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NFKB1
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<h2 id="interactions">Interactions</h2> <p>NFKB1 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/BCL3/ky09Gfmo">BCL3</a>,<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a></li> <li><a href="/facts/C22orf25/3Ygc9Ecc">C22orf25</a>,</li> <li><a href="/facts/HDAC1/6Ah3cBy1">HDAC1</a>,<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a></li> <li><a href="/facts/HMGA2/GS0BhhdN">HMGA2</a><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li> <li><a href="/facts/IKK2/a8seTc8A">IKK2</a>,<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a><a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a></li> <li><a href="/facts/ITGB3BP/T30FbugK">ITGB3BP</a>,<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a></li> <li><a href="/facts/I%25CE%25BAB%25CE%25B1/55gMooWs">IκBα</a>,<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a><a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a></li> <li><a href="/facts/LYL1/rqjMWm4U">LYL1</a>,<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a></li> <li><a href="/facts/MAP3K7IP2/lsoknLe4">MAP3K7IP2</a>,<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a></li> <li><a href="/facts/MAP3K8/WS1onG17">MAP3K8</a>,<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a><a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a></li> <li><a href="/facts/MEN1/SNDm7wqX">MEN1</a>,<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a></li> <li><a href="/facts/NFKB2/nMa9ISeh">NFKB2</a>,<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a></li> <li><a href="/facts/NFKBIE/dw8wke0x">NFKBIE</a>,<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a></li> <li><a href="/facts/NOTCH1/WjDFS8G4">NOTCH1</a>,<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a><a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a></li> <li><a href="/facts/Nuclear_receptor_coactivator_1/2K9PVkE1">Nuclear receptor coactivator 1</a>,<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a><a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a></li> <li><a href="/facts/RELA/qsU6M2ec">RELA</a>,<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a><a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a></li> <li><a href="/facts/RELB/bcDlbfk7">RELB</a>,<a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a></li> <li><a href="/facts/STAT3/8NS3V4Mj">STAT3</a>,<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a></li> <li><a href="/facts/STAT6/lfhIB0LS">STAT6</a>,<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a> and</li> <li><a href="/facts/TSC22D3/WGUoHhE7">TSC22D3</a>.<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Baldwin AS (1996). <a href="https://cdr.lib.unc.edu/record/uuid:ac4a905e-d22c-42a3-a3fa-656535b1143a">"The NF-kappa B and I kappa B proteins: new discoveries and insights"</a>. <i>Annu. Rev. Immunol</i>. 14: 649–83. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1146%2Fannurev.immunol.14.1.649">10.1146/annurev.immunol.14.1.649</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8717528">8717528</a>.</li> <li>Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". <i>Folia Biol. (Praha)</i>. 42 (5): 227–30. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2FBF02818986">10.1007/BF02818986</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8997639">8997639</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:7617882">7617882</a>.</li> <li>Chen F, Castranova V, Shi X, Demers LM (1999). <a href="https://doi.org/10.1093%2Fclinchem%2F45.1.7">"New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases"</a>. <i>Clin. Chem</i>. 45 (1): 7–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fclinchem%2F45.1.7">10.1093/clinchem/45.1.7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9895331">9895331</a>.</li> <li>Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". <i>Pathol. Biol</i>. 50 (3): 204–11. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fs0369-8114%2802%2900289-4">10.1016/s0369-8114(02)00289-4</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11980335">11980335</a>.</li> <li>Garg A, Aggarwal BB (2002). <a href="https://doi.org/10.1038%2Fsj.leu.2402482">"Nuclear transcription factor-kappaB as a target for cancer drug development"</a>. <i>Leukemia</i>. 16 (6): 1053–68. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.leu.2402482">10.1038/sj.leu.2402482</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12040437">12040437</a>.</li> <li>Sun Z, Andersson R (2003). <a href="https://doi.org/10.1097%2F00024382-200208000-00001">"NF-kappaB activation and inhibition: a review"</a>. <i>Shock</i>. 18 (2): 99–106. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2F00024382-200208000-00001">10.1097/00024382-200208000-00001</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12166787">12166787</a>.</li> <li>Mercurio AM (2003). <a href="https://doi.org/10.1016%2FS1535-6108%2803%2900049-7">"Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way"</a>. <i>Cancer Cell</i>. 3 (3): 201–2. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS1535-6108%2803%2900049-7">10.1016/S1535-6108(03)00049-7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12676577">12676577</a>.</li> <li>Sun SC, Xiao G (2004). "Deregulation of NF-kappaB and its upstream kinases in cancer". <i>Cancer Metastasis Rev</i>. 22 (4): 405–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1023%2FA%3A1023733231406">10.1023/A:1023733231406</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12884915">12884915</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:44227245">44227245</a>.</li> <li>Kucharczak J, Simmons MJ, Fan Y, Gélinas C (2004). <a href="https://doi.org/10.1038%2Fsj.onc.1207230">"To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis"</a>. <i>Oncogene</i>. 22 (56): 8961–82. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1207230">10.1038/sj.onc.1207230</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14663476">14663476</a>.</li> <li>Suh J, Rabson AB (2004). "NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?". <i>J. Cell. Biochem</i>. 91 (1): 100–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fjcb.10729">10.1002/jcb.10729</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14689584">14689584</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:84116960">84116960</a>.</li> <li>Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (2004). "HIV-1 Vpr and anti-inflammatory activity". <i>DNA Cell Biol</i>. 23 (4): 239–47. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1089%2F104454904773819824">10.1089/104454904773819824</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15142381">15142381</a>.</li> <li>Schmitz ML, Mattioli I, Buss H, Kracht M (2005). "NF-kappaB: a multifaceted transcription factor regulated at several levels". <i>ChemBioChem</i>. 5 (10): 1348–58. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fcbic.200400144">10.1002/cbic.200400144</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15457532">15457532</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:85775279">85775279</a>.</li> <li>Pise-Masison CA, Brady JN (2006). <a href="https://doi.org/10.2741%2F1586">"Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function"</a>. <i>Front. Biosci</i>. 10 (1–3): 919–30. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.2741%2F1586">10.2741/1586</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15569630">15569630</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:35215552">35215552</a>.</li> <li>Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". <i>Curr. HIV Res</i>. 3 (1): 87–94. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.2174%2F1570162052773013">10.2174/1570162052773013</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15638726">15638726</a>.</li> <li>Le Rouzic E, Benichou S (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554975">"The Vpr protein from HIV-1: distinct roles along the viral life cycle"</a>. <i>Retrovirology</i>. 2: 11. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1186%2F1742-4690-2-11">10.1186/1742-4690-2-11</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554975">554975</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15725353">15725353</a>.</li> <li>Zhao RY, Elder RT (2005). <a href="https://doi.org/10.1038%2Fsj.cr.7290279">"Viral infections and cell cycle G2/M regulation"</a>. <i>Cell Res</i>. 15 (3): 143–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cr.7290279">10.1038/sj.cr.7290279</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15780175">15780175</a>.</li> <li>Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". <i>Indian J. Med. Res</i>. 121 (4): 270–86. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15817944">15817944</a>.</li> <li>Muthumani K, Choo AY, Hwang DS, Ugen KE, Weiner DB (2006). "HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis". <i>Current Drug Delivery</i>. 1 (4): 335–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.2174%2F1567201043334614">10.2174/1567201043334614</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16305395">16305395</a>.</li> <li>Courtois G, Smahi A (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401841">"NF-kappaB-related genetic diseases"</a>. <i>Cell Death Differ</i>. 13 (5): 843–51. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401841">10.1038/sj.cdd.4401841</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16397577">16397577</a>.</li> <li>Mattson MP, Meffert MK (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401837">"Roles for NF-kappaB in nerve cell survival, plasticity, and disease"</a>. <i>Cell Death Differ</i>. 13 (5): 852–60. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401837">10.1038/sj.cdd.4401837</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16397579">16397579</a>.</li> <li>Schmitz ML, Krappmann D (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401845">"Controlling NF-kappaB activation in T cells by costimulatory receptors"</a>. <i>Cell Death Differ</i>. 13 (5): 834–42. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401845">10.1038/sj.cdd.4401845</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16410801">16410801</a>.</li> <li>Janssens S, Tschopp J (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401843">"Signals from within: the DNA-damage-induced NF-kappaB response"</a>. <i>Cell Death Differ</i>. 13 (5): 773–84. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401843">10.1038/sj.cdd.4401843</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16410802">16410802</a>.</li> <li>Perkins ND, Gilmore TD (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401838">"Good cop, bad cop: the different faces of NF-kappaB"</a>. <i>Cell Death Differ</i>. 13 (5): 759–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401838">10.1038/sj.cdd.4401838</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16410803">16410803</a>.</li> <li>Weil R, Israël A (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401856">"Deciphering the pathway from the TCR to NF-kappaB"</a>. <i>Cell Death Differ</i>. 13 (5): 826–33. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401856">10.1038/sj.cdd.4401856</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16439988">16439988</a>.</li> <li>Kim HJ, Hawke N, Baldwin AS (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401877">"NF-kappaB and IKK as therapeutic targets in cancer"</a>. <i>Cell Death Differ</i>. 13 (5): 738–47. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401877">10.1038/sj.cdd.4401877</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16485028">16485028</a>.</li> <li>Braun T, Carvalho G, Fabre C, Grosjean J, Fenaux P, Kroemer G (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401874">"Targeting NF-kappaB in hematologic malignancies"</a>. <i>Cell Death Differ</i>. 13 (5): 748–58. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401874">10.1038/sj.cdd.4401874</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16498458">16498458</a>.</li> <li>Bottero V, Withoff S, Verma IM (2006). <a href="https://doi.org/10.1038%2Fsj.cdd.4401888">"NF-kappaB and the regulation of hematopoiesis"</a>. <i>Cell Death Differ</i>. 13 (5): 785–97. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cdd.4401888">10.1038/sj.cdd.4401888</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16528384">16528384</a>.</li> <li>Xiao G (2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810660">"Autophagy and NF-κB fight for fate"</a>. <i>Cytokine Growth Factor Rev</i>. 18 (3–4): 233–43. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.cytogfr.2007.04.006">10.1016/j.cytogfr.2007.04.006</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810660">2810660</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17485237">17485237</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=NFKB1+protein%2C+human">NFKB1+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li> <li><a href="/facts/ENCODE/X7hhKpsg">FactorBook</a> <a href="http://www.factorbook.org/mediawiki/index.php/NFKB">NFKB</a></li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Meyer R, Hatada EN, Hohmann HP, Haiker M, Bartsch C, Röthlisberger U, Lahm HW, Schlaeger EJ, van Loon AP, Scheidereit C (March 1991). 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