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OR1A2
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<h2 id="ligands">Ligands</h2> <p>The known ligands of OR1A2 are near-identical to those of <a href="/facts/OR1A1/LIERQjQ1">OR1A1</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> Examples of known ligands, most of which have citrus or fruity smells:<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <ul><li>(S)-(−)-<a href="/facts/Citronellal/sGJYHs5D">citronellal</a></li> <li><a href="/facts/Helional/Xq2pAFRn">Helional</a></li> <li><a href="/facts/Heptanal/Jg6B7WTy">Heptanal</a></li> <li><a href="/facts/Octanal/CVugjVjW">Octanal</a></li> <li><a href="/facts/Nonanal/tHsDkPDA">Nonanal</a> (weaker than heptanal/octanal<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a>)</li> <li><a href="/facts/Hydroxycitronellal/CsD93aBK">Hydroxycitronellal</a></li> <li><a href="/facts/Citral/IhYxYo4U">Citral</a></li> <li>(S)-(−)-<a href="/facts/Citronellol/cggUaGxV">Citronellol</a> (in contrast to <a href="/facts/OR1A1/LIERQjQ1">OR1A1</a> only this enantiomer is effective; weaker than citronellal<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a>)</li></ul> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Olfactory_receptor/cY5n56yy">Olfactory receptor</a></li></ul> <h2 id="notes">Notes</h2> <ul><li><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". <i>Genomics</i>. 80 (3): 295–302. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.2002.6830">10.1006/geno.2002.6830</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12213199">12213199</a>.</li> <li>Strausberg RL, Feingold EA, Grouse LH, et al. (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li> <li>Malnic B, Godfrey PA, Buck LB (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC356993">"The human olfactory receptor gene family"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 101 (8): 2584–9. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2004PNAS..101.2584M">2004PNAS..101.2584M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.0307882100">10.1073/pnas.0307882100</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC356993">356993</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14983052">14983052</a>.</li> <li>Gerhard DS, Wagner L, Feingold EA, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"</a>. <i>Genome Res</i>. 14 (10B): 2121–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.2596504">10.1101/gr.2596504</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">528928</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15489334">15489334</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=OR1A2+protein%2C+human">OR1A2+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26189" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26189</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26189" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26189</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973694" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973694</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> </ol>