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LILRB4
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<h2 id="interactions">Interactions</h2> <p>LILRB4 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/PTPN6/gCEKFay6">PTPN6</a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> and <a href="/facts/INPP5D/8gnQQNMq">INPP5D</a> (SHIP-1).<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Cluster_of_differentiation/cLEuDQId">Cluster of differentiation</a></li> <li><a href="/facts/Immunoglobulin_superfamily/Wveu4BIL">Immunoglobulin superfamily</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. (October 2018). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296374">"LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration"</a>. <i>Nature</i>. 562 (7728): 605–609. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2018Natur.562..605D">2018Natur.562..605D</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fs41586-018-0615-z">10.1038/s41586-018-0615-z</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296374">6296374</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/30333625">30333625</a>.</li> <li>John S, Chen H, Deng M, Gui X, Wu G, Chen W, Li Z, Zhang N, An Z, Zhang CC (October 2018). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171100">"A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML"</a>. <i>Molecular Therapy</i>. 26 (10): 2487–2495. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.ymthe.2018.08.001">10.1016/j.ymthe.2018.08.001</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171100">6171100</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/30131301">30131301</a>.</li> <li>Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, et al. (August 2019). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677629">"Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development"</a>. <i>Cancer Immunology Research</i>. 7 (8): 1244–1257. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1158%2F2326-6066.CIR-19-0036">10.1158/2326-6066.CIR-19-0036</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677629">6677629</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/31213474">31213474</a>.</li> <li>Suciu-Foca N, Cortesini R (July 2007). "Central role of ILT3 in the T suppressor cell cascade". <i>Cellular Immunology</i>. 248 (1): 59–67. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.cellimm.2007.01.013">10.1016/j.cellimm.2007.01.013</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17923119">17923119</a>.</li> <li>Arm JP, Nwankwo C, Austen KF (September 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". <i>Journal of Immunology</i>. 159 (5): 2342–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4049%2Fjimmunol.159.5.2342">10.4049/jimmunol.159.5.2342</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9278324">9278324</a>.</li> <li>Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, et al. (January 1998). <a href="https://doi.org/10.1074%2Fjbc.273.2.1070">"Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene"</a>. <i>The Journal of Biological Chemistry</i>. 273 (2): 1070–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.2.1070">10.1074/jbc.273.2.1070</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9422771">9422771</a>.</li> <li>Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". <i>Journal of Immunology</i>. 159 (11): 5192–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4049%2Fjimmunol.159.11.5192">10.4049/jimmunol.159.11.5192</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9548455">9548455</a>.</li> <li>Torkar M, Norgate Z, Colonna M, Trowsdale J, Wilson MJ (December 1998). <a href="https://doi.org/10.1002%2F%28SICI%291521-4141%28199812%2928%3A12%3C3959%3A%3AAID-IMMU3959%3E3.0.CO%3B2-2">"Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex"</a>. <i>European Journal of Immunology</i>. 28 (12): 3959–67. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F%28SICI%291521-4141%28199812%2928%3A12%3C3959%3A%3AAID-IMMU3959%3E3.0.CO%3B2-2">10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9862332">9862332</a>.</li> <li>Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". <i>Journal of Immunology</i>. 162 (3): 1318–23. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4049%2Fjimmunol.162.3.1318">10.4049/jimmunol.162.3.1318</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9973385">9973385</a>.</li> <li>Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, et al. (April 2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18309">"Plasticity in the organization and sequences of human KIR/ILT gene families"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 97 (9): 4778–83. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2000PNAS...97.4778W">2000PNAS...97.4778W</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.080588597">10.1073/pnas.080588597</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18309">18309</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10781084">10781084</a>.</li> <li>Heinzmann A, Blattmann S, Forster J, Kuehr J, Deichmann KA (June 2000). "Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy". <i>European Journal of Immunogenetics</i>. 27 (3): 121–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1365-2370.2000.00214.x">10.1046/j.1365-2370.2000.00214.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10940079">10940079</a>.</li> <li>Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP (July 2000). "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4". <i>Immunogenetics</i>. 51 (8–9): 659–69. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs002510000183">10.1007/s002510000183</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10941837">10941837</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23687483">23687483</a>.</li> <li>Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". <i>Immunogenetics</i>. 53 (4): 270–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs002510100332">10.1007/s002510100332</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11491530">11491530</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:2819935">2819935</a>.</li> <li>Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al. (March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". <i>Nature Immunology</i>. 3 (3): 237–43. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fni760">10.1038/ni760</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11875462">11875462</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:35400503">35400503</a>.</li> <li>LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED (April 2005). <a href="https://doi.org/10.1096%2Ffj.04-1617fje">"HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells"</a>. <i>FASEB Journal</i>. 19 (6): 662–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1096%2Ffj.04-1617fje">10.1096/fj.04-1617fje</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15670976">15670976</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:24608530">24608530</a>.</li> <li>Garner LI, Salim M, Mohammed F, Willcox BE (June 2006). "Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies". <i>Protein Expression and Purification</i>. 47 (2): 490–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.pep.2005.11.020">10.1016/j.pep.2005.11.020</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16406677">16406677</a>.</li> <li>Kim-Schulze S, Seki T, Vlad G, Scotto L, Fan J, Colombo PC, et al. (January 2006). <a href="https://doi.org/10.1111%2Fj.1600-6143.2005.01162.x">"Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells"</a>. <i>American Journal of Transplantation</i>. 6 (1): 76–82. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1600-6143.2005.01162.x">10.1111/j.1600-6143.2005.01162.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16433759">16433759</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:7662795">7662795</a>.</li> <li>Kim-Schulze S, Scotto L, Vlad G, Piazza F, Lin H, Liu Z, et al. (March 2006). <a href="https://doi.org/10.4049%2Fjimmunol.176.5.2790">"Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells"</a>. <i>Journal of Immunology</i>. 176 (5): 2790–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4049%2Fjimmunol.176.5.2790">10.4049/jimmunol.176.5.2790</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16493035">16493035</a>.</li> <li>Vlad G, Liu Z, Zhang QY, Cortesini R, Suciu-Foca N (December 2006). "Immunosuppressive activity of recombinant ILT3". <i>International Immunopharmacology</i>. 6 (13–14): 1889–94. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.intimp.2006.07.017">10.1016/j.intimp.2006.07.017</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17161342">17161342</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=LILRB4+protein%2C+human">LILRB4+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196312" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196312</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182. <a href="https://doi.org/10.1002%2Feji.1830270313" target="_blank">https://doi.org/10.1002%2Feji.1830270313</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Sharma N, Atolagbe OT, Ge Z, Allison JP (July 2021). "LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy". The Journal of Experimental Medicine. 218 (7). doi:10.1084/jem.20201811. PMC 8117208. PMID 33974041. <a href="https://doi.org/10.1084/jem.20201811" target="_blank">https://doi.org/10.1084/jem.20201811</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>"Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. doi:10.4049/jimmunol.162.3.1318. PMID 9973385. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Zurli V, Wimmer G, Cattaneo F, Candi V, Cencini E, Gozzetti A, et al. (November 2017). "Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia". Blood. 130 (18): 2006–2017. doi:10.1182/blood-2017-03-775858. PMID 28931525. <a href="https://doi.org/10.1182%2Fblood-2017-03-775858" target="_blank">https://doi.org/10.1182%2Fblood-2017-03-775858</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> </ol>