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Indium-111
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<h2 id="uses-in-nuclear-medicine">Uses in nuclear medicine</h2> <p>When formulated as an 111InCl solution, it can be used to bind <a href="/facts/Antibodies/MX8pdTdP">antibodies</a>, <a href="/facts/Peptide/C4ltc7UG">peptides</a>, or other molecular targeted proteins or other molecules, typically using a chelate to bind the radionuclide (in this case 111In) to the targeting molecule during the <a href="/facts/Radiosynthesis/u3xnyyYA">radiosynthesis</a>/ <a href="/facts/Radioactive_tracer/0210Jncn">radiolabeling</a> process, which is tailored to the desired product. </p> <h3>111In labeled antibodies</h3> <ul><li>Ibritumomab Tiuxetan; Zevalin - For dosimetry estimates prior to <a href="/facts/Yttrium-90/psD38nkq">90Y</a> immunotherapy for <a href="/facts/Lymphoma/418wcMEl">lymphoma</a></li> <li>111In <a href="/facts/Indium_(111In)_capromab_pendetide/SAMUCKtH">ProstaScint</a> — PSMA antibody imaging of prostate cancer</li></ul> <h3>111In labeled peptides</h3> <ul><li>111In pentetreotide<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> (including in 111In (<a href="/facts/Pentetic_acid/muoEQd7o">diethylenetriaminopentaacetic</a> (DTPA)-<a href="/facts/Octreotide/A7su7kgD">octreotide</a>) and <a href="/facts/Octreoscan/LLskrRy6">Octreoscan</a>) <ul><li>Octreotide is an somatostatin receptor inhibitor pharmaceutical which binds with high affinity to somatostatin receptors 2 and 5, interfering with normal receptor function. It is used as a drug to treat several neuroendocrine tumors in which somatostatin receptors are overexpressed or overactive. Examples include: <ul><li>Sympathoadrenal system tumors: <a href="/facts/Pheochromocytoma/83IHw9gQ">pheochromocytoma</a>, neuroblastoma, ganglioneuroma, paraganglioma</li> <li>Gastroenteropancreatic (GEP) tumors: carcinoid, insulinoma</li> <li>Medullary thyroid cancer, pituitary adenoma, small cell lung cancer</li></ul></li> <li>111In pentetreotide<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> imaging can identify the presence, levels of somatostatin receptor 2,5 expression, extent of disease and response to therapy</li></ul></li> <li>111In can also be formulated in the chemical form 111In oxyquinoline (oxine)<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> for labeling blood cells and components</li></ul> <ul><li><a href="/facts/Platelets/I0xrDVGa">Platelets</a> for <a href="/facts/Thrombus/vH6FDIQG">thrombus</a> detection</li> <li>Leukocytes for localization of <a href="/facts/Inflammation/Ura86MIy">inflammation</a> and <a href="/facts/Abscesses/BW3TH8kb">abscesses</a>, detect and monitor <a href="/facts/Osteomyelitis/FUzsmRPf">osteomyelitis</a>, and detect <a href="/facts/Mycotic_aneurysm/RFzmGSR3">mycotic aneurysms</a>, <a href="/facts/Vascular_graft/ILXs10v3">vascular graft</a> and <a href="/facts/Shunt_(medical)/bp3tmFGn">shunt</a> infections and determination of <a href="/facts/Leukocyte/vsDunUK0">leukocyte</a> kinetics;<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li></ul> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Isotopes_of_indium/4AVSfBza">Isotopes of indium</a></li> <li><a href="/facts/Indium_white_blood_cell_scan/6HKuncxG">Indium white blood cell scan</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"FDA Label Document:Indium In-111 Chloride Sterile Solution". www.accessdata.fda.gov. Archived from the original on April 29, 2017. Retrieved 20 Aug 2018. <a href="https://web.archive.org/web/20170429204932/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019841" target="_blank">https://web.archive.org/web/20170429204932/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019841</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Takács, S.; Tárkányi, F.; Hermanne, A. (Dec 2005). "Validation and upgrading of the recommended cross-section data of charged particle reactions: Gamma emitter radioisotopes". Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 240 (4): 790–802. Bibcode:2005NIMPB.240..790T. doi:10.1016/j.nimb.2005.06.209. ISSN 0168-583X. <a href="/wiki/Bibcode_(identifier)" target="_blank">/wiki/Bibcode_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"FDA Label Document:Indium In-111 Chloride Sterile Solution". www.accessdata.fda.gov. Archived from the original on April 29, 2017. Retrieved 20 Aug 2018. <a href="https://web.archive.org/web/20170429204932/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019841" target="_blank">https://web.archive.org/web/20170429204932/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019841</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Pentetoreotide". National Center for Biotechnology Information. 7 June 2025. <a href="https://pubchem.ncbi.nlm.nih.gov/compound/636392" target="_blank">https://pubchem.ncbi.nlm.nih.gov/compound/636392</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>"Pentetoreotide". National Center for Biotechnology Information. 7 June 2025. <a href="https://pubchem.ncbi.nlm.nih.gov/compound/636392" target="_blank">https://pubchem.ncbi.nlm.nih.gov/compound/636392</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>"PubChem In-111 Oxyquinoline". pubchem.ncbi.nlm.nih.gov. Retrieved 20 Aug 2018. <a href="https://pubchem.ncbi.nlm.nih.gov/compound/119117#section=3D-Conformer" target="_blank">https://pubchem.ncbi.nlm.nih.gov/compound/119117#section=3D-Conformer</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>"IN-111 FACT SHEET" (PDF). Nordion(Canada), Inc. Archived from the original (PDF) on 3 December 2011. Retrieved 23 September 2012. <a href="https://web.archive.org/web/20111203082605/http://www.nordion.com/documents/products/In-111_Can.pdf" target="_blank">https://web.archive.org/web/20111203082605/http://www.nordion.com/documents/products/In-111_Can.pdf</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> </ol>