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Electroneutral sodium bicarbonate exchanger 1
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<h2 id="see-also">See also</h2> <ul><li><a href="/facts/Solute_carrier_family/Pnuz1TLA">Solute carrier family</a></li> <li><a href="/facts/Cotransporter/7YuBRRrR">cotransporter</a></li></ul> <h2 id="interactions">Interactions</h2> <p>SLC4A8 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/Sodium-hydrogen_antiporter_3_regulator_1/W0woMG9U">Sodium-hydrogen antiporter 3 regulator 1</a><a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> and <a href="/facts/Cystic_fibrosis_transmembrane_conductance_regulator/02a5WJ5n">Cystic fibrosis transmembrane conductance regulator</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Soleimani M (2002). "Na+:HCO3− cs (NBC): expression and regulation in the kidney". <i>J. Nephrol</i>. 15 (Suppl 5): S32–40. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12027220">12027220</a>.</li> <li>Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"</a>. <i>Genome Res</i>. 16 (1): 55–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.4039406">10.1101/gr.4039406</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">1356129</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16344560">16344560</a>.</li> <li>Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, <a href="/facts/Huda_Zoghbi/tEMTeyKH">Zoghbi HY</a>, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". <i>Nature</i>. 437 (7062): 1173–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R">2005Natur.437.1173R</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature04209">10.1038/nature04209</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16189514">16189514</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4427026">4427026</a>.</li> <li>Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3− cotransporter by carbonic anhydrase II and PKA". <i>Am. J. Physiol., Cell Physiol</i>. 286 (6): C1423–33. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1152%2Fajpcell.00382.2003">10.1152/ajpcell.00382.2003</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14736710">14736710</a>.</li> <li>Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". <i>Am. J. Physiol., Cell Physiol</i>. 284 (3): C667–73. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1152%2Fajpcell.00225.2002">10.1152/ajpcell.00225.2002</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12444018">12444018</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:7070088">7070088</a>.</li> <li>Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (2003). <a href="https://doi.org/10.1074%2Fjbc.M201862200">"The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3"</a>. <i>J. Biol. Chem</i>. 277 (52): 50503–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M201862200">10.1074/jbc.M201862200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12403779">12403779</a>.</li> <li>Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S (2002). "Immunolocalization of electroneutral Na+-HCO cotransporters in human and rat salivary glands". <i>Am. J. Physiol. Gastrointest. Liver Physiol</i>. 283 (2): G473–80. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1152%2Fajpgi.00421.2001">10.1152/ajpgi.00421.2001</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12121896">12121896</a>.</li> <li>Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na+/HCO3− cotransporter isoform NBC-3". <i>Am. J. Physiol</i>. 276 (6 Pt 2): F903–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1152%2Fajprenal.1999.276.6.F903">10.1152/ajprenal.1999.276.6.F903</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10362779">10362779</a>.</li> <li>Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). <a href="https://doi.org/10.1074%2Fjbc.274.23.16569">"Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family"</a>. <i>J. Biol. Chem</i>. 274 (23): 16569–75. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.274.23.16569">10.1074/jbc.274.23.16569</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10347222">10347222</a>.</li> <li>Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). <a href="https://doi.org/10.1093%2Fdnares%2F5.5.277">"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"</a>. <i>DNA Res</i>. 5 (5): 277–86. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F5.5.277">10.1093/dnares/5.5.277</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9872452">9872452</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na+-driven Cl−HCO3 exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997. <a href="https://doi.org/10.1074%2Fjbc.C000716200" target="_blank">https://doi.org/10.1074%2Fjbc.C000716200</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9498" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9498</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779. <a href="https://doi.org/10.1074%2Fjbc.M201862200" target="_blank">https://doi.org/10.1074%2Fjbc.M201862200</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779. <a href="https://doi.org/10.1074%2Fjbc.M201862200" target="_blank">https://doi.org/10.1074%2Fjbc.M201862200</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>