112–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1023%2FA%3A1012480829618">10.1023/A:1012480829618</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11736632">11736632</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:310781">310781</a>.</li> <li>Wang CL (2002). "Caldesmon and smooth-muscle regulation". <i>Cell Biochem. Biophys</i>. 35 (3): 275–88. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1385%2FCBB%3A35%3A3%3A275">10.1385/CBB:35:3:275</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11894847">11894847</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:195271255">195271255</a>.</li> <li>Mani RS, McCubbin WD, Kay CM (1992). "Calcium-dependent regulation of caldesmon by an 11-kDa smooth muscle calcium-binding protein, caltropin". <i>Biochemistry</i>. 31 (47): 11896–901. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi00162a031">10.1021/bi00162a031</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1445920">1445920</a>.</li> <li>Hayashi K, Yano H, Hashida T, et al. (1993). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50710">"Genomic structure of the human caldesmon gene"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 89 (24): 12122–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.89.24.12122">10.1073/pnas.89.24.12122</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50710">50710</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1465449">1465449</a>.</li> <li>Humphrey MB, Herrera-Sosa H, Gonzalez G, et al. (1992). "Cloning of cDNAs encoding human caldesmons". <i>Gene</i>. 112 (2): 197–204. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2892%2990376-Z">10.1016/0378-1119(92)90376-Z</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1555769">1555769</a>.</li> <li>Adam LP, Gapinski CJ, Hathaway DR (1992). <a href="https://doi.org/10.1016%2F0014-5793%2892%2980446-N">"Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas"</a>. <i>FEBS Lett</i>. 302 (3): 223–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0014-5793%2892%2980446-N">10.1016/0014-5793(92)80446-N</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1601129">1601129</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:46129878">46129878</a>.</li> <li>Horiuchi KY, Chacko S (1989). "Interaction between caldesmon and tropomyosin in the presence and absence of smooth muscle actin". <i>Biochemistry</i>. 27 (22): 8388–93. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi00422a014">10.1021/bi00422a014</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/3242591">3242591</a>.</li> <li>der Terrossian E, Deprette C, Lebbar I, Cassoly R (1994). <a href="https://doi.org/10.1111%2Fj.1432-1033.1994.tb19965.x">"Purification and characterization of erythrocyte caldesmon. Hypothesis for an actin-linked regulation of a contractile activity in the red blood cell membrane"</a>. <i>Eur. J. Biochem</i>. 219 (1–2): 503–11. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1432-1033.1994.tb19965.x">10.1111/j.1432-1033.1994.tb19965.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8307018">8307018</a>.</li> <li>Surgucheva I, Bryan J (1996). "Over-expression of smooth muscle caldesmon in mouse fibroblasts". <i>Cell Motil. Cytoskeleton</i>. 32 (3): 233–43. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fcm.970320307">10.1002/cm.970320307</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8581978">8581978</a>.</li> <li>Bonaldo MF, Lennon G, Soares MB (1997). <a href="https://doi.org/10.1101%2Fgr.6.9.791">"Normalization and subtraction: two approaches to facilitate gene discovery"</a>. <i>Genome Res</i>. 6 (9): 791–806. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.6.9.791">10.1101/gr.6.9.791</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8889548">8889548</a>.</li> <li>Graether SP, Heinonen TY, Raharjo WH, et al. (1997). "Tryptophan residues in caldesmon are major determinants for calmodulin binding". <i>Biochemistry</i>. 36 (2): 364–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi962008k">10.1021/bi962008k</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9003189">9003189</a>.</li> <li>Wang Z, Danielsen AJ, Maihle NJ, McManus MJ (1999). <a href="https://doi.org/10.1074%2Fjbc.274.47.33807">"Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex"</a>. <i>J. Biol. Chem</i>. 274 (47): 33807–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.274.47.33807">10.1074/jbc.274.47.33807</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10559276">10559276</a>.</li> <li>Adam L, Vadlamudi R, Mandal M, et al. (2000). <a href="https://doi.org/10.1074%2Fjbc.275.16.12041">"Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1"</a>. <i>J. Biol. Chem</i>. 275 (16): 12041–50. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.275.16.12041">10.1074/jbc.275.16.12041</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10766836">10766836</a>.</li> <li>Hall SM, Hislop AA, Pierce CM, Haworth SG (2000). "Prenatal origins of human intrapulmonary arteries: formation and smooth muscle maturation". <i>Am. J. Respir. Cell Mol. Biol</i>. 23 (2): 194–203. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1165%2Fajrcmb.23.2.3975">10.1165/ajrcmb.23.2.3975</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10919986">10919986</a>.</li> <li>Nimmrich I, Erdmann S, Melchers U, et al. (2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines". <i>Cancer Lett</i>. 160 (1): 37–43. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0304-3835%2800%2900553-X">10.1016/S0304-3835(00)00553-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11098082">11098082</a>.</li> <li>Hisaoka M, Wei-Qi S, Jian W, et al. (2003). "Specific but variable expression of h-caldesmon in leiomyosarcomas: an immunohistochemical reassessment of a novel myogenic marker". <i>Appl. Immunohistochem. Mol. Morphol</i>. 9 (4): 302–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2F00022744-200112000-00003">10.1097/00022744-200112000-00003</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11759055">11759055</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:25653139">25653139</a>.</li> <li>Sobue K, Muramoto Y, Fujita M, Kakiuchi S (Sep 1981). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC348816">"Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 78 (9): 5652–5. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1981PNAS...78.5652S">1981PNAS...78.5652S</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.78.9.5652">10.1073/pnas.78.9.5652</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC348816">348816</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/6946503">6946503</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=Caldesmon">Caldesmon</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem. 266 (25): 16917–24. doi:10.1016/S0021-9258(18)55390-4. PMID 1885618. <a href="https://doi.org/10.1016%2FS0021-9258%2818%2955390-4" target="_blank">https://doi.org/10.1016%2FS0021-9258%2818%2955390-4</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: CALD1 caldesmon 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: CALD1 caldesmon 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> </ol>