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PIK3C2B
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<h2 id="function">Function</h2> <p>The protein encoded by this gene belongs to the <a href="/facts/Phosphoinositide_3-kinase/e5rtq0VG">phosphoinositide 3-kinase</a> (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, <a href="/facts/Cell_migration/5ySAMquQ">cell migration</a>, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a <a href="/facts/C-terminal/ws4scHgT">C-terminal</a> C2 domain, a characteristic of class II PI3-kinases. C2 domains act as <a href="/facts/Calcium_in_biology/wgUxKej5">calcium</a>-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor <a href="/facts/Wortmannin/u2pCKs73">wortmannin</a>. The C2 domain of this protein was shown to bind phospholipids but not <a href="/facts/Calcium_in_biology/wgUxKej5">Ca2+</a>, which suggests that this enzyme may function in a calcium-independent manner.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (Nov 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". <i>Journal of Leukocyte Biology</i>. 74 (5): 676–82. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1189%2Fjlb.0503206">10.1189/jlb.0503206</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12960231">12960231</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:11362623">11362623</a>.</li> <li>Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (Oct 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". <i>Oncogene</i>. 9 (10): 2991–8. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8084603">8084603</a>.</li> <li>Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (Sep 1996). <a href="https://doi.org/10.1074%2Fjbc.271.38.22961">"Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells"</a>. <i>The Journal of Biological Chemistry</i>. 271 (38): 22961–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.38.22961">10.1074/jbc.271.38.22961</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8798481">8798481</a>.</li> <li>Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (Jun 1997). <a href="https://doi.org/10.1038%2Fsj.onc.1201153">"The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase"</a>. <i>Oncogene</i>. 14 (25): 3067–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1201153">10.1038/sj.onc.1201153</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9223670">9223670</a>.</li> <li>Mazerolles F, Barbat C, Fischer A (Sep 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". <i>European Journal of Immunology</i>. 27 (9): 2457–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Feji.1830270946">10.1002/eji.1830270946</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9341793">9341793</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:33397908">33397908</a>.</li> <li>Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S (Nov 1997). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". <i>European Journal of Immunology</i>. 27 (11): 2805–11. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Feji.1830271110">10.1002/eji.1830271110</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9394803">9394803</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:6303471">6303471</a>.</li> <li>Borgatti P, Zauli G, Cantley LC, Capitani S (Jan 1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". <i>Biochemical and Biophysical Research Communications</i>. 242 (2): 332–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.1997.7877">10.1006/bbrc.1997.7877</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9446795">9446795</a>.</li> <li>Milani D, Mazzoni M, Zauli G, Mischiati C, Gibellini D, Giacca M, Capitani S (Jul 1998). <a href="https://doi.org/10.1097%2F00002030-199811000-00008">"HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells"</a>. <i>AIDS</i>. 12 (11): 1275–84. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2F00002030-199811000-00008">10.1097/00002030-199811000-00008</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9708406">9708406</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:25758704">25758704</a>.</li> <li>Jauliac S, Mazerolles F, Jabado N, Pallier A, Bernard F, Peake J, Fischer A, Hivroz C (Oct 1998). <a href="https://doi.org/10.1002%2F%28SICI%291521-4141%28199810%2928%3A10%3C3183%3A%3AAID-IMMU3183%3E3.0.CO%3B2-A">"Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity"</a>. <i>European Journal of Immunology</i>. 28 (10): 3183–91. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F%28SICI%291521-4141%28199810%2928%3A10%3C3183%3A%3AAID-IMMU3183%3E3.0.CO%3B2-A">10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9808187">9808187</a>.</li> <li>Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J (Jun 2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85707">"Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors"</a>. <i>Molecular and Cellular Biology</i>. 20 (11): 3817–30. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.20.11.3817-3830.2000">10.1128/MCB.20.11.3817-3830.2000</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85707">85707</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10805725">10805725</a>.</li> <li>Park IW, Wang JF, Groopman JE (Jan 2001). <a href="https://doi.org/10.1182%2Fblood.V97.2.352">"HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes"</a>. <i>Blood</i>. 97 (2): 352–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood.V97.2.352">10.1182/blood.V97.2.352</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11154208">11154208</a>.</li> <li>Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (Feb 2001). <a href="https://doi.org/10.1096%2Ffj.00-0354com">"HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway"</a>. <i>FASEB Journal</i>. 15 (2): 483–91. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1096%2Ffj.00-0354com">10.1096/fj.00-0354com</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11156964">11156964</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:26315564">26315564</a>.</li> <li>Wheeler M, Domin J (Oct 2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99811">"Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2"</a>. <i>Molecular and Cellular Biology</i>. 21 (19): 6660–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.21.19.6660-6667.2001">10.1128/MCB.21.19.6660-6667.2001</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99811">99811</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11533253">11533253</a>.</li> <li>Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G (Jul 2002). <a href="https://doi.org/10.1074%2Fjbc.M200921200">"HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells"</a>. <i>The Journal of Biological Chemistry</i>. 277 (28): 25195–202. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M200921200">10.1074/jbc.M200921200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11994280">11994280</a>.</li> <li>Cook JA, August A, Henderson AJ (Jul 2002). <a href="https://doi.org/10.4049%2Fjimmunol.169.1.254">"Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism"</a>. <i>Journal of Immunology</i>. 169 (1): 254–60. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4049%2Fjimmunol.169.1.254">10.4049/jimmunol.169.1.254</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12077252">12077252</a>.</li> <li>Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ (Oct 2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC129034">"Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation"</a>. <i>The EMBO Journal</i>. 21 (19): 5097–108. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Femboj%2Fcdf512">10.1093/emboj/cdf512</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC129034">129034</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12356726">12356726</a>.</li> <li>Visnjić D, Crljen V, Curić J, Batinić D, Volinia S, Banfić H (Oct 2002). "The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells". <i>FEBS Letters</i>. 529 (2–3): 268–74. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2802%2903357-4">10.1016/S0014-5793(02)03357-4</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12372612">12372612</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:29067083">29067083</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry. 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063. <a href="https://doi.org/10.1074%2Fjbc.273.49.33082" target="_blank">https://doi.org/10.1074%2Fjbc.273.49.33082</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> </ol>