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Fas ligand
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<h2 id="structure">Structure</h2> <p>Fas ligand operates as a type-II <a href="/facts/Transmembrane_protein/0vQH5HrM">transmembrane protein</a> through its membership in the <a href="/facts/Tumor_necrosis_factor/5G0MA0dG">tumor necrosis factor</a> (TNF) superfamily. It operates under its official names FasL and CD95L or Apo-1L. With 281 amino acids the protein forms three identifiable structural components by including an intracellular <a href="/facts/N-terminal/yKYpuaBJ">N-terminal</a> domain then follows with one transmembrane domain that leads to an extracellular <a href="/facts/C-terminal/ws4scHgT">C-terminal</a> domain. The FasL binding activity rests in its extracellular domain which triggers Fas receptor engagement to start apoptotic signals.<a class="footnote-ref" id="fnref:1" href="#fn:1"><sup>1</sup></a><a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> </p> <p>The biological existence of FasL occurs through two different forms which are membrane-bound and soluble. The membrane-bound protein exists as three identical subunits which serve as both the receptor activation mechanism and primary factor for complete apoptotic functionality.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> The soluble form of FasL (sFasL) results from metalloproteinase-mediated proteolytic cleavage of the membrane-bound FasL particularly through <a href="/facts/MMP7/tCYGv7mV">matrix metalloproteinase-7</a> (MMP-7).<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> Despite its ability to attach with Fas receptors the soluble form of FasL possesses much less potency for <a href="/facts/Apoptosis/8dVzSm4y">apoptosis</a> induction while researchers assume it functions to modify immune system activities.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p><p>The apoptosis-relevant domain known as TNF homology domain (THD) enables FasL structural features common to other members of TNF family protein ligands to promote both receptor interaction and trimer formation. The structural properties enable the ligand to fulfill its biological role and its selective killing of Fas-expressing cells.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="function">Function</h2> <p>As the principal goal of Fas ligand exists to trigger target cell apoptotic processes by binding to its receptor Fas (CD95) which is present on numerous cell types.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> The Fas receptor changes from its <a href="/facts/Monomer/Gw3CltMb">monomeric</a> state to a trimeric form after ligand binding and attracts the <a href="/facts/FADD/kaRWCrCt">FADD</a> (Fas-associated death domain) protein.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> The recruitment of procaspase-8 occurs through FADD until the death-inducing signaling complex (DISC) is formed. The DISC complex triggers a succession of activated caspases that perform substrate cleavage activities resulting in apoptotic cellular break down.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p><p>FasL-mediated apoptosis plays several important biological functions in human physiology. The peripheral immune system depends on FasL to function properly because it removes lymphocytes that attack themselves.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> The immune response contraction phase is dependent on FasL because this molecule acts as a key factor to eliminate activated lymphocytes after pathogen elimination. FasL enables homeostatic maintenance of tissues by causing elimination of virus-infected cells and cells with transformed potential.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a><a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> </p><p>The apoptosis-related role of FasL has been identified while scientists have also discovered that FasL activates both <a href="/facts/NF-%25CE%25BAB/qcpt5vuQ">NF-κB</a> and <a href="/facts/Mitogen-activated_protein_kinase/YdDS5KkU">MAPK</a> signaling pathways that support cell survival conditions and cause cellular inflammation and proliferation.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a><a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> The Fas-FasL signaling system operates as apoptotic and non-apoptotic roles because of environmental elements. </p> <h3>Immune privilege</h3> <p>Fas ligand is a principal mediator of immune privilege, an immunoregulatory process found in some tissues to shield them from immune-mediated destruction. Immune-privileged sites are the eye, brain, testis, and placenta. These tissues express FasL constitutively or upon local immune stimulation to kill invading Fas-expressing lymphocytes by apoptosis.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> </p><p>In the eye, for instance, FasL expression by the <a href="/facts/Corneal_endothelium/N3rDqRXr">corneal endothelium</a> and <a href="/facts/Retinal_pigment_epithelium/VTR8z8LW">retinal pigment epithelium</a> is responsible for immune tolerance of the transplanted tissues and minimizing immune rejection.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a> Likewise, the testis and placenta employ FasL to shield the germ cells and the developing fetus, respectively, against potentially damaging immune attack. </p><p>The function of FasL in immune privilege is not purely protective; anomalous or inordinate FasL expression by these tissues potentially can lead to pathological inflammation or tissue injury.<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a> Nevertheless, FasL remains an important aspect of immune evasion, both physiologically as well as pathologically, such as in tumors that simulate the conditions of immune privilege. </p> <h3>Receptor</h3> <ul><li>FasR: The Fas receptor (FasR), also known as CD95, is one of the most studied members of the death receptor family. The gene encoding FasR is located on <a href="/facts/Chromosome_10/moVH2LEH">chromosome 10</a> in humans and chromosome 19 in mice.<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> Studies have identified up to eight splice variants, which give rise to seven different isoforms of the protein. Many of these isoforms are linked to rare <a href="/facts/Haplotype/0W2SEdu4">haplotypes</a>, often associated with disease states. The apoptosis-inducing Fas receptor, referred to as isoform 1, is a <a href="/facts/Type_I_transmembrane_protein/2fEb1WCB">type I transmembrane protein</a> that consists of three cysteine-rich pseudorepeats, a transmembrane domain, and an intracellular death domain.<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a></li> <li>DcR3: <a href="/facts/Decoy_receptor_3/uc3othh1">Decoy receptor 3</a> (DcR3) is a recently discovered decoy receptor in the tumor necrosis factor (TNF) superfamily. It binds to FasL, LIGHT, and TL1A. DcR3 is a soluble receptor that lacks signal transduction capabilities, hence its name "decoy." It functions to inhibit FasR-FasL interactions by competitively binding to membrane-bound Fas ligand, thereby neutralizing its activity.<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a><a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a></li></ul> <h2 id="expression">Expression</h2> <p>Active cytotoxic T lymphocytes (CTLs) and <a href="/facts/Natural_killer_cell/A3THWxrJ">natural killer</a> (NK) cells mainly express Fas ligand to use this molecule for target apoptosis regulation through their immune effector functions.<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a><a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a> Fas ligand localizes to regions of immune privilege including eye and testes and placenta to get rid of invading immune cells thus establishing immunological tolerance.<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a> </p><p>The regulatory processes for FasL expression function at both transcriptional and post-transcriptional phases. The gene expression of FasL gets controlled by cytokines that include interleukin-2 (IL-2) and <a href="/facts/Tumor_necrosis_factor-alpha/7NWNIaCb">tumor necrosis factor-alpha</a> (TNF-α) as well as <a href="/facts/Interferon_gamma/r51CXVph">interferon-gamma</a> (IFN-γ).<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a> The expression of FasL in immune cells gets significantly enhanced through exposure to stress signals as well as antigen stimulation combined with T cell receptor activation.<a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a> </p> <h2 id="regulation">Regulation</h2> <p>The expression and function of Fas ligand are regulated tightly at several levels to provide for correct immune responses and avoid tissue injury. </p> <h3>Transcriptional and post-transcriptional control</h3> <p>FasL gene expression is controlled by transcription factors like <a href="/facts/NFAT/u6cmVoaI">NFAT</a> (nuclear factor of activated T cells), AP-1 (activator protein 1), and NF-κB. These transcription factors are activated upon T cell receptor (TCR) stimulation, cytokine signaling, and cellular stress.<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a> Post-transcriptionally, the stability of FasL mRNA and translation may be controlled by <a href="/facts/RNA-binding_protein/qTPTczLC">RNA-binding proteins</a> and <a href="/facts/MicroRNA/UjqbYYpe">microRNAs</a>.<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a> </p> <h3>Proteolytic cleavage</h3> <p>The cleavage of membrane-bound FasL into its soluble form is facilitated by metalloproteinases, such as matrix metalloproteinase-7 (MMP-7). Cleavage diminishes the apoptotic activity of FasL and can serve to suppress immune responses or rechannel Fas signaling into non-apoptotic pathways.<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> </p> <h3>Intracellular modulators</h3> <p>In the cell, multiple regulatory proteins influence the downstream Fas signaling pathway. c-FLIP, a well-established <a href="/facts/Caspase_8/lm7NeEHw">caspase-8</a> recruitment inhibitor at the DISC and thus preventing apoptosis, is also present.<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a> Protein components in FasL ubiquitination and degradation help regulate its function to fine-tune it.<a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a> </p> <h2 id="signaling-pathways">Signaling pathways</h2> <p>When it binds to its receptor, FasL triggers the classical extrinsic apoptotic pathway but also induces a number of non-apoptotic signal transduction cascades based on the cellular context and availability of intracellular regulatory proteins.<a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a> </p> <h3>Apoptotic signaling</h3> <p>The apoptotic pathway starts with trimerization of Fas receptor and recruitment of the adaptor molecule FADD. FADD brings about the recruitment of procaspase-8, resulting in the formation of the death-inducing signaling complex (DISC). Activated caspase-8 subsequently activates downstream effector caspases, such as caspase-3, to cause apoptosis through DNA fragmentation, cell shrinkage, and membrane blebbing.<a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a> </p> <h3>Non-apoptotic signaling</h3> <p>FasL-Fas interaction in certain cell types activates non-apoptotic pathways. These are: </p> <ul><li>NF-κB pathway: Regulates the induction of pro-inflammatory cytokines and anti-apoptotic proteins.<a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a></li> <li>MAPK pathways: Regulate cell proliferation, differentiation, and survival.<a class="footnote-ref" id="fnref:35" href="#fn:35"><sup>35</sup></a> The result of Fas signaling—either apoptotic or non-apoptotic—is governed by the levels of expression of regulatory proteins including c-FLIP, inhibitor of apoptosis proteins (IAPs), and cellular surroundings (e.g., availability of survival factors or immune cytokines). Its dual capability renders Fas signaling versatile and complex in immune modulation and disease.<a class="footnote-ref" id="fnref:36" href="#fn:36"><sup>36</sup></a> </li></ul> <h2 id="interactions">Interactions</h2> <p>Fas ligand has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/Caspase_8/lm7NeEHw">CASP8</a>,<a class="footnote-ref" id="fnref:37" href="#fn:37"><sup>37</sup></a><a class="footnote-ref" id="fnref:38" href="#fn:38"><sup>38</sup></a></li> <li><a href="/facts/Ezrin/AGRXyzLQ">EZR</a>,<a class="footnote-ref" id="fnref:39" href="#fn:39"><sup>39</sup></a><a class="footnote-ref" id="fnref:40" href="#fn:40"><sup>40</sup></a></li> <li><a href="/facts/FADD/kaRWCrCt">FADD</a>,<a class="footnote-ref" id="fnref:41" href="#fn:41"><sup>41</sup></a><a class="footnote-ref" id="fnref:42" href="#fn:42"><sup>42</sup></a></li> <li><a href="/facts/FNBP1/y7mg88up">FNBP1</a>,<a class="footnote-ref" id="fnref:43" href="#fn:43"><sup>43</sup></a></li> <li><a href="/facts/FYN/Vap0K3Vn">FYN</a>,<a class="footnote-ref" id="fnref:44" href="#fn:44"><sup>44</sup></a><a class="footnote-ref" id="fnref:45" href="#fn:45"><sup>45</sup></a></li> <li><a href="/facts/Fas_receptor/nohCF0m9">FAS</a>,<a class="footnote-ref" id="fnref:46" href="#fn:46"><sup>46</sup></a><a class="footnote-ref" id="fnref:47" href="#fn:47"><sup>47</sup></a><a class="footnote-ref" id="fnref:48" href="#fn:48"><sup>48</sup></a><a class="footnote-ref" id="fnref:49" href="#fn:49"><sup>49</sup></a></li> <li><a href="/facts/Grb2/uaFzqAbM">Grb2</a>,<a class="footnote-ref" id="fnref:50" href="#fn:50"><sup>50</sup></a><a class="footnote-ref" id="fnref:51" href="#fn:51"><sup>51</sup></a></li> <li><a href="/facts/PACSIN2/WL5RtuMf">PACSIN2</a>,<a class="footnote-ref" id="fnref:52" href="#fn:52"><sup>52</sup></a> and</li> <li><a href="/facts/TNFRSF6B/uc3othh1">TNFRSF6B</a>.<a class="footnote-ref" id="fnref:53" href="#fn:53"><sup>53</sup></a><a class="footnote-ref" id="fnref:54" href="#fn:54"><sup>54</sup></a><a class="footnote-ref" id="fnref:55" href="#fn:55"><sup>55</sup></a></li></ul> <h2 id="clinical-significance">Clinical significance</h2> <p>FasL-Fas signaling axis is a central regulator of immune function, and its dysregulation has been implicated in the pathogenesis of many disease processes. Its clinical significance ranges across autoimmune diseases, cancer immunology, and transplant medicine. </p> <h3>Autoimmune diseases</h3> <p>Abnormal Fas-FasL signaling has been linked with survival of autoreactive T cells and B cells, leading to disruption of peripheral immune tolerance.<a class="footnote-ref" id="fnref:56" href="#fn:56"><sup>56</sup></a> One of the best-studied disorders in this regard is autoimmune lymphoproliferative syndrome (ALPS), a genetic disorder due to mutations in Fas or FasL that leads to lymphocytosis and the emergence of autoimmune disease.<a class="footnote-ref" id="fnref:57" href="#fn:57"><sup>57</sup></a> Likewise, reduced FasL function has been associated with systemic lupus erythematosus (SLE), where impaired apoptosis of self-reactive cells plays a role in disease etiology.<a class="footnote-ref" id="fnref:58" href="#fn:58"><sup>58</sup></a> </p> <h3>Cancer</h3> <p>FasL expression by cancer cells is a strategy of immune escape.<a class="footnote-ref" id="fnref:59" href="#fn:59"><sup>59</sup></a> Several tumor cells express FasL on their surface to trigger apoptosis among Fas-expressing TILs, especially cytotoxic CD8+ T cells.<a class="footnote-ref" id="fnref:60" href="#fn:60"><sup>60</sup></a> This is called the "Fas counterattack," by which tumors are enabled to evade immune surveillance and proceed with their proliferation.<a class="footnote-ref" id="fnref:61" href="#fn:61"><sup>61</sup></a> Additionally, the tumor environment can secrete soluble FasL, again contributing to local immunosuppression.<a class="footnote-ref" id="fnref:62" href="#fn:62"><sup>62</sup></a> </p> <h3>Transplantation</h3> <p>In transplantation environments, FasL participates in both graft tolerance and rejection. Although the expression of FasL within donor tissues can facilitate apoptosis in host immune cells and maintain graft survival,<a class="footnote-ref" id="fnref:63" href="#fn:63"><sup>63</sup></a> overexpression of FasL can have the opposite effect of causing inflammation and damage to the graft.<a class="footnote-ref" id="fnref:64" href="#fn:64"><sup>64</sup></a> Experimental evidence has indicated that manipulation of FasL levels would modulate the balance between graft tolerance and rejection.<a class="footnote-ref" id="fnref:65" href="#fn:65"><sup>65</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/FAF1/wkuugHbj">FAF1</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Choi C, Benveniste EN (January 2004). "Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses". <i>Brain Research. Brain Research Reviews</i>. 44 (1): 65–81. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.brainresrev.2003.08.007">10.1016/j.brainresrev.2003.08.007</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14739003">14739003</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:46587211">46587211</a>.</li> <li>Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (April 2004). "HIV/SIV escape from immune surveillance: focus on Nef". <i>Current HIV Research</i>. 2 (2): 141–151. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.2174%2F1570162043484924">10.2174/1570162043484924</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15078178">15078178</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=alps">GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome</a></li> <li><a href="/facts/Online_Mendelian_Inheritance_in_Man/PkW3zCCU">Online Mendelian Inheritance in Man</a> (OMIM): <a href="https://omim.org/entry/601859">601859</a></li> <li><a href="https://meshb.nlm.nih.gov/record/ui?name=Fas+Ligand+Protein">Fas+Ligand+Protein</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li> <li>Overview of all the structural information available in the <a href="/facts/Protein_Data_Bank/oUhq4ABD">PDB</a> for <a href="/facts/UniProt/lfDDHjAl">UniProt</a>: <i><a href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P48023">P48023</a></i> (Tumor necrosis factor ligand superfamily member 6) at the <a href="/facts/PDBe-KB/p1WX7lPH">PDBe-KB</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Levoin N, Jean M, Legembre P (2020). "CD95 Structure, Aggregation and Cell Signaling". Frontiers in Cell and Developmental Biology. 8: 314. doi:10.3389/fcell.2020.00314. PMC 7214685. PMID 32432115. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214685" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214685</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Zhao L, Fu Q, Pan L, Piai A, Chou JJ (2020-10-14). "The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors". Frontiers in Cell and Developmental Biology. 8: 569684. doi:10.3389/fcell.2020.569684. PMC 7591462. PMID 33163490. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591462" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591462</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Alderson MR, Lynch DH (January 1998). "FAS (CD95) and FAS Ligand". In Delves PJ (ed.). Encyclopedia of Immunology (Second ed.). Oxford: Elsevier. pp. 874–880. doi:10.1006/rwei.1999.0229. ISBN 978-0-12-226765-9. Retrieved 2025-04-16. <a href="978-0-12-226765-9" target="_blank">978-0-12-226765-9</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Vargo-Gogola T, Crawford HC, Fingleton B, Matrisian LM (December 2002). "Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand". Archives of Biochemistry and Biophysics. 408 (2): 155–161. doi:10.1016/S0003-9861(02)00525-8. PMID 12464266. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Nareznoi D, Konikov-Rozenman J, Petukhov D, Breuer R, Wallach-Dayan SB (February 2020). "Matrix Metalloproteinases Retain Soluble FasL-mediated Resistance to Cell Death in Fibrotic-Lung Myofibroblasts". Cells. 9 (2): 411. doi:10.3390/cells9020411. PMC 7072292. 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