Interposed nucleus

<h2 id="anatomy">Anatomy</h2>
<p>The interposed nucleus is located in the paravermis of the cerebellum.
</p><p>The interposed nucleus is smaller than the dentate but larger than the fastigial nucleus.
</p>
<h3>Afferents</h3>
<p>The interposed nuclei receives Purkine cell terminal afferents from the paravermal cortex of the <a href="/facts/Spinocerebellum/F5khxWKm">spinocerebellum</a>, as well as collaterals of cerebellar afferents from the <a href="/facts/Restiform_body/h2qeAwen">restiform body</a> and <a href="/facts/Ventral_spinocerebellar_tract/XVWD0Ld3">ventral spinocerebellar tract</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a>
</p><p>It receives input from the ipsilateral <a href="/facts/Posterior_external_arcuate_fibers/XVWD0Ld3">posterior external arcuate fibers</a> (cuneocerebellar tract) and the <a href="/facts/Dorsal_spinocerebellar_tract/XVWD0Ld3">dorsal spinocerebellar tract</a>, which originate in the <a href="/facts/Accessory_cuneate_nucleus/oKQxHMKT">accessory cuneate nucleus</a> and the <a href="/facts/Posterior_thoracic_nucleus/1U7B1bzJ">posterior thoracic nucleus</a>, respectively.
</p>
<h3>Efferents</h3>
<p>Afferents from the interposed nuclei leave the cerebellum through 
<a href="/facts/Superior_cerebellar_peduncle/aEtXMd30">superior cerebellar peduncle</a>. They project to:<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a>
</p>
<ul><li>contralateral (magnocellular division of) the <a href="/facts/Red_nucleus/sKT5R9Cu">red nucleus</a> (→ <a href="/facts/Rubrospinal_tract/1rLYaHPD">rubrospinal tract</a>). The red nucleus is the main target of tne interposed nuclei.</li>
<li>ipsilateral <a href="/facts/Ventral_lateral_nucleus/L2kvoaSh">ventral lateral nucleus of thalamus</a> (→ <a href="/facts/Premotor_cortex/M3H1DWnM">premotor cortex</a> and <a href="/facts/Primary_motor_cortex/DqdaQMNg">primary motor cortex</a> → <a href="/facts/Lateral_corticospinal_tract/cfNoQbW3">lateral corticospinal tract</a>).</li></ul>
<p>The rubrospinal and lateral corticospinal tracts are subsequently involved in control of the distal musculature of the extremities.
</p>
<h2 id="function">Function</h2>
<p>The interposed nucleus modulates muscle stretch reflexes of proximal limb muscles, and is also required in delayed <a href="/facts/Classical_conditioning/ddtohoz3">Pavlovian conditioning</a>.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a>
</p>

<h2 id="external-links">External links</h2>
<ul><li><a href="https://web.archive.org/web/20080405060224/http://www.lib.mcg.edu/edu/eshuphysio/program/section8/8ch6/s8ch6_30.htm">https://web.archive.org/web/20080405060224/http://www.lib.mcg.edu/edu/eshuphysio/program/section8/8ch6/s8ch6_30.htm</a></li>
<li><a href="http://www.neuroanatomy.wisc.edu/cere/text/P5/interp.htm">http://www.neuroanatomy.wisc.edu/cere/text/P5/interp.htm</a></li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>Purves, Dale (2012). Neuroscience (5. ed.). Sunderland, Mass: Sinauer. p. 419. ISBN 9780878936953. <a href="9780878936953" target="_blank">9780878936953</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
<li id="fn:2"><p>Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 292. ISBN 978-1-118-67746-9. <a href="978-1-118-67746-9" target="_blank">978-1-118-67746-9</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li>
<li id="fn:3"><p>Haines, Duane (2018). Fundamental neuroscience for basic and clinical applications (Fifth ed.). Philadelphia, PA: Elsevier. p. 396. ISBN 9780323396325. <a href="9780323396325" target="_blank">9780323396325</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li>
<li id="fn:4"><p>Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 292. ISBN 978-1-118-67746-9. <a href="978-1-118-67746-9" target="_blank">978-1-118-67746-9</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li>
<li id="fn:5"><p>Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 292. ISBN 978-1-118-67746-9. <a href="978-1-118-67746-9" target="_blank">978-1-118-67746-9</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li>
<li id="fn:6"><p>Clark, Robert E.; Zhang, Andrew A.; Lavond, David G. (1992). "Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior". Behavioral Neuroscience. 106 (6): 879–888. doi:10.1037/0735-7044.106.6.879. PMID 1335267. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li>
</ol>

Interposed nucleus open-in-new

Interposed nucleus