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ITPR2
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<h2 id="see-also">See also</h2> <ul><li><a href="/facts/Inositol_trisphosphate_receptor/qFX5WQSG">Inositol trisphosphate receptor</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Jardín I, Lápez JJ, Salido GM, Rosado JA (2008). "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets". <i>Cell. Signal</i>. 20 (4): 737–47. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.cellsig.2007.12.010">10.1016/j.cellsig.2007.12.010</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18249094">18249094</a>.</li> <li>Wilker E, Mittleman MA, Litonjua AA, et al. (2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702409">"Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter"</a>. <i>Environ. Health Perspect</i>. 117 (6): 935–40. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2009EnvHP.117..935W">2009EnvHP.117..935W</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1289%2Fehp.0800279">10.1289/ehp.0800279</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702409">2702409</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19590686">19590686</a>.</li> <li>Rosado JA, Sage SO (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221827">"Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets"</a>. <i>Biochem. J</i>. 356 (Pt 1): 191–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1042%2F0264-6021%3A3560191">10.1042/0264-6021:3560191</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221827">1221827</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11336651">11336651</a>.</li> <li>van Es MA, Van Vught PW, Blauw HM, et al. (2007). "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study". <i>Lancet Neurology</i>. 6 (10): 869–77. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS1474-4422%2807%2970222-3">10.1016/S1474-4422(07)70222-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17827064">17827064</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:12953367">12953367</a>.</li> <li>Harzheim D, Movassagh M, Foo RS, et al. (2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708695">"Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 106 (27): 11406–11. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2009PNAS..10611406H">2009PNAS..10611406H</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.0905485106">10.1073/pnas.0905485106</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708695">2708695</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19549843">19549843</a>.</li> <li>Rosado JA, Sage SO (2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221291">"Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted"</a>. <i>Biochem. J</i>. 350 Pt 3 (3): 631–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1042%2F0264-6021%3A3500631">10.1042/0264-6021:3500631</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221291">1221291</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10970773">10970773</a>.</li> <li>Uhl GR, Liu QR, Drgon T, et al. (2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430596">"Molecular genetics of successful smoking cessation: convergent genome-wide association study results"</a>. <i>Arch. Gen. Psychiatry</i>. 65 (6): 683–93. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1001%2Farchpsyc.65.6.683">10.1001/archpsyc.65.6.683</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430596">2430596</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18519826">18519826</a>.</li> <li>Chiò A, Schymick JC, Restagno G, et al. (2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664150">"A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis"</a>. <i>Hum. Mol. Genet</i>. 18 (8): 1524–32. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fhmg%2Fddp059">10.1093/hmg/ddp059</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664150">2664150</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19193627">19193627</a>.</li> <li>Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". <i>Mod Rheumatol</i>. 17 (2): 137–43. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs10165-006-0555-6">10.1007/s10165-006-0555-6</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17437169">17437169</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:36516047">36516047</a>.</li> <li>Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"</a>. <i>Genome Res</i>. 16 (1): 55–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.4039406">10.1101/gr.4039406</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">1356129</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16344560">16344560</a>.</li> <li>Mery L, Magnino F, Schmidt K, et al. (2001). <a href="https://doi.org/10.1016%2FS0014-5793%2800%2902362-0">"Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors"</a>. <i>FEBS Lett</i>. 487 (3): 377–83. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2001FEBSL.487..377M">2001FEBSL.487..377M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2800%2902362-0">10.1016/S0014-5793(00)02362-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11163362">11163362</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:44945442">44945442</a>.</li> <li>Diaz F, Bourguignon LY (2000). "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells". <i>Cell Calcium</i>. 27 (6): 315–28. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1054%2Fceca.2000.0126">10.1054/ceca.2000.0126</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11013462">11013462</a>.</li> <li>Mayne M, Holden CP, Nath A, Geiger JD (2000). <a href="https://doi.org/10.4049%2Fjimmunol.164.12.6538">"Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages"</a>. <i>J. Immunol</i>. 164 (12): 6538–42. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4049%2Fjimmunol.164.12.6538">10.4049/jimmunol.164.12.6538</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10843712">10843712</a>.</li> <li>Tanimura A, Tojyo Y, Turner RJ (2000). <a href="https://doi.org/10.1074%2Fjbc.M004495200">"Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins"</a>. <i>J. Biol. Chem</i>. 275 (35): 27488–93. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M004495200">10.1074/jbc.M004495200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10874040">10874040</a>.</li> <li>Jurkovicova D, Sedlakova B, Lacinova L, et al. (2008). "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line". <i>Ann. N. Y. Acad. Sci</i>. 1148 (1): 421–7. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2008NYASA1148..421J">2008NYASA1148..421J</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1196%2Fannals.1410.034">10.1196/annals.1410.034</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19120137">19120137</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:19136722">19136722</a>.</li> <li>Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). <a href="https://doi.org/10.1074%2Fjbc.M106609200">"Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling"</a>. <i>J. Biol. Chem</i>. 277 (2): 1340–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M106609200">10.1074/jbc.M106609200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11694504">11694504</a>.</li> <li>Suzuki Y, Yamashita R, Shirota M, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316">"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions"</a>. <i>Genome Res</i>. 14 (9): 1711–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.2435604">10.1101/gr.2435604</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316">515316</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15342556">15342556</a>.</li> <li>Tovey SC, Dedos SG, Taylor EJ, et al. (2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568025">"Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP"</a>. <i>J. Cell Biol</i>. 183 (2): 297–311. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1083%2Fjcb.200803172">10.1083/jcb.200803172</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568025">2568025</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18936250">18936250</a>.</li> <li>Johnson JM, Castle J, Garrett-Engele P, et al. (2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". <i>Science</i>. 302 (5653): 2141–4. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2003Sci...302.2141J">2003Sci...302.2141J</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1090100">10.1126/science.1090100</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14684825">14684825</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:10007258">10007258</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=ITPR2+protein%2C+human">ITPR2+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: inositol 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3709" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3709</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> </ol>