All of these CPUs require the Intel X299 chipset to work. So, the C422 chipset is strictly limited to work with workstation processors only.
Kaby Lake-X processors were discontinued in May 2018. Starting October 2019, BIOS updates for most of the X299-based motherboards removed support for Kaby Lake-X processors.2
(threads)
Clock
3.0
cache
3.0lanes
up to 64 GB
per core
up to 128 GB
up to 256 GB
Take note that certain types of Xeon processors will not work on this socket, like Skylake-P. There are four OEM variants that can be found in Apple Mac Pro: W-2140B and W-2150B (lower freq/TDP than their W-21x5 counterparts), W-2170B and W-2191B lack Trusted_Execution_Technology (TXT) in comparison.
cache3
up to 512 GB
(* = OEM CPU found in Apple Mac Pro with lower TDP)
Boost 3.0
cache4
up to 1 TB
"First Intel Core X-Series Processors Pre-Orders Begin Today, Available Starting June 26". Intel Newsroom. Retrieved 2020-05-18. https://newsroom.intel.com/news/first-intel-core-x-series-processors-pre-orders-begin-today-available-starting-june-26/ ↩
"X299 BIOS Update for Intel Cascade Lake-X Will Kill Kaby Lake-X Support".Tom's Hardware. https://www.tomshardware.com/news/x299-bios-updates-wont-support-intel-kaby-lake-x-cpus ↩
"Skylake-X's New L3 Cache Architecture". AnandTech. http://www.anandtech.com/show/11464/intel-announces-skylakex-bringing-18core-hcc-silicon-to-consumers-for-1999/3 ↩