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SLFN14
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<h2 id="function">Function</h2> <p>The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016]. </p> <h2 id="further-reading">Further reading</h2> <ul><li>Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Guiú IS, Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP, Morgan NV (September 2015). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588283">"SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects"</a>. <i>J. Clin. Invest</i>. 125 (9): 3600–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1172%2FJCI80347">10.1172/JCI80347</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588283">4588283</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/26280575">26280575</a>.</li> <li>Marconi C, Di Buduo CA, Barozzi S, Palombo F, Pardini S, Zaninetti C, Pippucci T, Noris P, Balduini A, Seri M, Pecci A (May 2016). "SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia". <i>Thromb. Haemost</i>. 115 (5): 1076–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1160%2FTH15-11-0884">10.1160/TH15-11-0884</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/26769223">26769223</a>.</li> <li>Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS (November 2017). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990420">"Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication"</a>. <i>Immunobiology</i>. 222 (11): 979–988. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.imbio.2017.07.002">10.1016/j.imbio.2017.07.002</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990420">5990420</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/28734654">28734654</a>.</li> <li>Fletcher SJ, Pisareva VP, Khan AO, Tcherepanov A, Morgan NV, Pisarev AV (July 2018). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004054">"Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation"</a>. <i>RNA</i>. 24 (7): 939–949. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1261%2Frna.066415.118">10.1261/rna.066415.118</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004054">6004054</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/29678925">29678925</a>.</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: Schlafen family member 14". Retrieved 2020-04-11. <a href="http://www.ncbi.nlm.nih.gov/gene/342618" target="_blank">http://www.ncbi.nlm.nih.gov/gene/342618</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> </ol>