Angular cheilitis

<h2 id="signs-and-symptoms">Signs and symptoms</h2>

Angular cheilitis is a fairly non specific term which describes the presence of an inflammatory lesion in a particular anatomic site (i.e. the corner of the mouth). As there are different possible causes and contributing factors from one person to the next, the appearance of the lesion is somewhat variable. The lesions are more commonly symmetrically present on both sides of the mouth,<a class="footnote-ref" id="fnref:21" href="#fn:21">21</a> but sometimes only one side may be affected. In some cases, the lesion may be confined to the mucosa of the lips, and in other cases the lesion may extend past the <a href="/facts/Vermilion_border/l50LFxj7">vermilion border</a> (the edge where the lining on the lips becomes the skin on the face) onto the facial skin. Initially, the corners of the mouth develop a gray-white thickening and adjacent <a href="/facts/Erythema/VUsgXRlB">erythema</a> (redness).<a class="footnote-ref" id="fnref:22" href="#fn:22">22</a> Later, the usual appearance is a roughly triangular area of erythema, <a href="/facts/Edema/Q6MI3KdH">edema</a> (swelling) and <a href="/facts/Cutaneous_condition/Vkr5XpeG">breakdown of skin</a> at either corner of the mouth.<a class="footnote-ref" id="fnref:23" href="#fn:23">23</a><a class="footnote-ref" id="fnref:24" href="#fn:24">24</a> The mucosa of the lip may become <a href="/facts/Skin_fissure/QUJ3cagg">fissured</a> (cracked), crusted, <a href="/facts/Mouth_ulcer/TSQ0UCqS">ulcerated</a> or <a href="/facts/Atrophy/QNxSoxDV">atrophied</a>.<a class="footnote-ref" id="fnref:25" href="#fn:25">25</a><a class="footnote-ref" id="fnref:26" href="#fn:26">26</a> There is not usually any bleeding.<a class="footnote-ref" id="fnref:27" href="#fn:27">27</a> Where the skin is involved, there may be radiating <a href="/facts/Rhagades/G3X7Bv3h">rhagades</a> (linear fissures) from the corner of the mouth. Infrequently, the <a href="/facts/Dermatitis/JwlyQBa2">dermatitis</a> (which may resemble <a href="/facts/Eczema/JwlyQBa2">eczema</a>) can extend from the corner of the mouth to the skin of the cheek or chin.<a class="footnote-ref" id="fnref:28" href="#fn:28">28</a> If Staphylococcus aureus is involved, the lesion may show golden yellow crusts.<a class="footnote-ref" id="fnref:29" href="#fn:29">29</a> In chronic angular cheilitis, there may be suppuration (<a href="/facts/Pus/jzNHzM70">pus</a> formation), exfoliation (scaling) and formation of <a href="/facts/Granulation_tissue/5NcJYJuw">granulation tissue</a>.<a class="footnote-ref" id="fnref:30" href="#fn:30">30</a><a class="footnote-ref" id="fnref:31" href="#fn:31">31</a>
Sometimes contributing factors can be readily seen, such as loss of lower face height from poorly made or worn dentures, which results in mandibular overclosure ("collapse of jaws").<a class="footnote-ref" id="fnref:32" href="#fn:32">32</a> If there is a nutritional deficiency underlying the condition, various other signs and symptoms such as glossitis (swollen tongue) may be present. In people with angular cheilitis who wear dentures, often there may be erythematous mucosa underneath the denture (normally the upper denture), an appearance consistent with denture-related stomatitis.<a class="footnote-ref" id="fnref:33" href="#fn:33">33</a> Typically the lesions give symptoms of soreness, pain, <a href="/facts/Pruritus/MBWq6SPc">pruritus</a> (itching) or burning or a raw feeling.<a class="footnote-ref" id="fnref:34" href="#fn:34">34</a><a class="footnote-ref" id="fnref:35" href="#fn:35">35</a>

<h2 id="causes">Causes</h2>
Angular cheilitis is thought to be a multifactorial disorder of infectious origin,<a class="footnote-ref" id="fnref:36" href="#fn:36">36</a> with many local and systemic predisposing factors.<a class="footnote-ref" id="fnref:37" href="#fn:37">37</a> The sores in angular cheilitis are often infected with <a href="/facts/Fungus/BHo5DP59">fungi</a> (yeasts), <a href="/facts/Bacteria/wC8xSCsU">bacteria</a>, or a combination thereof;<a class="footnote-ref" id="fnref:38" href="#fn:38">38</a> this may represent a <a href="/facts/Secondary_infection/182XrncP">secondary</a>, <a href="/facts/Opportunistic_infection/d6ndMynw">opportunistic infection</a> by these <a href="/facts/Pathogen/axMXtV1M">pathogens</a>. Some studies have linked the initial onset of angular cheilitis with nutritional deficiencies, especially of the B (B2-riboflavin) vitamin and iron (which causes <a href="/facts/Iron_deficiency_anemia/LK17js79">iron deficiency anemia</a>),<a class="footnote-ref" id="fnref:39" href="#fn:39">39</a> which in turn may be evidence of malnutrition or malabsorption. Angular cheilitis can be a manifestation of <a href="/facts/Contact_dermatitis/Xm6PEgcw">contact dermatitis</a>,<a class="footnote-ref" id="fnref:40" href="#fn:40">40</a> which is considered in two groups; irritational and allergic.

<h3>Infection</h3>
The involved organisms are:

<ul><li><a href="/facts/Candida_(genus)/IIYvWvx5">Candida</a> species alone (usually <a href="/facts/Candida_albicans/7o27aEFS">Candida albicans</a>), which accounts for about 20% of cases,<a class="footnote-ref" id="fnref:41" href="#fn:41">41</a></li>
<li>Bacterial species, either:
<ul><li><a href="/facts/Staphylococcus_aureus/9yDVBMsc">Staphylococcus aureus</a> alone, which accounts for about 20% of cases,<a class="footnote-ref" id="fnref:42" href="#fn:42">42</a></li>
<li><a href="/facts/Streptococcus/Fx8lJ0nz">β-hemolytic streptococci</a> alone. These types of bacteria have been detected in between 8–15% of cases of angular cheilitis,<a class="footnote-ref" id="fnref:43" href="#fn:43">43</a> but less commonly are they present in isolation,<a class="footnote-ref" id="fnref:44" href="#fn:44">44</a></li></ul></li>
<li>Or a combination of the above organisms, (a polymicrobial infection)<a class="footnote-ref" id="fnref:45" href="#fn:45">45</a> with about 60% of cases involving both C. albicans and S. aureus.<a class="footnote-ref" id="fnref:46" href="#fn:46">46</a><a class="footnote-ref" id="fnref:47" href="#fn:47">47</a></li></ul>
Candida can be detected in 93% of angular cheilitis lesions.<a class="footnote-ref" id="fnref:48" href="#fn:48">48</a> This organism is found in the mouths of about 40% of healthy individuals, and it is considered by some to be normal commensal component of the oral <a href="/facts/Skin_microbiota/jxUPFoB4">microbiota</a>.<a class="footnote-ref" id="fnref:49" href="#fn:49">49</a> However, Candida shows dimorphism, namely a yeast form which is thought to be relatively harmless and a <a href="/facts/Pathogenic/axMXtV1M">pathogenic</a> <a href="/facts/Hypha/xogd3AHz">hyphal</a> form which is associated with invasion of host tissues. <a href="/facts/Potassium_hydroxide/NBhPBuXc">Potassium hydroxide</a> preparation is recommended by some to help distinguish between the harmless and the pathogenic forms, and thereby highlight which cases of angular cheilitis are truly caused by Candida.<a class="footnote-ref" id="fnref:50" href="#fn:50">50</a> The mouth may act as a reservoir of Candida that reinfects the sores at the corners of the mouth and prevents the sores from healing.
A lesion caused by recurrence of a latent <a href="/facts/Herpes_simplex/8AQktlTV">herpes simplex</a> infection can occur in the corner of the mouth. This is <a href="/facts/Herpes_labialis/GhCFA4cI">herpes labialis</a> (a cold sore), and is sometimes termed "angular herpes simplex".<a class="footnote-ref" id="fnref:51" href="#fn:51">51</a> A cold sore at the corner of the mouth behaves similarly to elsewhere on the lips, and follows a pattern of <a href="/facts/Vesicle_(dermatology)/Vkr5XpeG">vesicle</a> (blister) formation followed by rupture leaving a crusted sore which resolves in about 7–10 days, and recurs in the same spot periodically, especially during periods of stress. Rather than utilizing antifungal creams, angular herpes simplex is treated in the same way as a cold sore, with topical <a href="/facts/Antiviral_drug/Xgbd2eI2">antiviral drugs</a> such as <a href="/facts/Aciclovir/TY5o1mYT">aciclovir</a>.

<h3>Irritation contact dermatitis</h3>

Main article: <a href="/facts/Irritant_contact_dermatitis/DPn2WxB9">Irritant contact dermatitis</a>
22% of cases of angular cheilitis are due to irritants.<a class="footnote-ref" id="fnref:52" href="#fn:52">52</a> <a href="/facts/Saliva/gK4nvayc">Saliva</a> contains <a href="/facts/Digestive_enzyme/aRYCbJHe">digestive enzymes</a>, which may have a degree of digestive action on tissues if they are left in contact.<a class="footnote-ref" id="fnref:53" href="#fn:53">53</a> The corner of the mouth is normally exposed to saliva more than any other part of the lips. Reduced lower facial height (vertical dimension or facial support) is usually caused by <a href="/facts/Edentulism/Wd4RET6K">edentulism</a> (tooth loss), or wearing worn down, old dentures or ones which are not designed optimally. This results in overclosure of the mandible (collapse of the jaws),<a class="footnote-ref" id="fnref:54" href="#fn:54">54</a> which extenuates the angular
skin folds at the corners of the mouth,<a class="footnote-ref" id="fnref:55" href="#fn:55">55</a> in effect creating an <a href="/facts/Intertriginous/od2707uk">intertriginous</a> skin crease. The tendency of saliva to pool in these areas is increased, constantly wetting the area,<a class="footnote-ref" id="fnref:56" href="#fn:56">56</a> which may cause tissue maceration and favors the development of a yeast infection.<a class="footnote-ref" id="fnref:57" href="#fn:57">57</a> As such, angular cheilitis is more commonly seen in edentulous people (people without any teeth).<a class="footnote-ref" id="fnref:58" href="#fn:58">58</a> It is by contrast uncommon in persons who retain their natural teeth.<a class="footnote-ref" id="fnref:59" href="#fn:59">59</a> Angular cheilitis is also commonly seen in denture wearers.<a class="footnote-ref" id="fnref:60" href="#fn:60">60</a> Angular cheilitis is present in about 30% of people with denture-related stomatitis.<a class="footnote-ref" id="fnref:61" href="#fn:61">61</a> It is thought that reduced vertical dimension of the lower face may be a contributing factor in up to 11% of elderly persons with angular cheilitis and in up to 18% of denture wearers who have angular cheilitis.<a class="footnote-ref" id="fnref:62" href="#fn:62">62</a> Reduced vertical dimension can also be caused by tooth migration, wearing orthodontic appliances, and elastic tissue damage caused by <a href="/facts/Ultraviolet_light/kncBUqn5">ultraviolet light</a> exposure and smoking.<a class="footnote-ref" id="fnref:63" href="#fn:63">63</a>
Habits or conditions that keep the corners of the mouth moist might include chronic lip licking, thumb sucking (or sucking on other objects such as pens, pipes, lollipops), dental cleaning (e.g. flossing), chewing gum, hypersalivation, drooling and <a href="/facts/Mouth_breathing/UhRpogWw">mouth breathing</a>.<a class="footnote-ref" id="fnref:64" href="#fn:64">64</a><a class="footnote-ref" id="fnref:65" href="#fn:65">65</a><a class="footnote-ref" id="fnref:66" href="#fn:66">66</a> Some consider habitual lip licking or picking to be a form of nervous <a href="/facts/Tic/hQG8GUfP">tic</a>, and do not consider this to be true angular cheilitis,<a class="footnote-ref" id="fnref:67" href="#fn:67">67</a> instead calling it perlèche (derived from the French word pourlècher meaning "to lick one's lips"),<a class="footnote-ref" id="fnref:68" href="#fn:68">68</a> or "<a href="/facts/Factitious_disorder/Y7Gv0jBm">factitious</a> cheilitis" is applied to this habit.<a class="footnote-ref" id="fnref:69" href="#fn:69">69</a> The term "cheilocandidiasis" describes exfoliative (flaking) lesions of the lips and the skin around the lips, and is caused by a superficial candidal infection due to chronic lip licking.<a class="footnote-ref" id="fnref:70" href="#fn:70">70</a> Less severe cases occur during cold, dry weather, and is a form of <a href="/facts/Chapped_lips/GPGDl3Uh">chapped lips</a>. Individuals may lick their lips in an attempt to provide a temporary moment of relief, only serving to worsen the condition.<a class="footnote-ref" id="fnref:71" href="#fn:71">71</a>
The sunscreen in some types of lip balm degrades over time into an irritant. Using expired lipbalm can initiate mild angular cheilitis, and when the person applies more lipbalm to alleviate the cracking, it only aggravates it. Because of the delayed onset of contact dermatitis and the recovery period lasting days to weeks, people typically do not make the connection between the causative agent and the symptoms.[medical citation needed]

<h3>Nutritional deficiencies</h3>
Several different <a href="/facts/Malnutrition/KasQy5MR">nutritional deficiency</a> states of <a href="/facts/Vitamin/SnW0LYBL">vitamins</a> or <a href="/facts/Mineral/LkUFbNmv">minerals</a> have been linked to angular cheilitis.<a class="footnote-ref" id="fnref:72" href="#fn:72">72</a> It is thought that in about 25% of people with AC, <a href="/facts/Iron_deficiency/wK3f3IuR">iron deficiency</a> or deficiency of <a href="/facts/B_vitamins/m6ekXy6A">B vitamins</a> are involved.<a class="footnote-ref" id="fnref:73" href="#fn:73">73</a> Nutritional deficiencies may be a more common cause of AC in <a href="/facts/Third_World/AcuEJmhE">Third World</a> countries.<a class="footnote-ref" id="fnref:74" href="#fn:74">74</a> Chronic iron deficiency may also cause <a href="/facts/Koilonychia/qysx1kjn">koilonychia</a> (spoon shaped deformity of the fingernails) and <a href="/facts/Glossitis/2kjMRrVA">glossitis</a> (inflammation of the tongue). It is not completely understood how iron deficiency causes AC, but it is known that it causes a degree of <a href="/facts/Immunodeficiency/CIEujXmc">immunocompromise</a> (decreased efficiency of the immune system) which may in turn allow an opportunistic infection of candida.<a class="footnote-ref" id="fnref:75" href="#fn:75">75</a> <a href="/facts/Riboflavin/M8D8EbmD">Vitamin B2 deficiency</a> (ariboflavinosis) may also cause AC, and other conditions such as redness of <a href="/facts/Mucous_membrane/oIw0vyel">mucous membranes</a>, magenta colored glossitis (pink inflammation of the tongue).<a class="footnote-ref" id="fnref:76" href="#fn:76">76</a> <a href="/facts/Pantothenic_acid/18EWLroq">Vitamin B5</a> deficiency may also cause AC, along with glossitis, and skin changes similar to <a href="/facts/Seborrhoeic_dermatitis/d1CfhTDG">seborrhoeic dermatitis</a> around the eyes, nose and mouth.<a class="footnote-ref" id="fnref:77" href="#fn:77">77</a> <a href="/facts/Vitamin_B12_deficiency/WeChf6H3">Vitamin B12 deficiency</a> is sometimes responsible for AC, and commonly occurs together with <a href="/facts/Folate_deficiency/aqffhQzn">folate deficiency</a> (a lack of <a href="/facts/Folate/8Eb7An6D">folic acid</a>), which also causes glossitis and <a href="/facts/Megaloblastic_anemia/Ru2zwG6C">megaloblastic anemia</a>.<a class="footnote-ref" id="fnref:78" href="#fn:78">78</a> <a href="/facts/Vitamin_B3_complex/sgjmUWzx">Vitamin B3</a> deficiency (<a href="/facts/Pellagra/gfJD7nL1">pellagra</a>) is another possible cause, and in which other association conditions such as <a href="/facts/Dermatitis/JwlyQBa2">dermatitis</a>, <a href="/facts/Diarrhea/6TBHaRdA">diarrhea</a>, <a href="/facts/Dementia/T0MRDE9I">dementia</a> and glossitis can occur.<a class="footnote-ref" id="fnref:79" href="#fn:79">79</a> <a href="/facts/Biotin/WAaVxyB7">Biotin</a> (vitamin B7) deficiency has also been reported to cause AC, along with <a href="/facts/Hair_loss/uEPKUafl">hair loss</a> (alopecia) and <a href="/facts/Xerophthalmia/5nsT0hp7">dry eyes</a>.<a class="footnote-ref" id="fnref:80" href="#fn:80">80</a> <a href="/facts/Zinc_deficiency/bfrcrw24">Zinc deficiency</a> is known to cause AC.<a class="footnote-ref" id="fnref:81" href="#fn:81">81</a> Other symptoms may include diarrhea, <a href="/facts/Alopecia/uEPKUafl">alopecia</a> and <a href="/facts/Dermatitis/JwlyQBa2">dermatitis</a>.<a class="footnote-ref" id="fnref:82" href="#fn:82">82</a> <a href="/facts/Acrodermatitis_enteropathica/kmpACrua">Acrodermatitis enteropathica</a> is an autosomal recessive genetic disorder causing impaired absorption of zinc, and is associated with AC.<a class="footnote-ref" id="fnref:83" href="#fn:83">83</a>
In general, these nutritional disorders may be caused by <a href="/facts/Malnutrition/KasQy5MR">malnutrition</a>, such as may occur in <a href="/facts/Alcoholism/KGPzpChp">alcoholism</a> or in poorly considered diets, or by <a href="/facts/Malabsorption/hWRQd4c5">malabsorption</a> secondary to gastrointestinal disorders (e.g. <a href="/facts/Coeliac_disease/AKd5PkTc">Coeliac disease</a> or <a href="/facts/Chronic_pancreatitis/r724VCAo">chronic pancreatitis</a>) or gastrointestinal surgeries (e.g. <a href="/facts/Vitamin_B12_deficiency_anemia/6WVBYjso">pernicious anemia</a> caused by <a href="/facts/Ileum/rCWGkFuf">ileal</a> resection in <a href="/facts/Crohn%27s_disease/zm55cBtd">Crohn's disease</a>).<a class="footnote-ref" id="fnref:84" href="#fn:84">84</a>

<h3>Systemic disorders</h3>
Some systemic disorders are involved in angular cheilitis by virtue of their association with malabsorption and the creation of nutritional deficiencies described above. Such examples include people with <a href="/facts/Anorexia_nervosa/00KSqEn7">anorexia nervosa</a>.<a class="footnote-ref" id="fnref:85" href="#fn:85">85</a> Other disorders may cause lip enlargement (e.g. <a href="/facts/Orofacial_granulomatosis/BHf6zABy">orofacial granulomatosis</a>),<a class="footnote-ref" id="fnref:86" href="#fn:86">86</a> which alters the local anatomy and extenuates the skin folds at the corners of the mouth. More still may be involved because they affect the immune system, allowing normally harmless organisms like Candida to become pathogenic and cause an infection. Xerostomia (dry mouth) is thought to account for about 5% of cases of AC.<a class="footnote-ref" id="fnref:87" href="#fn:87">87</a> Xerostomia itself has many possible causes, but commonly the cause may be side effects of medications, or conditions such as <a href="/facts/Sj%C3%B6gren%27s_syndrome/U1p9IbFU">Sjögren's syndrome</a>. Conversely, conditions which cause <a href="/facts/Drooling/XGNggmPS">drooling</a> or <a href="/facts/Sialorrhoea/fjDlJ6tj">sialorrhoea</a> (excessive salivation) can cause angular cheilitis by creating a constant wet environment in the corners of the mouth. About 25% of people with <a href="/facts/Down_syndrome/Y4XEQSMS">Down syndrome</a> appear to have AC.<a class="footnote-ref" id="fnref:88" href="#fn:88">88</a> This is due to relative <a href="/facts/Macroglossia/tm1C9y3G">macroglossia</a>, an apparently large tongue in a small mouth, which may constantly stick out of the mouth causing maceration of the corners of the mouth with saliva. <a href="/facts/Inflammatory_bowel_disease/RuxcPW5A">Inflammatory bowel diseases</a> (such as <a href="/facts/Crohn%27s_disease/zm55cBtd">Crohn's disease</a> or <a href="/facts/Ulcerative_colitis/BIkyFzRj">ulcerative colitis</a>) can be associated with angular cheilitis.<a class="footnote-ref" id="fnref:89" href="#fn:89">89</a> In Crohn's, it is likely the result of malabsorption and immunosuppressive therapy which gives rise to the sores at the corner of the mouth.<a class="footnote-ref" id="fnref:90" href="#fn:90">90</a> <a href="/facts/Glucagonoma/WY7Pofo8">Glucagonomas</a> are rare <a href="/facts/Pancreas/r0WPGjAq">pancreatic</a> <a href="/facts/Endocrine_tumor/FLblAFcv">endocrine tumors</a> which secrete <a href="/facts/Glucagon/NVEnH03n">glucagon</a>, and cause a syndrome of dermatitis, glucose intolerance, weight loss and anemia. AC is a common feature of glucagonoma syndrome.<a class="footnote-ref" id="fnref:91" href="#fn:91">91</a> Infrequently, angular cheilitis may be one of the manifestations of <a href="/facts/Chronic_mucocutaneous_candidiasis/16oGkkdH">chronic mucocutaneous candidiasis</a>,<a class="footnote-ref" id="fnref:92" href="#fn:92">92</a> and sometimes cases of oropharyngeal or esophageal candidiasis may accompany angular cheilitis.<a class="footnote-ref" id="fnref:93" href="#fn:93">93</a> Angular cheilitis may be present in <a href="/facts/Human_immunodeficiency_virus_infection/ulY2rgzu">human immunodeficiency virus infection</a>,<a class="footnote-ref" id="fnref:94" href="#fn:94">94</a> <a href="/facts/Neutropenia/qasEurVu">neutropenia</a>,<a class="footnote-ref" id="fnref:95" href="#fn:95">95</a> or <a href="/facts/Diabetes/2xeHXbsI">diabetes</a>.<a class="footnote-ref" id="fnref:96" href="#fn:96">96</a> Angular cheilitis is more common in people with <a href="/facts/Eczema/JwlyQBa2">eczema</a> because their skin is more sensitive to irritants.<a class="footnote-ref" id="fnref:97" href="#fn:97">97</a> Other conditions possibly associated include <a href="/facts/Plasma_cell_gingivitis/8Dd6upNj">plasma cell gingivitis</a>,<a class="footnote-ref" id="fnref:98" href="#fn:98">98</a> <a href="/facts/Melkersson%E2%80%93Rosenthal_syndrome/LIUpW0Yb">Melkersson–Rosenthal syndrome</a>,<a class="footnote-ref" id="fnref:99" href="#fn:99">99</a> or <a href="/facts/Sideropenic_dysphagia/UQ6LKkPw">sideropenic dysphagia</a> (also called Plummer–Vinson syndrome or Paterson–Brown–Kelly syndrome).<a class="footnote-ref" id="fnref:100" href="#fn:100">100</a>

<h3>Drugs</h3>
Several drugs may cause AC as a side effect, by various mechanisms, such as creating drug-induced xerostomia. Various examples include <a href="/facts/Isotretinoin/XBKv4fQJ">isotretinoin</a>, <a href="/facts/Indinavir/VBQdY7Pr">indinavir</a>, and <a href="/facts/Sorafenib/TBLhC5Kj">sorafenib</a>.<a class="footnote-ref" id="fnref:101" href="#fn:101">101</a> Isotretinoin (Accutane), an analog of <a href="/facts/Vitamin_A/5ewDf9LF">vitamin A</a>, is a medication which dries the skin. Less commonly, angular cheilitis is associated with primary <a href="/facts/Hypervitaminosis_A/awIhJJMC">hypervitaminosis A</a>,<a class="footnote-ref" id="fnref:102" href="#fn:102">102</a> which can occur when large amounts of liver (including cod liver oil and other fish oils) are regularly consumed or as a result from an excess intake of vitamin A in the form of vitamin supplements. Recreational drug users may develop AC. Examples include <a href="/facts/Cocaine/rdQP4zwF">cocaine</a>, <a href="/facts/Methamphetamine/vS1jloMe">methamphetamine</a>, <a href="/facts/Heroin/rYwrKHPk">heroin</a>, and <a href="/facts/Hallucinogen/gn35weCu">hallucinogens</a>.<a class="footnote-ref" id="fnref:103" href="#fn:103">103</a>

<h3>Allergic contact dermatitis</h3>
See also: <a href="/facts/Cheilitis/GPGDl3Uh">Cheilitis</a>, <a href="/facts/Allergic_contact_dermatitis/cNyAKVe7">Allergic contact dermatitis</a>, and <a href="/facts/Allergic_contact_stomatitis/REalMD0K">Allergic contact stomatitis</a>

Allergic reactions may account for about 25–34% of cases of generalized cheilitis (i.e., inflammation not confined to the angles of the mouth). It is unknown how frequently allergic reactions are responsible for cases of angular cheilitis, but any substance capable of causing generalized allergic cheilitis may present involving the corners of the mouth alone.
Examples of potential <a href="/facts/Allergen/bnM4cttq">allergens</a> include substances that may be present in some types of lipstick, toothpaste, acne products, cosmetics, chewing gum, mouthwash, foods, dental appliances, and materials from dentures or mercury containing amalgam fillings.<a class="footnote-ref" id="fnref:104" href="#fn:104">104</a> It is usually impossible to tell the difference between irritant contact dermatitis and allergic contact dermatitis without a <a href="/facts/Patch_test/TJaD3ERo">patch test</a>.

<h3>Loss of lower facial height</h3>
Severe tooth wear or ill fitting dentures may cause wrinkling at the corners of the lip that creates a favorable environment for the condition.<a class="footnote-ref" id="fnref:105" href="#fn:105">105</a> This can be corrected with onlays or crowns on the worn teeth to restore height or new dentures with "taller" teeth. The loss of vertical dimension has been associated with angular cheilitis in older individuals with an increase in facial laxity.<a class="footnote-ref" id="fnref:106" href="#fn:106">106</a>

<h2 id="diagnosis">Diagnosis</h2>

Angular cheilitis is normally a diagnosis made clinically. If the sore is unilateral, rather than bilateral, this suggests a local factor (e.g., trauma) or a split <a href="/facts/Syphilitic/fdnGLyLT">syphilitic</a> <a href="/facts/Papule/2J7QwJdE">papule</a>.<a class="footnote-ref" id="fnref:107" href="#fn:107">107</a><a class="footnote-ref" id="fnref:108" href="#fn:108">108</a> Angular cheilitis caused by <a href="/facts/Mandibular/1ATEfAQa">mandibular</a> overclosure, drooling, and other irritants is usually bilateral.<a class="footnote-ref" id="fnref:109" href="#fn:109">109</a>
The lesions are normally swabbed to detect if <a href="/facts/Candida_(fungus)/IIYvWvx5">Candida</a> or <a href="/facts/Pathogenic/axMXtV1M">pathogenic</a> <a href="/facts/Bacterial/wC8xSCsU">bacterial</a> <a href="/facts/Species/oDg6b96r">species</a> may be present. Persons with angular cheilitis who wear dentures often also will have their denture swabbed in addition. A <a href="/facts/Complete_blood_count/NF9lNJL3">complete blood count</a> (full blood count) may be indicated, including assessment of the levels of <a href="/facts/Iron/QK1JYy8E">iron</a>, <a href="/facts/Ferritin/w7G85xJg">ferritin</a>, <a href="/facts/Vitamin_B12/vCk613gD">vitamin B12</a> (and possibly other <a href="/facts/B_vitamins/m6ekXy6A">B vitamins</a>), and <a href="/facts/Folate/8Eb7An6D">folate</a>.<a class="footnote-ref" id="fnref:110" href="#fn:110">110</a>

<h3>Classification</h3>
Angular cheilitis could be considered to be a type of cheilitis or <a href="/facts/Stomatitis/REalMD0K">stomatitis</a>. Where Candida species are involved, angular cheilitis is classed as a type of <a href="/facts/Oral_candidiasis/joetTDM8">oral candidiasis</a>, specifically a primary (group I) Candida-associated lesion.<a class="footnote-ref" id="fnref:111" href="#fn:111">111</a> This form angular cheilitis which is caused by Candida is sometimes termed "Candida-associated angular cheilitis",<a class="footnote-ref" id="fnref:112" href="#fn:112">112</a> or less commonly, "monilial perlèche".<a class="footnote-ref" id="fnref:113" href="#fn:113">113</a> Angular cheilitis can also be classified as acute (sudden, short-lived appearance of the condition) or chronic (lasts a long time or keeps returning), or <a href="/facts/Refractory_disease/55eeQlGL">refractory</a> (the condition persists despite attempts to treat it).<a class="footnote-ref" id="fnref:114" href="#fn:114">114</a>

<h2 id="management">Management</h2>
There are four aspects to the treatment of angular cheilitis.<a class="footnote-ref" id="fnref:115" href="#fn:115">115</a> Firstly, potential reservoirs of infection inside the mouth are identified and treated.<a class="footnote-ref" id="fnref:116" href="#fn:116">116</a> <a href="/facts/Oral_candidiasis/joetTDM8">Oral candidiasis</a>, especially <a href="/facts/Denture-related_stomatitis/7Kee6hNq">denture-related stomatitis</a> is often found to be present where there is angular cheilitis, and if it is not treated, the sores at the corners of the mouth may often recur.<a class="footnote-ref" id="fnref:117" href="#fn:117">117</a><a class="footnote-ref" id="fnref:118" href="#fn:118">118</a> This involves having dentures properly fitted and disinfected. Commercial preparations are marketed for this purpose, although dentures may be left in dilute (1:10 concentration) household <a href="/facts/Bleach/QPxAysPl">bleach</a> overnight, but only if they are entirely plastic and do not contain any metal parts, and with rinsing under clean water before use.<a class="footnote-ref" id="fnref:119" href="#fn:119">119</a> Improved denture hygiene is often required thereafter, including not wearing the denture during sleep and cleaning it daily.<a class="footnote-ref" id="fnref:120" href="#fn:120">120</a>
Secondly, there may be a need to increase the vertical dimension of the lower face to prevent overclosure of the mouth and formation of deep skin folds.<a class="footnote-ref" id="fnref:121" href="#fn:121">121</a> This may require the construction of a new denture with an adjusted bite.<a class="footnote-ref" id="fnref:122" href="#fn:122">122</a> Rarely, in cases resistant to normal treatments, surgical procedures such as <a href="/facts/Collagen_injection/KsyAb72K">collagen injections</a> (or other facial fillers such as autologous fat or crosslinked <a href="/facts/Hyaluronic_acid/RVJWD32e">hyaluronic acid</a>) are used in an attempt to restore the normal facial contour.<a class="footnote-ref" id="fnref:123" href="#fn:123">123</a><a class="footnote-ref" id="fnref:124" href="#fn:124">124</a> Other measures which seek to reverse the local factors that may be contributing to the condition include improving <a href="/facts/Oral_hygiene/MddqTjwo">oral hygiene</a>, stopping smoking or other tobacco habits and use of a barrier cream (e.g. <a href="/facts/Zinc_oxide/P7sTyDez">zinc oxide</a> paste) at night.<a class="footnote-ref" id="fnref:125" href="#fn:125">125</a>
Thirdly, treatment of the infection and inflammation of the lesions themselves is addressed. This is usually with <a href="/facts/Topical_antifungal_drugs/3p3IupUY">topical antifungal</a> medication,<a class="footnote-ref" id="fnref:126" href="#fn:126">126</a> such as <a href="/facts/Clotrimazole/SRY1jAW9">clotrimazole</a>,<a class="footnote-ref" id="fnref:127" href="#fn:127">127</a> <a href="/facts/Amphotericin_B/c2H3NmRQ">amphotericin B</a>,<a class="footnote-ref" id="fnref:128" href="#fn:128">128</a> <a href="/facts/Ketoconazole/UQcvnER5">ketoconazole</a>,<a class="footnote-ref" id="fnref:129" href="#fn:129">129</a> or <a href="/facts/Nystatin/povtrmq3">nystatin</a> cream.<a class="footnote-ref" id="fnref:130" href="#fn:130">130</a> Some antifungal creams are combined with <a href="/facts/Corticosteroid/jeL2QeIL">corticosteroids</a> such as <a href="/facts/Hydrocortisone/zvRCrYXG">hydrocortisone</a><a class="footnote-ref" id="fnref:131" href="#fn:131">131</a> or <a href="/facts/Triamcinolone/egxMoRSg">triamcinolone</a><a class="footnote-ref" id="fnref:132" href="#fn:132">132</a> to reduce inflammation, and certain antifungals such as <a href="/facts/Miconazole/PjA5UgFB">miconazole</a> also have some <a href="/facts/Antibacterial/sF1kIfxg">antibacterial</a> action.<a class="footnote-ref" id="fnref:133" href="#fn:133">133</a> <a href="/facts/Diiodohydroxyquinoline/h044ftny">Diiodohydroxyquinoline</a> is another topical therapy for angular cheilitis.<a class="footnote-ref" id="fnref:134" href="#fn:134">134</a> If Staphylococcus aureus infection is demonstrated by microbiological culture to be responsible (or suspected), the treatment may be changed to <a href="/facts/Fusidic_acid/6fht8IQt">fusidic acid</a> cream,<a class="footnote-ref" id="fnref:135" href="#fn:135">135</a> an antibiotic which is effective against this type of bacteria. Aside from fusidic acid, <a href="/facts/Neomycin/rcK7U59h">neomycin</a>,<a class="footnote-ref" id="fnref:136" href="#fn:136">136</a> <a href="/facts/Mupirocin/6NUJQups">mupirocin</a>,<a class="footnote-ref" id="fnref:137" href="#fn:137">137</a> <a href="/facts/Metronidazole/pY5K5twk">metronidazole</a>,<a class="footnote-ref" id="fnref:138" href="#fn:138">138</a> and <a href="/facts/Chlorhexidine/Gyv5LNxf">chlorhexidine</a><a class="footnote-ref" id="fnref:139" href="#fn:139">139</a> are alternative options in this scenario.
Finally, if the condition appears resistant to treatment, investigations for underlying causes such as anemia or nutrient deficiencies or HIV infection.<a class="footnote-ref" id="fnref:140" href="#fn:140">140</a> Identification of the underlying cause is essential for treating chronic cases. The lesions may resolve when the underlying disease is treated, e.g. with a course of oral iron or vitamin B supplements.<a class="footnote-ref" id="fnref:141" href="#fn:141">141</a> <a href="/facts/Patch_test/TJaD3ERo">Patch testing</a> is recommended by some in cases which are resistant to treatment and where allergic contact dermatitis is suspected.<a class="footnote-ref" id="fnref:142" href="#fn:142">142</a>

<h2 id="prognosis">Prognosis</h2>
Most cases of angular cheilitis respond quickly when antifungal treatment is used.<a class="footnote-ref" id="fnref:143" href="#fn:143">143</a> In more long standing cases, the severity of the condition often follows a relapsing and remitting course over time.<a class="footnote-ref" id="fnref:144" href="#fn:144">144</a> The condition can be difficult to treat and can be prolonged.<a class="footnote-ref" id="fnref:145" href="#fn:145">145</a>

<h2 id="epidemiology">Epidemiology</h2>
AC is a relatively common condition,<a class="footnote-ref" id="fnref:146" href="#fn:146">146</a> accounting for between 0.7 – 3.8% of oral mucosal lesions in adults and between 0.2 – 15.1% in children, though overall it occurs most commonly in adults in the third to sixth decades of life.<a class="footnote-ref" id="fnref:147" href="#fn:147">147</a><a class="footnote-ref" id="fnref:148" href="#fn:148">148</a> It occurs worldwide, and both males and females are affected.<a class="footnote-ref" id="fnref:149" href="#fn:149">149</a> Angular cheilitis is the most common presentation of fungal and bacterial infections of the lips.<a class="footnote-ref" id="fnref:150" href="#fn:150">150</a>

<h2 id="etymology">Etymology</h2>
The term angular cheilitis comes from the <a href="/facts/Ancient_Greek/LIK7NlUh">Ancient Greek</a> χείλος, meaning 'lip', and -itis, referring to <a href="/facts/Inflammation/Ura86MIy">inflammation</a>.

<h2 id="external-links">External links</h2>

Wikimedia Commons has media related to Angular cheilitis.

<h2 id="references">References</h2>

<ol>
<li id="fn:1">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></li>
<li id="fn:2">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></li>
<li id="fn:3">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></li>
<li id="fn:4">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></li>
<li id="fn:5">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></li>
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<li id="fn:8">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></li>
<li id="fn:9">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></li>
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<li id="fn:13">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></li>
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<li id="fn:19">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></li>
<li id="fn:20">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></li>
<li id="fn:21">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></li>
<li id="fn:22">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:22" class="footnote-back-ref">↩</a></li>
<li id="fn:23">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:23" class="footnote-back-ref">↩</a></li>
<li id="fn:24">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:24" class="footnote-back-ref">↩</a></li>
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<li id="fn:26">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:26" class="footnote-back-ref">↩</a></li>
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<li id="fn:66">Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp. 100, 192, 196, 266. ISBN 978-0721690032. <a href="978-0721690032" target="_blank">978-0721690032</a> <a href="#fnref:66" class="footnote-back-ref">↩</a></li>
<li id="fn:67">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:67" class="footnote-back-ref">↩</a></li>
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<li id="fn:95">Greenberg MS, Glick M (2003). Burket's oral medicine diagnosis & treatment (10th ed.). Hamilton, Ont.: BC Decker. pp. 97–98, 550. ISBN 978-1550091861. <a href="978-1550091861" target="_blank">978-1550091861</a> <a href="#fnref:95" class="footnote-back-ref">↩</a></li>
<li id="fn:96">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:96" class="footnote-back-ref">↩</a></li>
<li id="fn:97">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:97" class="footnote-back-ref">↩</a></li>
<li id="fn:98">Wood, NK; Goaz, PW (1997). Differential diagnosis of oral and maxillofacial lesions (5th ed.). St. Louis [u.a.]: Mosby. pp. 64–65, 85. ISBN 978-0815194323. <a href="978-0815194323" target="_blank">978-0815194323</a> <a href="#fnref:98" class="footnote-back-ref">↩</a></li>
<li id="fn:99">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:99" class="footnote-back-ref">↩</a></li>
<li id="fn:100">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:100" class="footnote-back-ref">↩</a></li>
<li id="fn:101">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:101" class="footnote-back-ref">↩</a></li>
<li id="fn:102">Kliegman: Nelson Textbook of Pediatrics, 18th ed. <a href="#fnref:102" class="footnote-back-ref">↩</a></li>
<li id="fn:103">Park, KK; Brodell RT; Helms SE. (July 2011). "Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment" (PDF). Cutis. 88 (1): 27–32. PMID 21877503. Archived from the original (PDF) on 2014-04-19. <a href="https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf" target="_blank">https://web.archive.org/web/20140419015237/http://www.skinandallergynews.com/fileadmin/qhi_archive/ArticlePDF/CT/088010027.pdf</a> <a href="#fnref:103" class="footnote-back-ref">↩</a></li>
<li id="fn:104">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:104" class="footnote-back-ref">↩</a></li>
<li id="fn:105">Devani, Alim; Barankin, Benjamin (2007). "Answer: Can you identify this condition?". Canadian Family Physician. 53 (6): 1022–1023. ISSN 0008-350X. PMC 1949217. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949217" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949217</a> <a href="#fnref:105" class="footnote-back-ref">↩</a></li>
<li id="fn:106">"How Do I Manage a Patient with Angular Cheilitis? | jcda". www.jcda.ca. Retrieved 8 June 2018. <a href="http://www.jcda.ca/article/d68" target="_blank">http://www.jcda.ca/article/d68</a> <a href="#fnref:106" class="footnote-back-ref">↩</a></li>
<li id="fn:107">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:107" class="footnote-back-ref">↩</a></li>
<li id="fn:108">Leyse-Wallace, Ruth (29 January 2013). Nutrition and Mental Health. CRC Press. p. 246. ISBN 9781439863350. Archived from the original on 10 September 2017. Retrieved 17 September 2014. <a href="9781439863350" target="_blank">9781439863350</a> <a href="#fnref:108" class="footnote-back-ref">↩</a></li>
<li id="fn:109">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:109" class="footnote-back-ref">↩</a></li>
<li id="fn:110">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:110" class="footnote-back-ref">↩</a></li>
<li id="fn:111">Tyldesley WR, Field A, Longman L (2003). Tyldesley's Oral medicine (5th ed.). Oxford: Oxford University Press. pp. 37, 40, 46, 63–67. ISBN 978-0192631473. <a href="978-0192631473" target="_blank">978-0192631473</a> <a href="#fnref:111" class="footnote-back-ref">↩</a></li>
<li id="fn:112">Tyldesley WR, Field A, Longman L (2003). Tyldesley's Oral medicine (5th ed.). Oxford: Oxford University Press. pp. 37, 40, 46, 63–67. ISBN 978-0192631473. <a href="978-0192631473" target="_blank">978-0192631473</a> <a href="#fnref:112" class="footnote-back-ref">↩</a></li>
<li id="fn:113">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:113" class="footnote-back-ref">↩</a></li>
<li id="fn:114">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:114" class="footnote-back-ref">↩</a></li>
<li id="fn:115">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:115" class="footnote-back-ref">↩</a></li>
<li id="fn:116">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:116" class="footnote-back-ref">↩</a></li>
<li id="fn:117">Coulthard P, Horner K, Sloan P, Theaker E (2008). Master dentistry volume 1, oral and maxillofacial surgery, radiology, pathology and oral medicine (2nd ed.). Edinburgh: Churchill Livingstone/Elsevier. pp. 180–81. ISBN 9780443068966. <a href="9780443068966" target="_blank">9780443068966</a> <a href="#fnref:117" class="footnote-back-ref">↩</a></li>
<li id="fn:118">Peter C. Schalock, M.D.; Jeffrey T. S. Hsu, M.D.; Kenneth A. Arndt, eds. (2010-09-15). Primary Care Dermatology. Lippincott Williams & Wilkins, 2010. p. 265. ISBN 978-0-7817-9378-0. Archived from the original on 2017-09-10. <a href="978-0-7817-9378-0" target="_blank">978-0-7817-9378-0</a> <a href="#fnref:118" class="footnote-back-ref">↩</a></li>
<li id="fn:119">Treister NS, Bruch JM (2010). Clinical oral medicine and pathology. New York: Humana Press. pp. 92–93, 144. ISBN 978-1-60327-519-4. <a href="978-1-60327-519-4" target="_blank">978-1-60327-519-4</a> <a href="#fnref:119" class="footnote-back-ref">↩</a></li>
<li id="fn:120">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:120" class="footnote-back-ref">↩</a></li>
<li id="fn:121">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:121" class="footnote-back-ref">↩</a></li>
<li id="fn:122">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:122" class="footnote-back-ref">↩</a></li>
<li id="fn:123">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:123" class="footnote-back-ref">↩</a></li>
<li id="fn:124">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:124" class="footnote-back-ref">↩</a></li>
<li id="fn:125">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:125" class="footnote-back-ref">↩</a></li>
<li id="fn:126">Coulthard P, Horner K, Sloan P, Theaker E (2008). Master dentistry volume 1, oral and maxillofacial surgery, radiology, pathology and oral medicine (2nd ed.). Edinburgh: Churchill Livingstone/Elsevier. pp. 180–81. ISBN 9780443068966. <a href="9780443068966" target="_blank">9780443068966</a> <a href="#fnref:126" class="footnote-back-ref">↩</a></li>
<li id="fn:127">Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp. 100, 192, 196, 266. ISBN 978-0721690032. <a href="978-0721690032" target="_blank">978-0721690032</a> <a href="#fnref:127" class="footnote-back-ref">↩</a></li>
<li id="fn:128">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:128" class="footnote-back-ref">↩</a></li>
<li id="fn:129">Greenberg MS, Glick M (2003). Burket's oral medicine diagnosis & treatment (10th ed.). Hamilton, Ont.: BC Decker. pp. 97–98, 550. ISBN 978-1550091861. <a href="978-1550091861" target="_blank">978-1550091861</a> <a href="#fnref:129" class="footnote-back-ref">↩</a></li>
<li id="fn:130">Treister NS, Bruch JM (2010). Clinical oral medicine and pathology. New York: Humana Press. pp. 92–93, 144. ISBN 978-1-60327-519-4. <a href="978-1-60327-519-4" target="_blank">978-1-60327-519-4</a> <a href="#fnref:130" class="footnote-back-ref">↩</a></li>
<li id="fn:131">Coulthard P, Horner K, Sloan P, Theaker E (2008). Master dentistry volume 1, oral and maxillofacial surgery, radiology, pathology and oral medicine (2nd ed.). Edinburgh: Churchill Livingstone/Elsevier. pp. 180–81. ISBN 9780443068966. <a href="9780443068966" target="_blank">9780443068966</a> <a href="#fnref:131" class="footnote-back-ref">↩</a></li>
<li id="fn:132">Treister NS, Bruch JM (2010). Clinical oral medicine and pathology. New York: Humana Press. pp. 92–93, 144. ISBN 978-1-60327-519-4. <a href="978-1-60327-519-4" target="_blank">978-1-60327-519-4</a> <a href="#fnref:132" class="footnote-back-ref">↩</a></li>
<li id="fn:133">Coulthard P, Horner K, Sloan P, Theaker E (2008). Master dentistry volume 1, oral and maxillofacial surgery, radiology, pathology and oral medicine (2nd ed.). Edinburgh: Churchill Livingstone/Elsevier. pp. 180–81. ISBN 9780443068966. <a href="9780443068966" target="_blank">9780443068966</a> <a href="#fnref:133" class="footnote-back-ref">↩</a></li>
<li id="fn:134">Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp. 100, 192, 196, 266. ISBN 978-0721690032. <a href="978-0721690032" target="_blank">978-0721690032</a> <a href="#fnref:134" class="footnote-back-ref">↩</a></li>
<li id="fn:135">Coulthard P, Horner K, Sloan P, Theaker E (2008). Master dentistry volume 1, oral and maxillofacial surgery, radiology, pathology and oral medicine (2nd ed.). Edinburgh: Churchill Livingstone/Elsevier. pp. 180–81. ISBN 9780443068966. <a href="9780443068966" target="_blank">9780443068966</a> <a href="#fnref:135" class="footnote-back-ref">↩</a></li>
<li id="fn:136">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:136" class="footnote-back-ref">↩</a></li>
<li id="fn:137">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:137" class="footnote-back-ref">↩</a></li>
<li id="fn:138">Wood, NK; Goaz, PW (1997). Differential diagnosis of oral and maxillofacial lesions (5th ed.). St. Louis [u.a.]: Mosby. pp. 64–65, 85. ISBN 978-0815194323. <a href="978-0815194323" target="_blank">978-0815194323</a> <a href="#fnref:138" class="footnote-back-ref">↩</a></li>
<li id="fn:139">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:139" class="footnote-back-ref">↩</a></li>
<li id="fn:140">Samaranayake, LP (2009). Essential microbiology for dentistry (3rd ed.). Elseveier. pp. 296–97. ISBN 978-0702041679. <a href="978-0702041679" target="_blank">978-0702041679</a> <a href="#fnref:140" class="footnote-back-ref">↩</a></li>
<li id="fn:141">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:141" class="footnote-back-ref">↩</a></li>
<li id="fn:142">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:142" class="footnote-back-ref">↩</a></li>
<li id="fn:143">Greenberg MS, Glick M (2003). Burket's oral medicine diagnosis & treatment (10th ed.). Hamilton, Ont.: BC Decker. pp. 97–98, 550. ISBN 978-1550091861. <a href="978-1550091861" target="_blank">978-1550091861</a> <a href="#fnref:143" class="footnote-back-ref">↩</a></li>
<li id="fn:144">Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp. 100, 192, 196, 266. ISBN 978-0721690032. <a href="978-0721690032" target="_blank">978-0721690032</a> <a href="#fnref:144" class="footnote-back-ref">↩</a></li>
<li id="fn:145">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:145" class="footnote-back-ref">↩</a></li>
<li id="fn:146">Tyldesley WR, Field A, Longman L (2003). Tyldesley's Oral medicine (5th ed.). Oxford: Oxford University Press. pp. 37, 40, 46, 63–67. ISBN 978-0192631473. <a href="978-0192631473" target="_blank">978-0192631473</a> <a href="#fnref:146" class="footnote-back-ref">↩</a></li>
<li id="fn:147">Park, KK; Brodell, RT; Helms, SE (June 2011). "Angular cheilitis, part 1: local etiologies". Cutis. 87 (6): 289–95. PMID 21838086. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:147" class="footnote-back-ref">↩</a></li>
<li id="fn:148">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:148" class="footnote-back-ref">↩</a></li>
<li id="fn:149">Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 147–49. ISBN 9780443068188. <a href="9780443068188" target="_blank">9780443068188</a> <a href="#fnref:149" class="footnote-back-ref">↩</a></li>
<li id="fn:150">Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp. 100, 192, 196, 266. ISBN 978-0721690032. <a href="978-0721690032" target="_blank">978-0721690032</a> <a href="#fnref:150" class="footnote-back-ref">↩</a></li>
</ol>

Angular cheilitis open-in-new

Angular cheilitis