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RRAS2
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<h2 id="interactions">Interactions</h2> <p>RRAS2 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/C-Raf/NvJ0vMl6">C-Raf</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). <a href="https://doi.org/10.1016%2FS0301-472X%2802%2900904-9">"Ras and relatives--job sharing and networking keep an old family together"</a>. <i>Exp. Hematol</i>. 30 (10): 1089–106. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0301-472X%2802%2900904-9">10.1016/S0301-472X(02)00904-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12384139">12384139</a>.</li> <li>Rosário M, Paterson HF, Marshall CJ (1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171217">"Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells"</a>. <i>EMBO J</i>. 18 (5): 1270–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Femboj%2F18.5.1270">10.1093/emboj/18.5.1270</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171217">1171217</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10064593">10064593</a>.</li> <li>Linnemann T, Geyer M, Jaitner BK, et al. (1999). <a href="https://doi.org/10.1074%2Fjbc.274.19.13556">"Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily"</a>. <i>J. Biol. Chem</i>. 274 (19): 13556–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.274.19.13556">10.1074/jbc.274.19.13556</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10224125">10224125</a>.</li> <li>Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". <i>Blood</i>. 94 (7): 2433–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood.V94.7.2433.419k31_2433_2444">10.1182/blood.V94.7.2433.419k31_2433_2444</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10498616">10498616</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:40024826">40024826</a>.</li> <li>Movilla N, Crespo P, Bustelo XR (1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". <i>Oncogene</i>. 18 (43): 5860–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1202968">10.1038/sj.onc.1202968</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10557073">10557073</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:31576945">31576945</a>.</li> <li>Ohba Y, Mochizuki N, Yamashita S, et al. (2000). <a href="https://doi.org/10.1074%2Fjbc.M000981200">"Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3"</a>. <i>J. Biol. Chem</i>. 275 (26): 20020–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M000981200">10.1074/jbc.M000981200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10777492">10777492</a>.</li> <li>Figueroa C, Taylor J, Vojtek AB (2001). <a href="https://doi.org/10.1074%2Fjbc.M101763200">"Prenylated Rab acceptor protein is a receptor for prenylated small GTPases"</a>. <i>J. Biol. Chem</i>. 276 (30): 28219–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M101763200">10.1074/jbc.M101763200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11335720">11335720</a>.</li> <li>Murphy GA, Graham SM, Morita S, et al. (2002). <a href="https://doi.org/10.1074%2Fjbc.M109059200">"Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation"</a>. <i>J. Biol. Chem</i>. 277 (12): 9966–75. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M109059200">10.1074/jbc.M109059200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11788587">11788587</a>.</li> <li>Rong R, He Q, Liu Y, et al. (2002). <a href="https://doi.org/10.1038%2Fsj.onc.1205154">"TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway"</a>. <i>Oncogene</i>. 21 (7): 1062–70. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1205154">10.1038/sj.onc.1205154</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11850823">11850823</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:21196767">21196767</a>.</li> <li>Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". <i>Oncogene</i>. 21 (9): 1381–90. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1205192">10.1038/sj.onc.1205192</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11857081">11857081</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:240243">240243</a>.</li> <li>Strausberg RL, Feingold EA, Grouse LH, et al. (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li> <li>Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". <i>Genomics</i>. 81 (2): 112–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0888-7543%2802%2900008-3">10.1016/S0888-7543(02)00008-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12620389">12620389</a>.</li> <li>Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). <a href="https://doi.org/10.1074%2Fjbc.M312867200">"Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization"</a>. <i>J. Biol. Chem</i>. 279 (21): 22353–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M312867200">10.1074/jbc.M312867200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15031288">15031288</a>.</li> <li>Kho Y, Kim SC, Jiang C, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515085">"A tagging-via-substrate technology for detection and proteomics of farnesylated proteins"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 101 (34): 12479–84. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2004PNAS..10112479K">2004PNAS..10112479K</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.0403413101">10.1073/pnas.0403413101</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515085">515085</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15308774">15308774</a>.</li> <li>Suzuki Y, Yamashita R, Shirota M, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316">"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions"</a>. <i>Genome Res</i>. 14 (9): 1711–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.2435604">10.1101/gr.2435604</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316">515316</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15342556">15342556</a>.</li> <li>Gerhard DS, Wagner L, Feingold EA, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"</a>. <i>Genome Res</i>. 14 (10B): 2121–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.2596504">10.1101/gr.2596504</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">528928</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15489334">15489334</a>.</li> <li>Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". <i>Science</i>. 307 (5715): 1621–5. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2005Sci...307.1621B">2005Sci...307.1621B</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1105776">10.1126/science.1105776</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15761153">15761153</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:39457788">39457788</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. doi:10.1128/mcb.10.4.1793. PMC 362288. PMID 2108320. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC362288" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC362288</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A. 91 (16): 7558–62. Bibcode:1994PNAS...91.7558C. doi:10.1073/pnas.91.16.7558. PMC 44441. PMID 8052619. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44441" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44441</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22800" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22800</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Li W, Han M, Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8). UNITED STATES: 895–900. doi:10.1101/gad.14.8.895. ISSN 0890-9369. PMC 316541. PMID 10783161. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316541" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316541</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Movilla N, Crespo P, Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. 18 (43). ENGLAND: 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073. S2CID 31576945. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>