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Integrin alpha 10
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<h2 id="function">Function</h2> <p><a href="/facts/Integrins/DNYUGbBp">Integrins</a> are <a href="/facts/Integral_membrane_protein/Vztpmlu1">integral membrane proteins</a> composed of an alpha chain and a beta chain, and are known to participate in <a href="/facts/Cell_adhesion/Vg4alzxb">cell adhesion</a> as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (<a href="/facts/ITGB1/oxU074e8">ITGB1</a>) to form a novel <a href="/facts/Collagen/KsyAb72K">collagen</a> type II-binding integrin expressed in <a href="/facts/Cartilage/vxy2qzKN">cartilage</a> tissue.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="related-gene-problems">Related gene problems</h2> <ul><li><a href="/facts/TAR_syndrome/xajkTdqF">TAR syndrome</a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a></li> <li><a href="/facts/1q21.1_deletion_syndrome/enkeMwhh">1q21.1 deletion syndrome</a></li> <li><a href="/facts/1q21.1_duplication_syndrome/CfgmacBa">1q21.1 duplication syndrome</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Camper L, Hellman U, Lundgren-Akerlund E (1998). <a href="https://doi.org/10.1074%2Fjbc.273.32.20383">"Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes"</a>. <i>J. Biol. Chem</i>. 273 (32): 20383–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.32.20383">10.1074/jbc.273.32.20383</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9685391">9685391</a>.</li> <li>Bengtsson T, Camper L, Schneller M, Lundgren-Akerlund E (2001). "Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants". <i>Matrix Biol</i>. 20 (8): 565–76. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0945-053X%2801%2900164-0">10.1016/S0945-053X(01)00164-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11731273">11731273</a>.</li> <li>Brakebusch C, Hirsch E, Potocnik A, Fässler R (1997). "Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules". <i>J. Cell Sci</i>. 110 (23): 2895–904. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1242%2Fjcs.110.23.2895">10.1242/jcs.110.23.2895</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9359872">9359872</a>.</li> <li>Clark HF, Gurney AL, Abaya E, et al. (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697">"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment"</a>. <i>Genome Res</i>. 13 (10): 2265–70. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.1293003">10.1101/gr.1293003</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697">403697</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12975309">12975309</a>.</li> <li>Lehnert K, Ni J, Leung E, et al. (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". <i>Cytogenet. Cell Genet</i>. 87 (3–4): 238–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1159%2F000015434">10.1159/000015434</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10702680">10702680</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:85257405">85257405</a>.</li> <li>Strausberg RL, Feingold EA, Grouse LH, et al. (2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li> <li>Svoboda KK (1998). <a href="https://doi.org/10.1002%2F%28SICI%291097-0029%2819981015%2943%3A2%3C111%3A%3AAID-JEMT4%3E3.0.CO%3B2-O">"Chondrocyte-matrix attachment complexes mediate survival and differentiation"</a>. <i>Microsc. Res. Tech</i>. 43 (2): 111–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F%28SICI%291097-0029%2819981015%2943%3A2%3C111%3A%3AAID-JEMT4%3E3.0.CO%3B2-O">10.1002/(SICI)1097-0029(19981015)43:2<111::AID-JEMT4>3.0.CO;2-O</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9822998">9822998</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:15611353">15611353</a>.</li> <li>Bengtsson T, Aszodi A, Nicolae C, et al. (2005). <a href="https://doi.org/10.1242%2Fjcs.01678">"Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes"</a>. <i>J. Cell Sci</i>. 118 (Pt 5): 929–36. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1242%2Fjcs.01678">10.1242/jcs.01678</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15713743">15713743</a>.</li> <li>Wenke AK, Rothhammer T, Moser M, Bosserhoff AK (2006). "Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1". <i>Biochem. Biophys. Res. Commun</i>. 345 (1): 495–501. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.bbrc.2006.04.123">10.1016/j.bbrc.2006.04.123</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16684505">16684505</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://archive.today/20130414113138/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=8515">ITGA10</a> Info with links in the <a href="http://www.cellmigration.org/index.shtml">Cell Migration Gateway</a> <a href="https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml">Archived</a> 2014-12-11 at the <a href="/facts/Wayback_Machine/nmQ3a6JC">Wayback Machine</a></li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: ITGA10 integrin, alpha 10". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8515" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8515</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383. PMID 9685391. <a href="http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9685391" target="_blank">http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9685391</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405. <a href="http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=ccg87238" target="_blank">http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=ccg87238</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: ITGA10 integrin, alpha 10". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8515" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8515</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785342" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785342</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>