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LAPC4
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<h2 id="characteristics">Characteristics</h2> <p>LAPC4 are a lowly adherent, epithelial cell line with high <a href="/facts/Androgen_receptor/NBPRszqm">Androgen receptor</a> and <a href="/facts/Prostate_specific_antigen/HaylgTdR">Prostate specific antigen</a> expression.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> Unlike the other commonly utilized, Androgen receptor positive prostate cancer cell lines <a href="/facts/LNCaP/gC2bRBU3">LNCaP</a> and <a href="/facts/VCaP/JP3nUslW">VCaP</a>, LAPC4 have high expression of <a href="/facts/Keratin_5/KrgMbWSN">Keratin 5</a>, a basal marker, as well as the luminal markers <a href="/facts/Keratin_8/HkXu1I7w">Keratin 8</a> and <a href="/facts/Keratin_18/o7TPWhYk">Keratin 18</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> LAPC4 also expresses mutated P53 (R175H). <a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p><p>The cells have an approximate doubling time of 72 hours under typical culture conditions.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <h2 id="external-links">External links</h2> <ul><li><a href="https://www.cellosaurus.org/CVCL_4744">Cellosaurus entry for LAPC4</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Klein, KA; Reiter, RE; Redula, J; Moradi, H; Zhu, XL; Brothman, AR; Lamb, DJ; Marcelli, M; Belldegrun, A; Witte, ON; Sawyers, CL (April 1997). "Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice". Nature Medicine. 3 (4): 402–8. doi:10.1038/nm0497-402. PMID 9095173. S2CID 21273888. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Russell, Pamela J.; Kingsley, Elizabeth A. (2003). "Chapter 2: Human Prostate Cancer Cell Lines" (PDF). In Russell, Pamela J.; Jackson, Paul; Kingsley, Elizabeth A. (eds.). Prostate cancer methods and protocols. Totowa, N.J.: Humana Press. pp. 21–39. ISBN 978-1-59259-372-9. <a href="978-1-59259-372-9" target="_blank">978-1-59259-372-9</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Garcia, RR; Masoodi, KZ; Pascal, LE; Nelson, JB; Wang, Z (2014). "Growth of LAPC4 prostate cancer xenograft tumor is insensitive to 5α-reductase inhibitor dutasteride". American Journal of Clinical and Experimental Urology. 2 (1): 82–91. PMC 4219295. PMID 25374909. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219295" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219295</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>van Bokhoven, A; Varella-Garcia, M; Korch, C; Johannes, WU; Smith, EE; Miller, HL; Nordeen, SK; Miller, GJ; Lucia, MS (1 November 2003). "Molecular characterization of human prostate carcinoma cell lines". The Prostate. 57 (3): 205–25. doi:10.1002/pros.10290. PMID 14518029. S2CID 32949167. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>van Bokhoven, A; Varella-Garcia, M; Korch, C; Johannes, WU; Smith, EE; Miller, HL; Nordeen, SK; Miller, GJ; Lucia, MS (1 November 2003). "Molecular characterization of human prostate carcinoma cell lines". The Prostate. 57 (3): 205–25. doi:10.1002/pros.10290. PMID 14518029. S2CID 32949167. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>van Bokhoven, A; Varella-Garcia, M; Korch, C; Johannes, WU; Smith, EE; Miller, HL; Nordeen, SK; Miller, GJ; Lucia, MS (1 November 2003). "Molecular characterization of human prostate carcinoma cell lines". The Prostate. 57 (3): 205–25. doi:10.1002/pros.10290. PMID 14518029. S2CID 32949167. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>"Cell line LAPC-4 (CVCL_4744)". Cellosaurus. Retrieved 29 January 2018. <a href="https://web.expasy.org/cellosaurus/CVCL_4744" target="_blank">https://web.expasy.org/cellosaurus/CVCL_4744</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> </ol>