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Ultrashort pulse laser
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<h2 id="use-in-pathogen-inactivation">Use in pathogen inactivation</h2> <p>Tsen and colleagues developed a <a href="/facts/SEPHODIS/QAVTDEnb">SEPHODIS</a> (selective photonic disinfection) technology using an ultrashort pulse laser to kill viruses including <a href="/facts/HIV/ulY2rgzu">HIV</a>, <a href="/facts/Influenza_virus/3gqqgCMp">influenza virus</a>, and <a href="/facts/Norovirus/nqkVRj8I">noroviruses</a>.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> The technique appears to damage viral capsids while preserving other proteins and biological materials, although these claims have been disputed elsewhere.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> The ultrashort pulse laser treatment may have potential applications in the disinfection of medicines, in the production of inactivated vaccines,<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> and in the possible future treatment of blood-borne viral infections from agents such as <a href="/facts/HIV/ulY2rgzu">HIV</a> and <a href="/facts/Ebola_virus/BneCtC2m">Ebola virus</a>.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Optical_parametric_amplification/brn6XMuy">Optical parametric amplification</a></li> <li><a href="/facts/List_of_laser_articles/pV4G2xvW">List of laser articles</a></li></ul> <h2 id="external-links">External links</h2> <ul><li>Ultrafast Lasers: <a href="http://people.bath.ac.uk/vkv23/English/UltrafastLasers.htm">An animated guide to the functioning of Ti:Sapphire lasers and amplifiers.</a></li> <li>Tsen, Kong-Thon (2009). "Selective destruction of viruses with ultrashort pulsed lasers". <i>SPIE Newsroom</i>. <a href="/facts/CiteSeerX_(identifier)/SceDmd3c">CiteSeerX</a> <a href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.506.3551">10.1.1.506.3551</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1117%2F2.1200911.1845">10.1117/2.1200911.1845</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Weiss, Peter (November 12, 2002). "Hot flashes, cold cuts: ultrafast lasers give power tools a new edge". Science News. Society for Science & the Public. <a href="http://www.thefreelibrary.com/Hot+flashes%2c+cold+cuts%3a+ultrafast+lasers+give+power+tools+a+new+edge-a094774392" target="_blank">http://www.thefreelibrary.com/Hot+flashes%2c+cold+cuts%3a+ultrafast+lasers+give+power+tools+a+new+edge-a094774392</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Paschotta, Rüdiger. "Ultrashort pulses". Encyclopedia of Laser Physics and Technology. RP Photonics. Retrieved Oct 21, 2014. <a href="https://www.rp-photonics.com/ultrashort_pulses.html" target="_blank">https://www.rp-photonics.com/ultrashort_pulses.html</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Christensen, Bill (November 19, 2007). "Laser Zaps Viruses". Live Science. <a href="http://www.livescience.com/4719-laser-zaps-viruses.html" target="_blank">http://www.livescience.com/4719-laser-zaps-viruses.html</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Laser treatment 'could kill HIV'". BBC News. November 6, 2007. <a href="http://news.bbc.co.uk/2/hi/health/7071750.stm" target="_blank">http://news.bbc.co.uk/2/hi/health/7071750.stm</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Won, Rachel (2010). "Biophotonics: Selective disinfection". Nature Photonics. 4 (3): 136. Bibcode:2010NaPho...4..136W. doi:10.1038/nphoton.2010.10. <a href="https://doi.org/10.1038%2Fnphoton.2010.10" target="_blank">https://doi.org/10.1038%2Fnphoton.2010.10</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Tsen, Shaw-Wei D; Wu, Tzyy; Kiang, Juliann G; Tsen, Kong-Thon (2012). "Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation". Journal of Biomedical Science. 19 (1): 62. doi:10.1186/1423-0127-19-62. PMC 3495397. PMID 22768792. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495397" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495397</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Wigle, Jeffrey C.; Holwitt, Eric A.; Estlack, Larry E.; Noojin, Gary D.; Saunders, Katharine E.; Yakovlev, Valdislav V.; Rockwell, Benjamin A. (2014). "No effect of femtosecond laser pulses on M13,E. coli, DNA, or protein". Journal of Biomedical Optics. 19 (1): 15008. Bibcode:2014JBO....19a5008W. doi:10.1117/1.JBO.19.1.015008. PMID 24474502. S2CID 20774027. <a href="https://doi.org/10.1117%2F1.JBO.19.1.015008" target="_blank">https://doi.org/10.1117%2F1.JBO.19.1.015008</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>"Tsen Technologies". Tsen Technologies (Company). <a href="http://www.tsentechnologies.com" target="_blank">http://www.tsentechnologies.com</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Tsen, Shaw-Wei (2016). Selective photonic disinfection: A ray of hope in the war against pathogens. San Rafael, CA: Morgan & Claypool. ISBN 978-1681743523. <a href="978-1681743523" target="_blank">978-1681743523</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> </ol>