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<h2 id="history">History</h2> <p>While chemosensors were first defined in the 1980s, the first example of such a fluorescent chemosensor can be documented to be that of <a href="/facts/Friedrich_Goppelsroeder/KRkWrFmx">Friedrich Goppelsroder</a>, who in 1867, developed a method for the determination/sensing of aluminium ion, using fluorescent ligand/chelate. This and subsequent work by others, gave birth to what is considered as modern analytical chemistry. </p><p>In the 1980s the development of chemosensing was achieved by Anthony W. Czarnik,<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a><a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a><a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> A. Prasanna de Silva<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a><a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a><a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a> and <a href="/facts/Roger_Tsien/TMl3LvSN">Roger Tsien</a>,<a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a><a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a><a class="footnote-ref" id="fnref:35" href="#fn:35"><sup>35</sup></a> in the book <i>Fluorescent Chemosensors for Ion and Molecule Recognition</i>. They focused on the analysis of various types of luminescent probes for ions and molecules in solutions and within biological cells, for real-time applications.<a class="footnote-ref" id="fnref:36" href="#fn:36"><sup>36</sup></a> Czarnik introduced the term ‘chemosensor’ to describe synthetic compounds capable of binding to analytes and providing a reversible signaling response.<a class="footnote-ref" id="fnref:37" href="#fn:37"><sup>37</sup></a> Tsien went on to studying and developing this area of research further by developing and studding fluorescent proteins for applications in biology, such as <a href="/facts/Green_fluorescent_protein/6nWDMhSC">green fluorescent proteins</a> (GFP) for which he was awarded the Nobel Prize in Chemistry in 2008. The work of Lynn Sousa in the late 1970s, on the detection of alkali metal ions, possibly resulting in one of the first examples of the use of supramolecular chemistry in fluorescent sensing design,<a class="footnote-ref" id="fnref:38" href="#fn:38"><sup>38</sup></a> as well as that of <a href="/facts/Jean-Marie_Lehn/5AKDlGbE">J.-M. Lehn</a>, H. Bouas-Laurent and co-workers at Université Bordeaux I, France.<a class="footnote-ref" id="fnref:39" href="#fn:39"><sup>39</sup></a> The development of PET sensing of <a href="/facts/Transition_metal/0slGWoLQ">transition metal</a> ions was developed by L. Fabbrizzi, among others.<a class="footnote-ref" id="fnref:40" href="#fn:40"><sup>40</sup></a> </p><p>In chemosensing, the use of <a href="/facts/Fluorophore/wDWBmYhn">fluorophore</a> connected to the receptor via a covalent spacer is now commonly referred to as fluorophores-spacer-receptor principle. In such systems, the sensing event is normally described as being due to changes in the photophysical properties of the chemosensor systems due to chelation induced enhanced fluorescence (CHEF),<a class="footnote-ref" id="fnref:41" href="#fn:41"><sup>41</sup></a><a class="footnote-ref" id="fnref:42" href="#fn:42"><sup>42</sup></a><a class="footnote-ref" id="fnref:43" href="#fn:43"><sup>43</sup></a> and <a href="/facts/Photoinduced_electron_transfer/5p4Jb7uK">photoinduced electron transfer</a> (PET),<a class="footnote-ref" id="fnref:44" href="#fn:44"><sup>44</sup></a><a class="footnote-ref" id="fnref:45" href="#fn:45"><sup>45</sup></a><a class="footnote-ref" id="fnref:46" href="#fn:46"><sup>46</sup></a> mechanisms. In principle the two mechanisms are based on the same idea; the communication pathway is in the form of a through-space electron transfer from the electron rich receptors to the electron deficient fluorophores (through space). This results in fluorescence quenching (active electron transfer), and the emission from the chemosensor is 'switched off,' for both mechanisms in the absence of the analytes. However, upon forming a host–guest complex between the analyte and receptor, the communication pathway is broken and the fluorescence emission from the fluorophores is enhanced, or 'switched on'. In other words, the fluorescence intensity and quantum yield are enhanced upon analyte recognition. </p> <p>The fluorophores-receptor can also be integrated within the chemosensor. This leads to changes in the emission wavelength, which often results in change in colour. When the sensing event results in the formation of a signal that is visible to the naked eye, such sensors are normally referred to as <a href="/facts/Colorimetric/CuchJjFL">colorimetric</a>. Many examples of colorimetric chemosensors for ions such as <a href="/facts/Fluoride/LpqNMzwa">fluoride</a> have been developed.<a class="footnote-ref" id="fnref:47" href="#fn:47"><sup>47</sup></a> A <a href="/facts/PH_indicator/Levp3yqq">pH indicator</a> can be consider as a colorimetric chemosensors for protons. Such sensors have been developed for other cations, as well as anions and larger organic and biological molecules, such as proteins and carbohydrates.<a class="footnote-ref" id="fnref:48" href="#fn:48"><sup>48</sup></a> </p> <h2 id="design-principles">Design principles</h2> <p>Chemosensors are nano-sized molecules and for application <a href="/facts/In_vivo/kWcWyl6f">in vivo</a> need to be non-toxic. A chemosensor must be able to give a measurable signal in direct response to the analyte recognition. Hence, the signal response is directly related to the magnitude of the sensing event (and, in turn concentration of the analyte). While the signalling moiety acts as a signal transducer, converting the recognition event into an optical response. The recognition moiety is responsible for binding to the analyte in a selective and reversible manner. If the binding sites are 'irreversible chemical reactions,' the indicators are described as fluorescent chemodosimeters, or <a href="/facts/Fluorescent_probes/wDWBmYhn">fluorescent probes</a>. </p><p>An active communication pathway has to be open between the two moieties for the sensor to operate. In colorimetric chemosensors, this usually relies on the receptor and transducer to be structurally integrated. In luminescent/fluorescent chemosensing these two parts can be 'spaced' out or connected with a covalent spacer. The communication pathway is through <a href="/facts/Electron_transfer/BIdASS9R">electron transfer</a> or <a href="/facts/Energy_transfer/wd8PrQM7">energy transfer</a> for such fluorescent chemosensors. The effectiveness of the <a href="/facts/Host%E2%80%93guest_chemistry/q62EsHeX">host–guest</a> recognition between the receptor and the analyte depends on several factors, including the design of the receptor moiety, which is objective is to match as much the nature of the structural nature of the target analyte, as well as the nature of the environment that the sensing event occurs within (e.g. the type of media, i.e. blood, saliva, urine, etc. in biological samples). An extension to this approach is the development of <a href="/facts/Molecular_beacon/InEra73Y">molecular beacons</a>, which are oligonucleotide hybridization probes based on fluorescence signalling where the recognition or the sensing event is communicated through enhancement or reduction in luminescence through the use of <a href="/facts/F%C3%B6rster_resonance_energy_transfer/6dJTdAC6">Förster resonance energy transfer</a> (FRET) mechanism. </p> <h2 id="fluorescent-chemosensing">Fluorescent chemosensing</h2> <p>All chemosensors are designed to contain a signalling moiety and a recognition moiety. These are integrated directly or connected with a short covalent spacer depending on the mechanism involved in the signalling event. The chemosensor can be based on <a href="/facts/Self-assembly/HgFyhl6q">self-assembly</a> of the sensor and the analyte. An example of such a design are the (indicator) displacement assays IDA.<a class="footnote-ref" id="fnref:49" href="#fn:49"><sup>49</sup></a> IDA sensor for anions such as citrate or phosphate ions have been developed whereby these ions can displace a fluorescent indicator in an indicator-host complex.<a class="footnote-ref" id="fnref:50" href="#fn:50"><sup>50</sup></a> The so-called UT taste chip (University of Texas) is a prototype electronic tongue and combines supramolecular chemistry with charge-coupled devices based on silicon wafers and immobilized receptor molecules. </p><p>Most examples of chemosensors for <a href="/facts/Ions/wrbwhF3z">ions</a>, such as those of <a href="/facts/Alkali_metal/IkWbCLk2">alkali metal</a> ions (Li+, Na+, K+, etc.) and <a href="/facts/Alkali_earth_metal/Ts4U5zIe">alkali earth metal</a> ions (Mg2+, Ca2+, etc.) are designed so that the excited state of the fluorophore component of the chemosensor is quenched by an electron transfer when the sensor is not complexed to these ions. No emission is thus observed, and the sensor is sometimes referred to as being 'switched off'. By complexing the sensor with a cation, the conditions for electron transfer are altered so that the quenching process is blocked, and fluorescence emission is 'switched on'. The probability of PET is governed by the overall free energy of the system (the <a href="/facts/Gibbs_free_energy/bvenDuzh">Gibbs free energy</a> ΔG). The driving force for PET is represented by ΔGET, the overall changes in the free energy for the electron transfer can be estimated using the Rehm-Weller equation.<a class="footnote-ref" id="fnref:51" href="#fn:51"><sup>51</sup></a> Electron transfer is distance dependent and decreases with increasing spacer length. Quenching by electron transfer between uncharged species leads to the formation of a radical ion pair. This is sometimes referred to as being the primary electron transfer. The possible electron transfer, which takes place after the PET, is referred to as the 'secondary electron transfer'. Chelation Enhancement Quenching (CHEQ) is the opposite effect seen for CHEF.<a class="footnote-ref" id="fnref:52" href="#fn:52"><sup>52</sup></a> In CHEQ, a reduction is observed in fluorescent emission of the chemosensor in comparison to that seen the originally for the 'free' sensor upon host–guest formation. As electron transfer is directional, such systems have also been described by the PET principle, being described as an enhancement in PET from the receptor to the fluorophore with enhanced degree of quenching. Such an effect has been demonstrated for the sensing of <a href="/facts/Anions/wrbwhF3z">anions</a> such as carboxylates and fluorides.<a class="footnote-ref" id="fnref:53" href="#fn:53"><sup>53</sup></a> </p><p>A large number of examples of chemosensors have been developed by scientists in physical, life and environmental sciences. The advantages of fluorescence emission being 'switched on' from 'off' upon the recognition event enabling the chemosensors to be compared to 'beacons in the night'. As the process is reversible, the emission enhancement is concentration dependent, only becoming 'saturated' at high concentrations (fully bound receptor). Hence, a correlation can be made between luminescence (intensity, quantum yield and in some cases lifetime) and the analyte concentration. Through careful design, and evaluation of the nature of the communication pathway, similar sensors based on the use of 'on-off' switching, or 'on-off-on,' or 'off-on-off' switching have been designed. The incorporation of chemosensors onto surfaces, such as <a href="/facts/Quantum_dots/K5Ytv8Yw">quantum dots</a>, <a href="/facts/Nanoparticles/k8kNxX4E">nanoparticles</a>, or into <a href="/facts/Polymers/eF32E50K">polymers</a> is also a fast-growing area of research.<a class="footnote-ref" id="fnref:54" href="#fn:54"><sup>54</sup></a><a class="footnote-ref" id="fnref:55" href="#fn:55"><sup>55</sup></a><a class="footnote-ref" id="fnref:56" href="#fn:56"><sup>56</sup></a> Fluorescence sensing has also been combined with electrochemical techniques, conferring the advantages of both methods.<a class="footnote-ref" id="fnref:57" href="#fn:57"><sup>57</sup></a> Other examples of chemosensors that work on the principle of switching fluorescent emission either on or off include, <a href="/facts/F%C3%B6rster_resonance_energy_transfer/6dJTdAC6">Förster resonance energy transfer</a> (FRET), internal charge transfer (ICT), twisted internal charge transfer (TICT), metal-based emission (such as in lanthanide luminescence),<a class="footnote-ref" id="fnref:58" href="#fn:58"><sup>58</sup></a><a class="footnote-ref" id="fnref:59" href="#fn:59"><sup>59</sup></a> and <a href="/facts/Excimer/u5gfyLUI">excimer</a> and <a href="/facts/Exciplex/u5gfyLUI">exciplex</a> emission and <a href="/facts/Aggregation-induced_emission/F6DxShgb">aggregation-induced emission</a> (AIE).<a class="footnote-ref" id="fnref:60" href="#fn:60"><sup>60</sup></a><a class="footnote-ref" id="fnref:61" href="#fn:61"><sup>61</sup></a> Chemosensors were one of the first examples of molecules that could result in switching between 'on' or 'off' states through the use of external stimuli and as such can be classed as synthetic <a href="/facts/Molecular_machine/5VvXFnoq">molecular machine</a>, to which the <a href="/facts/Nobel_Prize_in_Chemistry/8Nb8Ajjy">Nobel Prize in Chemistry</a> was awarded to in 2016 to <a href="/facts/Jean-Pierre_Sauvage/LwoDLQLY">Jean-Pierre Sauvage</a>, <a href="/facts/Fraser_Stoddart/WvPH3uuQ">Fraser Stoddart</a> and <a href="/facts/Bernard_L._Feringa/ogBPctGA">Bernard L. Feringa</a>. </p><p>The application of these same design principles used in chemosensing also paved the way for the development of <a href="/facts/Molecular_logic_gates/Hoasat7d">molecular logic gates</a> mimics (MLGMs),<a class="footnote-ref" id="fnref:62" href="#fn:62"><sup>62</sup></a><a class="footnote-ref" id="fnref:63" href="#fn:63"><sup>63</sup></a> being first proposed using PET based fluorescent chemosensors by de Silva and co-workers in 1993.<a class="footnote-ref" id="fnref:64" href="#fn:64"><sup>64</sup></a> Molecules have been made to operate in accordance with <a href="/facts/Boolean_algebra/VkCToAmg">Boolean algebra</a> that performs a logical operation based on one or more physical or chemical inputs. The field has advanced from the development of simple logic systems based on a single chemical input to molecules capable of carrying out complex and sequential operations. </p> <h2 id="applications-of-chemosensors">Applications of Chemosensors</h2> <p>Chemosensors have been incorporated through surface functionalization onto particles and beads such as metal based <a href="/facts/Nanoparticles/k8kNxX4E">nanoparticles</a>, <a href="/facts/Quantum_dot/K5Ytv8Yw">quantum dots</a>, carbon-based particles and into <a href="/facts/Soft_matter/62NTslbq">soft materials</a> such as polymers to facilitate their various applications. </p><p>Other receptors are sensitive not to a specific molecule but to a molecular compound class, these chemosensors are used in array- (or microarray) based sensors. Array-based sensors utilize analyte binding by the differential receptors. One example is the grouped analysis of several tannic acids that accumulate in ageing Scotch whisky in oak barrels. The grouped results demonstrated a correlation with the age but the individual components did not. A similar receptor can be used to analyze tartrates in wine. </p><p>The application of chemosensors in cellular imaging is particularly promising as most biological process are now monitored by using imaging technologies such as <a href="/facts/Confocal_microscopy/Gh7pY9Cl">confocal fluorescence</a> and <a href="/facts/Super-resolution_microscopy/CeSvdSIQ">super resolution microscopy</a>, among others. </p> <p>The compound saxitoxin is a neurotoxin found in shellfish and a chemical weapon. An experimental sensor for this compound is again based on PET. Interaction of saxitoxin with the sensor's crown ether moiety kills its PET process towards the fluorophore and fluorescence is switched from off to on.<a class="footnote-ref" id="fnref:65" href="#fn:65"><sup>65</sup></a> The unusual boron moiety causes the fluorescence to occur in the visible light part of the electromagnetic spectrum. </p><p>Chemosensors also have applications in chemistry, biochemistry, immunology, physiology, medicine and landmine detection.<a class="footnote-ref" id="fnref:66" href="#fn:66"><sup>66</sup></a> In 2003, Czarnik outlined a way to use chemosensors to track glucose levels in diabetic patients which, along with contributions from others, created an FDA-approved implantable continuous glucose monitor.<a class="footnote-ref" id="fnref:67" href="#fn:67"><sup>67</sup></a><a class="footnote-ref" id="fnref:68" href="#fn:68"><sup>68</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Boronic_acid/BtN4s5B4">Boronic acids in supramolecular chemistry: Saccharide recognition</a></li> <li><a href="/facts/Host%E2%80%93guest_chemistry/q62EsHeX">Host–guest chemistry</a></li> <li><a href="/facts/Molecular_machine/5VvXFnoq">Molecular machine</a></li> <li><a href="/facts/Molecular_recognition/a3QRaYN4">Molecular recognition</a></li> <li><a href="/facts/Microwave_chemistry_sensor/TDlY3vIj">Microwave chemistry sensor</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Wu, Di; Sedgwick, Adam C.; Gunnlaugsson, Thorfinnur; Akkaya, Engin U.; Yoon, Juyoung; James, Tony D. 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