It is also used in the production of some antimalarial drugs including pyrimethamine.4
Ethyl propionate can be synthesized by the Fischer esterification of ethanol and propionic acid:
It participates in condensation reactions by virtue of the weakly acidic methylene group.5
"Ethyl Propionate | Cameo Chemicals | Noaa". Cameochemicals.noaa.gov. Retrieved 2015-02-27. http://cameochemicals.noaa.gov/chemical/710 ↩
Bartley, J. P.; Schwede, A. M. (1989). "Production of volatile compounds in ripening kiwi fruit (Actinidia chinensis)". Journal of Agricultural and Food Chemistry. 37 (4): 1023. doi:10.1021/jf00088a046. /wiki/Doi_(identifier) ↩
Perez, A. G.; Rios, J. J.; Sanz, C.; Olias, J. M. (1992). "Aroma components and free amino acids in strawberry variety Chandler during ripening". Journal of Agricultural and Food Chemistry. 40 (11): 2232. doi:10.1021/jf00023a036. /wiki/Doi_(identifier) ↩
MacDonald, Thomas (29 January 2016). "Pyrimethamine synthesis: Status at end of 2015". Daraprim Synthesis. Open Source Malaria. Archived from the original on 26 April 2018. https://web.archive.org/web/20180426233859/http://malaria.ourexperiment.org/daraprim_synthesis/13962/Pyrimethamine_synthesis_Status_at_end_of_2015.html ↩
Cox, Richard F. B.; McElvain, S. M. (1937). "Ethyl Ethoxalylpropionate". Organic Syntheses. 17: 54. doi:10.15227/orgsyn.017.0054. /wiki/Doi_(identifier) ↩