Founded in 1928 as Samnium Isernia, the club spent the majority of its history in semi-professional and regional levels of Italian football. In the seasons 1984–85,1 1985–862 and 2003–04,34 Isernia played in Serie C2 (currently Lega Pro Seconda Divisione), the 4th Italian professional football level.
After going bankrupt in 2004, the club was immediately re-founded as A.S.D. Sporting Isernia and in 2007 was merged with A.S.D. Aesernia to form A.S.D. Sporting Aesernia.
In the summer of 2009, the new club that played in Promozione was merged with A.S.D. Real Rocca d'Evandro 2006 of Scapoli, in Eccellenza Molise, founding A.S.D. Real Isernia.
First classified in 2010–11 Eccellenza Molise,5 in the summer 2011 the club was renamed Isernia F.C. playing from the 2011–2012 season in Serie D.
Its colours are white and sky blue.
The home ground is the Stadio Mario Lancellotta.
See also: it:Serie C2 1984-1985#Girone D https://it.wikipedia.org/wiki/Serie_C2_1984-1985#Girone_D ↩
See also: it:Serie C2 1985-1986#Girone C https://it.wikipedia.org/wiki/Serie_C2_1985-1986#Girone_C ↩
See also: it:Serie C2 2003-2004#Girone C https://it.wikipedia.org/wiki/Serie_C2_2003-2004#Girone_C ↩
2003–04 Serie C2 archive http://www.dossier.net/calcio/archivio/c2c0304.htm ↩
(in Italian) Article on iserniaoggi.net http://www.iserniaoggi.net/archivio_focus/2010/campionato-di-calcio-eccellenza--molise-2010-2011_39.php ↩