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Adenosine thiamine triphosphate
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<h2 id="structure-and-function">Structure and function</h2> <p>The molecule is made up of thiamine and adenosine joined together with phosphate groups. It is similar in structure to NAD+. The function of AThTP is not currently known but it has been shown to inhibit the activity of PARP-1.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="external-links">External links</h2> <ul><li><a href="https://doi.org/10.1038%2F446112a">"A first for vitamins"</a>. <i>Nature</i>. 446 (7132): 112–113. 2007. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2F446112a">10.1038/446112a</a>.</li> <li>Jordan F (2007). "Adenosine triphosphate and thiamine cross paths". <i>Nat. Chem. Biol</i>. 3 (4): 202–3. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnchembio0407-202">10.1038/nchembio0407-202</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17372602">17372602</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Bettendorff L, Wirtzfeld B, Makarchikov AF, et al. (2007). "Discovery of a natural thiamine adenine nucleotide". Nat. Chem. Biol. 3 (4): 211–2. doi:10.1038/nchembio867. hdl:2268/518. PMID 17334376. S2CID 28498198. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Tanaka T, Yamamoto D, Sato T, Tanaka S, Usui K, Manabe M, Aoki Y, Iwashima Y, Saito Y, Mino Y, Deguchi H (2011). "Adenosine thiamine triphosphate (AThTP) inhibits poly(ADP-ribose) polymerase-1(PARP-1) activity". J Nutr Sci Vitaminol (Tokyo). 57 (2): 192–6. doi:10.3177/jnsv.57.192. PMID 21697640. <a href="https://doi.org/10.3177%2Fjnsv.57.192" target="_blank">https://doi.org/10.3177%2Fjnsv.57.192</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Makarchikov AF, Brans A, Bettendorff L (2007). "Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate". BMC Biochem. 8: 17. doi:10.1186/1471-2091-8-17. PMC 1976097. PMID 17705845. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976097" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976097</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Tanaka T, Yamamoto D, Sato T, Tanaka S, Usui K, Manabe M, Aoki Y, Iwashima Y, Saito Y, Mino Y, Deguchi H (2011). "Adenosine thiamine triphosphate (AThTP) inhibits poly(ADP-ribose) polymerase-1(PARP-1) activity". J Nutr Sci Vitaminol (Tokyo). 57 (2): 192–6. doi:10.3177/jnsv.57.192. PMID 21697640. <a href="https://doi.org/10.3177%2Fjnsv.57.192" target="_blank">https://doi.org/10.3177%2Fjnsv.57.192</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> </ol>