WIPI1

<h2 id="structure-and-function">Structure and function</h2>
<p><a href="/facts/WD40_repeat/0DxvU1fg">WD40 repeat</a> proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a <a href="/facts/Beta-propeller/0pdAMVxQ">beta-propeller</a> platform for simultaneous and reversible <a href="/facts/Protein%25E2%2580%2593protein_interaction/etvm9Wmg">protein–protein interactions</a>. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with <a href="/facts/Phospholipid/u6GhNCF5">phospholipids</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a>
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<h2 id="see-also">See also</h2>
<ul><li><a href="/facts/WIPI_protein_family/s4jpocJS">WIPI protein family</a></li></ul>

<h2 id="further-reading">Further reading</h2>

<ul><li>Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777390">"Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis"</a>. <i>PLOS Genet</i>. 5 (11): e1000730. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1371%2Fjournal.pgen.1000730">10.1371/journal.pgen.1000730</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777390">2777390</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19936222">19936222</a>.</li>
<li>Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901998">"Network organization of the human autophagy system"</a>. <i>Nature</i>. 466 (7302): 68–76. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2010Natur.466...68B">2010Natur.466...68B</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature09204">10.1038/nature09204</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901998">2901998</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20562859">20562859</a>.</li>
<li>Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007). <a href="https://doi.org/10.1016%2Fj.febslet.2007.06.040">"Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy"</a>. <i>FEBS Lett</i>. 581 (18): 3396–404. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.febslet.2007.06.040">10.1016/j.febslet.2007.06.040</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17618624">17618624</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23430881">23430881</a>.</li></ul>

<p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i>
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<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>"Entrez Gene: WD repeat domain". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55062" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55062</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
<li id="fn:2"><p>Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420090" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420090</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li>
<li id="fn:3"><p>Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li>
<li id="fn:4"><p>"Entrez Gene: WD repeat domain". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55062" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55062</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li>
<li id="fn:5"><p>Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li>
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WIPI1 open-in-new

WIPI1