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CHRNB2
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<h2 id="interactive-pathway-map">Interactive pathway map</h2> <p><i>Click on genes, proteins and metabolites below to link to respective articles.</i><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Nicotinic_acetylcholine_receptor/k2s2pPHr">Nicotinic acetylcholine receptor</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Skorupska E, Rózycka A, Trzeciak WH (2002). "[Molecular and genetic basis of idiopathic nocturnal frontal lobe epilepsy]". <i>Neurol. Neurochir. Pol</i>. 36 (3): 513–25. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12185808">12185808</a>.</li> <li>Bracci L, Lozzi L, Rustici M, Neri P (1992). <a href="https://doi.org/10.1016%2F0014-5793%2892%2981380-5">"Binding of HIV-1 gp120 to the nicotinic receptor"</a>. <i>FEBS Lett</i>. 311 (2): 115–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1992FEBSL.311..115B">1992FEBSL.311..115B</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0014-5793%2892%2981380-5">10.1016/0014-5793(92)81380-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1397297">1397297</a>.</li> <li>Anand R, Lindstrom J (1990). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC331211">"Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene"</a>. <i>Nucleic Acids Res</i>. 18 (14): 4272. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F18.14.4272">10.1093/nar/18.14.4272</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC331211">331211</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2377478">2377478</a>.</li> <li>Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". <i>J. Mol. Neurosci</i>. 7 (3): 217–28. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2FBF02736842">10.1007/BF02736842</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8906617">8906617</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:45737923">45737923</a>.</li> <li>Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". <i>FEBS Lett</i>. 400 (3): 309–14. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2896%2901383-X">10.1016/S0014-5793(96)01383-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9009220">9009220</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:82364119">82364119</a>.</li> <li>Rempel N, Heyers S, Engels H, et al. (1999). "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)". <i>Hum. Genet</i>. 103 (6): 645–53. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs004390050885">10.1007/s004390050885</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9921897">9921897</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23791981">23791981</a>.</li> <li>Lueders KK, Elliott RW, Marenholz I, et al. (1999). <a href="https://zenodo.org/record/1232695">"Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes"</a>. <i>Mamm. Genome</i>. 10 (9): 900–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs003359901111">10.1007/s003359901111</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10441742">10441742</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:13160005">13160005</a>.</li> <li>Steinlein OK (2000). "Neuronal nicotinic receptors in human epilepsy". <i>Eur. J. Pharmacol</i>. 393 (1–3): 243–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-2999%2800%2900065-0">10.1016/S0014-2999(00)00065-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10771020">10771020</a>.</li> <li>De Fusco M, Becchetti A, Patrignani A, et al. (2000). "The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy". <i>Nat. Genet</i>. 26 (3): 275–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2F81566">10.1038/81566</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11062464">11062464</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:21818633">21818633</a>.</li> <li>Phillips HA, Favre I, Kirkpatrick M, et al. (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234917">"CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy"</a>. <i>Am. J. Hum. Genet</i>. 68 (1): 225–31. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1086%2F316946">10.1086/316946</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234917">1234917</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11104662">11104662</a>.</li> <li>Samochocki M, Zerlin M, Jostock R, et al. (2001). "Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR". <i>Acta Neurol. Scand. Suppl</i>. 176: 68–73. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1034%2Fj.1600-0404.2000.00310.x">10.1034/j.1600-0404.2000.00310.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11261808">11261808</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:39916984">39916984</a>.</li> <li>Engidawork E, Gulesserian T, Balic N, Cairns N, Lubec G (2002). "Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease". In Lubec G (ed.). <i>Protein Expression in Down Syndrome Brain</i>. <i>Journal of Neural Transmission. Supplementum</i>. No. 61. Springer. pp. 211–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2F978-3-7091-6262-0_17">10.1007/978-3-7091-6262-0_17</a>. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-3-211-83704-7. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11771745">11771745</a>.</li> <li>Lueders KK, Hu S, McHugh L, et al. (2002). "Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)". <i>Nicotine Tob. Res</i>. 4 (1): 115–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1080%2F14622200110098419">10.1080/14622200110098419</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11906688">11906688</a>.</li> <li>Duga S, Asselta R, Bonati MT, et al. (2002). <a href="https://doi.org/10.1046%2Fj.1528-1157.2002.39001.x">"Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy"</a>. <i>Epilepsia</i>. 43 (4): 362–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1528-1157.2002.39001.x">10.1046/j.1528-1157.2002.39001.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11952766">11952766</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:34970690">34970690</a>.</li> <li>Heeschen C, Weis M, Aicher A, et al. (2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150415">"A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors"</a>. <i>J. Clin. Invest</i>. 110 (4): 527–36. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1172%2FJCI14676">10.1172/JCI14676</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150415">150415</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12189247">12189247</a>.</li> <li>Lin L, Jeanclos EM, Treuil M, et al. (2003). <a href="https://doi.org/10.1074%2Fjbc.M206857200">"The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor"</a>. <i>J. Biol. Chem</i>. 277 (44): 41872–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M206857200">10.1074/jbc.M206857200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12202488">12202488</a>.</li> <li>Kawamata J, Shimohama S (2002). "Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease". <i>J. Alzheimers Dis</i>. 4 (2): 71–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.3233%2FJAD-2002-4201">10.3233/JAD-2002-4201</a>. <a href="/facts/Hdl_(identifier)/rdebSxmC">hdl</a>:<a href="https://hdl.handle.net/2433%2F149693">2433/149693</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12214130">12214130</a>.</li> <li>Strausberg RL, Feingold EA, Grouse LH, et al. (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=CHRNB2+protein%2C+human">CHRNB2+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li> <li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CHRNB2"><i>CHRNB2</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CHRNB2"><i>CHRNB2</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/facts/Protein_Data_Bank/oUhq4ABD">PDB</a> for <a href="/facts/UniProt/lfDDHjAl">UniProt</a>: <i><a href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P17787">P17787</a></i> (Neuronal acetylcholine receptor subunit beta-2) at the <a href="/facts/PDBe-KB/p1WX7lPH">PDBe-KB</a>.</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1141" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1141</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1141" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1141</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". <a href="http://www.wikipathways.org/index.php/Pathway:WP1602" target="_blank">http://www.wikipathways.org/index.php/Pathway:WP1602</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> </ol>