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CYP2A6
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<h2 id="interactive-pathway-map">Interactive pathway map</h2> <p><i>Click on genes, proteins and metabolites below to link to respective articles.</i><a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> </p> <h2 id="distribution">Distribution</h2> <p>CYP2A6 localizes to the <a href="/facts/Endoplasmic_reticulum/DVbLA7GE">endoplasmic reticulum</a> and is found predominantly in the liver. </p> <h2 id="variability">Variability</h2> <p>Significant interindividual variability in CYP2A6 apoprotein and mRNA levels has been observed. </p> <h2 id="induction">Induction</h2> <p>CYP2A6 is known to be <a href="/facts/Enzyme_induction_and_inhibition/xsqdeWf3">inducible</a> by <a href="/facts/Phenobarbital/G236GSuW">phenobarbital</a> and <a href="/facts/Rifampicin/9naa8C5l">rifampicin</a>, and it is suspected that other antiepileptic drugs may also have this effect. </p> <h2 id="cyp2a6-ligands">CYP2A6 Ligands</h2> Selected inducers, inhibitors and substrates of CYP2A6<table><tbody><tr><th>Substrates</th><th>Inhibitors</th><th>Inducers</th></tr><tr><td><ul><li>Many <a href="/facts/Carcinogen/soH8Y9CE">Carcinogens</a><ul><li><a href="/facts/MNAN/MUydhNSJ">MNAN</a></li><li><a href="/facts/NNK/0WBRjd2M">NNK</a></li><li><a href="/facts/N-Nitrosodiethylamine/T9CMSV7g">NDEA</a></li><li><a href="/facts/MTBE/A0nL0kHv">MTBE</a></li></ul></li><li>Other <a href="/facts/Toxin/11oUNk7n">toxins</a><ul><li><a href="/facts/Aflatoxin/EUu21Ywp">aflatoxin</a> B1 (<a href="/facts/Mycotoxin/11dL2teq">mycotoxin</a>)</li><li><a href="/facts/1,3-butadiene/j9W2LxGv">1,3-butadiene</a> (in synthetic rubber)</li><li><a href="/facts/Coumarin/bW8bsSzK">coumarin</a> (<a href="/facts/Anticoagulant/cARpjm0G">anticoagulant</a>, found in <a href="/facts/Cinnamon/Aag9baI6">cinnamon</a>)</li><li><a href="/facts/DCBN/qTPMus3S">DCBN</a> (<a href="/facts/Herbicide/FN93bvrk">herbicide</a>)</li><li>7-ethoxycoumarin (test substrate)</li><li><a href="/facts/Skatole/ndGDpItB">skatole</a></li><li><a href="/facts/Quinoline/kJyUItFu">quinoline</a></li><li><a href="/facts/4,4%E2%80%99-methylene-bis(2-chloroaniline)/CAMhmoPk">MOCA</a> (in <a href="/facts/Polyurethane/qNo2KSXA">polyurethane</a> production)</li></ul></li><li><a href="/facts/Halothane/PQ58E6ah">halothane</a> (<a href="/facts/Anaesthetic/0xG7I2ou">anaesthetic</a>)</li><li><a href="/facts/Losigamone/etzQkvX8">losigamone</a> (<a href="/facts/Anticonvulsant/uR8cxJbj">anticonvulsant</a>)</li><li><a href="/facts/Methoxyflurane/vJJfP5HH">methoxyflurane</a> (<a href="/facts/Anaesthetic/0xG7I2ou">anaesthetic</a>)</li><li><a href="/facts/Cotinine/5hesUlxJ">cotinine</a> (<a href="/facts/Metabolite/nAyywVtA">metabolite</a> of <a href="/facts/Nicotine/VQ6HcIrY">nicotine</a>)</li><li><a href="/facts/Nicotine/VQ6HcIrY">nicotine</a> (<a href="/facts/Stimulant/nmBdAXM5">stimulant</a>)</li><li><a href="/facts/SM-12502/JJ1H5YVr">SM-12502</a> (<a href="/facts/Platelet-activating_factor/JJ1H5YVr">PAF</a> <a href="/facts/Receptor_antagonist/PuXHVNdV">antagonist</a>)</li><li><a href="/facts/Valproic_acid/q31XYzd9">valproic acid</a> (<a href="/facts/Anticonvulsant/uR8cxJbj">anticonvulsant</a>, <a href="/facts/Mood-stabilizing/9sj4E0wx">mood-stabilizing</a>)</li><li><a href="/facts/Dexmedetomidine/PfMrGLg6">dexmedetomidine</a> (<a href="/facts/Sedative/JWzvq66P">sedative</a>)<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a></li></ul></td><td><ul><li><a href="/facts/Amiodarone/rywCcA6L">amiodarone</a> (<a href="/facts/Antiarrhythmic_agent/RJPHtxKr">antiarrhythmic agent</a>)<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a></li><li><a href="/facts/Amlodipine/vTR2cPqe">amlodipine</a> (<a href="/facts/Calcium_channel_blocker/st91pD2K">calcium channel blocker</a>)<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a></li><li><a href="/facts/Buprenorphine/Mou2qrHm">buprenorphine</a> (<a href="/facts/Opioid/EGnE2x99">semisynthetic opioid</a>)<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a></li><li><a href="/facts/Clofibrate/5tyjpuQY">clofibrate</a> (<a href="/facts/Fibrate/IuI8Dqjd">fibrate</a>)<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li><li><a href="/facts/Clotrimazole/SRY1jAW9">clotrimazole</a> (<a href="/facts/Antifungal/WEk5nS2B">antifungal</a>)<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a></li><li><a href="/facts/Desipramine/1NvuPY6M">desipramine</a> (<a href="/facts/Tricyclic_antidepressant/vpBLER2Q">tricyclic antidepressant</a>)<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a></li><li><a href="/facts/Disulfiram/kDsupF9F">disulfiram</a> (<a href="/facts/Acetaldehyde_dehydrogenase/72qsce26">acetaldehyde dehydrogenase</a> inhibitor)<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a></li><li><a href="/facts/Entacapone/4m7Qa7BN">entacapone</a> (<a href="/facts/Catechol-O-methyl_transferase/GlKMEABG">COMT</a> inhibitor, used in <a href="/facts/Parkinson%27s_disease/xpekKj6x">Parkinson's disease</a>)<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a></li><li><a href="/facts/Fenofibrate/TWSTQ0PM">fenofibrate</a> (<a href="/facts/Fibrate/IuI8Dqjd">fibrate</a>)<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a></li><li><a href="/facts/Gabapentin/QgRxFbfX">gabapentin</a> (<a href="/facts/Anticonvulsant/uR8cxJbj">anticonvulsant</a>)</li><li><a href="/facts/Grapefruit/6zAuyqWT">grapefruit</a> juice <a href="/facts/Flavonoids/J7FEAtLE">flavonoids</a></li><li><a href="/facts/Isoniazid/kaFX7E6u">isoniazid</a> (<a href="/facts/Antibiotics/sF1kIfxg">antibacterial</a>)<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a><a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a></li><li><a href="/facts/Ketoconazole/UQcvnER5">ketoconazole</a> (<a href="/facts/Antifungal_medication/WEk5nS2B">antifungal</a>)<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a></li><li><a href="/facts/Letrozole/23LLQw13">letrozole</a> (<a href="/facts/Aromatase_inhibitor/G1LhNlsh">aromatase inhibitor</a>, used in <a href="/facts/Breast_cancer/6hME580v">breast cancer</a>)<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a></li><li><a href="/facts/Methimazole/xfFBnLl3">methimazole</a> (<a href="/facts/Antithyroid_agent/5DmvHoff">antithyroid agent</a>)<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a></li><li><a href="/facts/Methoxsalen/XGEzpt3M">methoxsalen</a> (<a href="/facts/Furanocoumarin/SVQNNAfM">furanocoumarin</a>, used in <a href="/facts/Psoriasis/WW1k1LsH">psoriasis</a>)<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a></li><li><a href="/facts/Metyrapone/AzhBuueY">metyrapone</a> (used to diagnose <a href="/facts/Adrenal_insufficiency/7oxdJtF4">adrenal insufficiency</a>)<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a></li><li><a href="/facts/Miconazole/PjA5UgFB">miconazole</a> (<a href="/facts/Antifungal/WEk5nS2B">antifungal</a>)<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a></li><li><a href="/facts/Modafinil/u8xDYgDU">modafinil</a> (<a href="/facts/Wakefulness-promoting_agent/nNnzmhNN">wakefulness-promoting agent</a>)<a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a></li><li><a href="/facts/Nicotine/VQ6HcIrY">nicotine</a> (<a href="/facts/Stimulant/nmBdAXM5">stimulant</a>)<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a></li><li><a href="/facts/Orphenadrine/3BEpUdvx">orphenadrine</a> (<a href="/facts/Antihistamine/HuMC25lt">antihistamine</a>)<a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a></li><li><a href="/facts/Pilocarpine/dVnhPSWP">pilocarpine</a> (<a href="/facts/Muscarinic_receptor/caIdoqrW">muscarinic receptor</a> agonist)<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a></li><li><a href="/facts/Pregabalin/JD1gRfTl">pregabalin</a> (<a href="/facts/Anticonvulsant/uR8cxJbj">anticonvulsant</a>)</li><li><a href="/facts/Selegiline/2K3IEPMT">selegiline</a> (<a href="/facts/Monoamine_oxidase_inhibitor/obewT56a">monoamine oxidase inhibitor</a>)<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a><a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a></li><li><a href="/facts/Sulconazole/zC8TTIpV">sulconazole</a> (<a href="/facts/Antifungal/WEk5nS2B">antifungal</a>)<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a></li><li><a href="/facts/Tioconazole/LHQ7UtRQ">tioconazole</a> (<a href="/facts/Antifungal/WEk5nS2B">antifungal</a>)<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a></li><li><a href="/facts/Tranylcypromine/YVIArwgA">tranylcypromine</a> (<a href="/facts/Monoamine_oxidase_inhibitor/obewT56a">monoamine oxidase inhibitor</a>)<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a></li></ul></td><td><ul><li><a href="/facts/Barbiturate/d3PhtK8b">Barbiturates</a><ul><li><a href="/facts/Amobarbital/4SPH2Hp3">amobarbital</a><a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a></li><li><a href="/facts/Pentobarbital/DQgBJ2jC">pentobarbital</a><a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a></li><li><a href="/facts/Phenobarbital/G236GSuW">phenobarbital</a><a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a></li><li><a href="/facts/Secobarbital/5mgQfXgy">secobarbital</a><a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a></li></ul></li><li><a href="/facts/Rifampicin/9naa8C5l">rifampicin</a> (<a href="/facts/Antibiotics/sF1kIfxg">antibacterial</a>)<a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a></li></ul></td></tr></tbody></table> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/List_of_cytochrome_P450_modulators/7y2gW521">List of cytochrome P450 modulators</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Pelkonen O, Rautio A, Raunio H, Pasanen M (2000). "CYP2A6: a human coumarin 7-hydroxylase". <i>Toxicology</i>. 144 (1–3): 139–47. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0300-483X%2899%2900200-0">10.1016/S0300-483X(99)00200-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10781881">10781881</a>.</li> <li>Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis". <i>Pharmacogenetics</i>. 5 (Special Issue): S123–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2F00008571-199512001-00013">10.1097/00008571-199512001-00013</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7581481">7581481</a>.</li> <li>Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". <i>Xenobiotica</i>. 28 (12): 1129–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1080%2F004982598238868">10.1080/004982598238868</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9890157">9890157</a>.</li> <li>Pelkonen O, Rautio A, Raunio H, Pasanen M (2000). "CYP2A6: a human coumarin 7-hydroxylase". <i>Toxicology</i>. 144 (1–3): 139–47. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0300-483X%2899%2900200-0">10.1016/S0300-483X(99)00200-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10781881">10781881</a>.</li> <li>Tyndale RF, Sellers EM (2002). "Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior". <i>Therapeutic Drug Monitoring</i>. 24 (1): 163–71. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1097%2F00007691-200202000-00026">10.1097/00007691-200202000-00026</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11805739">11805739</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:12837210">12837210</a>.</li> <li>Xu C, Goodz S, Sellers EM, Tyndale RF (2003). "CYP2A6 genetic variation and potential consequences". <i>Adv. Drug Deliv. Rev</i>. 54 (10): 1245–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0169-409X%2802%2900065-0">10.1016/S0169-409X(02)00065-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12406643">12406643</a>.</li> <li>Kamataki T, Fujieda M, Kiyotani K, et al. (2005). "Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk". <i>Biochem. Biophys. Res. Commun</i>. 338 (1): 306–10. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.bbrc.2005.08.268">10.1016/j.bbrc.2005.08.268</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16176798">16176798</a>.</li> <li>Maurice M, Emiliani S, Dalet-Beluche I, et al. (1991). "Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes". <i>Eur. J. Biochem</i>. 200 (2): 511–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1432-1033.1991.tb16212.x">10.1111/j.1432-1033.1991.tb16212.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1889415">1889415</a>.</li> <li>Yun CH, Shimada T, Guengerich FP (1991). "Purification and characterization of human liver microsomal cytochrome P-450 2A6". <i>Mol. Pharmacol</i>. 40 (5): 679–85. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1944238">1944238</a>.</li> <li>Yamano S, Tatsuno J, Gonzalez FJ (1990). "The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes". <i>Biochemistry</i>. 29 (5): 1322–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi00457a031">10.1021/bi00457a031</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2322567">2322567</a>.</li> <li>Miles JS, Bickmore W, Brook JD, et al. (1989). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317701">"Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity"</a>. <i>Nucleic Acids Res</i>. 17 (8): 2907–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F17.8.2907">10.1093/nar/17.8.2907</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317701">317701</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2726448">2726448</a>.</li> <li>Yamano S, Nagata K, Yamazoe Y, et al. (1989). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC318052">"cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)"</a>. <i>Nucleic Acids Res</i>. 17 (12): 4888. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F17.12.4888">10.1093/nar/17.12.4888</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC318052">318052</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2748347">2748347</a>.</li> <li>Phillips IR, Shephard EA, Ashworth A, Rabin BR (1985). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC397177">"Isolation and sequence of a human cytochrome P-450 cDNA clone"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 82 (4): 983–7. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1985PNAS...82..983P">1985PNAS...82..983P</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.82.4.983">10.1073/pnas.82.4.983</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC397177">397177</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/3856261">3856261</a>.</li> <li>Wainwright BJ, Watson EK, Shephard EA, Phillips IR (1985). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321810">"RFLP for a human cytochrome P-450 gene at 19q13.1-qter (HGM8 provisional designation CYPI)"</a>. <i>Nucleic Acids Res</i>. 13 (12): 4610. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F13.12.4610">10.1093/nar/13.12.4610</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321810">321810</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/4011450">4011450</a>.</li> <li>Fernandez-Salguero P, Hoffman SM, Cholerton S, et al. (1995). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801261">"A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles"</a>. <i>Am. J. Hum. Genet</i>. 57 (3): 651–60. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801261">1801261</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7668294">7668294</a>.</li> <li>Ding S, Lake BG, Friedberg T, Wolf CR (1995). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136496">"Expression and alternative splicing of the cytochrome P-450 CYP2A7"</a>. <i>Biochem. J</i>. 306. ( Pt 1) (Pt 1): 161–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1042%2Fbj3060161">10.1042/bj3060161</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136496">1136496</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7864805">7864805</a>.</li> <li>Hoffman SM, Fernandez-Salguero P, Gonzalez FJ, Mohrenweiser HW (1996). "Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19". <i>J. Mol. 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"Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase". <i>FEBS Lett</i>. 438 (3): 201–5. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1998FEBSL.438..201O">1998FEBSL.438..201O</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2898%2901297-6">10.1016/S0014-5793(98)01297-6</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9827545">9827545</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:1250823">1250823</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CPA6"><i>CPA6</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CPA6"><i>CPA6</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CYP2A6"><i>CYP2A6</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CYP2A6"><i>CYP2A6</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>This article incorporates public domain material from "Entrez Gene: CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6". Reference Sequence collection. National Center for Biotechnology Information. <a href="/wiki/Copyright_status_of_works_by_the_federal_government_of_the_United_States" target="_blank">/wiki/Copyright_status_of_works_by_the_federal_government_of_the_United_States</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". <a href="http://www.wikipathways.org/index.php/Pathway:WP1601" target="_blank">http://www.wikipathways.org/index.php/Pathway:WP1601</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Lacy CF, Armstrong LL, Goldman MP, Lance LL (2007). Cytochrome P450 Enzymes: Substrates, Inhibitors, and Inducers. Hudson, OH: LexiComp Inc. pp. 1899–1912. <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Lacy CF, Armstrong LL, Goldman MP, Lance LL (2007). Cytochrome P450 Enzymes: Substrates, Inhibitors, and Inducers. 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