Novartis

<h2 id="history">History</h2>
Novartis was created in March 1996 and began operations on 20 December from the merger of Ciba-Geigy and Sandoz Laboratories, both Swiss companies.<a class="footnote-ref" id="fnref:11" href="#fn:11">11</a>

<h3>Ciba-Geigy</h3>
Ciba-Geigy was formed in 1970 by the merger of J. R. Geigy Ltd (founded in Basel in 1857) and CIBA (founded in Basel in 1859).<a class="footnote-ref" id="fnref:12" href="#fn:12">12</a>
Ciba began in 1859, when Alexander Clavel (1805–1873) took up the production of <a href="/facts/Fuchsine/UnnPmw5n">fuchsine</a> in his factory for <a href="/facts/Silk/XhxPpvvS">silk</a>-dyeing works in Basel. By 1873, he sold his dye factory to the company Bindschedler and Busch. In 1884, Bindschedler and Busch was transformed into a joint-stock company named "Gesellschaft für Chemische Industrie Basel" (Company for Chemical Industry Basel). The <a href="/facts/Acronym/nlHK7aRt">acronym</a>, CIBA, was adopted as the company's name in 1945.<a class="footnote-ref" id="fnref:13" href="#fn:13">13</a>
The foundation for Geigy was established in 1857, when Johann Rudolf Geigy-Merian (1830–1917) and Johann Muller-Pack acquired a site in Basel, where they built a <a href="/facts/Dyewood/sD7dTxBN">dyewood</a> mill and a <a href="/facts/Dye/a1NSlcsG">dye</a> extraction plant. Two years later, they began the production of synthetic fuchsine.<a class="footnote-ref" id="fnref:14" href="#fn:14">14</a> In 1901, they formed the <a href="/facts/Public_limited_company/PzReaSle">public limited company</a> Geigy, and the name of the company was changed to J. R. Geigy Ltd in 1914.<a class="footnote-ref" id="fnref:15" href="#fn:15">15</a>
CIBA and Geigy merged in 1970 to form Ciba‑Geigy Ltd. /ˌsiːbə ˈɡaɪɡi/.<a class="footnote-ref" id="fnref:16" href="#fn:16">16</a>

<h3>Mid-1990s controversy</h3>
In the mid-1990s, state and federal health and environmental agencies identified an increased incidence of childhood cancers in <a href="/facts/Toms_River,_New_Jersey/Rw5yN2r0">Toms River, New Jersey</a>, from the 1970–1995 period. Multiple investigations by state and federal environmental and health agencies indicated that the likely source of the increased cancer risk was contamination from Toms River Chemical Plant (then operated by Ciba-Geigy), which had been in operation since 1952, and the Reich Farm/<a href="/facts/Union_Carbide/kCE5YHal">Union Carbide</a>.<a class="footnote-ref" id="fnref:17" href="#fn:17">17</a>
The area was designated a <a href="/facts/United_States_Environmental_Protection_Agency/ghI985SI">United States Environmental Protection Agency</a> <a href="/facts/Superfund/FFJJqmmu">Superfund</a> <a href="/facts/List_of_Superfund_sites/7b5qSKGu">site</a> in 1983 after an underground plume of toxic chemicals was identified. The following year, a discharge pipe was shut down after a sinkhole at the corner of Bay Avenue and Vaughn Avenue revealed that it had been leaking. The plant ceased operation in 1996. A follow-up study from the 1996–2000 period indicated that while there were more cancer cases than expected, rates had significantly fallen and the difference was statistically insignificant compared to normal statewide cancer rates. Since 1996, the Toms River water system has been subject to the most stringent water testing in New Jersey and is considered safe for consumption. <a href="/facts/Dan_Fagin/RCAzC4DC">Dan Fagin</a>'s <a href="/facts/Toms_River_(book)/96WWQp69">Toms River: A Story of Science and Salvation</a>, the 2014 <a href="/facts/Pulitzer_Prize/wD4PN6Xs">Pulitzer Prize</a> winning book, examined the issue of industrial pollution at the site in detail.

<h3>Sandoz</h3>
Main article: <a href="/facts/Sandoz/jDregKez">Sandoz</a>

Sandoz is the <a href="/facts/Generic_drug/IF6AXDVX">generic drugs</a> division of Novartis. Before the 1996 merger with Ciba-Geigy to form Novartis, Sandoz Pharmaceuticals (Sandoz AG) was a <a href="/facts/Pharmaceutical/h9mhwWP2">pharmaceutical</a> company headquartered in <a href="/facts/Basel/EzXbzbUx">Basel</a>, Switzerland (as was Ciba-Geigy), and was best known for developing drugs such as <a href="/facts/Sandimmune/tcIToHvK">Sandimmune</a> for <a href="/facts/Organ_transplantation/1jNvVJn6">organ transplantation</a>, the <a href="/facts/Antipsychotic/7bNTg7T3">antipsychotic</a> <a href="/facts/Clozaril/N0Lqztg1">Clozaril</a>, <a href="/facts/Mellaril/um69HuvU">Mellaril</a> Tablets and <a href="/facts/Serentil/1nDwgJ4f">Serentil</a> Tablets for treating <a href="/facts/Psychiatric_disorders/EPNjFtFf">psychiatric disorders</a>, and <a href="/facts/Cafergot/yM05QDsA">Cafergot</a> Tablets and <a href="/facts/Torecan/UBlBf7jU">Torecan</a> Suppositories for treating <a href="/facts/Migraine_headaches/5XaE1W25">migraine headaches</a>.
The Chemiefirma Kern und Sandoz ("Kern and Sandoz Chemistry Firm") was founded in 1886 by Alfred Kern (1850–1893) and Edouard Sandoz (1853–1928). The first dyes manufactured by them were <a href="/facts/Alizarin/WBG6gj39">alizarinblue</a> and <a href="/facts/Auramine/3KEYWkk5">auramine</a>. After Kern's death, the partnership became the corporation Chemische Fabrik vormals Sandoz in 1895. The company began producing the fever-reducing drug <a href="/facts/Antipyrin/M5cwXn5d">antipyrin</a> in the same year. In 1899, the company began producing the sugar substitute <a href="/facts/Saccharin/PCIjSpIh">saccharin</a>. Further pharmaceutical research began in 1917 under <a href="/facts/Arthur_Stoll/04wLKAWL">Arthur Stoll</a> (1887–1971), who is the founder of Sandoz's pharmaceutical department in 1917.<a class="footnote-ref" id="fnref:18" href="#fn:18">18</a> In 1918, Arthur Stoll isolated <a href="/facts/Ergotamine/o3mIe2ct">ergotamine</a> from <a href="/facts/Ergot/aqQFKBqP">ergot</a>; the substance was eventually used to treat migraine and headaches and was introduced under the trade name Gynergen in 1921.
Between the World Wars, Gynergen (1921) and Calcium-Sandoz (1929) were brought to market. Sandoz also produced chemicals for textiles, paper, and <a href="/facts/Leather/kvQtwHPH">leather</a>, beginning in 1929. In 1939, the company began producing agricultural chemicals.
The <a href="/facts/Psychedelic_drug/aj9GNANW">psychedelic</a> effects of <a href="/facts/Lysergic_acid_diethylamide/o5qq0grH">lysergic acid diethylamide</a> (LSD) were discovered at the Sandoz laboratories in 1943 by <a href="/facts/Arthur_Stoll/04wLKAWL">Arthur Stoll</a> and <a href="/facts/Albert_Hofmann/aMkarPVc">Albert Hofmann</a>.<a class="footnote-ref" id="fnref:19" href="#fn:19">19</a><a class="footnote-ref" id="fnref:20" href="#fn:20">20</a> Sandoz began clinical trials and marketed the substance, from 1947 through the mid-1960s, under the name Delysid as a <a href="/facts/Psychiatry/uzS7vEo0">psychiatric</a> drug, thought useful for treating a wide variety of <a href="/facts/Mental_disorder/EPNjFtFf">mental ailments</a>, ranging from <a href="/facts/Alcoholism/KGPzpChp">alcoholism</a> to <a href="/facts/Sexual_deviancy/MWfMWXmT">sexual deviancy</a>. Sandoz suggested in its marketing literature that psychiatrists take LSD themselves,<a class="footnote-ref" id="fnref:21" href="#fn:21">21</a> to gain a better subjective understanding of the <a href="/facts/Schizophrenia/FMP4lQ57">schizophrenic</a> experience, and many did exactly that and so did other scientific researchers. The Sandoz product received mass publicity as early as 1954, in a <a href="/facts/Time_(magazine)/N4FXc99l">Time</a> magazine feature.<a class="footnote-ref" id="fnref:22" href="#fn:22">22</a> Research on LSD peaked in the 1950s and early 1960s. The <a href="/facts/CIA/U7urmQYL">CIA</a> purchased quantities of LSD from Sandoz for use in its illegal human experimentation program known as <a href="/facts/MKUltra/AIz0S18a">MKUltra</a>.<a class="footnote-ref" id="fnref:23" href="#fn:23">23</a> Sandoz withdrew the drug from the market in 1965. The drug became a cultural novelty of the 1960s after psychologist <a href="/facts/Timothy_Leary/KeHK0FuP">Timothy Leary</a> at <a href="/facts/Harvard_University/Lhy9L1cx">Harvard University</a> began to promote its use for recreational and spiritual experiences among the general public.
Sandoz opened its first foreign offices in 1964. In 1967, Sandoz merged with <a href="/facts/Wander_AG/aRvqxgyu">Wander AG</a> (known for <a href="/facts/Ovomaltine/dkYplVhq">Ovomaltine</a> and <a href="/facts/Isostar/IuQ24Voj">Isostar</a>). Sandoz acquired the companies <a href="/facts/Delmark/dpe0F7PI">Delmark</a>, <a href="/facts/Wasabr%C3%B6d/JhLftNyY">Wasabröd</a> (a <a href="/facts/Sweden/u3qC7lyj">Swedish</a> manufacturer of <a href="/facts/Crisp_bread/Tk4uEYgk">crisp bread</a>), and <a href="/facts/Gerber_Products_Company/8IafcR4E">Gerber Products Company</a> (a <a href="/facts/Baby_food/G8EleSXk">baby food</a> company). On 1 November 1986, a fire broke out in a production plant storage room, which led to the <a href="/facts/Sandoz_chemical_spill/qoCPR6Mf">Sandoz chemical spill</a> and a large amount of <a href="/facts/Pesticide/Uhf4KnwJ">pesticide</a> being released into the upper <a href="/facts/Rhine/MgJ88oaz">Rhine</a> river. This exposure killed many fish and other aquatic life. In 1995, Sandoz spun off its <a href="/facts/Specialty_chemicals/t1EBkh0W">specialty chemicals</a> business to form <a href="/facts/Clariant/WYdXk1VI">Clariant</a>. In 1997, Clariant merged with the specialty chemicals business that was spun off from <a href="/facts/Hoechst_AG/jC4ydehg">Hoechst AG</a> in Germany.<a class="footnote-ref" id="fnref:24" href="#fn:24">24</a>

<h3>Merger</h3>
In 1996, Ciba-Geigy merged with Sandoz, with the pharmaceutical and agrochemical divisions of both staying together to form Novartis. Other Ciba-Geigy and Sandoz businesses were spun off as independent companies.<a class="footnote-ref" id="fnref:25" href="#fn:25">25</a><a class="footnote-ref" id="fnref:26" href="#fn:26">26</a> notably <a href="/facts/Ciba_Specialty_Chemicals/oNsp800z">Ciba Specialty Chemicals</a>.<a class="footnote-ref" id="fnref:27" href="#fn:27">27</a><a class="footnote-ref" id="fnref:28" href="#fn:28">28</a> Sandoz's Master Builders Technologies, a producer of chemicals for the construction industry, was sold off to SKW Trostberg A.G., a subsidiary of the German energy company <a href="/facts/E.ON/XK5MBNvF">VIAG</a>, while its North American corn herbicide business became part of the German chemical maker <a href="/facts/BASF/cdtGr0TK">BASF</a>.<a class="footnote-ref" id="fnref:29" href="#fn:29">29</a>

<h3>Post-merger</h3>

In 1998, the company entered into a <a href="/facts/Biotechnology/8eFnI6FB">biotechnology</a> licensing agreement with the <a href="/facts/UC_Berkeley/MXVEjklr">University of California at Berkeley</a> Department of Plant and <a href="/facts/Microbe/pysJYcE2">Microbial</a> <a href="/facts/Biology/1M1ee3pB">Biology</a>.<a class="footnote-ref" id="fnref:30" href="#fn:30">30</a> Critics of the agreement expressed concern over prospects that the agreement would diminish academic objectivity, or lead to the commercialization of <a href="/facts/Genetically_modified/vwdlDR61">genetically modified</a> plants.<a class="footnote-ref" id="fnref:31" href="#fn:31">31</a> The agreement expired in 2003.<a class="footnote-ref" id="fnref:32" href="#fn:32">32</a>

<h4>2000–2010</h4>
In 2000, Novartis and <a href="/facts/AstraZeneca/KTPcnWfE">AstraZeneca</a> combined their <a href="/facts/Agrobusiness/fMxWfwQV">agrobusiness</a> divisions to create a new company, <a href="/facts/Syngenta/rcmWokr7">Syngenta</a>.<a class="footnote-ref" id="fnref:33" href="#fn:33">33</a><a class="footnote-ref" id="fnref:34" href="#fn:34">34</a>
In 2003, Novartis organized all its generics businesses into one division, and merged some of its subsidiaries into one company, reusing the predecessor brand name of Sandoz.<a class="footnote-ref" id="fnref:35" href="#fn:35">35</a>
In 2005, Novartis expanded its subsidiary Sandoz significantly through the US$8.29 billion acquisition of Hexal, one of Germany's leading <a href="/facts/Generic_drug/IF6AXDVX">generic drug</a> companies, and Eon Labs, a fast-growing United States generic pharmaceutical company.<a class="footnote-ref" id="fnref:36" href="#fn:36">36</a>
In 2006, Novartis acquired the California-based <a href="/facts/Chiron_Corporation/pw5UdRoq">Chiron Corporation</a>. Chiron had been divided into three units: Chiron Vaccines, Chiron Blood Testing, and Chiron BioPharmaceuticals. The biopharmaceutical unit was integrated into Novartis Pharmaceuticals, while the vaccines and blood testing units were made into a new Novartis Vaccines and Diagnostics division.<a class="footnote-ref" id="fnref:37" href="#fn:37">37</a> Also in 2006, Sandoz became the first company to have a <a href="/facts/Biosimilar/QmgnUAzK">biosimilar</a> drug approved in Europe with its recombinant <a href="/facts/Human_growth_hormone/SLEJ1fws">human growth hormone</a> drug.<a class="footnote-ref" id="fnref:38" href="#fn:38">38</a>
In 2007, Novartis sold the <a href="/facts/Gerber_Products_Company/8IafcR4E">Gerber Products Company</a> to <a href="/facts/Nestl%C3%A9/1GgldXdF">Nestlé</a> as part of its continuing effort to shed old Sandoz and Ciba-Geigy businesses and focus on healthcare.<a class="footnote-ref" id="fnref:39" href="#fn:39">39</a>
In 2009, Novartis reached an agreement to acquire an 85 percent stake in the Chinese vaccines company Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. as part of a strategic initiative to build a vaccines industry leader in this country and expand the group's limited presence in this fast-growing market segment. This proposed acquisition will require government and regulatory approvals in China.<a class="footnote-ref" id="fnref:40" href="#fn:40">40</a>
In 2010, Novartis offered to pay US$39.3 billion to fully acquire <a href="/facts/Alcon/Veyhdk4R">Alcon</a>, the world's largest eye-care company, including a majority stake held by Nestlé. Novartis had bought 25 percent of Alcon in 2008.<a class="footnote-ref" id="fnref:41" href="#fn:41">41</a> Novartis created a new division and called it Alcon, under which it placed its CIBA VISION subsidiary and Novartis Ophthalmics, which became the second-largest division of Novartis.<a class="footnote-ref" id="fnref:42" href="#fn:42">42</a> The total cost for Alcon amounted to $60 billion.<a class="footnote-ref" id="fnref:43" href="#fn:43">43</a>

<h4>2011–present</h4>
In 2011, Novartis acquired the medical laboratory diagnostics company Genoptix to "serve as a strong foundation for our (Novartis') individualized treatment programs".<a class="footnote-ref" id="fnref:44" href="#fn:44">44</a>
In 2012, the Company cut approximately 2,000 positions in the United States, primarily in sales, in response to anticipated revenue downturns from the <a href="/facts/Hypertension/wlAvBfcf">hypertension</a> drug <a href="/facts/Diovan/oFBA3SDq">Diovan</a>, which was losing patent protection, and the realization that the anticipated successor to Diovan, <a href="/facts/Rasilez/yJQ8Comr">Rasilez</a>, was failing in clinical trials.<a class="footnote-ref" id="fnref:45" href="#fn:45">45</a> The 2012 personnel reductions follow ~2000 cut positions in Switzerland and the United States in 2011, ~1400 cut positions in the United States in 2010, and a reduction of "thousands" and several site closures in previous years.<a class="footnote-ref" id="fnref:46" href="#fn:46">46</a> Also in 2012, Novartis became the biggest manufacturer of generic skin care medicine, after agreeing to buy Fougera Pharmaceuticals for $1.525 billion in cash.<a class="footnote-ref" id="fnref:47" href="#fn:47">47</a>
In 2013, <a href="/facts/Novartis_v._Union_of_India_%26_Others/uJkqf51K">the Indian Supreme Court issued a decision</a> rejecting Novartis' patent application in India on the final form of <a href="/facts/Gleevec/PSpRplHy">Gleevec</a>, Novartis's cancer drug; the case caused great controversy.<a class="footnote-ref" id="fnref:48" href="#fn:48">48</a> In 2013, Novartis was sued again by the US government, this time for allegedly bribing doctors for a decade so that their patients are steered towards the company's drugs.<a class="footnote-ref" id="fnref:49" href="#fn:49">49</a>
In January 2014, Novartis announced plans to cut 500 jobs from its pharmaceuticals division.<a class="footnote-ref" id="fnref:50" href="#fn:50">50</a> In February 2014, Novartis announced that it acquired CoStim Pharmaceuticals.<a class="footnote-ref" id="fnref:51" href="#fn:51">51</a>
In May 2014, Novartis purchased the rights to market Ophthotech's Fovista (an anti-<a href="/facts/PDGF/fYpbl1qA">PDGF</a> <a href="/facts/Aptamer/3UvhuQP4">aptamer</a>, also being investigated for use in combination with anti-<a href="/facts/VEGF/kNDc0Xj0">VEGF</a> treatments) outside the U.S. for up to $1 billion.<a class="footnote-ref" id="fnref:52" href="#fn:52">52</a> Novartis acquired exclusive rights to market the eye drug outside of the states while retaining U.S. marketing rights. The company agreed to pay Ophthotech $200 million upfront, and $130 million in milestone payments relating to Phase III trials.<a class="footnote-ref" id="fnref:53" href="#fn:53">53</a> Ophthotech is also eligible to receive up to $300 million dependent upon future marketing approval milestones outside of America and up to $400 million relating to sales milestones.<a class="footnote-ref" id="fnref:54" href="#fn:54">54</a> In September 2014, Ophthotech received its first $50 million phase III trial milestone payment from Novartis.<a class="footnote-ref" id="fnref:55" href="#fn:55">55</a> In April 2014, Novartis announced that it would acquire <a href="/facts/GlaxoSmithKline/NrnnxFNW">GlaxoSmithKline</a>'s cancer drug business for $16 billion as well as selling its vaccines business to GlaxoSmithKline for $7.1 billion.<a class="footnote-ref" id="fnref:56" href="#fn:56">56</a> In August 2014 Genetic Engineering & Biotechnology News reported that Novartis had acquired a 15 percent stake in Gamida Cell for $35 million, with the option to purchase the whole company for approximately $165 million.<a class="footnote-ref" id="fnref:57" href="#fn:57">57</a> In October 2014, Novartis announced its intention to sell its influenza vaccine business (inclusive of its development pipeline), subject to regulatory approval, to <a href="/facts/CSL_Limited/KBN62Tpq">CSL</a> for $275 million.<a class="footnote-ref" id="fnref:58" href="#fn:58">58</a>
In March 2015, the company announced BioPharma had completed its acquisition of two Phase III cancer-drug candidates; the <a href="/facts/MEK_inhibitor/WhmMusyG">MEK inhibitor</a> <a href="/facts/Binimetinib/ac4tjKXF">binimetinib</a> (MEK 162) and the <a href="/facts/BRAF_inhibitor/BYNJuQBg">BRAF inhibitor</a> <a href="/facts/Encorafenib/XIk0nHTF">encorafenib</a> (LGX818), for $85 million.<a class="footnote-ref" id="fnref:59" href="#fn:59">59</a> In addition, the company sold its <a href="/facts/RNAi/oJRWBXJH">RNAi</a> portfolio to <a href="/facts/Arrowhead_Research/qhTpGPbC">Arrowhead Research</a> for $10 million and $25 million in stock.<a class="footnote-ref" id="fnref:60" href="#fn:60">60</a> In June, the company announced it would acquire Spinifex Pharmaceuticals for more than $200 million.<a class="footnote-ref" id="fnref:61" href="#fn:61">61</a> In August, the company acquired the remaining rights to the <a href="/facts/CD20/jaVQpvfy">CD20</a> monoclonal antibody <a href="/facts/Ofatumumab/X0PsaRlc">Ofatumumab</a> from GlaxoSmithKline for up to $1 billion.<a class="footnote-ref" id="fnref:62" href="#fn:62">62</a><a class="footnote-ref" id="fnref:63" href="#fn:63">63</a> In October the company acquired Admune Therapeutics for an undisclosed sum, as well as licensing PBF-509, an <a href="/facts/Adenosine/MwyTJ2wR">adenosine</a> <a href="/facts/A2A_receptor/vds2yBur">A2A receptor</a> antagonist which is in Phase I clinical trials for non-small cell lung cancer, from Palobiofarma.<a class="footnote-ref" id="fnref:64" href="#fn:64">64</a>
In November 2016, the company announced it would acquire Selexys Pharmaceuticals for $665 million.<a class="footnote-ref" id="fnref:65" href="#fn:65">65</a> In December, the company acquired Encore Vision, gaining the company's principle compound, EV06, is a first-in-class topical therapy for <a href="/facts/Presbyopia/SYtUhl2D">presbyopia</a>.<a class="footnote-ref" id="fnref:66" href="#fn:66">66</a> In December Novartis acquired Ziarco Group Limited, bolstering its presence in eczema treatments.<a class="footnote-ref" id="fnref:67" href="#fn:67">67</a>
In late October 2017, <a href="/facts/Reuters/tDd1EUrd">Reuters</a> announced that Novartis would acquire <a href="/facts/Advanced_Accelerator_Applications/X6lL65dI">Advanced Accelerator Applications</a> for $3.9 billion, paying $41 per ordinary share and $82 per American depositary share representing a 47 percent premium.<a class="footnote-ref" id="fnref:68" href="#fn:68">68</a>
In March 2018, GlaxoSmithKline announced that it has reached an agreement with Novartis to acquire Novartis' 36.5 percent stake in their Consumer Healthcare Joint Venture for $13 billion (£9.2 billion).<a class="footnote-ref" id="fnref:69" href="#fn:69">69</a><a class="footnote-ref" id="fnref:70" href="#fn:70">70</a> In April of the same year, the business utilised some of the proceeds from the aforementioned GlaxoSmithKline deal to acquire <a href="/facts/Avexis/dr4cjYVW">Avexis</a> for $218 per share or $8.7 billion in total, gaining the lead compound <a href="/facts/AVXS-101/urcBCb49">AVXS-101</a> used to treat <a href="/facts/Spinal_muscular_atrophy/rBzq7qzU">spinal muscular atrophy</a>.<a class="footnote-ref" id="fnref:71" href="#fn:71">71</a> In August 2018, Novartis signed a deal with Laekna-a Shanghai-based pharmaceutical company for its two clinical-stage cancer drugs.<a class="footnote-ref" id="fnref:72" href="#fn:72">72</a> Novartis gave Laekna the exclusive international rights for the drugs that are oral pan-Akt <a href="/facts/Kinase_inhibitor/uG5lnQ3C">kinase inhibitors</a> namely; afuresertib (ASB138) and uprosertib (UPB795).<a class="footnote-ref" id="fnref:73" href="#fn:73">73</a> In mid-October, the company announced it would acquire <a href="/facts/Endocyte/gR45T5Kp">Endocyte</a> Inc for $2.1 billion ($24 per share) merging it with a newly created subsidiary.<a class="footnote-ref" id="fnref:74" href="#fn:74">74</a><a class="footnote-ref" id="fnref:75" href="#fn:75">75</a> Endocyte will bolster Novartis' offering in its radiopharmaceuticals business, with Endocyte's first in class candidate <a href="/facts/Lutetium_(177Lu)_vipivotide_tetraxetan/A5vTXC7U">177Lu-PSMA-617</a> being targeted against metastatic castration-resistant prostate cancer.<a class="footnote-ref" id="fnref:76" href="#fn:76">76</a> In late December the company announced it would acquire France-based contract manufacturer, CellforCure from <a href="/facts/LFB/QIfzyzs3">LFB</a>, boosting its capacity to produce cell and gene therapies.<a class="footnote-ref" id="fnref:77" href="#fn:77">77</a>
On 9 April 2019, Novartis announced that it had completed the spin-off of <a href="/facts/Alcon/Veyhdk4R">Alcon</a> as a separate commercial entity. Alcon was listed on the SIX exchange in Switzerland and NYSE exchange in the U.S.<a class="footnote-ref" id="fnref:78" href="#fn:78">78</a> Novartis announced during late 2019 a five-year <a href="/facts/Artificial_intelligence/lJGauQwX">artificial intelligence</a> "alliance" with Microsoft. The companies aim to create applications for "Microsoft's AI capabilities", in turn improving the other's drug development processes. Microsoft seeks to "test AI products it is already working on in 'real-life' situations". The deal will pursue solutions for "organizing and using" data generated from Novartis' laboratory experiments, clinical trials, and manufacturing plants. It will also look at improving manufacturing of <a href="/facts/Chimeric_antigen_receptor_T_cell/jtvECFR6">Chimeric antigen receptor T cell</a> (CAR T cells). Finally, the deal "will also apply AI to generative chemistry to enhance drug design".<a class="footnote-ref" id="fnref:79" href="#fn:79">79</a> In November 2019, Sandoz announced it would acquire the Japanese business of Aspen Global inc for €300 million (around $330 million), boosting the business's presence in Asia.<a class="footnote-ref" id="fnref:80" href="#fn:80">80</a> In late November 2019, the business announced it would acquire The Medicines Company for US$9.7 billion ($85 per share) in order to acquire amongst other assets, the cholesterol lowering therapy; <a href="/facts/Inclisiran/wplMLT2t">inclisiran</a>.<a class="footnote-ref" id="fnref:81" href="#fn:81">81</a><a class="footnote-ref" id="fnref:82" href="#fn:82">82</a>
In April 2020, the company announced it would acquire Amblyotech.<a class="footnote-ref" id="fnref:83" href="#fn:83">83</a>
In September 2020, Novartis was imposed a fine of €385 million by the French competition authority on accusations of abusive practices to preserve sales of <a href="/facts/Ranibizumab/oUvts4E1">Lucentis</a> over a cheaper drug.<a class="footnote-ref" id="fnref:84" href="#fn:84">84</a> Also in September, <a href="/facts/BioNTech/8f9h6cwq">BioNTech</a> has leased a large production facility from Novartis to follow all advance demands for its coronavirus vaccine in Europe and sell it to China.<a class="footnote-ref" id="fnref:85" href="#fn:85">85</a>
In July 2020, Novartis agreed to pay $678 million to settle allegations that the company violated the False Claims Act and Anti-Kickback Statute by paying physicians to induce them to prescribe certain of the company's drugs. Novartis allegedly spent hundreds of millions of dollars on fraudulent speaker programs that served as a means to bribe doctors with cash payments and other extravagant rewards.<a class="footnote-ref" id="fnref:86" href="#fn:86">86</a> Many of these speaking programs were allegedly nothing more than social gatherings at expensive restaurants, with limited or no discussion about the Novartis drugs.<a class="footnote-ref" id="fnref:87" href="#fn:87">87</a>
In October Novartis announced it would acquire Vedere Bio for $280 million boosting the businesses cell and gene therapy offerings.<a class="footnote-ref" id="fnref:88" href="#fn:88">88</a><a class="footnote-ref" id="fnref:89" href="#fn:89">89</a>
In October 2020, as part of a joint venture to develop therapeutic drugs to combat <a href="/facts/COVID-19/YsUgvsaX">COVID-19</a>, Novartis bought 6% of all shares outstanding in Swiss <a href="/facts/DARPin/yFxT3xUv">DARPin</a> research company <a href="/facts/Molecular_Partners/ddEDI7yq">Molecular Partners</a> AG at CHF 23 per share.<a class="footnote-ref" id="fnref:90" href="#fn:90">90</a>
In December 2020, Novartis announced it would acquire <a href="http://www.cadenttx.com/">Cadent Therapeutics</a> for up to $770 million, gaining full rights to CAD-9303 (a <a href="/facts/NMDA_receptor/BqMhXEbU">NMDAr positive allosteric modulator</a>), <a href="/facts/Onfasprodil/kxFg7NTc">MIJ-821</a> (a <a href="/facts/NMDA_receptor/BqMhXEbU">NMDAr negative allosteric modulator</a>) and CAD-1883 a clinical-stage <a href="/facts/SK_channel/3MlUG5EH">SK channel</a> positive allosteric modulator.<a class="footnote-ref" id="fnref:91" href="#fn:91">91</a><a class="footnote-ref" id="fnref:92" href="#fn:92">92</a>
In September 2021, the company announced it would acquire gene-therapy business, Arctos Medical, broadening its <a href="/facts/Optogenetics/RbYYcrr2">optogenetics</a> range.<a class="footnote-ref" id="fnref:93" href="#fn:93">93</a> In December, Novartis announced it would purchase Gyroscope Therapeutics from health care investment company, Syncona Ltd, for up to $1.5 billion.<a class="footnote-ref" id="fnref:94" href="#fn:94">94</a>
In February 2022, New York City-based biotechnology company Cambrian Biopharma announced it had licensed rights to <a href="/facts/MTOR_inhibitors/1TsIPrLs">mTOR inhibitor</a> programs from Novartis.<a class="footnote-ref" id="fnref:95" href="#fn:95">95</a> As part of the deal, Cambrian was setting up a subsidiary called Tornado Therapeutics.<a class="footnote-ref" id="fnref:96" href="#fn:96">96</a>
In August 2022, the company announced its plan to spin off Sandoz generic drugs unit to form a publicly traded business as part of a restructuring.<a class="footnote-ref" id="fnref:97" href="#fn:97">97</a> With the unit having generated US$9.69 billion in 2021, the spin-off would create the biggest generic drugs company in Europe by sales.<a class="footnote-ref" id="fnref:98" href="#fn:98">98</a>
In June 2023, Novartis announced it would acquire Chinook Therapeutics and its drug pipeline for up to $3.5 billion.<a class="footnote-ref" id="fnref:99" href="#fn:99">99</a>
In July 2023, Novartis acquired DTx Pharma, a developer of technology for delivering RNA-based therapies, upfront for $500 million and an additional $500 million subject to reaching certain targets.<a class="footnote-ref" id="fnref:100" href="#fn:100">100</a> Also in June, Novartis announced it would it would sell <a href="/facts/Xiidra/aHCKEIDd">Xiidra</a> to <a href="/facts/Bausch_%26_Lomb/pDoWkovR">Bausch & Lomb</a> for $1.75 billion and receive additional $750 million linked to future sales for Xiidra as well as two pipeline assets.<a class="footnote-ref" id="fnref:101" href="#fn:101">101</a><a class="footnote-ref" id="fnref:102" href="#fn:102">102</a>
In September 2023, Novartis announced that the spin-off had been approved by its shareholders and that it would be completed by the next month, resulting in Novartis shareholders receiving one Sandoz share for every five Novartis shares.<a class="footnote-ref" id="fnref:103" href="#fn:103">103</a><a class="footnote-ref" id="fnref:104" href="#fn:104">104</a> Sandoz will be listed on the <a href="/facts/SIX_Swiss_Exchange/xrjJWgVL">SIX Swiss Exchange</a> with a market capitalization between $18 billion and $25bn.<a class="footnote-ref" id="fnref:105" href="#fn:105">105</a><a class="footnote-ref" id="fnref:106" href="#fn:106">106</a>
On 4 October 2023, Novartis completed the spin-off of Sandoz as a stand-alone company.<a class="footnote-ref" id="fnref:107" href="#fn:107">107</a>
In November 2023, Legend Biotech and Novartis signed an out-license deal to develop and manufacture Legend's <a href="/facts/CAR_T_cell/jtvECFR6">chimeric antigen receptor</a> (CAR-T) therapies, that go after delta-like ligand protein 3 (DLL3) including large cell <a href="/facts/Neuroendocrine_tumor/WWrDG6m2">neuroendocrine carcinoma</a> candidate LB2102 for $100 million upfront, and Legend Biotech will be eligible to receive up to $1.01 billion in clinical, regulatory, and commercial milestone payments and tiered royalties.<a class="footnote-ref" id="fnref:108" href="#fn:108">108</a>
In December 2023, Novartis sold its 15 ophthalmology drugs to JB Chemicals for ₹1,089 crore ($116 million).<a class="footnote-ref" id="fnref:109" href="#fn:109">109</a>
In 2023, the <a href="/facts/World_Intellectual_Property_Organization/lenC10SK">World Intellectual Property Organization (WIPO)</a>’s Madrid Yearly Review ranked Novartis's number of marks applications filled under the <a href="/facts/Madrid_Protocol/28sV7zNg">Madrid System</a> as 4th in the world, with 110 <a href="/facts/Trademarks/B23H8IS0">trademarks</a> applications submitted during 2023.<a class="footnote-ref" id="fnref:110" href="#fn:110">110</a>
In February 2024, Novartis announced it would acquire the German biotech firm <a href="/facts/MorphoSys/JXfuYHUQ">MorphoSys AG</a> for €2.7bn.<a class="footnote-ref" id="fnref:111" href="#fn:111">111</a> Germany's antitrust regulator, the Federal Cartel Office, approved the takeover in March 2024.<a class="footnote-ref" id="fnref:112" href="#fn:112">112</a>
In May 2024, Novartis announced it would acquire Mariana Oncology for $1 billion upfront and up to $750 million more if certain milestones were met.<a class="footnote-ref" id="fnref:113" href="#fn:113">113</a>
In July 2024, Novartis entered into a strategic collaboration with <a href="https://www.drenbio.com/">Dren Bio</a> to develop therapeutic <a href="/facts/Bispecific_monoclonal_antibody/7xpSyYS1">bispecific antibodies</a> for cancer, with the deal worth up to $3 billion.<a class="footnote-ref" id="fnref:114" href="#fn:114">114</a><a class="footnote-ref" id="fnref:115" href="#fn:115">115</a>
In November 2024, Novartis and Ratio Therapeutics entered into a worldwide licence and collaboration agreement worth $745m to advance a <a href="/facts/Somatostatin_receptor_2/pxMPNgBp">somatostatin receptor 2</a> (SSTR2)-targeting <a href="/facts/Radiation_therapy/j60q5EC6">radiotherapeutic</a> candidate for cancer.<a class="footnote-ref" id="fnref:116" href="#fn:116">116</a>
In February 2025, Novartis announced the acquisition of Anthos Therapeutics for $925m.<a class="footnote-ref" id="fnref:117" href="#fn:117">117</a>

<h3>Acquisition history</h3>

<h2 id="corporate-structure">Corporate structure</h2>

Novartis AG is a publicly traded Swiss holding company that operates through the Novartis Group and owns, directly or indirectly, all companies worldwide that operate as subsidiaries of the Novartis Group.<a class="footnote-ref" id="fnref:118" href="#fn:118">118</a>
Novartis's businesses are divided into two operating divisions: Innovative Medicines and Sandoz (generics).<a class="footnote-ref" id="fnref:119" href="#fn:119">119</a> The eye-care division <a href="/facts/Alcon/Veyhdk4R">Alcon</a> was spun off into an independent company in April 2019.<a class="footnote-ref" id="fnref:120" href="#fn:120">120</a><a class="footnote-ref" id="fnref:121" href="#fn:121">121</a><a class="footnote-ref" id="fnref:122" href="#fn:122">122</a><a class="footnote-ref" id="fnref:123" href="#fn:123">123</a> In August 2022, Novartis announced plans to spin off Sandoz as part of restructuring. The spin-off was completed in October 2023.<a class="footnote-ref" id="fnref:124" href="#fn:124">124</a><a class="footnote-ref" id="fnref:125" href="#fn:125">125</a><a class="footnote-ref" id="fnref:126" href="#fn:126">126</a>
The Innovative Medicines business is made up of two commercial units: Innovative Medicines International and Innovative Medicines US.<a class="footnote-ref" id="fnref:127" href="#fn:127">127</a><a class="footnote-ref" id="fnref:128" href="#fn:128">128</a> The two business units combine the pharmaceutical and oncology divisions and commercially focus on global and US market respectively.<a class="footnote-ref" id="fnref:129" href="#fn:129">129</a><a class="footnote-ref" id="fnref:130" href="#fn:130">130</a>
Novartis operates directly through subsidiaries, each of which fall under one of the divisions, and that Novartis categorizes as fulfilling one or more of the following functions: Holding/Finance, Sales, Production, and Research<a class="footnote-ref" id="fnref:131" href="#fn:131">131</a><a class="footnote-ref" id="fnref:132" href="#fn:132">132</a>: 251–253 
Novartis AG also held 33.3 percent of the shares of <a href="/facts/Hoffmann-La_Roche/e4Wdasmz">Roche</a> until 2022, however it did not exercise control over Roche.<a class="footnote-ref" id="fnref:133" href="#fn:133">133</a> Novartis also has two significant license agreements with <a href="/facts/Genentech/DPahQBr4">Genentech</a>, a Roche subsidiary.<a class="footnote-ref" id="fnref:134" href="#fn:134">134</a> One agreement is for <a href="/facts/Lucentis/oUvts4E1">Lucentis</a>;<a class="footnote-ref" id="fnref:135" href="#fn:135">135</a> the other is for <a href="/facts/Xolair/EyDGUak5">Xolair</a>.<a class="footnote-ref" id="fnref:136" href="#fn:136">136</a><a class="footnote-ref" id="fnref:137" href="#fn:137">137</a>: 239 
In 2014, Novartis established a center in <a href="/facts/Hyderabad/APPUtNqU">Hyderabad</a>, India, in order to offshore several of its R&D, clinical development, medical writing and administrative functions.<a class="footnote-ref" id="fnref:138" href="#fn:138">138</a> The center supports the drug major's operations in the pharmaceuticals (Novartis), eye care (Alcon), and generic drugs segments (Sandoz).<a class="footnote-ref" id="fnref:139" href="#fn:139">139</a>

<h2 id="place-in-its-market-segments">Place in its market segments</h2>

Novartis is the world's first largest in life sciences and agribusiness markets.<a class="footnote-ref" id="fnref:140" href="#fn:140">140</a> It is also the second-largest pharmaceutical company by market cap in 2019.<a class="footnote-ref" id="fnref:141" href="#fn:141">141</a> 

<ul><li>Alcon: At the time Novartis bought Alcon, they had annual sales of $6.5 billion and a net income of $2 billion.<a class="footnote-ref" id="fnref:142" href="#fn:142">142</a> In April 2019, Novartis completed the spin-off of Alcon as a separate commercial entity.<a class="footnote-ref" id="fnref:143" href="#fn:143">143</a></li>
<li>Sandoz: As of 2013<a href="https://en.wikipedia.org/w/index.php?title=Novartis&action=edit">[update]</a>, Sandoz has been recognized as the world's second-largest generic drug company. Sandoz' <a href="/facts/Biosimilars/QmgnUAzK">biosimilars</a> lead its field, getting the first biosimilar approvals in the EU.<a class="footnote-ref" id="fnref:144" href="#fn:144">144</a><a class="footnote-ref" id="fnref:145" href="#fn:145">145</a> In 2018, Sandoz reported US$9.9 billion in net sales.<a class="footnote-ref" id="fnref:146" href="#fn:146">146</a> In August 2022, Novartis announced plans to spin off Sandoz by second half of 2023.<a class="footnote-ref" id="fnref:147" href="#fn:147">147</a></li>
<li>Vaccines and Diagnostics Division: In 2013, Novartis announced it was considering selling the vaccines and diagnostics division off.<a class="footnote-ref" id="fnref:148" href="#fn:148">148</a> This sale was completed in late 2015, and the division was integrated into <a href="/facts/CSL_Limited/KBN62Tpq">CSL</a>'s BioCSL operation, with the combined entity trading as Seqirus.<a class="footnote-ref" id="fnref:149" href="#fn:149">149</a><a class="footnote-ref" id="fnref:150" href="#fn:150">150</a> In 2018, Novartis sold its consumer healthcare joint venture vaccines division to GlaxoSmithKline for US$13.0 billion.<a class="footnote-ref" id="fnref:151" href="#fn:151">151</a></li>
<li>Consumer: Novartis is not a leader in the over-the-counter or animal health segments; its leading OTC brands are <a href="/facts/Excedrin/cFU6dpgH">Excedrin</a> and <a href="/facts/Theraflu/2Qe0AjMx">Theraflu</a>, but sales have been slowed by problems at its key US manufacturing plant.<a class="footnote-ref" id="fnref:152" href="#fn:152">152</a></li></ul>
In 2018, Novartis ranked second on the <a href="/facts/Access_to_Medicine_Index/FDSDQN4X">Access to Medicine Index</a>,<a class="footnote-ref" id="fnref:153" href="#fn:153">153</a>: 88  which "ranks companies on how readily they make their products available to the world's poor."<a class="footnote-ref" id="fnref:154" href="#fn:154">154</a><a class="footnote-ref" id="fnref:155" href="#fn:155">155</a>

<h3>Finance</h3>
As of January 31, 2025, Novartis shares traded at over $104.72 per share, and its market capitalization was valued at $210.39B.<a class="footnote-ref" id="fnref:156" href="#fn:156">156</a>

<table><tbody><tr><th>Year</th><th>Revenuein mil. US$</th><th>Net incomein mil. US$</th><th>Price per Sharein US$</th><th>Employees</th></tr><tr><td>2005</td><td>29,753</td><td>6,130</td><td>32.03</td><td></td></tr><tr><td>2006</td><td>35,105</td><td>7,175</td><td>36.99</td><td></td></tr><tr><td>2007</td><td>38,947</td><td>11,946</td><td>37.10</td><td></td></tr><tr><td>2008</td><td>42,584</td><td>8,195</td><td>35.44</td><td></td></tr><tr><td>2009</td><td>45,103</td><td>8,400</td><td>31.98</td><td></td></tr><tr><td>2010</td><td>51,561</td><td>9,794</td><td>39.41</td><td></td></tr><tr><td>2011</td><td>59,375</td><td>8,940</td><td>44.42</td><td></td></tr><tr><td>2012</td><td>51,971</td><td>9,270</td><td>46.50</td><td></td></tr><tr><td>2013</td><td>52,716</td><td>9,175</td><td>61.40</td><td>135,696</td></tr><tr><td>2014</td><td>53,634</td><td>10,210</td><td>76.50</td><td>133,413</td></tr><tr><td>2015</td><td>50,387</td><td>17,783</td><td>86.92</td><td>122,966</td></tr><tr><td>2016</td><td>49,436</td><td>6,712</td><td>71.10</td><td>122,985</td></tr><tr><td>2017</td><td>50,135</td><td>7,703</td><td>77.33</td><td>126,457</td></tr><tr><td>2018</td><td>46,099</td><td>12,614</td><td>91.13</td><td>129,924</td></tr><tr><td>2019</td><td>48,677</td><td>11,732</td><td>88.14</td><td>103,914</td></tr><tr><td>2020</td><td>49,898</td><td>8,072</td><td>84.38</td><td>110,000</td></tr><tr><td>2021</td><td>51,626</td><td>24,018</td><td>87.47</td><td>110,000</td></tr><tr><td>2022</td><td>50,545</td><td>6,955</td><td>80.56</td><td>101,703</td></tr><tr><td>2023</td><td>45,440</td><td>14,854</td><td>100.34</td><td>76,057</td></tr><tr><td>2024</td><td>50,317</td><td>11,939</td><td>104.72</td><td>75,883</td></tr></tbody></table>
<h3>Pricing</h3>
<h4>Entresto (sacubitril/valsartan)</h4>
In 2023, the Institute for Clinical and Economic Review (ICER) identified Entresto as one of five high-expenditure drugs that experienced significant net price increases without new clinical evidence to justify the hikes. Specifically, Entresto's wholesale acquisition cost rose by 7%, leading to an additional $72 million in costs to U.S. payers.<a class="footnote-ref" id="fnref:157" href="#fn:157">157</a>

<h2 id="research">Research</h2>

The company's global research operations, called "Novartis Institutes for BioMedical Research (NIBR)" have their global headquarters in <a href="/facts/Cambridge,_Massachusetts/k9UMIJ7U">Cambridge, Massachusetts</a>, United States.<a class="footnote-ref" id="fnref:158" href="#fn:158">158</a><a class="footnote-ref" id="fnref:159" href="#fn:159">159</a> Two research institutes reside within NIBR that focus on diseases in the developing world: Novartis Institute for Tropical Diseases, which works on tuberculosis, dengue, and malaria, and Novartis Vaccines Institute for Global Health, which works on salmonella typhi (typhoid fever) and shigella.<a class="footnote-ref" id="fnref:160" href="#fn:160">160</a>
Novartis is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of <a href="/facts/Pre-clinical_development/WSI14rnq">non-clinical</a> safety assessment is the InnoMed PredTox project.<a class="footnote-ref" id="fnref:161" href="#fn:161">161</a><a class="footnote-ref" id="fnref:162" href="#fn:162">162</a> The company is expanding its activities in joint research projects within the framework of the <a href="/facts/Innovative_Medicines_Initiative/0wh6pump">Innovative Medicines Initiative</a> of <a href="/facts/EFPIA/btMusG9l">EFPIA</a> and the <a href="/facts/European_Commission/Cc5JgbEI">European Commission</a>.<a class="footnote-ref" id="fnref:163" href="#fn:163">163</a>
Novartis is working with <a href="/facts/Science_37/o0mUA3jP">Science 37</a> in order to allow video based <a href="/facts/Telemedicine/zVSkAFrz">telemedicine</a> visits instead of physical traveling to clinics for patients. It is planning for ten clinical trials over three years using <a href="/facts/Mobile_technology/WcCjQ83p">mobile technology</a> to help free patients from burdensome hospital trips.<a class="footnote-ref" id="fnref:164" href="#fn:164">164</a>

<h2 id="products">Products</h2>
<h3>Pharmaceuticals (66 in total as of 28 April 2023)</h3>
<table><tbody><tr><th>Name</th><th><a href="/facts/Indication_(medicine)/DLdGwxDY">Indication(s)</a> or drug type/class</th><th>Sales <a href="/facts/United_States_dollar/naEEDUhC">US$</a>1,000,000</th><th>Sales year</th><th>% Change</th><th>Notes</th></tr><tr><td>Aclasta/Reclast (<a href="/facts/Zoledronic_acid/g3oMtI5Q">zoledronic acid</a>)</td><td><a href="/facts/Osteoporosis/xa1W00Tj">Osteoporosis</a></td><td>590</td><td>2012<a class="footnote-ref" id="fnref:165" href="#fn:165">165</a></td><td>−4%</td><td></td></tr><tr><td>Adelphane-Esidrex (<a href="/facts/Reserpine/Hkb4T1oE">reserpine</a>/<a href="/facts/Dihydralazine/4hUESqRd">dihydralazine</a>/<a href="/facts/Hydrochlorothiazide/2LuDQVCu">hydrochlorothiazide</a>)</td><td><a href="/facts/Hypertension/wlAvBfcf">Hypertension</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Afinitor/Certican/Zortress (<a href="/facts/Everolimus/nKvnvSD8">everolimus</a>)</td><td>Prevention of <a href="/facts/Transplant_rejection/d9jSqs2x">transplant rejection</a>, various cancers</td><td>797</td><td>2012<a class="footnote-ref" id="fnref:166" href="#fn:166">166</a></td><td>80%</td><td></td></tr><tr><td>Amturnide (<a href="/facts/Aliskiren/yJQ8Comr">aliskiren</a>/<a href="/facts/Amlodipine/vTR2cPqe">amlodipine</a>/hydrochlorothiazide)</td><td>Hypertension</td><td></td><td></td><td></td><td></td></tr><tr><td>Anafranil (<a href="/facts/Clomipramine/wnhL4NfS">clomipramine</a>)</td><td><a href="/facts/Major_depressive_disorder/l2lQeWqr">Major depressive disorder</a>, <a href="/facts/Obsessive-compulsive_disorder/bIhDh4dz">obsessive-compulsive disorder</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Arcapta Neohaler/Onbrez Breezhaler (<a href="/facts/Indacaterol/tuwSQSvj">indacaterol</a>)</td><td><a href="/facts/COPD/ud3oXGCr">COPD</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Brinaldix (<a href="/facts/Clopamide/8SmHAXIG">clopamide</a>)</td><td>Hypertension</td><td></td><td></td><td></td><td></td></tr><tr><td>Clozaril/Leponex (<a href="/facts/Clozapine/N0Lqztg1">clozapine</a>)</td><td>Treatment-resistant <a href="/facts/Schizophrenia/FMP4lQ57">schizophrenia</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Co-Diovan (<a href="/facts/Valsartan/hydrochlorothiazide/SF2M5zoq">Valsartan/hydrochlorothiazide</a>)</td><td>Hypertension</td><td></td><td></td><td></td><td></td></tr><tr><td>Coartem/Riamet (<a href="/facts/Artemether/lumefantrine/zuCbq6fb">artemether/lumefantrine</a>)</td><td><a href="/facts/Malaria/rN3g58CX">Malaria</a> (uncomplicated)</td><td></td><td></td><td></td><td></td></tr><tr><td>Comtan (<a href="/facts/Entacapone/4m7Qa7BN">entacapone</a>)</td><td><a href="/facts/Parkinson%27s_disease/xpekKj6x">Parkinson's disease</a></td><td>530</td><td>2012<a class="footnote-ref" id="fnref:167" href="#fn:167">167</a></td><td>−14%</td><td></td></tr><tr><td>Cosentyx (<a href="/facts/Secukinumab/DM0Nm99T">secukinumab</a>)</td><td><a href="/facts/Psoriasis/WW1k1LsH">Psoriasis</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Diovan (<a href="/facts/Valsartan/oFBA3SDq">valsartan</a>)</td><td>Hypertension</td><td>4,417</td><td>2012<a class="footnote-ref" id="fnref:168" href="#fn:168">168</a></td><td>−22%</td><td></td></tr><tr><td>Entresto (<a href="/facts/Sacubitril/valsartan/mJ1krlNA">sacubitril/valsartan</a>)</td><td><a href="/facts/Heart_failure/7fckX3Jm">Heart failure</a></td><td></td><td></td><td></td><td>One of five high-expenditure drugs that experienced significant net price increases without new clinical evidence to justify the hikes.<a class="footnote-ref" id="fnref:169" href="#fn:169">169</a></td></tr><tr><td>Enterovioform (<a href="/facts/Clioquinol/f9rDIBo5">clioquinol</a>)</td><td><a href="/facts/Amoebiasis/VdNpYVKC">Amoebiasis</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Eucreas/Galvus Met (<a href="/facts/Vildagliptin/lzXcED9M">vildagliptin</a>/<a href="/facts/Metformin/ScXHFaPT">metformin</a>)</td><td><a href="/facts/Diabetes_mellitus_type_2/zCMXksmt">Diabetes mellitus type 2</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Exelon Patch (<a href="/facts/Rivastigmine/wzJnEUz6">rivastigmine</a>)</td><td><a href="/facts/Alzheimer%27s_disease/w7Ad6tdg">Alzheimer's disease</a></td><td>1,050</td><td>2012<a class="footnote-ref" id="fnref:170" href="#fn:170">170</a></td><td>−2%</td><td></td></tr><tr><td>Exforge (<a href="/facts/Amlodipine/valsartan/PE5QadoM">amlodipine/valsartan</a>)</td><td>Hypertension</td><td>1,352</td><td>2012<a class="footnote-ref" id="fnref:171" href="#fn:171">171</a></td><td>12%</td><td></td></tr><tr><td>Exjade (<a href="/facts/Deferasirox/ElRhYua8">deferasirox</a>)</td><td>Chronic <a href="/facts/Iron_overload/b7jEdAGr">iron overload</a></td><td>870</td><td>2012<a class="footnote-ref" id="fnref:172" href="#fn:172">172</a></td><td>2%</td><td>Manufactured as tablets for oral suspension; tablets for oral use are marketed under the brand name Jadenu</td></tr><tr><td>Famvir (<a href="/facts/Famciclovir/r9Fc4YRC">famciclovir</a>)</td><td><a href="/facts/Herpes_zoster/2rEq69rr">Herpes zoster</a> and other Herpesvirus infection</td><td></td><td></td><td></td><td></td></tr><tr><td>Fanapt (<a href="/facts/Iloperidone/gqI7MvpE">iloperidone</a>)</td><td>Schizophrenia</td><td></td><td></td><td></td><td></td></tr><tr><td>Femara (<a href="/facts/Letrozole/23LLQw13">letrozole</a>)</td><td><a href="/facts/Breast_cancer/6hME580v">Breast cancer</a></td><td>438</td><td>2012<a class="footnote-ref" id="fnref:173" href="#fn:173">173</a></td><td>−52%</td><td></td></tr><tr><td>Focalin (<a href="/facts/Dexmethylphenidate/lfTTXJXo">dexmethylphenidate</a>)</td><td><a href="/facts/ADHD/uSqjIyhd">ADHD</a></td><td></td><td></td><td></td><td>First US generics of Focalin became available in 2007.<a class="footnote-ref" id="fnref:174" href="#fn:174">174</a> Focalin XR became available in 2012.<a class="footnote-ref" id="fnref:175" href="#fn:175">175</a></td></tr><tr><td>Foradil/Foradile (<a href="/facts/Formoterol/EhK6qGUo">formoterol</a>)</td><td><a href="/facts/Asthma/7GkJvxn3">Asthma</a>, COPD</td><td></td><td></td><td></td><td></td></tr><tr><td>Galvus (<a href="/facts/Vildagliptin/lzXcED9M">vildagliptin</a>)</td><td>Diabetes mellitus type 2</td><td>910</td><td>2012<a class="footnote-ref" id="fnref:176" href="#fn:176">176</a></td><td>39%</td><td></td></tr><tr><td>Gilenya (<a href="/facts/Fingolimod/m6aNDmTA">fingolimod</a>)</td><td><a href="/facts/Multiple_sclerosis/vghXl0IQ">Multiple sclerosis</a></td><td>1,195</td><td>2012<a class="footnote-ref" id="fnref:177" href="#fn:177">177</a></td><td>142%</td><td></td></tr><tr><td>Gleevec/Glivec (<a href="/facts/Imatinib/PSpRplHy">imatinib</a>)</td><td><a href="/facts/Oncology/t2CUAEJQ">Oncology</a>, <a href="/facts/Chronic_myelogenous_leukemia/FA9TdgQn">Chronic myelogenous leukemia</a></td><td>4,675</td><td>2012<a class="footnote-ref" id="fnref:178" href="#fn:178">178</a></td><td>0%</td><td></td></tr><tr><td>Hygroton (<a href="/facts/Chlortalidone/BvYtPJyj">chlortalidone</a>)</td><td>Hypertension</td><td></td><td></td><td></td><td></td></tr><tr><td>Ilaris (<a href="/facts/Canakinumab/e9zbk11U">canakinumab</a>)</td><td><a href="/facts/Cryopyrin-associated_periodic_syndrome/ChNnUMuN">Cryopyrin-associated periodic syndrome</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Jadenu (<a href="/facts/Deferasirox/ElRhYua8">deferasirox</a>)</td><td>Chronic iron overload</td><td></td><td></td><td></td><td>Deferasirox tablets for oral use—a new formulation of Exjade (which comes in tablets for oral suspension)</td></tr><tr><td>Jakavi/Jakafi (<a href="/facts/Ruxolitinib/WUkFQnnW">ruxolitinib</a>)</td><td><a href="/facts/Myelofibrosis/2UHM1T5R">Myelofibrosis</a> (of intermediate to high risk)</td><td></td><td></td><td></td><td></td></tr><tr><td>Kisqali (<a href="/facts/Ribociclib/qX2RMecU">ribociclib</a>)</td><td><a href="/facts/Breast_Cancer/6hME580v">Breast Cancer</a></td><td>1,231</td><td>2022<a class="footnote-ref" id="fnref:179" href="#fn:179">179</a></td><td></td><td></td></tr><tr><td>Kymriah (<a href="/facts/Tisagenlecleucel/PuKbxFnL">tisagenlecleucel</a>)</td><td><a href="/facts/Acute_lymphoblastic_leukemia/vRIAjkRJ">Acute lymphoblastic leukemia</a></td><td></td><td></td><td></td></tr><tr><td>Lamisil (<a href="/facts/Terbinafine/7qBCjoYW">terbinafine</a>)</td><td><a href="/facts/Fungal_infections/YVK551qC">Fungal infections</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Lescol (<a href="/facts/Fluvastatin/tH55UdPj">fluvastatin</a>)</td><td><a href="/facts/Hypercholesterolemia/UlIDdQuT">Hypercholesterolemia</a></td><td>665</td><td>2007<a class="footnote-ref" id="fnref:180" href="#fn:180">180</a></td><td>−8%</td><td></td></tr><tr><td>Lioresal (<a href="/facts/Baclofen/CI3r45RA">baclofen</a>)</td><td><a href="/facts/Spasticity/XLnsqIDJ">Spasticity</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Lotrel (<a href="/facts/Amlodipine/benazepril/bIjxF903">amlodipine/benazepril</a>)</td><td>Hypertension</td><td>748</td><td>2007<a class="footnote-ref" id="fnref:181" href="#fn:181">181</a></td><td>−34%</td><td></td></tr><tr><td>Lucentis (<a href="/facts/Ranibizumab/oUvts4E1">ranibizumab</a>)</td><td>Age-related <a href="/facts/Macular_degeneration/9pFARaka">macular degeneration</a></td><td>2,398</td><td>2012<a class="footnote-ref" id="fnref:182" href="#fn:182">182</a></td><td>17%</td><td></td></tr><tr><td>Ludiomil (<a href="/facts/Maprotiline/uE3Gp71o">maprotiline</a>)</td><td>Major depressive disorder</td><td></td><td></td><td></td><td></td></tr><tr><td>Mayzent<a class="footnote-ref" id="fnref:183" href="#fn:183">183</a> (<a href="/facts/Siponimod/KTIYqyUM">siponimod</a>)</td><td>Treatment for <a href="/facts/Multiple_sclerosis/vghXl0IQ">secondary progressive multiple sclerosis</a> (SPMS)</td><td></td><td></td><td></td><td>FDA approved 26 March 2019<a class="footnote-ref" id="fnref:184" href="#fn:184">184</a></td></tr><tr><td>Mellaril (<a href="/facts/Thioridazine/um69HuvU">thioridazine</a>)</td><td>Schizophrenia</td><td></td><td></td><td></td><td></td></tr><tr><td>Myfortic (<a href="/facts/Mycophenolic_acid/kHpk0USt">mycophenolic acid</a>)</td><td>Prevention of transplant rejection</td><td>579</td><td>2012<a class="footnote-ref" id="fnref:185" href="#fn:185">185</a></td><td>12%</td><td></td></tr><tr><td>Navoban (<a href="/facts/Tropisetron/tv9CTt86">tropisetron</a>)</td><td><a href="/facts/Chemotherapy-induced_nausea_and_vomiting/jlRkqdHW">Chemotherapy-induced nausea and vomiting</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Odomzo (<a href="/facts/Sonidegib/0r3S1dhN">sonidegib</a>)</td><td>Locally advanced <a href="/facts/Basal_cell_carcinoma/NLHsYND7">basal cell carcinoma</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Ritalin (<a href="/facts/Methylphenidate/PHmG2R5p">methylphenidate</a>)</td><td><a href="/facts/ADHD/uSqjIyhd">ADHD</a></td><td>554</td><td>2012<a class="footnote-ref" id="fnref:186" href="#fn:186">186</a></td><td>1%</td><td></td></tr><tr><td>Sandimmune/Neoral (<a href="/facts/Ciclosporin/tcIToHvK">ciclosporin</a>)</td><td>Prevention of transplant rejection</td><td>821</td><td>2012<a class="footnote-ref" id="fnref:187" href="#fn:187">187</a></td><td>−9%</td><td></td></tr><tr><td>Sandostatin (<a href="/facts/Octreotide/A7su7kgD">octreotide</a>)</td><td><a href="/facts/Acromegaly/caqcbMmM">Acromegaly</a></td><td>1,512</td><td>2012<a class="footnote-ref" id="fnref:188" href="#fn:188">188</a></td><td>5%</td><td></td></tr><tr><td>Scemblix (<a href="/facts/Asciminib/7ISYYmW9">Asciminib</a>)</td><td>Philadelphia chromosome-positive chronic myeloid leukemia</td><td></td><td></td><td></td><td></td></tr><tr><td>Sertraline Sandoz (<a href="/facts/Sertraline/SBk6L0Jr">sertraline hydrochloride</a>)</td><td>Depression, obsessive-compulsive disorder, <a href="/facts/Panic_disorder/jRfhx14r">panic disorder</a><a class="footnote-ref" id="fnref:189" href="#fn:189">189</a></td><td></td><td></td><td></td><td>Generic form of sertraline.</td></tr><tr><td>Signifor (<a href="/facts/Pasireotide/MlycKY4l">pasireotide</a>)</td><td><a href="/facts/Cushing%27s_disease/HqfLkI5J">Cushing's disease</a><a class="footnote-ref" id="fnref:190" href="#fn:190">190</a><a class="footnote-ref" id="fnref:191" href="#fn:191">191</a></td></tr><tr><td>Simulect (<a href="/facts/Basiliximab/6BLvotys">basiliximab</a>)</td><td>Prevention of transplant rejection</td><td></td><td></td><td></td><td></td></tr><tr><td>Sirdalud (<a href="/facts/Tizanidine/2ny5FuRt">tizanidine</a>)</td><td>Spasticity</td><td></td><td></td><td></td><td></td></tr><tr><td>Spersallerg (<a href="/facts/Antazoline/mGcoefCP">antazoline</a>/<a href="/facts/Tetrahydrozoline/PH8r1oh4">tetrahydrozoline</a>)</td><td><a href="/facts/Allergic_conjunctivitis/5xwNBMUe">Allergic conjunctivitis</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Stalevo (<a href="/facts/Carbidopa/E7ULm1KM">carbidopa</a>/<a href="/facts/Levodopa/4R7qahlh">levodopa</a>/<a href="/facts/Entacapone/4m7Qa7BN">entacapone</a>)</td><td>Parkinson's disease</td><td></td><td></td><td></td><td></td></tr><tr><td>Tasigna (<a href="/facts/Nilotinib/5dvWNTAb">nilotinib</a>)</td><td>Chronic myelogenous leukemia (first-line treatment<a class="footnote-ref" id="fnref:192" href="#fn:192">192</a>)</td><td>998</td><td>2012<a class="footnote-ref" id="fnref:193" href="#fn:193">193</a></td><td>39%</td><td><a href="/facts/NICE/83vtP8Lk">NICE</a> formulary approval, January 2012<a class="footnote-ref" id="fnref:194" href="#fn:194">194</a></td></tr><tr><td>Tegretol (<a href="/facts/Carbamazepine/Hd1By1Mj">carbamazepine</a>)</td><td><a href="/facts/Epilepsy/wawyp56a">Epilepsy</a>, <a href="/facts/Bipolar_disorder/aMDwXbV0">bipolar disorder</a></td><td>413</td><td>2007<a class="footnote-ref" id="fnref:195" href="#fn:195">195</a></td><td>6%</td><td></td></tr><tr><td>Tekamlo (<a href="/facts/Aliskiren/amlodipine/YLUtEQWI">aliskiren/amlodipine</a>)</td><td>Hypertension</td><td></td><td></td><td></td><td></td></tr><tr><td>Tekturna/Rasilez (<a href="/facts/Aliskiren/yJQ8Comr">aliskiren</a>)</td><td>Hypertension</td><td></td><td></td><td></td><td></td></tr><tr><td>Termalgin (<a href="/facts/Paracetamol/SNDfQWcf">paracetamol</a>)</td><td><a href="/facts/Fever/waVxR2Ac">Fever</a>, mild pain</td><td></td><td></td><td></td><td></td></tr><tr><td>Tobi (<a href="/facts/Tobramycin/BS2cm58u">tobramycin</a>)</td><td>Prevention of <a href="/facts/Pseudomonas_aeruginosa/HBhyIxAn">Pseudomonas aeruginosa</a> infection in <a href="/facts/Cystic_fibrosis/tlNK5BAH">cystic fibrosis</a></td><td>350 (US only)</td><td>2012<a class="footnote-ref" id="fnref:196" href="#fn:196">196</a></td><td></td><td>Teva introduced generic in the US in 2013<a class="footnote-ref" id="fnref:197" href="#fn:197">197</a></td></tr><tr><td>Tofranil (<a href="/facts/Imipramine/3ppWvEKp">imipramine</a>)</td><td>Major depressive disorder, <a href="/facts/Enuresis/dksPvGRh">enuresis</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Trileptal (<a href="/facts/Oxcarbazepine/jstz7RYM">oxcarbazepine</a>)</td><td>Epilepsy, bipolar disorder</td><td>690 (US only)</td><td>2007<a class="footnote-ref" id="fnref:198" href="#fn:198">198</a></td><td></td><td>Teva introduced generic in 2008<a class="footnote-ref" id="fnref:199" href="#fn:199">199</a></td></tr><tr><td>Tyzeca/Sebivo (<a href="/facts/Telbivudine/6uM0uBcV">telbivudine</a>)</td><td>Chronic <a href="/facts/Hepatitis_B/qqPTEY3p">hepatitis B</a></td><td></td><td></td><td></td><td></td></tr><tr><td>Visudyne (<a href="/facts/Verteporfin/XI4S22IM">verteporfin</a>)</td><td>Age-related macular degeneration (wet form)</td><td></td><td></td><td></td><td></td></tr><tr><td>Voltaren (<a href="/facts/Diclofenac/JwjJ8fcP">diclofenac</a>)</td><td>Acute pain, <a href="/facts/Inflammatory_disorders/Ura86MIy">inflammatory disorders</a> (such as <a href="/facts/Rheumatoid_arthritis/qFK4Xwv7">rheumatoid arthritis</a>)</td><td>759 (excl. OTC)</td><td>2012<a class="footnote-ref" id="fnref:200" href="#fn:200">200</a></td><td>−4%</td><td></td></tr><tr><td>Zometa (<a href="/facts/Zoledronic_acid/g3oMtI5Q">zoledronic acid</a>)</td><td>Prevention of bone fractures in cancer patients</td><td>1,288</td><td>2012<a class="footnote-ref" id="fnref:201" href="#fn:201">201</a></td><td>−13%</td><td></td></tr><tr><td>Xolair (<a href="/facts/Omalizumab/EyDGUak5">omalizumab</a>)</td><td>Moderate-to-severe <a href="/facts/Asthma/7GkJvxn3">asthma</a> not controlled by inhaled <a href="/facts/Glucocorticoid/2P91Aj3S">steroids</a><a href="/facts/Chronic_idiopathic_urticaria/zMkVo9qL">Chronic idiopathic urticaria</a></td><td>504</td><td>2012<a class="footnote-ref" id="fnref:202" href="#fn:202">202</a></td><td>4%</td><td></td></tr><tr><td>Zaditen (<a href="/facts/Ketotifen/MrkANhwx">ketotifen</a>)</td><td>Asthma, allergic conjunctivitis</td><td></td><td></td><td></td><td></td></tr></tbody></table>
<h3>Consumer health</h3>

<ul><li><a href="/facts/Benefiber/mhNKyPNS">Benefiber</a></li>
<li>Bialcol Alcohol</li>
<li><a href="/facts/Buckley%27s/9JGKbYvM">Buckley's</a> cold and cough formula</li>
<li><a href="/facts/Bufferin/opMK4qLk">Bufferin</a></li>
<li><a href="/facts/ChestEze/H1acrVn5">ChestEze</a></li>
<li>Comtrex cold and cough</li>
<li><a href="/facts/Penciclovir/gXPemlLD">Denavir/Vectavir</a></li>
<li><a href="/facts/Miconazole/PjA5UgFB">Desenex</a></li>
<li><a href="/facts/Doan%27s/BhacRFb8">Doan's</a> pain relief</li>
<li><a href="/facts/Ex-Lax/uXfdAJ8o">Ex-Lax</a></li>
<li><a href="/facts/Excedrin/cFU6dpgH">Excedrin</a></li>
<li><a href="/facts/Fenistil/88mt5rXU">Fenistil</a></li>
<li><a href="/facts/Gas-X/uzAf4IYV">Gas-X</a></li>
<li><a href="/facts/Habitrol/AolqwkJ8">Habitrol</a></li>
<li><a href="/facts/Keri/CRz6r8Po">Keri</a> skin care</li>
<li><a href="/facts/Lamisil/7qBCjoYW">Lamisil</a> foot care</li>
<li>Lipactin <a href="/facts/Herpes_simplex/8AQktlTV">herpes</a> symptomatic treatment</li>
<li><a href="/facts/Maalox/SAsqCjc9">Maalox</a></li>
<li><a href="/facts/Nicotine_replacement_therapy/NVndtPso">Nicotinell</a></li>
<li><a href="/facts/No-doz/Hx6E2QC5">No-doz</a></li>
<li><a href="/facts/Quinvaxem/pcTajuot">Quinvaxem</a> (<a href="/facts/DTwP-HepB-Hib_vaccine/AUfwNNGx">Pentavalent vaccine</a>)</li>
<li><a href="/facts/Xylometazoline/bLSBCzou">Otrivine</a></li>
<li><a href="/facts/Lansoprazole/rV4V9hNt">Prevacid 24HR</a></li>
<li><a href="/facts/Savlon/TNLzxgXH">Savlon</a></li>
<li><a href="/facts/Tavist/qJELSNrv">Tavist</a></li>
<li><a href="/facts/Theraflu/2Qe0AjMx">Theraflu</a></li>
<li><a href="/facts/Tioconazole/LHQ7UtRQ">Vagistat</a></li>
<li>Tixylix</li>
<li><a href="/facts/Diclofenac/JwjJ8fcP">Voltaren</a></li></ul>

In January 2009, the <a href="/facts/United_States_Department_of_Health_and_Human_Services/eS90vYmd">United States Department of Health and Human Services</a> awarded Novartis a $486 million contract for construction of the first US plant to produce cell-based <a href="/facts/Influenza_vaccine/6J8BBKN1">influenza vaccine</a>, to be located in <a href="/facts/Holly_Springs,_North_Carolina/YQ7Sq5YF">Holly Springs, North Carolina</a>. The stated goal of this program is the capability of producing 150,000,000 doses of <a href="/facts/Influenza_research/nWuFzh6L">pandemic vaccine</a> within six months of declaring a flu pandemic.<a class="footnote-ref" id="fnref:203" href="#fn:203">203</a>
In April 2014, Novartis divested its consumer health section with $3.5 billion worth of assets into a new joint venture with <a href="/facts/GlaxoSmithKline/NrnnxFNW">GlaxoSmithKline</a>, named GSK Consumer Healthcare, of which Novartis will hold a 36.5% stake.<a class="footnote-ref" id="fnref:204" href="#fn:204">204</a> In March 2018, GSK announced that it has reached an agreement with Novartis to acquire Novartis' 36.5% stake in their Consumer Healthcare Joint Venture for $13 billion (£9.2 billion).<a class="footnote-ref" id="fnref:205" href="#fn:205">205</a>

<h3>Animal health</h3>
<h4>Pet care</h4>
<ul><li>Interceptor (<a href="/facts/Milbemycin_oxime/vC92pBwt">Milbemycin oxime</a>), oral worm control product</li>
<li><a href="/facts/Sentinel_Flavor_Tabs/gCEqwrQM">Sentinel Flavor Tabs</a> (Milbemycin oxime, <a href="/facts/Lufenuron/oWuPT884">Lufenuron</a>), oral flea control product</li>
<li>Deramaxx (<a href="/facts/Deracoxib/duGTnUFY">Deracoxib</a>), oral treatment for pain and inflammation from osteoarthritis in dogs</li>
<li>Capstar (<a href="/facts/Nitenpyram/soH6VaKT">Nitenpyram</a>), oral tablet for flea control</li>
<li>Milbemax (<a href="/facts/Milbemycin_oxime/vC92pBwt">Milbemycin oxime</a>, <a href="/facts/Praziquantel/fNpEJ2Te">Praziquantel</a>), oral worm treatment</li>
<li>Program (<a href="/facts/Lufenuron/oWuPT884">Lufenuron</a>), oral tablet for flea control</li></ul>
<h4>Livestock</h4>
<ul><li>Acatalk Duostar (Fluazuron, <a href="/facts/Ivermectin/6H3H05nI">Ivermectin</a>), tick control for cattle</li>
<li>CLiK (Dicyclanil), blowfly control for sheep</li>
<li>Denagard (<a href="/facts/Tiamulin/lz68fF78">Tiamulin</a>), antibiotic for the treatment of swine dysentery associated with <a href="/facts/Brachyspira/DFErXR81">Brachyspira</a> (formerly Serpulina or Treponema)</li>
<li>Fasinex (<a href="/facts/Triclabendazole/IrBlvFoT">Triclabendazole</a>), oral drench for cattle that is used for the treatment and control of all three stages of liver fluke</li>
<li>ViraShield, For use in healthy cattle, including pregnant cows and heifers, as an aid in the prevention of disease caused by infectious bovine rhinotracheitis (IBR), bovine virus diarrhoea (BVD Type 1 and BVD Type 2), parainfluenza Type 3 (PI3), and bovine respiratory syncytial (BRSV) viruses</li></ul>
<h4>Bioprotection (insect and rodent control)</h4>
<ul><li>Actara (<a href="/facts/Thiamethoxam/3zR38XoI">Thiamethoxam</a>)</li>
<li>Atrazine (<a href="/facts/Atrazine/cPx70RaK">Atrazine</a>)</li>
<li>Larvadex (<a href="/facts/Cyromazine/kj2RsJgk">Cyromazine</a>)</li>
<li>Neporex (<a href="/facts/Cyromazine/kj2RsJgk">Cyromazine</a>)</li>
<li>Oxyfly (<a href="/facts/Lambda-cyhalothrin/9D0D6k00">Lambda-cyhalothrin</a>)</li>
<li>Virusnip (<a href="/facts/Potassium_monopersulfate/3c8jfaUE">Potassium monopersulfate</a>)</li></ul>
<h2 id="controversies-and-criticism">Controversies and criticism</h2>
<h3>Challenge to India's patent laws</h3>
Main article: <a href="/facts/Novartis_v._Union_of_India_%26_Others/uJkqf51K">Novartis v. Union of India & Others</a>
Novartis fought a seven-year, controversial battle to patent <a href="/facts/Imatinib/PSpRplHy">Gleevec</a> in India, and took the case all the way to the <a href="/facts/Indian_Supreme_Court/GfYduSqA">Indian Supreme Court</a>, where the patent application was finally rejected. The patent application at the center of the case was filed by Novartis in India in 1998, after India had agreed to enter the <a href="/facts/World_Trade_Organization/p7hgb1lP">World Trade Organization</a> and to abide by worldwide intellectual property standards under the <a href="/facts/TRIPS/2DFYN3pU">TRIPS</a> agreement. As part of this agreement, India made changes to its patent law; the biggest of which was that prior to these changes, patents on products were not allowed, afterwards they were, albeit with restrictions. These changes came into effect in 2005, so Novartis' patent application waited in a "mailbox" with others until then, under procedures that India instituted to manage the transition. India also passed certain amendments to its patent law in 2005, just before the laws came into effect, which played a key role in the rejection of the patent application.<a class="footnote-ref" id="fnref:206" href="#fn:206">206</a>
The patent application<a class="footnote-ref" id="fnref:207" href="#fn:207">207</a><a class="footnote-ref" id="fnref:208" href="#fn:208">208</a> claimed the final form of Gleevec (the beta crystalline form of imatinib <a href="/facts/Mesylate/h0GRcGo6">mesylate</a>).<a class="footnote-ref" id="fnref:209" href="#fn:209">209</a>: 3  In 1993 before India allowed patents on products, Novartis had patented imatinib, with <a href="/facts/Salt_(chemistry)/lsSKwGpn">salts</a> vaguely specified, in many countries but could not patent it in India.<a class="footnote-ref" id="fnref:210" href="#fn:210">210</a><a class="footnote-ref" id="fnref:211" href="#fn:211">211</a> The key differences between the two patent applications were that the 1998 patent application specified the <a href="/facts/Counterion/RNwGeM3l">counterion</a> (Gleevec is a specific salt—imatinib mesylate) while the 1993 patent application did not claim any specific salts nor did it mention mesylate, and the 1998 patent application specified the solid form of Gleevec—the way the individual molecules are packed together into a solid when the <a href="/facts/Active_ingredient/oeDx5S19">drug itself</a> is manufactured (this is separate from processes by which the drug itself is <a href="/facts/Pharmaceutical_formulation/lH90KTRq">formulated</a> into pills or capsules)—while the 1993 patent application did not. The solid form of imatinib mesylate in Gleevec is beta crystalline.<a class="footnote-ref" id="fnref:212" href="#fn:212">212</a>
As provided under the TRIPS agreement, Novartis applied for Exclusive Marketing Rights (EMR) for Gleevec from the Indian Patent Office and the EMR was granted in November 2003.<a class="footnote-ref" id="fnref:213" href="#fn:213">213</a> Novartis made use of the EMR to obtain orders against some generic manufacturers who had already launched Gleevec in India.<a class="footnote-ref" id="fnref:214" href="#fn:214">214</a> Novartis set the price of Gleevec at US$2666 per patient per month; generic companies were selling their versions at US$177 to 266 per patient per month.<a class="footnote-ref" id="fnref:215" href="#fn:215">215</a> Novartis also initiated a program to assist patients who could not afford its version of the drug, concurrent with its product launch.<a class="footnote-ref" id="fnref:216" href="#fn:216">216</a>
When examination of Novartis' patent application began in 2005, it came under immediate attack from <a href="/facts/Opposition_proceeding/r9KLBE12">oppositions</a> initiated by generic companies that were already selling Gleevec in India and by advocacy groups. The application was rejected by the patent office and by an appeal board. The key basis for the rejection was the part of Indian patent law that was created by amendment in 2005, describing the patentability of new uses for known drugs and modifications of known drugs. That section, Paragraph 3d, specified that such inventions are patentable only if "they differ significantly in properties with regard to efficacy."<a class="footnote-ref" id="fnref:217" href="#fn:217">217</a><a class="footnote-ref" id="fnref:218" href="#fn:218">218</a> At one point, Novartis went to court to try to invalidate Paragraph 3d; it argued that the provision was unconstitutionally vague and that it violated TRIPS. Novartis lost that case and did not appeal.<a class="footnote-ref" id="fnref:219" href="#fn:219">219</a> Novartis did appeal the rejection by the patent office to India's Supreme Court, which took the case.
The Supreme Court case hinged on the interpretation of Paragraph 3d. The Supreme Court decided that the substance that Novartis sought to patent was indeed a modification of a known drug (the raw form of imatinib, which was publicly disclosed in the 1993 patent application and in scientific articles), that Novartis did not present evidence of a difference in therapeutic efficacy between the final form of Gleevec and the raw form of imatinib, and that therefore the patent application was properly rejected by the patent office and lower courts.<a class="footnote-ref" id="fnref:220" href="#fn:220">220</a>
Although the court ruled narrowly,<a class="footnote-ref" id="fnref:221" href="#fn:221">221</a> and took care to note that the subject application was filed during a time of transition in Indian patent law,<a class="footnote-ref" id="fnref:222" href="#fn:222">222</a> the decision generated widespread global news coverage and reignited debates on balancing public good with monopolistic pricing, innovation with affordability etc.<a class="footnote-ref" id="fnref:223" href="#fn:223">223</a><a class="footnote-ref" id="fnref:224" href="#fn:224">224</a><a class="footnote-ref" id="fnref:225" href="#fn:225">225</a>
Had Novartis won and had its patent issued, it could not have prevented generics companies in India from selling generic Gleevec, but it could have obliged them to pay a reasonable royalty under a grandfather clause included in India's patent law.<a class="footnote-ref" id="fnref:226" href="#fn:226">226</a><a class="footnote-ref" id="fnref:227" href="#fn:227">227</a>
In reaction to the decision, Ranjit Shahani, vice-chairman and managing director of Novartis India Ltd was quoted as saying "This ruling is a setback for patients that will hinder medical progress for diseases without effective treatment options."<a class="footnote-ref" id="fnref:228" href="#fn:228">228</a> He also said that companies like Novartis would invest less money in research in India as a result of the ruling.<a class="footnote-ref" id="fnref:229" href="#fn:229">229</a> Novartis also emphasised that it continues to be committed to good access to its drugs; according to Novartis, by 2013, "95% of patients in India—roughly 16,000 people—receive Glivec free of charge... and it has provided more than $1.7 billion worth of Glivec to Indian patients in its support program since it was started...."<a class="footnote-ref" id="fnref:230" href="#fn:230">230</a>

<h3>Sexual discrimination</h3>
On 17 May 2010, a jury in the United States District Court for the Southern District of New York awarded $3,367,250 in <a href="/facts/Compensatory_damages/bEb5khbU">compensatory damages</a> against Novartis, finding that the company had committed <a href="/facts/Sexual_discrimination/laBoxq0Q">sexual discrimination</a> against twelve female <a href="/facts/Sales_representative/dW1KLb52">sales representatives</a> and entry-level <a href="/facts/Management/8KMV9yMM">managers</a> since 2002, in matters of pay, promotion, and treatment after learning that the employees were <a href="/facts/Pregnancy/vEKYGpep">pregnant</a>. Two months later the company settled with the remaining plaintiffs for $152.5 million plus attorney fees.<a class="footnote-ref" id="fnref:231" href="#fn:231">231</a>

<h3>Marketing violations</h3>
In September 2008, the US <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> (FDA) sent a notice to Novartis Pharmaceuticals regarding its advertising of <a href="/facts/Focalin/lfTTXJXo">Focalin</a> XR, an <a href="/facts/ADHD/uSqjIyhd">ADHD</a> drug, in which the company overstated its efficacy while marketing to the public and medical professionals.<a class="footnote-ref" id="fnref:232" href="#fn:232">232</a>
In 2005, federal prosecutors opened an investigation into Novartis' marketing of several drugs: <a href="/facts/Trileptal/jstz7RYM">Trileptal</a>, an antiseizure drug; three drugs for heart conditions—<a href="/facts/Diovan/oFBA3SDq">Diovan</a> (the company's top-selling product), <a href="/facts/Exforge/PE5QadoM">Exforge</a>, and <a href="/facts/Tekturna/yJQ8Comr">Tekturna</a>; <a href="/facts/Sandostatin/A7su7kgD">Sandostatin</a>, a drug to treat a growth hormone disorder; and <a href="/facts/Zelnorm/DaUMlpRh">Zelnorm</a>, a drug for irritable bowel syndrome.<a class="footnote-ref" id="fnref:233" href="#fn:233">233</a> In September 2010, Novartis agreed to pay US$422.5 million in criminal and civil claims and to enter into a <a href="/facts/Corporate_integrity_agreement/HnUUkltn">corporate integrity agreement</a> with the US Office of the Inspector General.<a class="footnote-ref" id="fnref:234" href="#fn:234">234</a> According to The New York Times, "Federal prosecutors accused Novartis of paying illegal kickbacks to health care professionals through speaker programs, advisory boards, entertainment, travel and meals. But aside from pleading guilty to one misdemeanor charge of mislabeling in an agreement that Novartis announced in February, the company denied wrongdoing."<a class="footnote-ref" id="fnref:235" href="#fn:235">235</a> In the same New York Times article, Frank Lichtenberg, a Columbia professor who receives pharmaceutical financing for research on innovation in the industry, said off-label prescribing was encouraged by the American Medical Association and paid for by insurers, but <a href="/facts/Off-label_use/0PDs5VWS">off-label marketing</a> was clearly illegal. "So it's not surprising that they would settle because they don't have a legal leg to stand on."
In April 2013, federal prosecutors filed two lawsuits against Novartis under the <a href="/facts/False_Claims_Act/v3pJPSds">False Claims Act</a> for off-label marketing and kickbacks; in both suits, prosecutors are seeking <a href="/facts/Treble_damages/W9c2wYyE">treble damages</a>.<a class="footnote-ref" id="fnref:236" href="#fn:236">236</a><a class="footnote-ref" id="fnref:237" href="#fn:237">237</a> The first suit "accused Novartis of inducing pharmacies to switch thousands of kidney transplant patients to its immunosuppressant drug Myfortic in exchange for kickbacks disguised as rebates and discounts".<a class="footnote-ref" id="fnref:238" href="#fn:238">238</a> In the second, the Justice Department joined a <a href="/facts/Qui_tam/BNTla6C3">qui tam</a>, or whistleblower, lawsuit brought by a former sales rep over off-label marketing of three drugs: <a href="/facts/Lotrel/bIjxF903">Lotrel</a> and Valturna (both <a href="/facts/Hypertension/wlAvBfcf">hypertension</a> drugs), and the diabetes drug, <a href="/facts/Starlix/RfMufv13">Starlix</a>.<a class="footnote-ref" id="fnref:239" href="#fn:239">239</a> Twenty-seven states, the District of Columbia and Chicago and New York also joined.<a class="footnote-ref" id="fnref:240" href="#fn:240">240</a>

<h3>Avastin</h3>
Outside the US, Novartis markets the drug <a href="/facts/Ranibizumab/oUvts4E1">ranibizumab</a> (trade name Lucentis), which is a <a href="/facts/Monoclonal_antibody/4rUBWB87">monoclonal antibody</a> fragment derived from the same parent mouse antibody as <a href="/facts/Bevacizumab/CXXMF9rL">bevacizumab</a> (Avastin). Both Avastin and Lucentis were created by <a href="/facts/Genentech/DPahQBr4">Genentech</a> which is owned by Roche; Roche markets Avastin worldwide, and also markets Lucentis in the US. Lucentis has been approved worldwide as a treatment for wet <a href="/facts/Macular_degeneration/9pFARaka">macular degeneration</a> and other retinal disorders; Avastin is used to treat certain cancers. Because the price of Lucentis is much higher than Avastin, many ophthalmologists began having <a href="/facts/Compounding_pharmacies/U96yYcbG">compounding pharmacies</a> formulate Avastin for administration to the eye and began treating their patients with Avastin.<a class="footnote-ref" id="fnref:241" href="#fn:241">241</a> In 2011, four trusts of the <a href="/facts/National_Health_Service/lTzheqYw">National Health Service</a> in the UK issued policies approving use and payment for administering Avastin for macular degeneration, in order to save money, even though Avastin had not been approved for that indication.<a class="footnote-ref" id="fnref:242" href="#fn:242">242</a> In April 2012, after failing to persuade the trusts that it was uncertain whether Avastin was as safe and effective as Lucentis, and in order to retain the market for Lucentis, Novartis announced it would sue the trusts.<a class="footnote-ref" id="fnref:243" href="#fn:243">243</a><a class="footnote-ref" id="fnref:244" href="#fn:244">244</a> However, in July Novartis offered significant discounts (kept confidential) to the trusts, and the trusts agreed to change their policy,<a class="footnote-ref" id="fnref:245" href="#fn:245">245</a> and in November, Novartis dropped the litigation.<a class="footnote-ref" id="fnref:246" href="#fn:246">246</a>

<h3>Valsartan</h3>
In the summer of 2013, two Japanese universities retracted several publications of clinical trials that purported to show that <a href="/facts/Valsartan/oFBA3SDq">Valsartan</a> (branded as Diovan) had cardiovascular benefits, when it was found that statistical analysis had been manipulated, and that a Novartis employee had participated in the statistical analysis but had not disclosed his relationship with Novartis but only his affiliation with Osaka City University, where he was a lecturer.<a class="footnote-ref" id="fnref:247" href="#fn:247">247</a><a class="footnote-ref" id="fnref:248" href="#fn:248">248</a> As a result, several Japanese hospitals stopped using the drug, and media outlets ran reports on the scandal in Japan.<a class="footnote-ref" id="fnref:249" href="#fn:249">249</a> In January 2014 Japan's Health Ministry filed a criminal complaint with the <a href="/facts/Tokyo/GTvuw4ct">Tokyo</a> public prosecutor's office against Novartis and an unspecified number of employees, for allegedly misleading consumers through advertisements that used the research to support the benefits of Diovan.<a class="footnote-ref" id="fnref:250" href="#fn:250">250</a> On 1 July 2014 the prosecutor's office announced it was formally charging the company and one of its employees.<a class="footnote-ref" id="fnref:251" href="#fn:251">251</a>

<h3>Corruption</h3>
In January 2018, Novartis began being investigated by US and Greek authorities for allegedly bribing Greek public officials in the 2006–2015 period, in a scheme which included two former prime ministers, several former health ministers, many high ranking party members of the <a href="/facts/Nea_Dimokratia/3J1zAGrc">Nea Dimokratia</a> and <a href="/facts/PASOK/e5XCmsl2">PASOK</a> ruling parties, as well as bankers.<a class="footnote-ref" id="fnref:252" href="#fn:252">252</a> The manager of Novartis' Greek branch was prohibited from leaving the country.<a class="footnote-ref" id="fnref:253" href="#fn:253">253</a> The minister's deputy described the allegations as "the biggest scandal since the creation of the Greek state", which caused "annual state expenditure on medicine to explode".<a class="footnote-ref" id="fnref:254" href="#fn:254">254</a> Most of the ministers involved in the scandal have denied the allegations and sought to paint the case as "political targeting" and "fabrication" by the <a href="/facts/Syriza/KUUgBDNH">Syriza</a> opposition party.<a class="footnote-ref" id="fnref:255" href="#fn:255">255</a> However, the Greek Judicial Council ruled that the scandal was real.<a class="footnote-ref" id="fnref:256" href="#fn:256">256</a> Besides bribery that involves artificial increases in the price of several medicines, the case also involves money laundering, with suspicions of "illegal funds of more than four billion euros ($4.2 billion)" were involved.<a class="footnote-ref" id="fnref:257" href="#fn:257">257</a>
In June 2020, Novartis reached settlements with the <a href="/facts/US_Department_of_Justice/2SuTuevo">US Department of Justice (DOJ)</a> and the <a href="/facts/U.S._Securities_and_Exchange_Commission/IM9Pl2gK">US Securities and Exchange Commission (SEC)</a> resolving all <a href="/facts/Foreign_Corrupt_Practices_Act/wHfP6qlP">Foreign Corrupt Practices Act (FCPA)</a> investigations into historical conduct by the company and its subsidiaries. As part of the resolutions, Novartis and some of its current and former subsidiaries would pay US$233.9 million to the DOJ and US$112.8 million to the SEC.<a class="footnote-ref" id="fnref:258" href="#fn:258">258</a><a class="footnote-ref" id="fnref:259" href="#fn:259">259</a>

<h3>Michael Cohen</h3>

Novartis paid $1.2 million to Essential Consultants, an entity owned by <a href="/facts/Michael_Cohen_(lawyer)/wJ1nBpcw">Michael Cohen</a>, following the 2017 inauguration of Donald Trump. Cohen was paid monthly, with each payment just under $100,000. Novartis claims it paid Cohen to help it understand and influence the new administration's approach to drug pricing and regulation.<a class="footnote-ref" id="fnref:260" href="#fn:260">260</a>
In July 2018, the <a href="/facts/US_Senate_committee/rG81K7yM">US Senate committee</a> report "White House Access for Sale" revealed that Novartis Ag's relationship with Cohen was "longer and more detailed". Novartis initially stated that the relationship ceased a month after entering the US$1.2 million contract with Cohen's consulting firm since the consultants were not able to provide the information the pharmaceutical company needed. Later, it became clear, however, that then-CEO <a href="/facts/Joseph_Jimenez/ktaFpIVw">Joseph Jimenez</a> and Cohen communicated via email multiple times during 2017, which included ideas to lower drug prices to be discussed with the president. According to the report, several of the ideas appeared later in Trump's drug pricing plan, released in early 2018, in which pharmaceutical companies were protected from reduced revenues.<a class="footnote-ref" id="fnref:261" href="#fn:261">261</a><a class="footnote-ref" id="fnref:262" href="#fn:262">262</a>

<h3>AveXis data integrity</h3>
Having already received approval for Zolgensma in May 2019, on 28 June AveXis (a Novartis company) voluntarily disclosed to the FDA that some data previously submitted to the agency as part of the Biologics License Application (BLA) package was inaccurate. Specifically, the data manipulation related to an in vivo murine potency assay used in the early development of the product but the issue the FDA and wider community has taken is that AveXis was aware of the data manipulation as early as 14 March 2019, almost two months before the BLA was approved. To compound the problem in early August it emerged a senior manager sold almost $1 million worth of stock immediately before the FDA probe became public on 6 August, but after the company had informed the FDA of the problem. As of September 2019, the FDA was still preparing its response to the scandal. 

<h2 id="philanthropy">Philanthropy</h2>
<h3>Fight against leprosy</h3>
Novartis has been committed for decades to eliminate <a href="/facts/Leprosy/FSjTpMEB">leprosy</a> by providing free, multidrug therapy to all endemic countries since 2000.<a class="footnote-ref" id="fnref:263" href="#fn:263">263</a><a class="footnote-ref" id="fnref:264" href="#fn:264">264</a><a class="footnote-ref" id="fnref:265" href="#fn:265">265</a>

<h2 id="see-also">See also</h2>
<ul><li><a href="/facts/List_of_pharmaceutical_companies/6Do5vAp2">List of pharmaceutical companies</a></li>
<li><a href="/facts/Pharmaceutical_industry_in_Switzerland/PQKPGAbl">Pharmaceutical industry in Switzerland</a></li></ul>

<h2 id="further-reading">Further reading</h2>
<ul><li>Kirkland, Rik; Jimenez, Joseph (June 2015). <a href="http://www.mckinsey.com/insights/leading_in_the_21st_century/novartis_on_digitizing_medicine_in_an_aging_world">"Novartis on digitizing medicine in an aging world"</a>. Insights & Publications (Interview). McKinsey & Company. Retrieved 16 August 2015.</li></ul>
<h2 id="external-links">External links</h2>

Wikimedia Commons has media related to Novartis.

<ul><li><a href="https://www.novartis.com">Official website</a></li>
<li><a href="https://www.opensecrets.org/orgs/summary?id=D000022163">Novartis</a> on <a href="/facts/OpenSecrets/oCR0Gqkd">OpenSecrets</a>, a website that tracks and publishes data on campaign finance and lobbying </li>
<li>Business data for Novartis AG: <ul><li><a href="https://www.google.com/finance/quote/NVS:NYSE">Google</a></li><li><a href="https://www.reuters.com/markets/companies/NVS">Reuters</a></li><li><a href="https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=1114448">SEC filings</a></li><li><a href="https://finance.yahoo.com/quote/NVS">Yahoo!</a></li></ul></li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1">"Who are the top 10 pharmaceutical companies in the world (2022)? | Proclinical Blogs". Proclinical. Archived from the original on 6 February 2023. Retrieved 11 July 2023. <a href="https://www.proclinical.com/blogs/2022-6/who-are-the-top-10-pharma-companies-in-the-world-2022" target="_blank">https://www.proclinical.com/blogs/2022-6/who-are-the-top-10-pharma-companies-in-the-world-2022</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></li>
<li id="fn:2">Pistilli, Melissa. "top-10-pharma-companies-revenue-updated-2024". Nasdaq. <a href="https://www.nasdaq.com/articles/top-10-pharma-companies-revenue-updated-2024" target="_blank">https://www.nasdaq.com/articles/top-10-pharma-companies-revenue-updated-2024</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></li>
<li id="fn:3">Mendenhall, Mark E. (2005). Mergers and Acquisitions: Managing Culture and Human Resources. Stanford, CA: Stanford University Press. p. 380. ISBN 0-8047-4661-3. <a href="0-8047-4661-3" target="_blank">0-8047-4661-3</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></li>
<li id="fn:4">Mendenhall, Mark E. (2005). Mergers and Acquisitions: Managing Culture and Human Resources. Stanford, CA: Stanford University Press. p. 380. ISBN 0-8047-4661-3. <a href="0-8047-4661-3" target="_blank">0-8047-4661-3</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></li>
<li id="fn:5">Mendenhall, Mark E. (2005). Mergers and Acquisitions: Managing Culture and Human Resources. Stanford, CA: Stanford University Press. p. 380. ISBN 0-8047-4661-3. <a href="0-8047-4661-3" target="_blank">0-8047-4661-3</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></li>
<li id="fn:6">Mendenhall, Mark E. (2005). Mergers and Acquisitions: Managing Culture and Human Resources. Stanford, CA: Stanford University Press. p. 380. ISBN 0-8047-4661-3. <a href="0-8047-4661-3" target="_blank">0-8047-4661-3</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></li>
<li id="fn:7">"The Pharmaceutical Industry in Figures - 2008 Edition". European Federation of Pharmaceutical Industries and Associations (EFPIA). p. 49. Archived from the original (PDF) on 16 September 2008. Retrieved 25 August 2008. <a href="https://archive.today/20080916100937/http://www.efpia.eu/content/default.asp?PageID=559&DocID=4883" target="_blank">https://archive.today/20080916100937/http://www.efpia.eu/content/default.asp?PageID=559&DocID=4883</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></li>
<li id="fn:8">"BIO Member Directory | BIO". www.bio.org. Archived from the original on 30 September 2022. Retrieved 1 March 2024. <a href="https://www.bio.org/bio-member-directory" target="_blank">https://www.bio.org/bio-member-directory</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></li>
<li id="fn:9">"IFPMA Member List". Archived from the original on 7 February 2014. Retrieved 29 January 2021. <a href="https://web.archive.org/web/20140207235721/http://www.ifpma.org/about-ifpma/members/companies.html" target="_blank">https://web.archive.org/web/20140207235721/http://www.ifpma.org/about-ifpma/members/companies.html</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></li>
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<li id="fn:247">Kana Inagaki for The Wall Street Journal. 11 August 2013 Novartis Hit by Scandal Over Japanese Drug Studies: Probes Uncover Altered Research Data; Swiss Giant Stands by Heart Medicine Diovan Archived 13 October 2013 at the Wayback Machine <a href="https://online.wsj.com/news/articles/SB10001424127887323838204579000403952581982" target="_blank">https://online.wsj.com/news/articles/SB10001424127887323838204579000403952581982</a> <a href="#fnref:247" class="footnote-back-ref">↩</a></li>
<li id="fn:248">Kana Inagaki for The Wall Street Journal. 12 August 2013. Novartis Drug Studies in Japan–Tracing Back the Questions Archived 18 October 2013 at the Wayback Machine <a href="https://blogs.wsj.com/japanrealtime/2013/08/12/novartis-drug-studies-in-japan-tracing-back-the-questions/" target="_blank">https://blogs.wsj.com/japanrealtime/2013/08/12/novartis-drug-studies-in-japan-tracing-back-the-questions/</a> <a href="#fnref:248" class="footnote-back-ref">↩</a></li>
<li id="fn:249">Kana Inagaki for The Wall Street Journal. 11 August 2013 Novartis Hit by Scandal Over Japanese Drug Studies: Probes Uncover Altered Research Data; Swiss Giant Stands by Heart Medicine Diovan Archived 13 October 2013 at the Wayback Machine <a href="https://online.wsj.com/news/articles/SB10001424127887323838204579000403952581982" target="_blank">https://online.wsj.com/news/articles/SB10001424127887323838204579000403952581982</a> <a href="#fnref:249" class="footnote-back-ref">↩</a></li>
<li id="fn:250">"Japan Criminal Probe Could Spell More Trouble for Novartis". The Wall Street Journal. 10 January 2014. Archived from the original on 2 March 2014. <a href="https://online.wsj.com/news/articles/SB10001424052702303933104579307443220022558" target="_blank">https://online.wsj.com/news/articles/SB10001424052702303933104579307443220022558</a> <a href="#fnref:250" class="footnote-back-ref">↩</a></li>
<li id="fn:251">"Data manipulation by staff gets Novartis into legal mess in Japan". Japan Herald. Archived from the original on 29 August 2014. Retrieved 2 July 2014. <a href="https://web.archive.org/web/20140829181210/http://www.japanherald.com/index.php/sid/223435459/scat/c4f2dd8ca8c78044/ht/Data-manipulation-by-staff-gets-Novartis-into-legal-mess-in-Japan" target="_blank">https://web.archive.org/web/20140829181210/http://www.japanherald.com/index.php/sid/223435459/scat/c4f2dd8ca8c78044/ht/Data-manipulation-by-staff-gets-Novartis-into-legal-mess-in-Japan</a> <a href="#fnref:251" class="footnote-back-ref">↩</a></li>
<li id="fn:252">"Greek Officials Hit Back at Novartis Bribery Allegations | GreekReporter.com". greece.greekreporter.com. 6 February 2018. Archived from the original on 1 November 2020. Retrieved 7 February 2018. <a href="http://greece.greekreporter.com/2018/02/06/greek-officials-hit-back-at-novartis-bribery-allegations/" target="_blank">http://greece.greekreporter.com/2018/02/06/greek-officials-hit-back-at-novartis-bribery-allegations/</a> <a href="#fnref:252" class="footnote-back-ref">↩</a></li>
<li id="fn:253">"Greek officials ban Novartis manager from leaving the country amid widening bribery probe: report | FiercePharma". www.fiercepharma.com. 6 February 2018. Archived from the original on 9 November 2020. Retrieved 7 February 2018. <a href="https://www.fiercepharma.com/legal/greek-officials-ban-novartis-manager-from-leaving-country-amid-widening-bribery-probe-report" target="_blank">https://www.fiercepharma.com/legal/greek-officials-ban-novartis-manager-from-leaving-country-amid-widening-bribery-probe-report</a> <a href="#fnref:253" class="footnote-back-ref">↩</a></li>
<li id="fn:254">"Greek Govt Alleges Official Ties to Drug Bribery Scandal". The New York Times. Associated Press. 5 February 2018. ISSN 0362-4331. Archived from the original on 16 November 2018. Retrieved 7 February 2018. <a href="https://www.nytimes.com/aponline/2018/02/05/world/europe/ap-eu-greece-pharma-scandal.html" target="_blank">https://www.nytimes.com/aponline/2018/02/05/world/europe/ap-eu-greece-pharma-scandal.html</a> <a href="#fnref:254" class="footnote-back-ref">↩</a></li>
<li id="fn:255">"Greek Officials Hit Back at Novartis Bribery Allegations | GreekReporter.com". greece.greekreporter.com. 6 February 2018. Archived from the original on 1 November 2020. Retrieved 7 February 2018. <a href="http://greece.greekreporter.com/2018/02/06/greek-officials-hit-back-at-novartis-bribery-allegations/" target="_blank">http://greece.greekreporter.com/2018/02/06/greek-officials-hit-back-at-novartis-bribery-allegations/</a> <a href="#fnref:255" class="footnote-back-ref">↩</a></li>
<li id="fn:256">"Ν. Ηλιόπουλος: Και με τη βούλα της Δικαιοσύνης υπαρκτό το σκάνδαλο Novartis". capital.gr. Archived from the original on 27 July 2022. Retrieved 27 July 2022. <a href="https://www.capital.gr/politiki/3644684/n-iliopoulos-kai-me-ti-boula-tis-dikaiosunis-uparkto-to-skandalo-novartis" target="_blank">https://www.capital.gr/politiki/3644684/n-iliopoulos-kai-me-ti-boula-tis-dikaiosunis-uparkto-to-skandalo-novartis</a> <a href="#fnref:256" class="footnote-back-ref">↩</a></li>
<li id="fn:257">"Novartis under investigation for bribery in Greece". DW.COM. Archived from the original on 12 November 2020. Retrieved 7 February 2018. <a href="http://www.dw.com/en/novartis-under-investigation-for-bribery-in-greece/a-37230558" target="_blank">http://www.dw.com/en/novartis-under-investigation-for-bribery-in-greece/a-37230558</a> <a href="#fnref:257" class="footnote-back-ref">↩</a></li>
<li id="fn:258">"SEC.gov | SEC Charges Novartis AG with FCPA Violations". www.sec.gov. Archived from the original on 18 January 2021. Retrieved 25 June 2020. <a href="https://www.sec.gov/news/press-release/2020-144" target="_blank">https://www.sec.gov/news/press-release/2020-144</a> <a href="#fnref:258" class="footnote-back-ref">↩</a></li>
<li id="fn:259">"Novartis Hellas S.A.C.I. and Alcon Pte Ltd Agree to Pay over $233 Million Combined to Resolve Criminal FCPA Cases". www.justice.gov. 25 June 2020. Archived from the original on 13 January 2021. Retrieved 25 June 2020. <a href="https://www.justice.gov/opa/pr/novartis-hellas-saci-and-alcon-pte-ltd-agree-pay-over-233-million-combined-resolve-criminal" target="_blank">https://www.justice.gov/opa/pr/novartis-hellas-saci-and-alcon-pte-ltd-agree-pay-over-233-million-combined-resolve-criminal</a> <a href="#fnref:259" class="footnote-back-ref">↩</a></li>
<li id="fn:260">"Novartis admits $1.2m in payments to Trump lawyer". Financial Times. Archived from the original on 9 November 2020. Retrieved 10 May 2018. <a href="https://www.ft.com/content/61e2cca8-5363-11e8-b3ee-41e0209208ec" target="_blank">https://www.ft.com/content/61e2cca8-5363-11e8-b3ee-41e0209208ec</a> <a href="#fnref:260" class="footnote-back-ref">↩</a></li>
<li id="fn:261">Emma Court (16 July 2018.) Novartis had 'longer and more detailed' relationship with Trump lawyer Michael Cohen, Senate report finds Archived 15 November 2020 at the Wayback Machine. MarketWatch. Retrieved 21 August 2018. <a href="https://www.marketwatch.com/story/novartis-had-longer-and-more-detailed-relationship-with-trump-lawyer-michael-cohen-senate-report-finds-2018-07-13" target="_blank">https://www.marketwatch.com/story/novartis-had-longer-and-more-detailed-relationship-with-trump-lawyer-michael-cohen-senate-report-finds-2018-07-13</a> <a href="#fnref:261" class="footnote-back-ref">↩</a></li>
<li id="fn:262">White House Access for Sale: Michael Cohen, Novartis and the bid to sell access to the Trump administration Archived 13 November 2020 at the Wayback Machine. Retrieved 21 August 2018. <a href="https://www.finance.senate.gov/imo/media/doc/REPORT%20White%20House%20Access%20for%20Sale%20Michael%20Cohen%20and%20Novartis.pdf" target="_blank">https://www.finance.senate.gov/imo/media/doc/REPORT%20White%20House%20Access%20for%20Sale%20Michael%20Cohen%20and%20Novartis.pdf</a> <a href="#fnref:262" class="footnote-back-ref">↩</a></li>
<li id="fn:263">"Leprosy". www.who.int. Archived from the original on 31 January 2021. Retrieved 19 January 2021. <a href="https://www.who.int/news-room/fact-sheets/detail/leprosy" target="_blank">https://www.who.int/news-room/fact-sheets/detail/leprosy</a> <a href="#fnref:263" class="footnote-back-ref">↩</a></li>
<li id="fn:264">"WHO | WHO and Novartis extend agreement to treat millions of leprosy patients with free medicines". WHO. Archived from the original on 19 October 2015. Retrieved 19 January 2021. <a href="https://web.archive.org/web/20151019071648/http://www.who.int/neglected_diseases/news/WHO_Novartis_agreement_to_treat_leprosy_patients/en/" target="_blank">https://web.archive.org/web/20151019071648/http://www.who.int/neglected_diseases/news/WHO_Novartis_agreement_to_treat_leprosy_patients/en/</a> <a href="#fnref:264" class="footnote-back-ref">↩</a></li>
<li id="fn:265">"WHO | New Memorandum of Understanding for MDT". WHO. Archived from the original on 11 October 2014. Retrieved 19 January 2021. <a href="https://web.archive.org/web/20141011061238/http://www.who.int/lep/resources/press_releases/en/" target="_blank">https://web.archive.org/web/20141011061238/http://www.who.int/lep/resources/press_releases/en/</a> <a href="#fnref:265" class="footnote-back-ref">↩</a></li>
</ol>

Novartis open-in-new

Novartis