Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
6-Phosphogluconate dehydrogenase
open-in-new
<h2 id="biotechnological-significance">Biotechnological significance</h2> <p>Recently, 6PGD was demonstrated to catalyze also the reverse reaction (i.e. reductive <a href="/facts/Carboxylation/8zNzYvnP">carboxylation</a>) <i>in vivo</i>.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> Experiments using <i>Escherichia coli</i> selection strains revealed that this reaction was efficient enough to support the formation of biomass based solely on <a href="/facts/Carbon_dioxide/xGzpppEp">CO2</a> and <a href="/facts/Pentose/BScECY9L">pentose sugars</a>. In the future, this property could be exploited for synthetic <a href="/facts/Carbon_fixation/JqvfmCdH">carbon fixation</a> routes. </p> <h2 id="clinical-significance">Clinical significance</h2> <p>Mutations within the gene coding this enzyme result in <a href="/facts/6-phosphogluconate_dehydrogenase_deficiency/JAeYmCag">6-phosphogluconate dehydrogenase deficiency</a>, an <a href="/facts/Autosomal/uN3B2AhI">autosomal</a> hereditary disease affecting the red blood cells. </p> <h3>As a possible drug target</h3> <p>6PGD is involved in cancer cell metabolism so 6PGD inhibitors have been sought.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Parietin/m6G8S7cs">Parietin</a>, a 6PGD inhibitor</li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Frampton EW, Wood WA (October 1961). <a href="https://doi.org/10.1016%2FS0021-9258%2819%2961700-X">"Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate"</a>. <i>The Journal of Biological Chemistry</i>. 236: 2571–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2819%2961700-X">10.1016/S0021-9258(19)61700-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/13894458">13894458</a>.</li></ul> This article incorporates text from the public domain <a href="/facts/Pfam/BKJa293w">Pfam</a> and <a href="/facts/InterPro/pKwNm8t7">InterPro</a>: <a href="https://www.ebi.ac.uk/interpro/entry/IPR006114">IPR006114</a> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Broedel SE, Wolf RE (July 1990). "Genetic tagging, cloning, and DNA sequence of the Synechococcus sp. strain PCC 7942 gene (gnd) encoding 6-phosphogluconate dehydrogenase". J. Bacteriol. 172 (7): 4023–31. doi:10.1128/jb.172.7.4023-4031.1990. PMC 213388. PMID 2113917. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC213388" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC213388</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW (1983). "The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution". EMBO J. 2 (6): 1009–14. doi:10.1002/j.1460-2075.1983.tb01535.x. PMC 555222. PMID 6641716. <a href="/wiki/John_R._Helliwell" target="_blank">/wiki/John_R._Helliwell</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Reizer A, Deutscher J, Saier MH, Reizer J (May 1991). "Analysis of the gluconate (gnt) operon of Bacillus subtilis". Mol. Microbiol. 5 (5): 1081–9. doi:10.1111/j.1365-2958.1991.tb01880.x. PMID 1659648. S2CID 2006623. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW (1983). "The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution". EMBO J. 2 (6): 1009–14. doi:10.1002/j.1460-2075.1983.tb01535.x. PMC 555222. PMID 6641716. <a href="/wiki/John_R._Helliwell" target="_blank">/wiki/John_R._Helliwell</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW (1983). "The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution". EMBO J. 2 (6): 1009–14. doi:10.1002/j.1460-2075.1983.tb01535.x. PMC 555222. PMID 6641716. <a href="/wiki/John_R._Helliwell" target="_blank">/wiki/John_R._Helliwell</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW (1983). "The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution". EMBO J. 2 (6): 1009–14. doi:10.1002/j.1460-2075.1983.tb01535.x. PMC 555222. PMID 6641716. <a href="/wiki/John_R._Helliwell" target="_blank">/wiki/John_R._Helliwell</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Satanowski A, Dronsella B, Noor E, Vögeli B, He H, Wichmann P, et al. (November 2020). "Awakening a latent carbon fixation cycle in Escherichia coli". Nature Communications. 11 (1): 5812. Bibcode:2020NatCo..11.5812S. doi:10.1038/s41467-020-19564-5. PMC 7669889. PMID 33199707. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669889" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669889</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling. 2015 <a href="http://www.nature.com/ncb/journal/v17/n11/full/ncb3255.html" target="_blank">http://www.nature.com/ncb/journal/v17/n11/full/ncb3255.html</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> </ol>