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HOXB9
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<h2 id="function">Function</h2> <p>This gene is a member of the Abd-B homeobox family and encodes a protein with a <a href="/facts/Homeobox/bpvuuw3v">homeobox</a> <a href="/facts/DNA-binding_domain/x2vlHUKl">DNA-binding domain</a>. It is included in a <a href="/facts/Gene_cluster/0Goyb8eB">cluster</a> of homeobox B genes located on <a href="/facts/Chromosome_17/SzAlnKTV">chromosome 17</a>. The encoded nuclear protein functions as a sequence-specific <a href="/facts/Transcription_factor/wro0DPHe">transcription factor</a> that is involved in <a href="/facts/Cell_proliferation/Jp3hWo2t">cell proliferation</a> and <a href="/facts/Cell_differentiation/bCVqUG7w">differentiation</a>. Increased expression of this gene is associated with some cases of <a href="/facts/Leukemia/WpEfW0Qh">leukemia</a>, <a href="/facts/Prostate_cancer/Mx7XuDhm">prostate cancer</a> and <a href="/facts/Lung_cancer/LHLdR454">lung cancer</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="interactions">Interactions</h2> <p>HOXB9 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/BTG2/WzRVF9xK">BTG2</a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> and <a href="/facts/BTG1/dUqfoM1Q">BTG1</a>.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Homeobox/bpvuuw3v">Homeobox</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Deguchi Y, Kehrl JH (1991). <a href="https://doi.org/10.1182%2Fblood.V78.2.323.323">"Selective expression of two homeobox genes in CD34-positive cells from human bone marrow"</a>. <i>Blood</i>. 78 (2): 323–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood.V78.2.323.323">10.1182/blood.V78.2.323.323</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1712647">1712647</a>.</li> <li>Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". <i>Differentiation</i>. 45 (1): 61–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1432-0436.1990.tb00458.x">10.1111/j.1432-0436.1990.tb00458.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1981366">1981366</a>.</li> <li>Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". <i>Differentiation</i>. 40 (3): 191–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1432-0436.1989.tb00598.x">10.1111/j.1432-0436.1989.tb00598.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2570724">2570724</a>.</li> <li>Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC335308">"The human HOX gene family"</a>. <i>Nucleic Acids Res</i>. 17 (24): 10385–402. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F17.24.10385">10.1093/nar/17.24.10385</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC335308">335308</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2574852">2574852</a>.</li> <li>Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". <i>Genome</i>. 31 (2): 745–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1139%2Fg89-133">10.1139/g89-133</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2576652">2576652</a>.</li> <li>Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". <i>Cytogenet. Cell Genet</i>. 73 (1–2): 114–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1159%2F000134320">10.1159/000134320</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8646877">8646877</a>.</li> <li>Ohnishi K, Tobita T, Sinjo K, Takeshita A, Ohno R (1998). "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation". <i>Leuk. Lymphoma</i>. 31 (5–6): 599–608. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.3109%2F10428199809057620">10.3109/10428199809057620</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9922051">9922051</a>.</li> <li>Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (2000). <a href="https://doi.org/10.1074%2Fjbc.275.1.147">"The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation"</a>. <i>J. Biol. Chem</i>. 275 (1): 147–53. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.275.1.147">10.1074/jbc.275.1.147</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10617598">10617598</a>.</li> <li>Calvo R, West J, Franklin W, Erickson P, Bemis L, Li E, Helfrich B, Bunn P, Roche J, Brambilla E, Rosell R, Gemmill RM, Drabkin HA (2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18840">"Altered HOX and WNT7A expression in human lung cancer"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 97 (23): 12776–81. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2000PNAS...9712776C">2000PNAS...9712776C</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.97.23.12776">10.1073/pnas.97.23.12776</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18840">18840</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11070089">11070089</a>.</li> <li>de Pinieux G, Legrier ME, Poirson-Bichat F, Courty Y, Bras-Gonçalves R, Dutrillaux AM, Némati F, Oudard S, Lidereau R, Broqua P, Junien JL, Dutrillaux B, Poupon MF (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850557">"Clinical and experimental progression of a new model of human prostate cancer and therapeutic approach"</a>. <i>Am. J. Pathol</i>. 159 (2): 753–64. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0002-9440%2810%2961746-4">10.1016/S0002-9440(10)61746-4</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850557">1850557</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11485933">11485933</a>.</li> <li>Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99922">"The HOX homeodomain proteins block CBP histone acetyltransferase activity"</a>. <i>Mol. Cell. Biol</i>. 21 (21): 7509–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.21.21.7509-7522.2001">10.1128/MCB.21.21.7509-7522.2001</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99922">99922</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11585930">11585930</a>.</li> <li>Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (2002). "Complete mutation analysis panel of the 39 human HOX genes". <i>Teratology</i>. 65 (2): 50–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Ftera.10009">10.1002/tera.10009</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11857506">11857506</a>.</li> <li>Hori Y, Gu X, Xie X, Kim SK (2005). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087208">"Differentiation of insulin-producing cells from human neural progenitor cells"</a>. <i>PLOS Med</i>. 2 (4): e103. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1371%2Fjournal.pmed.0020103">10.1371/journal.pmed.0020103</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087208">1087208</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15839736">15839736</a>.</li> <li>Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, <a href="/facts/Huda_Zoghbi/tEMTeyKH">Zoghbi HY</a>, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". <i>Nature</i>. 437 (7062): 1173–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R">2005Natur.437.1173R</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature04209">10.1038/nature04209</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16189514">16189514</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4427026">4427026</a>.</li> <li>Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"</a>. <i>Genome Res</i>. 16 (1): 55–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.4039406">10.1101/gr.4039406</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">1356129</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16344560">16344560</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=HOXB9+protein%2C+human">HOXB9+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: HOXB9 homeobox B9". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3219" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3219</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: HOXB9 homeobox B9". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3219" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3219</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598. <a href="https://doi.org/10.1074%2Fjbc.275.1.147" target="_blank">https://doi.org/10.1074%2Fjbc.275.1.147</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598. <a href="https://doi.org/10.1074%2Fjbc.275.1.147" target="_blank">https://doi.org/10.1074%2Fjbc.275.1.147</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>