Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
InaD-like protein
open-in-new
<h2 id="function">Function</h2> <p>This gene encodes a protein with multiple <a href="/facts/PDZ_domain/kSanExq4">PDZ domains</a>. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="interactions">Interactions</h2> <p>INADL has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/MPP5/xDY2dLb6">MPP5</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Fanning AS, Anderson JM (1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC408156">"PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane"</a>. <i>J. Clin. Invest</i>. 103 (6): 767–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1172%2FJCI6509">10.1172/JCI6509</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC408156">408156</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10079096">10079096</a>.</li> <li>Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). <a href="https://doi.org/10.1006%2Fgeno.1996.0177">"The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression"</a>. <i>Genomics</i>. 33 (1): 151–2. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.1996.0177">10.1006/geno.1996.0177</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8617505">8617505</a>.</li> <li>Kurschner C, Mermelstein PG, Holden WT, <a href="/facts/D._James_Surmeier/2lka0bsV">Surmeier DJ</a> (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". <i>Mol. Cell. Neurosci</i>. 11 (3): 161–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fmcne.1998.0679">10.1006/mcne.1998.0679</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9647694">9647694</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:36534759">36534759</a>.</li> <li>Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L (2001). <a href="https://doi.org/10.1074%2Fjbc.M104208200">"Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster"</a>. <i>J. Biol. Chem</i>. 276 (45): 42122–30. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M104208200">10.1074/jbc.M104208200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11509564">11509564</a>.</li> <li>Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (2002). <a href="https://doi.org/10.1074%2Fjbc.M201087200">"The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons"</a>. <i>J. Biol. Chem</i>. 277 (19): 16655–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M201087200">10.1074/jbc.M201087200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11872753">11872753</a>.</li> <li>Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173254">"The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost"</a>. <i>J. Cell Biol</i>. 157 (1): 161–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1083%2Fjcb.200109010">10.1083/jcb.200109010</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173254">2173254</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11927608">11927608</a>.</li> <li>Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (2002). <a href="https://doi.org/10.1074%2Fjbc.M202196200">"hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells"</a>. <i>J. Biol. Chem</i>. 277 (28): 25408–15. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M202196200">10.1074/jbc.M202196200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11964389">11964389</a>.</li> <li>Roh MH, Liu CJ, Laurinec S, Margolis B (2002). <a href="https://doi.org/10.1074%2Fjbc.M201177200">"The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions"</a>. <i>J. Biol. Chem</i>. 277 (30): 27501–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M201177200">10.1074/jbc.M201177200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12021270">12021270</a>.</li> <li>Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". <i>Gene</i>. 302 (1–2): 21–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0378111902010843">10.1016/S0378111902010843</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12527193">12527193</a>.</li> <li>Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". <i>J. Cell Sci</i>. 116 (Pt 14): 2895–906. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1242%2Fjcs.00500">10.1242/jcs.00500</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12771187">12771187</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4482921">4482921</a>.</li> <li>Li Y, Karnak D, Demeler B, Margolis B, Lavie A (2005). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514954">"Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes"</a>. <i>EMBO J</i>. 23 (14): 2723–33. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.emboj.7600294">10.1038/sj.emboj.7600294</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514954">514954</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15241471">15241471</a>.</li> <li>Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A (2005). "PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells". <i>J. Cell Sci</i>. 118 (Pt 17): 4049–57. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1242%2Fjcs.02528">10.1242/jcs.02528</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16129888">16129888</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:19826254">19826254</a>.</li> <li>Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533859">"Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays"</a>. <i>J. Am. Chem. Soc</i>. 128 (17): 5913–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fja060943h">10.1021/ja060943h</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533859">2533859</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16637659">16637659</a>.</li> <li>Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T (2006). <a href="https://doi.org/10.1016%2Fj.cell.2006.02.045">"A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells"</a>. <i>Cell</i>. 125 (3): 535–48. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.cell.2006.02.045">10.1016/j.cell.2006.02.045</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16678097">16678097</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:18651810">18651810</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=INADL"><i>INADL</i></a> human gene location in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li><a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=INADL"><i>INADL</i></a> human gene details in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/facts/Protein_Data_Bank/oUhq4ABD">PDB</a> for <a href="/facts/UniProt/lfDDHjAl">UniProt</a>: <i><a href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q8NI35">Q8NI35</a></i> (InaD-like protein) at the <a href="/facts/PDBe-KB/p1WX7lPH">PDBe-KB</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster". FEBS Lett. 413 (2): 243–8. doi:10.1016/S0014-5793(97)00877-6. PMID 9280290. <a href="https://doi.org/10.1016%2FS0014-5793%2897%2900877-6" target="_blank">https://doi.org/10.1016%2FS0014-5793%2897%2900877-6</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: INADL InaD-like (Drosophila)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: INADL InaD-like (Drosophila)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173254" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173254</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>