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SSH3
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<h2 id="function">Function</h2> <p>The <a href="/facts/Cofilin/wYS09rVM">ADF (actin-depolymerizing factor)/cofilin family</a> (see MIM 601442) is composed of stimulus-responsive mediators of <a href="/facts/Actin/Hu3qIUL9">actin</a> dynamics. ADF/cofilin <a href="/facts/Proteins/Jxmagu3E">proteins</a> are inactivated by <a href="/facts/Kinases/dhlHpjnD">kinases</a> such as LIM domain kinase-1 (<a href="/facts/LIMK1/6esH801p">LIMK1</a>; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754063">"The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes"</a>. <i>The Journal of Biological Chemistry</i>. 282 (44): 32520–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M707041200">10.1074/jbc.M707041200</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754063">2754063</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17848544">17848544</a>.</li> <li>Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". <i>Nature Biotechnology</i>. 24 (10): 1285–92. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnbt1240">10.1038/nbt1240</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16964243">16964243</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:14294292">14294292</a>.</li> <li>Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548651">"Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin"</a>. <i>The EMBO Journal</i>. 24 (3): 473–86. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.emboj.7600543">10.1038/sj.emboj.7600543</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548651">548651</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15660133">15660133</a>.</li> <li>Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". <i>Genes to Cells</i>. 8 (10): 811–24. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1365-2443.2003.00678.x">10.1046/j.1365-2443.2003.00678.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14531860">14531860</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:24247372">24247372</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208. <a href="https://doi.org/10.1016%2FS0092-8674%2801%2900638-9" target="_blank">https://doi.org/10.1016%2FS0092-8674%2801%2900638-9</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> </ol>