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Sciatic nerve
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<h2 id="structure">Structure</h2> <p>In humans, the sciatic nerve is formed from the L4 to S3 segments of the sacral plexus, a collection of nerve fibres that emerge from the <a href="/facts/Sacrum/CTFnjSm0">sacral</a> part of the <a href="/facts/Spinal_cord/XbWLr917">spinal cord</a>. The lumbosacral trunk from the L4 and L5 roots descends between the sacral promontory and ala, and the S1 to S3 roots emerge from the ventral sacral foramina. These nerve roots unite to form a single nerve in front of the <a href="/facts/Piriformis_muscle/H7PntRQb">piriformis muscle</a>. The nerve passes beneath the piriformis and through the <a href="/facts/Greater_sciatic_foramen/c26g5kFs">greater sciatic foramen</a>, exiting the pelvis. <a class="footnote-ref" id="fnref:1" href="#fn:1"><sup>1</sup></a>: 422–4 From here, it travels down the posterior thigh to the <a href="/facts/Popliteal_fossa/mcl1blqQ">popliteal fossa</a>. The nerve travels in the <a href="/facts/Posterior_compartment_of_thigh/bSAKNKDp">posterior compartment of the thigh</a> behind (superficial to) the <a href="/facts/Adductor_magnus_muscle/4fo8Mcu2">adductor magnus muscle</a> and is itself in front of (deep to) the long head of the <a href="/facts/Biceps_femoris_muscle/MaaDJeD8">biceps femoris muscle</a>. At the popliteal fossa, the nerve divides into its two branches: <a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a>: 532 </p> <ul><li>The <a href="/facts/Tibial_nerve/D5NXIgJb">tibial nerve</a>, which travels down the <a href="/facts/Posterior_compartment_of_the_leg/1rpodbRX">posterior compartment of the leg</a> into the foot</li> <li>The <a href="/facts/Common_fibular_nerve/02JmSfyP">common fibular nerve</a> (also called the <a href="/facts/Common_peroneal_nerve/02JmSfyP">common peroneal nerve</a>), which travels down the <a href="/facts/Anterior_compartment_of_leg/oKD0C8zN">anterior</a> and <a href="/facts/Lateral_compartment_of_leg/rVLUPYTd">lateral compartments of the leg</a> into the foot</li></ul> <p>The sciatic nerve is the largest nerve in the human body.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a>: 422–4 <a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h3>Development</h3> <h2 id="function">Function</h2> <p>The sciatic nerve supplies sensation to the <a href="/facts/Skin/4havlLzG">skin</a> of the <a href="/facts/Foot/gnX2RTz7">foot</a>, as well as the entire lower leg (except for its inner side). Sensation to skin to the sole of the foot is provided by the <a href="/facts/Tibial_nerve/D5NXIgJb">tibial nerve</a>, and the lower leg and upper surface of the foot via the <a href="/facts/Common_fibular_nerve/02JmSfyP">common fibular nerve</a>.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a>: 422–4 </p><p>The sciatic nerve also innervates muscles. In particular:<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a>: 422–4 </p> <ul><li>Via the <a href="/facts/Tibial_nerve/D5NXIgJb">tibial nerve</a>, the muscles in the <a href="/facts/Posterior_compartment_of_the_leg/1rpodbRX">posterior compartment of the leg</a> and sole of the foot (plantar aspect).<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a></li> <li>Via the <a href="/facts/Common_fibular_nerve/02JmSfyP">common fibular nerve</a>, the muscles in the <a href="/facts/Anterior_compartment_of_the_leg/oKD0C8zN">anterior</a> and <a href="/facts/Lateral_compartment_of_the_leg/rVLUPYTd">lateral compartments</a> of the leg.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a></li></ul> <h2 id="clinical-significance">Clinical significance</h2> <h3>Sciatica</h3> <p class="note">Main article: <a href="/facts/Sciatica/yux9tHrW">Sciatica</a></p> <p>Pain caused by compression or irritation of the sciatic nerve by a problem in the lower back is called <a href="/facts/Sciatica/yux9tHrW">sciatica</a>. Common causes of sciatica include the following lower back and hip conditions: <a href="/facts/Spinal_disc_herniation/T4zvLoub">spinal disc herniation</a>, <a href="/facts/Degenerative_disc_disease/A9Lu3RK8">degenerative disc disease</a>, <a href="/facts/Lumbar_spinal_stenosis/KsAqT4Tv">lumbar spinal stenosis</a>, <a href="/facts/Spondylolisthesis/FuzTuhkd">spondylolisthesis</a>, and <a href="/facts/Piriformis_syndrome/430RRw21">piriformis syndrome</a>.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> Other acute causes of sciatica include <a href="/facts/Cough/mqyhR6zj">coughing</a>, muscular <a href="/facts/Hypertension/wlAvBfcf">hypertension</a>, and <a href="/facts/Sneezing/Nxj3dJbc">sneezing</a>.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> </p> <h3>Injury</h3> <p>A sciatic nerve injury occurs between 0.5% and 2.0% of the time during a <a href="/facts/Hip_replacement/YcdY8GGC">hip</a> replacement. <a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> Sciatic nerve palsy is a complication of total hip arthroplasty with an incidence of 0.2% to 2.8% of the time, or with an incidence of 1.7% to 7.6% following revision. <a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> Following the procedure, in rare cases, a screw, broken piece of trochanteric wire, fragment of <a href="/facts/Methyl_methacrylate/dRnCjAUC">methyl methacrylate</a> bone cement, or Burch-Schneider antiprofusio cage can impinge on the nerve; this can cause sciatic nerve <a href="/facts/Palsy/U32D9N4p">palsy</a>, which may resolve after the fragment is removed and the nerve is freed. The nerve can be surrounded by oxidised, regenerated cellulose to prevent further scarring. Sciatic nerve palsy can also result from severe <a href="/facts/Spinal_stenosis/VejAI6nL">spinal stenosis</a> following the procedure, which can be addressed by <a href="/facts/Spinal_decompression/Rc9wEv4p">spinal decompression</a> surgery.<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a><a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> It is unclear if <a href="/facts/Inversion_therapy/e3tnAhEe">inversion therapy</a> is able to decompress the sacral vertebrae; it may only work on the lumbar aspects of the sciatic nerves. </p><p>A sciatic nerve injury may also occur from improperly performed injections into the buttock, and may result in sensory loss.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a>: 66 </p> <h3>Other disease</h3> <p>Bernese periacetabular <a href="/facts/Osteotomy/NKTRtyha">osteotomy</a> resulted in major nerve deficits in the sciatic or femoral nerves in 2.1% of 1760 patients, of whom approximately half experienced complete recovery within a mean of 5.5 months.<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a> </p><p>Sciatic nerve exploration can be done by <a href="/facts/Endoscopy/L4V1fGPN">endoscopy</a> in a <a href="/facts/Minimally_invasive/Lm4xbpYG">minimally invasive</a> procedure to assess lesions of the nerve.<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> Endoscopic treatment for sciatic nerve entrapment has been investigated in <a href="/facts/Deep_gluteal_syndrome/430RRw21">deep gluteal syndrome</a>. Patients were treated with sciatic nerve decompression by <a href="/facts/Segmental_resection/Lsvle5Cs">resection</a> of fibrovascular scar bands, <a href="/facts/Piriformis/H7PntRQb">piriformis</a> tendon release, <a href="/facts/Obturator_internus/YK4TGb3j">obturator internus</a>, or <a href="/facts/Quadratus_femoris/zqs5r9IT">quadratus femoris</a>, or by <a href="/facts/Hamstring/svAuCSev">hamstring</a> tendon scarring. <a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a> </p> <h3>Anaesthetic</h3> <p>Signals from the sciatic nerve and its branches can be blocked, in order to interrupt the transmission of <a href="/facts/Pain_signal/70E79oUn">pain signals</a> from the innervation area, by performing a <a href="/facts/Local_anesthetic_nerve_block/Bq5FNvbd">regional nerve blockade</a> called a <a href="/facts/Sciatic_nerve_block/Lv9eUUUR">sciatic nerve block</a>. </p> <h2 id="society-and-culture">Society and culture</h2> <p>According to <a href="/facts/Jewish_law/RLYnjLBJ">Jewish law</a>, the sciatic nerve (<a href="/facts/Hebrew/hqKCSy9d">Hebrew</a>: <a href="/facts/Gid_hanasheh/ID89gNS6">Gid hanasheh</a>) may not be eaten by Jews to commemorate <a href="/facts/Jacob/z6lKzP3W">Jacob</a>'s injury in his struggle with an <a href="/facts/Angel/67pduP9P">angel</a>.<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a> </p> <h2 id="additional-images">Additional images</h2> <h2 id="see-also">See also</h2> <p class="note">This article uses <a href="/facts/Anatomical_terminology/n3IASQlr">anatomical terminology</a>.</p> <ul><li><a href="/facts/Lesser_sciatic_notch/INPe0Fe7">Lesser sciatic notch</a></li> <li><a href="/facts/Greater_sciatic_notch/Pd2NCrth">Greater sciatic notch</a></li> <li><a href="/facts/Lumbosacral_plexus/34UDETJf">Lumbosacral plexus</a></li> <li><a href="/facts/Sacral_plexus/6HVyBl1m">Sacral plexus</a></li> <li><a href="/facts/Tibial_nerve/D5NXIgJb">Tibial nerve</a></li> <li><a href="/facts/Common_peroneal_nerve/02JmSfyP">Common peroneal nerve</a></li> <li><a href="/facts/Peripheral_nervous_system/KjVpVnHU">Peripheral nervous system</a></li> <li><a href="/facts/Sciatica/yux9tHrW">Sciatica</a></li> <li><a href="/facts/Spinal_disc_herniation/T4zvLoub">Spinal disc herniation</a></li> <li><a href="/facts/Piriformis_syndrome/430RRw21">Piriformis syndrome</a></li> <li><a href="/facts/Deep_gluteal_syndrome/430RRw21">Deep gluteal syndrome</a></li></ul> <h2 id="notes">Notes</h2> <p> <i>This article incorporates text in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a> from <a href="https://archive.org/stream/anatomyofhumanbo1918gray#page/960/mode/2up">page 960</a> of the 20th edition of</i> <a href="/facts/Gray%27s_Anatomy/dLMyjr2p">Gray's Anatomy</a> <i>(1918)</i> </p> <h2 id="external-links">External links</h2> <ul><li><a href="http://www.wheelessonline.com/ortho/sciatic_nerve">Sciatic nerve</a> at the <a href="/facts/Duke_University_Health_System/XBd4cbPM">Duke University Health System</a>'s Orthopedics program</li> <li><a href="/facts/MedlinePlus/bl3BjdjK">MedlinePlus Image</a> <i><a href="https://medlineplus.gov/ency/imagepages/19503.htm">19503</a></i></li> <li><a href="http://www.wesnorman.com/pelvis.htm">pelvis</a> at The Anatomy Lesson by Wesley Norman (Georgetown University) (<i><a href="http://www.wesnorman.com/Images/pelvicnerves.jpg">pelvicnerves</a></i>)</li> <li><a href="http://www.wesnorman.com/glutealregion.htm">glutealregion</a> at The Anatomy Lesson by Wesley Norman (Georgetown University) (<i><a href="http://www.wesnorman.com/Images/glutealner.jpg">glutealner</a></i>)</li> <li><a href="http://www.norcc.org/wiki/Sciatica">Sciatica and the Sciatic Nerve</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. ISBN 978-0-8089-2306-0. <a href="978-0-8089-2306-0" target="_blank">978-0-8089-2306-0</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. ISBN 978-0-8089-2306-0. <a href="978-0-8089-2306-0" target="_blank">978-0-8089-2306-0</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. ISBN 978-0-8089-2306-0. <a href="978-0-8089-2306-0" target="_blank">978-0-8089-2306-0</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"What Is Sciatica?". WebMD. Medically Reviewed by Tyler Wheeler. Retrieved 12 May 2022.{{cite web}}: CS1 maint: others (link) <a href="https://www.webmd.com/back-pain/what-is-sciatica" target="_blank">https://www.webmd.com/back-pain/what-is-sciatica</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Winn, Richard; Youmans, Julian (2017). Youmans & Winn neurological surgery. Elsevier. ISBN 9780323287821. <a href="9780323287821" target="_blank">9780323287821</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. ISBN 978-0-8089-2306-0. <a href="978-0-8089-2306-0" target="_blank">978-0-8089-2306-0</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. ISBN 978-0-8089-2306-0. <a href="978-0-8089-2306-0" target="_blank">978-0-8089-2306-0</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Namely the flexor hallicus longus, flexor digitorum longus, tibialis posterior and popliteus of the deep part of the compartment, and the gastrocnemius, soleus and plantaris of the superficial part of the compartment. <a href="/wiki/Flexor_hallicus_longus" target="_blank">/wiki/Flexor_hallicus_longus</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Namely the tibialis anterior, extensor hallucis longus, extensor digitorum longus, and fibularis tertius (peroneus tertius) of the anterior compartment, and the Fibularis longus and brevis of the lateral compartment. <a href="/wiki/Tibialis_anterior_muscle" target="_blank">/wiki/Tibialis_anterior_muscle</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>"Sciatica - Topic Overview". WebMD. 21 July 2010. Retrieved 23 April 2012. <a href="http://www.webmd.com/back-pain/tc/sciatica-topic-overview" target="_blank">http://www.webmd.com/back-pain/tc/sciatica-topic-overview</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>"What is sciatica: What causes sciatica?". MedicalBug. 11 April 2012. Retrieved 23 April 2012. <a href="http://www.medicalbug.com/what-is-sciatica-what-causes-sciatica/" target="_blank">http://www.medicalbug.com/what-is-sciatica-what-causes-sciatica/</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Stiehl JB, Stewart WA (1998). "Late sciatic nerve entrapment following pelvic plate reconstruction in total hip arthroplasty". J Arthroplasty. 13 (5): 586–8. doi:10.1016/s0883-5403(98)90060-2. PMID 9726326. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Alessandro Bistolfi; et al. (2011). "Operative Management of Sciatic Nerve Palsy due to Impingement on the Metal Cage after Total Hip Revision: Case Report". Case Rep Med. 2011: 1–3. doi:10.1155/2011/830296. PMC 3163138. PMID 21876701. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163138" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163138</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Stiehl JB, Stewart WA (1998). "Late sciatic nerve entrapment following pelvic plate reconstruction in total hip arthroplasty". J Arthroplasty. 13 (5): 586–8. doi:10.1016/s0883-5403(98)90060-2. PMID 9726326. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>Abitbol JJ, Gendron D, Laurin CA, Beaulieu MA (1990). "Gluteal nerve damage following total hip arthroplasty. A prospective analysis". J Arthroplasty. 5 (4): 319–22. doi:10.1016/s0883-5403(08)80090-3. PMID 2290087.is cited by Stiehl and Stewart for the 0.5-2.0% figure. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6. <a href="978-0-7216-2921-6" target="_blank">978-0-7216-2921-6</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>Sierra RJ, Beaule P, Zaltz I, Millis MB, Clohisy JC, Trousdale RT (2012). "Prevention of nerve injury after periacetabular osteotomy". Clin. Orthop. Relat. Res. 470 (8): 2209–19. doi:10.1007/s11999-012-2409-1. PMC 3392380. PMID 22684336. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392380" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392380</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Mobbs RJ, Teo C (2004). "Endoscopic-assisted sciatic nerve exploration". Minim Invasive Neurosurg. 47 (3): 178–80. doi:10.1055/s-2004-818488. PMID 15343436. S2CID 260241055. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Martin HD, Shears SA, Johnson JC, Smathers AM, Palmer IJ (2011). "The endoscopic treatment of sciatic nerve entrapment/deep gluteal syndrome". Arthroscopy. 27 (2): 172–81. doi:10.1016/j.arthro.2010.07.008. PMID 21071168. <a href="http://www.arthroscopyjournal.org/article/S0749806310006870/pdf" target="_blank">http://www.arthroscopyjournal.org/article/S0749806310006870/pdf</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>Goldberger, Moshe. "1: Not to Eat the Gid HaNasheh". The First Prohibitions. Retrieved 10 March 2014. <a href="http://www.torah.org/learning/mitzvah/firstprohibition.html" target="_blank">http://www.torah.org/learning/mitzvah/firstprohibition.html</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> </ol>