Argetsinger is a native of Alexandria, Virginia. She attended the St. Agnes School, graduating in 1986, after which she attended the University of Virginia, earning a degree in Political and Social Thought in 1990. Argetsinger was named an Echols Scholar, an honors program for incoming students at the University of Virginia. She edited the school's weekly paper The Declaration.
Argetsinger started her journalism career in 1991 in the Illinois/Iowa Quad Cities, at the Rock Island Argus and Moline Daily Dispatch. She joined The Washington Post in December 1995 as a Metro staff writer in the paper's Annapolis bureau, and later covered higher education. Just prior to her "Reliable Source" appointment in 2005, she covered the West Coast for the Post's National staff as Los Angeles bureau chief.
In September 2021, she published her first book, There She Was, a history of the Miss America pageant, from Simon & Schuster's One Signal Publishers.
Garrett (August 17, 2005). "Argetsinger and Roberts To Share Gossip Column". Mediabistro. Retrieved August 9, 2014. http://www.mediabistro.com/fishbowldc/argetsinger-and-roberts-to-share-gossip-column_b996 ↩