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CCL8
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<h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CCL8"><i>CCL8</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CCL8"><i>CCL8</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Struyf S, Proost P, Vandercappellen J, et al. (2009). "Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects". <i>Eur. J. Immunol</i>. 39 (3): 843–57. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Feji.200838660">10.1002/eji.200838660</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19224633">19224633</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:41872921">41872921</a>.</li> <li>Rom S, Rom I, Passiatore G, et al. (2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887261">"CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells"</a>. <i>FASEB J</i>. 24 (7): 2292–300. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1096%2Ffj.09-143503">10.1096/fj.09-143503</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887261">2887261</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20181935">20181935</a>.</li> <li>Menon R, Pearce B, Velez DR, et al. (2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714850">"Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants"</a>. <i>Reprod. Biol. Endocrinol</i>. 7: 62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1186%2F1477-7827-7-62">10.1186/1477-7827-7-62</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714850">2714850</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19527514">19527514</a>.</li> <li>Segat L, Brandão LA, Guimarães RL, et al. (2010). <a href="https://doi.org/10.1016%2Fj.vaccine.2009.12.056">"Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment"</a>. <i>Vaccine</i>. 28 (10): 2201–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.vaccine.2009.12.056">10.1016/j.vaccine.2009.12.056</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20056178">20056178</a>.</li> <li>Rajaraman P, Brenner AV, Butler MA, et al. (2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771723">"Common variation in genes related to innate immunity and risk of adult glioma"</a>. <i>Cancer Epidemiol. Biomarkers Prev</i>. 18 (5): 1651–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1158%2F1055-9965.EPI-08-1041">10.1158/1055-9965.EPI-08-1041</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771723">2771723</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19423540">19423540</a>.</li> <li>Han S, Lan Q, Park AK, et al. (2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967770">"Polymorphisms in innate immunity genes and risk of childhood leukemia"</a>. <i>Hum. Immunol</i>. 71 (7): 727–30. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.humimm.2010.04.004">10.1016/j.humimm.2010.04.004</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967770">2967770</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20438785">20438785</a>.</li> <li>Velez DR, Fortunato SJ, Thorsen P, et al. (2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553267">"Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants"</a>. <i>PLOS ONE</i>. 3 (9): e3283. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2008PLoSO...3.3283V">2008PLoSO...3.3283V</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1371%2Fjournal.pone.0003283">10.1371/journal.pone.0003283</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553267">2553267</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18818748">18818748</a>.</li> <li>Villa C, Venturelli E, Fenoglio C, et al. (2009). "CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration". <i>J. Neurol</i>. 256 (8): 1379–81. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs00415-009-5138-y">10.1007/s00415-009-5138-y</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19415413">19415413</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:3147096">3147096</a>.</li> <li>Siezen CL, Bont L, Hodemaekers HM, et al. (2009). <a href="https://doi.org/10.1097%2FINF.0b013e31818e2aa9">"Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes"</a>. <i>Pediatr. Infect. Dis. J</i>. 28 (4): 333–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2FINF.0b013e31818e2aa9">10.1097/INF.0b013e31818e2aa9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19258923">19258923</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:25601837">25601837</a>.</li> <li>Vyshkina T, Sylvester A, Sadiq S, et al. (2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301077">"CCL genes in multiple sclerosis and systemic lupus erythematosus"</a>. <i>J. Neuroimmunol</i>. 200 (1–2): 145–52. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.jneuroim.2008.05.016">10.1016/j.jneuroim.2008.05.016</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301077">5301077</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18602166">18602166</a>.</li> <li>Ruhwald M, Bodmer T, Maier C, et al. (2008). <a href="https://doi.org/10.1183%2F09031936.00055508">"Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis"</a>. <i>Eur. Respir. J</i>. 32 (6): 1607–15. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1183%2F09031936.00055508">10.1183/09031936.00055508</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18684849">18684849</a>.</li> <li>Skibola CF, Bracci PM, Halperin E, et al. (2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474696">"Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma"</a>. <i>PLOS ONE</i>. 3 (7): e2816. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2008PLoSO...3.2816S">2008PLoSO...3.2816S</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1371%2Fjournal.pone.0002816">10.1371/journal.pone.0002816</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474696">2474696</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18636124">18636124</a>.</li> <li>Ockinger J, Stridh P, Beyeen AD, et al. (2010). <a href="https://doi.org/10.1038%2Fgene.2009.82">"Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis"</a>. <i>Genes Immun</i>. 11 (2): 142–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fgene.2009.82">10.1038/gene.2009.82</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19865101">19865101</a>.</li> <li>Rajaraman P, Brenner AV, Neta G, et al. (2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169167">"Risk of meningioma and common variation in genes related to innate immunity"</a>. <i>Cancer Epidemiol. Biomarkers Prev</i>. 19 (5): 1356–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1158%2F1055-9965.EPI-09-1151">10.1158/1055-9965.EPI-09-1151</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169167">3169167</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20406964">20406964</a>.</li> <li>Velez DR, Fortunato S, Thorsen P, et al. (2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829203">"Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants"</a>. <i>Am. J. Obstet. Gynecol</i>. 200 (2): 209.e1–27. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.ajog.2008.08.051">10.1016/j.ajog.2008.08.051</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829203">4829203</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19019335">19019335</a>.</li> <li>Dean RA, Cox JH, Bellac CL, et al. (2008). <a href="https://doi.org/10.1182%2Fblood-2007-12-129080">"Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx"</a>. <i>Blood</i>. 112 (8): 3455–64. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood-2007-12-129080">10.1182/blood-2007-12-129080</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18660381">18660381</a>.</li> <li>Hori T, Naishiro Y, Sohma H, et al. (2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288733">"CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease"</a>. <i>Blood</i>. 111 (8): 4403–12. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood-2007-06-097287">10.1182/blood-2007-06-097287</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288733">2288733</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18256320">18256320</a>.</li> <li>Schuurhof A, Bont L, Siezen CL, et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". <i>Pediatr. Pulmonol</i>. 45 (6): 608–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fppul.21229">10.1002/ppul.21229</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20503287">20503287</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:24678182">24678182</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: chemokine (C-C motif) ligand 8". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6355" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6355</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Van Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G (March 1997). "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2". Genomics. 40 (2): 323–31. doi:10.1006/geno.1996.4594. PMID 9119400. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Van Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G (March 1997). "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2". Genomics. 40 (2): 323–31. doi:10.1006/geno.1996.4594. PMID 9119400. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Van Damme J, Proost P, Lenaerts JP, Opdenakker G (July 1992). "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family". J. Exp. Med. 176 (1): 59–65. doi:10.1084/jem.176.1.59. PMC 2119277. PMID 1613466. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119277" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119277</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Proost P, Wuyts A, Van Damme J (January 1996). "Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1". J. Leukoc. Biol. 59 (1): 67–74. doi:10.1002/jlb.59.1.67. PMID 8558070. S2CID 30445255. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM (February 1998). "Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication". J. Biol. Chem. 273 (8): 4289–92. doi:10.1074/jbc.273.8.4289. PMID 9468473. <a href="https://doi.org/10.1074%2Fjbc.273.8.4289" target="_blank">https://doi.org/10.1074%2Fjbc.273.8.4289</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM (February 1998). "Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication". J. Biol. Chem. 273 (8): 4289–92. doi:10.1074/jbc.273.8.4289. PMID 9468473. <a href="https://doi.org/10.1074%2Fjbc.273.8.4289" target="_blank">https://doi.org/10.1074%2Fjbc.273.8.4289</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Ge B, Li J, Wei Z, Sun T, Song Y, Khan NU (2017). "Functional expression of CCL8 and its interaction with chemokine receptor CCR3". BMC Immunol. 18 (1): 54. doi:10.1186/s12865-017-0237-5. PMC 5745793. PMID 29281969. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745793" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745793</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>PDB: 1ESR; Blaszczyk J, Coillie EV, Proost P, Damme JV, Opdenakker G, Bujacz GD, Wang JM, Ji X (November 2000). "Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors". Biochemistry. 39 (46): 14075–81. doi:10.1021/bi0009340. PMID 11087354. <a href="/wiki/Protein_Data_Bank" target="_blank">/wiki/Protein_Data_Bank</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Farmaki E, Chatzistamou I, Kaza V, Kiaris H (2016). "A CCL8 gradient drives breast cancer cell dissemination". Oncogene. 35 (49): 6309–6318. doi:10.1038/onc.2016.161. PMC 5112152. PMID 27181207. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112152" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112152</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Hamilton SA, Tower CL, Jones RL (2013). "Identification of chemokines associated with the recruitment of decidual leukocytes in human labour: potential novel targets for preterm labour". PLOS ONE. 8 (2): e56946. Bibcode:2013PLoSO...856946H. doi:10.1371/journal.pone.0056946. PMC 3579936. PMID 23451115. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579936" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579936</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> </ol>