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Functional divergence
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<h2 id="see-also">See also</h2> <ul><li><a href="/facts/Heterotachy/504dLeDG">Heterotachy</a></li> <li><a href="/facts/Subfunctionalization/0SDWfvcf">Subfunctionalization</a></li> <li><a href="/facts/Neofunctionalization/BCfPYEhz">Neofunctionalization</a></li></ul> <ul><li>Gu, X (Oct 2006). <a href="https://doi.org/10.1093%2Fmolbev%2Fmsl056">"A simple statistical method for estimating type-II (cluster-specific) functional divergence of protein sequences"</a>. <i>Mol Biol Evol</i>. 23 (10): 1937–45. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fmolbev%2Fmsl056">10.1093/molbev/msl056</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16864604">16864604</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Gu, X (Jul 2003). "Functional divergence in protein (Family) sequence evolution". Origin and Evolution of New Gene Functions. Contemporary Issues in Genetics and Evolution. Vol. 118. pp. 133–41. doi:10.1007/978-94-010-0229-5_4. ISBN 978-94-010-3982-6. PMID 12868604. {{cite book}}: |journal= ignored (help) <a href="978-94-010-3982-6" target="_blank">978-94-010-3982-6</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Fay, JC; Wu, CI (2003). "Sequence divergence, functional constraint, and selection in protein evolution". Annu Rev Genom Hum Genet. 4: 213–35. doi:10.1146/annurev.genom.4.020303.162528. PMID 14527302. <a href="https://doi.org/10.1146%2Fannurev.genom.4.020303.162528" target="_blank">https://doi.org/10.1146%2Fannurev.genom.4.020303.162528</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Dvornyk, V; Vinogradova, ON; Nevo, E (2002). "Long-term microclimatic stress causes rapid adaptive radiation of kaiABC clock gene family in a cyanobacterium, Nostoc linckia, from "Evolution Canyons" I and II, Israel". Proc Natl Acad Sci USA. 99 (4): 2082–2087. Bibcode:2002PNAS...99.2082D. doi:10.1073/pnas.261699498. PMC 123721. PMID 11842226. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC123721" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC123721</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Studer, RA; Robinson-Rechavi, M (2009). "How confident can we be that orthologs are similar, but paralogs differ?". Trends in Genetics. 25 (5): 210–6. doi:10.1016/j.tig.2009.03.004. PMID 19368988. <a href="https://serval.unil.ch/notice/serval:BIB_39F8106EE698" target="_blank">https://serval.unil.ch/notice/serval:BIB_39F8106EE698</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Studer; Robinson-Rechavi, M (2010). "Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution". Molecular Biology and Evolution. 27 (11): 2618–2627. doi:10.1093/molbev/msq149. PMC 2955734. PMID 20551039. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955734" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955734</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Gharib, WH; Robinson-Rechavi, M (2011). "When orthologs diverge between human and mouse". Briefings in Bioinformatics. 12 (5): 436–441. doi:10.1093/bib/bbr031. PMC 3178054. PMID 21677033. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178054" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178054</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Nehrt, NL; Clark, WT; Radivojac, P; Hahn, MW (2011). "Testing the ortholog conjecture with comparative functional genomic data from mammals". PLOS Computational Biology. 7 (6): e1002073. Bibcode:2011PLSCB...7E2073N. doi:10.1371/journal.pcbi.1002073. PMC 3111532. PMID 21695233. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111532" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111532</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Storz, Jay F.; Hoffmann, Federico G.; Opazo, Juan C.; Moriyama, Hideaki (March 2008). "Adaptive Functional Divergence Among Triplicated α-Globin Genes in Rodents". Genetics. 178 (3): 1623–1638. doi:10.1534/genetics.107.080903. PMC 2278084. PMID 18245844. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278084" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278084</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Zheng, Y; Xu, D; Gu, X (2007). "Functional divergence after gene duplication and sequence-structure relationship: a case study of G-protein alpha subunits". Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 308 (1): 85–96. doi:10.1002/jez.b.21140. PMID 17094082. <a href="https://lib.dr.iastate.edu/rtd/15063" target="_blank">https://lib.dr.iastate.edu/rtd/15063</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> </ol>