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Pentolinium
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<h2 id="route-of-administration-and-dose">Route of administration and dose</h2> <p>Pentolinium can be given orally (20mg three times a day), injected <a href="/facts/Intramuscular_injection/PPNwW2wB">intramuscularly</a>, or administered <a href="/facts/Intravenous_therapy/AwwuD3Nu">intravenously</a>.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> </p> <h2 id="use">Use</h2> <p>Pentolinium and <a href="/facts/Hexamethonium/5xpAm1T2">hexamethonium</a> combined with <i><a href="/facts/Rauvolfia/EjSGwf74">Rauvolfia</a></i> was reported in 1955 to be effective in the outpatient management of moderate to severe hypertension, with satisfactory orthostatic reduction in blood pressure but there are significant untoward effects attributable to the use of the hexamethonium. Pentolinium has been reported to offer more prolonged ganglionic blockade and has less severe untoward effects than hexamethonium.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p> <h2 id="external-links">External links</h2> <ul><li><a href="http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00038.txt">DrugBank: Pentolinium</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Agrest A, Hoobler SW (March 1955). "Long-term management of hypertension with pentolinium tartrate (ansolysen)". Journal of the American Medical Association. 157 (12): 999–1003. doi:10.1001/jama.1955.02950290019006. PMID 14353636. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Budhiraja RD (2009). Elementary Pharmacology & Toxicology. Popular Prakashan. p. 189. ISBN 97881-7991-472-4. <a href="97881-7991-472-4" target="_blank">97881-7991-472-4</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Dennis E, Ford R, Herschberger R, Moyer JH (October 1955). "Pentolinium and hexamethonium combined with Rauwolfia in the treatment of hypertension". The New England Journal of Medicine. 253 (14): 597–600. doi:10.1056/NEJM195510062531404. PMID 13266002. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> </ol>