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APEX1
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<h2 id="interactions">Interactions</h2> <p>APEX1 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/MUTYH/s1l19TW4">MUTYH</a>,<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> <a href="/facts/Flap_structure-specific_endonuclease_1/VjkW5CS8">Flap structure-specific endonuclease 1</a><a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> and <a href="/facts/XRCC1/A0SNJWBV">XRCC1</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="aging">Aging</h2> <p>Deficiency of APEX1 causes accummulation of <a href="/facts/DNA_damage_(naturally_occurring)/CjGTLKGl">DNA damage</a> leading to both <a href="/facts/Cellular_senescence/w6f0gfrB">cellular senescence</a> and features of premature <a href="/facts/Ageing/AxL4qCW4">aging</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> This finding is consistent with the theory that DNA damage is a primary cause of aging.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Mol CD, Hosfield DJ, Tainer JA (August 2000). <a href="https://doi.org/10.1016%2Fs0921-8777%2800%2900028-8">"Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means"</a>. <i>Mutation Research</i>. 460 (3–4): 211–29. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fs0921-8777%2800%2900028-8">10.1016/s0921-8777(00)00028-8</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10946230">10946230</a>.</li> <li>Fritz G (September 2000). "Human APE/Ref-1 protein". <i>The International Journal of Biochemistry & Cell Biology</i>. 32 (9): 925–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS1357-2725%2800%2900045-5">10.1016/S1357-2725(00)00045-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11084372">11084372</a>.</li> <li>Fritz G, Grösch S, Tomicic M, Kaina B (November 2003). "APE/Ref-1 and the mammalian response to genotoxic stress". <i>Toxicology</i>. 193 (1–2): 67–78. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0300-483X%2803%2900290-7">10.1016/S0300-483X(03)00290-7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14599768">14599768</a>.</li> <li>Tell G, Damante G, Caldwell D, Kelley MR (2005). "The intracellular localization of APE1/Ref-1: more than a passive phenomenon?". <i>Antioxidants & Redox Signaling</i>. 7 (3–4): 367–84. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1089%2Fars.2005.7.367">10.1089/ars.2005.7.367</a>. <a href="/facts/Hdl_(identifier)/rdebSxmC">hdl</a>:<a href="https://hdl.handle.net/1805%2F4802">1805/4802</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15706084">15706084</a>.</li> <li>Hung RJ, Hall J, Brennan P, Boffetta P (November 2005). <a href="https://doi.org/10.1093%2Faje%2Fkwi318">"Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review"</a>. <i>American Journal of Epidemiology</i>. 162 (10): 925–42. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Faje%2Fkwi318">10.1093/aje/kwi318</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16221808">16221808</a>.</li> <li>Dyrkheeva NS, Khodyreva SN, Lavrik OI (2007). "[Multifunctional human apurinic/apyrimidinic endonuclease 1: the role of additional functions]". <i>Molekuliarnaia Biologiia</i>. 41 (3): 450–66. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17685223">17685223</a>.</li> <li>Harrison L, Ascione G, Menninger JC, Ward DC, Demple B (December 1992). "Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12)". <i>Human Molecular Genetics</i>. 1 (9): 677–80. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fhmg%2F1.9.677">10.1093/hmg/1.9.677</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1284593">1284593</a>.</li> <li>Cheng XB, Bunville J, Patterson TA (January 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310384">"Nucleotide sequence of a cDNA for an apurinic/apyrimidinic endonuclease from HeLa cells"</a>. <i>Nucleic Acids Research</i>. 20 (2): 370. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F20.2.370">10.1093/nar/20.2.370</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310384">310384</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1371347">1371347</a>.</li> <li>Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T (September 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556867">"Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme"</a>. <i>The EMBO Journal</i>. 11 (9): 3323–35. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fj.1460-2075.1992.tb05411.x">10.1002/j.1460-2075.1992.tb05411.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556867">556867</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1380454">1380454</a>.</li> <li>Zhao B, Grandy DK, Hagerup JM, Magenis RE, Smith L, Chauhan BC, Henner WD (August 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC334100">"The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12"</a>. <i>Nucleic Acids Research</i>. 20 (15): 4097–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F20.15.4097">10.1093/nar/20.15.4097</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC334100">334100</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1380694">1380694</a>.</li> <li>Robson CN, Hochhauser D, Craig R, Rack K, Buckle VJ, Hickson ID (September 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC334166">"Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12"</a>. <i>Nucleic Acids Research</i>. 20 (17): 4417–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F20.17.4417">10.1093/nar/20.17.4417</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC334166">334166</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1383925">1383925</a>.</li> <li>Seki S, Hatsushika M, Watanabe S, Akiyama K, Nagao K, Tsutsui K (July 1992). "cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III". <i>Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression</i>. 1131 (3): 287–99. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0167-4781%2892%2990027-w">10.1016/0167-4781(92)90027-w</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1627644">1627644</a>.</li> <li>Robson CN, Hickson ID (October 1991). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC328951">"Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants"</a>. <i>Nucleic Acids Research</i>. 19 (20): 5519–23. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F19.20.5519">10.1093/nar/19.20.5519</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC328951">328951</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1719477">1719477</a>.</li> <li>Demple B, Herman T, Chen DS (December 1991). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53153">"Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 88 (24): 11450–4. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1991PNAS...8811450D">1991PNAS...8811450D</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.88.24.11450">10.1073/pnas.88.24.11450</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53153">53153</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1722334">1722334</a>.</li> <li>Okazaki T, Chung U, Nishishita T, Ebisu S, Usuda S, Mishiro S, Xanthoudakis S, Igarashi T, Ogata E (November 1994). <a href="https://doi.org/10.1016%2FS0021-9258%2818%2946865-2">"A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium"</a>. <i>The Journal of Biological Chemistry</i>. 269 (45): 27855–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2818%2946865-2">10.1016/S0021-9258(18)46865-2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7961715">7961715</a>.</li> <li>Akiyama K, Seki S, Oshida T, Yoshida MC (September 1994). "Structure, promoter analysis and chromosomal assignment of the human APEX gene". <i>Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression</i>. 1219 (1): 15–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0167-4781%2894%2990241-0">10.1016/0167-4781(94)90241-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8086453">8086453</a>.</li> <li>Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". <i>Analytical Biochemistry</i>. 236 (1): 107–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fabio.1996.0138">10.1006/abio.1996.0138</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8619474">8619474</a>.</li> <li>Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T (April 1996). <a href="https://doi.org/10.1074%2Fjbc.271.15.8593">"The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium"</a>. <i>The Journal of Biological Chemistry</i>. 271 (15): 8593–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.15.8593">10.1074/jbc.271.15.8593</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8621488">8621488</a>.</li> <li>Rothwell DG, Hickson ID (November 1996). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146231">"Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1"</a>. <i>Nucleic Acids Research</i>. 24 (21): 4217–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F24.21.4217">10.1093/nar/24.21.4217</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146231">146231</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8932375">8932375</a>.</li> <li>Izumi T, Henner WD, Mitra S (November 1996). "Negative regulation of the major human AP-endonuclease, a multifunctional protein". <i>Biochemistry</i>. 35 (47): 14679–83. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi961995u">10.1021/bi961995u</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8942627">8942627</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=APEX1"><i>APEX1</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=APEX1"><i>APEX1</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=328" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=328</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Parker A, Gu Y, Mahoney W, Lee SH, Singh KK, Lu AL (February 2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". The Journal of Biological Chemistry. 276 (8): 5547–55. doi:10.1074/jbc.M008463200. PMID 11092888. <a href="https://doi.org/10.1074%2Fjbc.M008463200" target="_blank">https://doi.org/10.1074%2Fjbc.M008463200</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Dianova II, Bohr VA, Dianov GL (October 2001). "Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair". Biochemistry. 40 (42): 12639–44. doi:10.1021/bi011117i. PMID 11601988. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Vidal AE, Boiteux S, Hickson ID, Radicella JP (November 2001). "XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions". The EMBO Journal. 20 (22): 6530–9. doi:10.1093/emboj/20.22.6530. PMC 125722. PMID 11707423. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125722" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125722</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Li M, Yang X, Lu X, Dai N, Zhang S, Cheng Y, et al. (June 2018). "APE1 deficiency promotes cellular senescence and premature aging features". Nucleic Acids Research. 46 (11): 5664–5677. doi:10.1093/nar/gky326. PMC 6009672. PMID 29750271. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009672" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009672</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Gensler HL, Bernstein H (September 1981). "DNA damage as the primary cause of aging". The Quarterly Review of Biology. 56 (3): 279–303. doi:10.1086/412317. PMID 7031747. S2CID 20822805. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>