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Colibactin
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<h2 id="references">References</h2> <ol> <li id="fn:1"><p>Arthur JC (2020). "Microbiota and colorectal cancer: colibactin makes its mark". Nature Reviews Gastroenterology & Hepatology. 17 (6): 317–318. doi:10.1038/s41575-020-0303-y. PMID 32317778. S2CID 216033220. <a href="/wiki/Nature_Reviews_Gastroenterology_%26_Hepatology" target="_blank">/wiki/Nature_Reviews_Gastroenterology_%26_Hepatology</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Zhou T, Hirayama Y, Watanabe K (2021). "Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative". Journal of the American Chemical Society. 143 (14): 5526–5533. doi:10.1021/jacs.1c01495. PMID 33787233. S2CID 232431632. <a href="/wiki/Journal_of_the_American_Chemical_Society" target="_blank">/wiki/Journal_of_the_American_Chemical_Society</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Helmink BA, Khan M, Wargo JA (2019). "The microbiome, cancer, and cancer therapy". Nature Medicine. 25 (3): 377–388. doi:10.1038/s41591-019-0377-7. PMID 30842679. S2CID 71145949. <a href="/wiki/Nature_Medicine" target="_blank">/wiki/Nature_Medicine</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Wernke KM, Xue M, Herzon SB (2020). "Structure and bioactivity of colibactin". Bioorganic & Medicinal Chemistry Letters. 30 (15): 127280. doi:10.1016/j.bmcl.2020.127280. PMC 7309967. PMID 32527463. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309967" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309967</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Díaz-Gay, Marcos; dos Santos, Wellington; Moody, Sarah; Kazachkova, Mariya; Abbasi, Ammal; Steele, Christopher D.; Vangara, Raviteja; Senkin, Sergey; Wang, Jingwei; Fitzgerald, Stephen; Bergstrom, Erik N.; Khandekar, Azhar; Otlu, Burçak; Abedi-Ardekani, Behnoush; de Carvalho, Ana Carolina; Cattiaux, Thomas; Penha, Ricardo Cortez Cardoso; Gaborieau, Valérie; Chopard, Priscilia; Carreira, Christine; Cheema, Saamin; Latimer, Calli; Teague, Jon W.; Mukeriya, Anush; Zaridze, David; Cox, Riley; Albert, Monique; Phouthavongsy, Larry; Gallinger, Steven; Malekzadeh, Reza; Niavarani, Ahmadreza; Miladinov, Marko; Erić, Katarina; Milosavljevic, Sasa; Sangrajrang, Suleeporn; Curado, Maria Paula; Aguiar, Samuel; Reis, Rui Manuel; Reis, Monise Tadin; Romagnolo, Luis Gustavo; Guimarães, Denise Peixoto; Holcatova, Ivana; Kalvach, Jaroslav; Vaccaro, Carlos Alberto; Piñero, Tamara Alejandra; Świątkowska, Beata; Lissowska, Jolanta; Roszkowska-Purska, Katarzyna; Huertas-Salgado, Antonio; Shibata, Tatsuhiro; Shiba, Satoshi; Sangkhathat, Surasak; Chitapanarux, Taned; Roshandel, Gholamreza; Ashton-Prolla, Patricia; Damin, Daniel C.; de Oliveira, Francine Hehn; Humphreys, Laura; Lawley, Trevor D.; Perdomo, Sandra; Stratton, Michael R.; Brennan, Paul; Alexandrov, Ludmil B. (23 April 2025). "Geographic and age variations in mutational processes in colorectal cancer". Nature. doi:10.1038/s41586-025-09025-8. PMID 40267983. Retrieved 23 April 2025. <a href="https://www.nature.com/articles/s41586-025-09025-8" target="_blank">https://www.nature.com/articles/s41586-025-09025-8</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Zhou T, Hirayama Y, Watanabe K (2021). "Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative". Journal of the American Chemical Society. 143 (14): 5526–5533. doi:10.1021/jacs.1c01495. PMID 33787233. S2CID 232431632. <a href="/wiki/Journal_of_the_American_Chemical_Society" target="_blank">/wiki/Journal_of_the_American_Chemical_Society</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Arthur JC (2020). "Microbiota and colorectal cancer: colibactin makes its mark". Nature Reviews Gastroenterology & Hepatology. 17 (6): 317–318. doi:10.1038/s41575-020-0303-y. PMID 32317778. S2CID 216033220. <a href="/wiki/Nature_Reviews_Gastroenterology_%26_Hepatology" target="_blank">/wiki/Nature_Reviews_Gastroenterology_%26_Hepatology</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Wernke KM, Xue M, Herzon SB (2020). "Structure and bioactivity of colibactin". Bioorganic & Medicinal Chemistry Letters. 30 (15): 127280. doi:10.1016/j.bmcl.2020.127280. PMC 7309967. PMID 32527463. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309967" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309967</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Balskus EP (2015). "Colibactin: understanding an elusive gut bacterial genotoxin". Natural Product Reports. 32 (11): 1534–40. doi:10.1039/c5np00091b. PMID 26390983. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Mäklin T, Taira A, Arredondo-Alonso S, Shao Y, Stratton MR, Lawley TD, Aaltonen LA, Corander J (2024). "Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli". The Lancet Microbe. doi:10.1016/j.lanmic.2024.101015. PMID 39644909. <a href="https://doi.org/10.1016%2Fj.lanmic.2024.101015" target="_blank">https://doi.org/10.1016%2Fj.lanmic.2024.101015</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Wernke KM, Xue M, Herzon SB (2020). "Structure and bioactivity of colibactin". Bioorganic & Medicinal Chemistry Letters. 30 (15): 127280. doi:10.1016/j.bmcl.2020.127280. PMC 7309967. PMID 32527463. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309967" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309967</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Silpe, Justin E.; Wong, Joel W. H.; Owen, Siân V.; Baym, Michael; Balskus, Emily P. (2022-02-23). "The bacterial toxin colibactin triggers prophage induction". Nature. 603 (7900): 315–320. Bibcode:2022Natur.603..315S. doi:10.1038/s41586-022-04444-3. ISSN 1476-4687. PMC 8907063. PMID 35197633. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907063" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907063</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; Rosendahl Huber, Axel; van Hoeck, Arne; Wood, Henry M.; Nomburg, Jason; Gurjao, Carino; Manders, Freek; Dalmasso, Guillaume; Stege, Paul B.; Paganelli, Fernanda L.; Geurts, Maarten H.; Beumer, Joep; Mizutani, Tomohiro; Miao, Yi (April 2020). "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli". Nature. 580 (7802): 269–273. doi:10.1038/s41586-020-2080-8. ISSN 1476-4687. PMC 8142898. PMID 32106218. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142898" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142898</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Díaz-Gay, Marcos; dos Santos, Wellington; Moody, Sarah; Kazachkova, Mariya; Abbasi, Ammal; Steele, Christopher D.; Vangara, Raviteja; Senkin, Sergey; Wang, Jingwei; Fitzgerald, Stephen; Bergstrom, Erik N.; Khandekar, Azhar; Otlu, Burçak; Abedi-Ardekani, Behnoush; de Carvalho, Ana Carolina; Cattiaux, Thomas; Penha, Ricardo Cortez Cardoso; Gaborieau, Valérie; Chopard, Priscilia; Carreira, Christine; Cheema, Saamin; Latimer, Calli; Teague, Jon W.; Mukeriya, Anush; Zaridze, David; Cox, Riley; Albert, Monique; Phouthavongsy, Larry; Gallinger, Steven; Malekzadeh, Reza; Niavarani, Ahmadreza; Miladinov, Marko; Erić, Katarina; Milosavljevic, Sasa; Sangrajrang, Suleeporn; Curado, Maria Paula; Aguiar, Samuel; Reis, Rui Manuel; Reis, Monise Tadin; Romagnolo, Luis Gustavo; Guimarães, Denise Peixoto; Holcatova, Ivana; Kalvach, Jaroslav; Vaccaro, Carlos Alberto; Piñero, Tamara Alejandra; Świątkowska, Beata; Lissowska, Jolanta; Roszkowska-Purska, Katarzyna; Huertas-Salgado, Antonio; Shibata, Tatsuhiro; Shiba, Satoshi; Sangkhathat, Surasak; Chitapanarux, Taned; Roshandel, Gholamreza; Ashton-Prolla, Patricia; Damin, Daniel C.; de Oliveira, Francine Hehn; Humphreys, Laura; Lawley, Trevor D.; Perdomo, Sandra; Stratton, Michael R.; Brennan, Paul; Alexandrov, Ludmil B. (23 April 2025). "Geographic and age variations in mutational processes in colorectal cancer". Nature. doi:10.1038/s41586-025-09025-8. PMID 40267983. Retrieved 23 April 2025. <a href="https://www.nature.com/articles/s41586-025-09025-8" target="_blank">https://www.nature.com/articles/s41586-025-09025-8</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> </ol>