Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
TEX9
open-in-new
<h2 id="gene">Gene</h2> <h3><a href="/facts/Locus_(genetics)/JcIT8wLm">Locus</a></h3> <p>TEX9 is located at 15q21.3 and has 18 <a href="/facts/Exon/8KWJtLuN">exons</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> However, some exons overlap; therefore, there are only 13 distinguishable exons in the <a href="/facts/Human_genome/VTV85pbn">human genome</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> TEX9 is on the <a href="/facts/Sense_strand/uRstgP8B">sense strand</a> and spans from base 56,365,573 to 56,428,441. TEX9 is located in the gene neighborhood of <a href="/facts/CD2BP2/2MHSLhzK">CD24P2</a>, <a href="/facts/RFX1/MNDjBrYS">RFX7</a>, <a href="/facts/MNX1/gXPWNf6u">MNS1</a>, and HMGB1P33.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <h3>Transcription Regulation</h3> <p>The <a href="/facts/Promoter_(genetics)/YDYBzLfg">promoter</a> for TEX9 was determined using 19 supporting transcripts to be GXP_7531542, spanning from base 56,364,254 to base 56,365,775 on the sense strand of chromosome 15.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> A number of <a href="/facts/Transcription_factor/wro0DPHe">transcription factors</a> with a <a href="/facts/Matrix_similarity/ySevpav1">matrix similarity</a> greater than or equal to 0.780 that are predicted to regulate <a href="/facts/Transcription_(biology)/bDgp9HDN">transcription</a> of TEX9 are listed below with their respective <a href="/facts/Binding_site/gd9r9Rw7">binding site</a>: </p> <table><tbody><tr><th>Transcription Factor</th><th>Binding Site</th><th>Strand</th></tr><tr><td><a href="/facts/Hormone_response_element/oPMF4nxm">Estrogen response elements</a> (ER alpha)</td><td>ATTGGTCAGGCTGGTCTTG</td><td>+</td></tr><tr><td><i>Retinoid receptor-related testis-associated receptor</i></td><td>CCGACCAGAACTTGAGGGT and<p>TTGTAATTCAAGGTCATAA</p></td><td>- and +</td></tr><tr><td><i>Hypermethylated in cancer 1</i></td><td>CTCTGCCCAGCCT and CTTCACCCGTGAT</td><td>+ and -</td></tr><tr><td><i>T-box TF TBX21, dimeric binding site</i></td><td>TACTGCTTTTGGTGTCATATCTAAG</td><td>+</td></tr><tr><td><i>Sine oculis homeobox homolog 4</i></td><td>CTTTTGGTGTCATAT</td><td>+</td></tr><tr><td><i>Ecotropic viral integration site 1 encoded factor, amino-terminal zinc finger domain</i></td><td>AAAACCACAGTATAGAT</td><td>-</td></tr><tr><td><i><a href="/facts/Estrogen-related_receptor_alpha/IAP9T85A">Estrogen-related receptor alpha</a></i></td><td>GAATTGTAATTCAAGGTCATAAA and AGTGATTTGCCCAAGG/CCATATA</td><td>+ and +</td></tr><tr><td><i>Regulatory factor X, 4</i></td><td>TTAGGTCTTTGATACATT and AGCCATTGGCGCAGCGTCA</td><td>+ and -</td></tr><tr><td><i><a href="/facts/Thyroid_hormone_receptor_beta/BeGGB9K9">Thyroid hormone receptor, beta</a></i></td><td>TCGAGGATTCAAATCCAGAAACT and CTGGTATGTAGTATAGTGCCA</td><td>- and -</td></tr><tr><td><i>Homeodomain protein NKX3.2</i></td><td>ACTGTGAAGTGGGCACTAT</td><td>+</td></tr><tr><td><i><a href="/facts/Lentivirus/ThuASV8M">Lentivirus</a> LTR TATA box</i></td><td>CCATATAACTGGTAAGT</td><td>+</td></tr><tr><td><i>Cdx-2 mammalian caudal related intestinal TF</i></td><td>GTTCCGGTATATTGACCAT</td><td>-</td></tr><tr><td><i>GA binding protein TF, alpha</i></td><td>CTCTCGCGGGAAGATGCGTCG</td><td>+</td></tr><tr><td><i>Olfactory neuron-specific factor</i></td><td>ACCTTTGAGAGCGCCCTTCTACG</td><td>-</td></tr><tr><td><i>Kidney-enriched kruppel-like factor</i></td><td>GAAGATGGCGGGGCGAAGT</td><td>+</td></tr></tbody></table> <h3>Expression</h3> <p>The expression of <i>TEX9</i> is highest in the <a href="/facts/Testis/Doy40hoq">testis</a>, followed by the <a href="/facts/Thyroid/bjovTJVu">thyroid</a>, <a href="/facts/Duodenum/IAIgHBmq">duodenum</a>, and <a href="/facts/Kidney/HBspPrv9">kidney</a>, although other tissues have been shown to express TEX9.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> TEX9 is expected to have a subcellular localization in the cytoplasm or nucleus.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> </p> <h2 id="mrna"><a href="/facts/Messenger_RNA/oUL6qxQn">mRNA</a></h2> <h3>Characteristics of Isoform 1</h3> <p><a href="/facts/Protein_isoform/oWmzfg4l">Isoform</a> 1 of TEX9 has a <a href="/facts/Five_prime_untranslated_region/xv930kS8">5' UTR</a> region of 27 base pairs and a <a href="/facts/Three_prime_untranslated_region/wB0oYfKd">3' UTR</a> region of 356 base pairs.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> The transcript is 1,559 base pairs long.<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> </p> <h3>Additional <a href="/facts/Protein_primary_structure/QNBoERdu">Primary Sequence</a> and Variants (Isoforms)</h3> <p>Less common isoforms of TEX9 include isoforms: 2, X1, X2, X3, X4, X5, and X6.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> </p> <h2 id="protein">Protein</h2> <p>The theoretical <a href="/facts/Molecular_mass/FWueGMed">molecular weight</a> of the 391 amino acid TEX9 protein is 45kDa and the theoretical <a href="/facts/Isoelectric_point/2nYR03c8">pI</a> is 6.<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> However, the experimental molecular weight has been shown to be ~55kDa.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> </p> <h3>Domains, Motifs, and <a href="/facts/Protein_secondary_structure/MMgXXbQ2">Secondary Structure</a></h3> <p>The most pronounced <a href="/facts/Protein_domain/oUpFcSsl">domains</a> in TEX9 are the two coiled-coil regions, which include amino acids 32-59 and 194-351.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a> Repetitive domains within the protein include ALEE (34-37 and 302-305) and EKYK (251-254 and 307-310).<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a> TEX9 has more <a href="/facts/Glutamic_acid/7oXbNcvu">glutamate</a>, <a href="/facts/Lysine/CEetgA9L">lysine</a>, and <a href="/facts/Glutamine/t94zX4SK">glutamine</a> residues and less <a href="/facts/Glycine/3nXI1hqW">glycine</a> residues compared to a typical human protein.<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> </p> <h3><a href="/facts/Post-translational_modification/KMUayTIc">Post-translational Modifications</a></h3> <p>TEX9 has been shown to be <a href="/facts/Phosphorylation/LXUEEeIL">phosphorylated</a> at tyrosine (Y) residues 85 and 264, and have a <a href="/facts/Ubiquitin/hpulmU3m">ubiquitylation</a> site at the lysine (K) residue at 159.<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a> It is predicted that there are multiple other phosphorylation, <a href="/facts/Glycation/3CHvekIg">glycation</a>, 0-beta-GlcNAc, and <a href="/facts/SUMO_protein/T5vYKlQd">SUMO</a> protein attachment sites.<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a><a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a><a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a><a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a> </p> <h3><a href="/facts/Protein_tertiary_structure/1QJVj1V1">Tertiary Structure</a></h3> <p>TEX9's two coiled-coil regions make up its tertiary structure and can be visualized using the predicted structure from Phyre2.<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a> Shown on the structure are the two known phosphorylated sites and one ubiquitylation site. </p> <h3><a href="/facts/Protein_quaternary_structure/ukuyKJfj">Quaternary Structure</a> and Protein Interactions</h3> <p>TEX9 has been experimentally determined to have interactions including <a href="/facts/Coiled_coil/U0YEzcB4">coiled-coil</a> containing 112 (CCDC112), chromosome 20 <a href="/facts/Open_reading_frame/Saams83e">open reading frame</a> 112 (C20orf112), and nucleolar protein 4 (<a href="/facts/NOL4/g3xV6cHS">NOL4</a>).<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a> <a href="/facts/Text_mining/5QsIa3Cz">Textmining</a> has suggested that TEX9 also interacts with <a href="/facts/Olfactory_receptor/cY5n56yy">olfactory</a> receptor, family 4, subfamily C, member 3, odorant receptor (<a href="/facts/OR4C3/BxPxknYo">OR4C3</a>).<a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a> Other interactions include gene products of human genes <i><a href="/facts/NOL4/g3xV6cHS">NOL4-2</a></i> (at an unknown location), <i>GOGA2</i> (in the cis-<a href="/facts/Golgi_apparatus/F91pGb3t">Golgi</a> network membrane, spindle pole of <a href="/facts/Cytoskeleton/1sWlJRX9">cytoskeleton</a>, and <a href="/facts/ER-Golgi_intermediate_compartment/9rHdPtWU">ER-Golgi</a> intermediate compartment membrane), and <i><a href="/facts/KDM1A/cx8nBCRB">KDM1A</a></i> (in the <a href="/facts/Cell_nucleus/D7sFRa3c">nucleus</a>).<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a> Another proposed interaction between TEX9 involves attachment with the SUMO protein, which has a molecular weight of 11kDa.<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a> The realized MW of TEX9 is 55kDa but the theoretical MW is 45kDa, which provides evidence for this interaction.<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> </p> <h2 id="homology-and-evolution">Homology and Evolution</h2> <h3>Paralogs</h3> <p>There are no <a href="/facts/Sequence_homology/mCIVStrA">paralogs</a> of TEX9 in humans.<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a> </p> <h3>Orthologs</h3> <p><i>TEX9</i> has <a href="/facts/Homology_(biology)/muctKlyT">homologs</a> in over 260 other organisms, including <a href="/facts/Vertebrate/tT54FSTT">vertebrates</a>, <a href="/facts/Invertebrate/3CyqCVnN">invertebrates</a>, <a href="/facts/Archaea/Adxh0aHw">archaea</a>, and one species of <a href="/facts/Bacteria/wC8xSCsU">bacteria</a>.<a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a> TEX9 has been found in all clades of organisms except land plants.<a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a> </p> <table><tbody><tr><th>Genus species</th><th>Common Name</th><th>Taxonomic Group</th><th>Divergence (MYA)</th><th>Accession Number</th><th>Seq. Length (aa)</th><th>Corr. ID to HP (%)</th><th>Corr. Sim. To HP (%)</th></tr><tr><td><i><a href="/facts/Homo_sapiens/rlcTENsr">Homo sapiens</a></i></td><td>Human</td><td><a href="/facts/Homininae/qht13cx6">Hominini</a></td><td>0</td><td>NP_940926.1</td><td>391</td><td>100</td><td>100</td></tr><tr><td><i><a href="/facts/Bonobo/B4ddCJK4">Pan paniscus</a></i></td><td>Bonobo</td><td><a href="/facts/Primate/Hl8RNE2X">Primate</a></td><td>6.65</td><td>XP_008951441.1</td><td>391</td><td>99</td><td>99</td></tr><tr><td><i><a href="/facts/African_bush_elephant/ochFm1XU">Loxodonta africana</a></i></td><td>African bush/savanna elephant</td><td><a href="/facts/Mammal/phSwTzBo">Mammal</a></td><td>105</td><td>XP_010596294.1</td><td>391</td><td>83</td><td>90</td></tr><tr><td><i><a href="/facts/Okarito_kiwi/eIN8t8FK">Apteryx rowi</a></i></td><td>Okarito (brown) kiwi</td><td><a href="/facts/Bird/RJF6zwLP">Bird</a></td><td>312</td><td>XP_025916696.1</td><td>422</td><td>61</td><td>74</td></tr><tr><td><i><a href="/facts/Schlegel%2527s_Japanese_gecko/1xrkHUq5">Gekko japonicus</a></i></td><td>Calling gecko</td><td><a href="/facts/Reptile/04n1uKf1">Reptile</a></td><td>312</td><td>XP_015264647.1</td><td>359</td><td>49</td><td>63</td></tr><tr><td><i><a href="/facts/African_clawed_frog/khG1KPrd">Xenopus laevis</a></i></td><td>African clawed frog</td><td><a href="/facts/Amphibian/r2BleD2W">Amphibian</a></td><td>352</td><td>XP_018108534.1</td><td>434</td><td>60</td><td>76</td></tr><tr><td><i><a href="/facts/Mexican_tetra/pfnDPtbk">Astyanax mexicanus</a></i></td><td>Mexican tetra/blind cave fish</td><td><a href="/facts/Osteichthyes/nXoXEj3a">Bony fish</a></td><td>432</td><td>XP_007244936.2</td><td>394</td><td>51</td><td>68</td></tr><tr><td><i><a href="/facts/Apostichopus_japonicus/6McXtRCw">Apostichopus japonicus</a></i></td><td>Japanese (spiky) sea cucumber</td><td><a href="/facts/Echinoderm/j2rd8qwt">Echinodermata</a></td><td>684</td><td>PIK45906.1</td><td>404</td><td>43</td><td>56</td></tr><tr><td><i><a href="/facts/Capitella_teleta/Q7Jnaz8C">Capitella teleta</a></i></td><td>Capitella</td><td><a href="/facts/Annelid/PQvb7NAM">Annelida</a></td><td>797</td><td>ELT92672.1</td><td>257</td><td>34</td><td>45</td></tr><tr><td><i><a href="/facts/Asian_long-horned_beetle/1t2PsrNs">Anoplophora glabripennis</a></i></td><td>Asian long-horned beetle</td><td><a href="/facts/Mollusca/1elgknsQ">Mollusca</a></td><td>797</td><td>XP_018561745.1</td><td>259</td><td>18</td><td>31</td></tr><tr><td><i><a href="/facts/Pocillopora_damicornis/j9nLEVfp">Pocillopora damicornis</a></i></td><td>Cauliflower (lace) coral</td><td><a href="/facts/Cnidaria/d0HRc6w0">Cnidaria</a></td><td>824</td><td>XP_027039795.1</td><td>387</td><td>42</td><td>60</td></tr><tr><td><i><a href="/facts/Clonorchis_sinensis/YFc6cj7C">Clonorchis sinensis</a></i></td><td>Chinese liver fluke</td><td><a href="/facts/Flatworm/lvqbrb2V">Platyhelminthes</a></td><td>824</td><td>RJW72461.1</td><td>952</td><td>27</td><td>41</td></tr><tr><td><i><a href="/facts/Echinococcus_multilocularis/51mM73WX">Echinococcus multilocularis</a></i></td><td>Echinococcus</td><td><a href="/facts/Flatworm/lvqbrb2V">Platyhelminthes</a></td><td>824</td><td>CDS43228.1</td><td>299</td><td>18</td><td>33</td></tr><tr><td><i><a href="/facts/Trichoplax/v4MFoEoD">Trichoplax sp. H2</a></i></td><td>Trichoplax</td><td><a href="/facts/Placozoa/F9NcYdAz">Placozoa</a></td><td>948</td><td>RDD37208.1</td><td>451</td><td>30</td><td>44</td></tr><tr><td><i><a href="/facts/Amphimedon_queenslandica/0gzeWlFx">Amphimedon queenslandica</a></i></td><td>Amphimedon</td><td><a href="/facts/Sponge/E9T2WFWA">Porifera</a></td><td>951.8</td><td>XP_003384031.2</td><td>339</td><td>27</td><td>41</td></tr><tr><td><i><a href="/facts/Spizellomycetales/gpJM9Ede">Spizellomyces punctatus DAOM BR117</a></i></td><td>Spizellomyces</td><td><a href="/facts/Chytridiomycota/EEn8uquv">Chytrid</a> (fungi)</td><td>1105</td><td>XP_016611327.1</td><td>373</td><td>31</td><td>52</td></tr><tr><td><i>Planoprotostelium fungivorum</i></td><td>Planoprotostelium</td><td><a href="/facts/Amoebozoa/6wBSrR9h">Amoebozoa</a> (protist)</td><td>1480</td><td>PRP73397.1</td><td>373</td><td>12</td><td>18</td></tr><tr><td><i><a href="/facts/Klebsormidium/K8MSu8za">Klebsormidium nitens</a></i></td><td>Klebsormidium</td><td><a href="/facts/Charophyta/pIudJKKj">Charophyte</a> (green algae)</td><td>1496</td><td>GAQ91967.1</td><td>345</td><td>29</td><td>45</td></tr><tr><td><i>Hondaea fermentalgiana</i></td><td>Hondaea</td><td><a href="/facts/Stramenopiles/6zmwHPEU">Stramenopiles</a> (protist)</td><td>1768</td><td>GBG25987.1</td><td>379</td><td>22</td><td>35</td></tr><tr><td><i><a href="/facts/Apusomonadida/UR2TsXMM">Thecamonas trahens ATCC 50062</a></i></td><td>Thecamonas</td><td><a href="/facts/Apusozoa/rlcYEPEl">Apusozoa</a> (protist)</td><td>2101</td><td>XP_013753981.1</td><td>324</td><td>13</td><td>23</td></tr><tr><td><i><a href="/facts/Chlamydia_trachomatis/54QHKFWC">Chlamydia trachomatis</a></i></td><td>Chlamydia</td><td><a href="/facts/Bacteria/wC8xSCsU">Bacteria</a></td><td>4290</td><td>CPS19605.1</td><td>72</td><td>14</td><td>14</td></tr></tbody></table> <p>The relative rate of change for TEX9 is fairly slow compared to <a href="/facts/Fibrinogen/5dSBwGVo">fibrinogen</a> and <a href="/facts/HBB/qJRdFIWP">beta-globin</a>, but not as slow as <a href="/facts/Cytochrome_c/8gXbxw9z">cytochrome c</a>.<a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a> </p> <h3>Homologous Domains</h3> <p>TEX9 sequences that are most conserved between humans and other organisms are found within the two coiled-coil regions, where some amino acids are conserved in vertebrates, invertebrates, and microorganisms. The bacterial ortholog is most similar to vertebrates than invertebrates or microorganisms. </p> <h3>Phylogeny</h3> <p>All of the orthologs of TEX9 are derived from the same common ancestor except the gene found in <a href="/facts/Chlamydia_(genus)/zbm60vHX">Chlamydia</a>, which is thought to have transferred from humans into the bacterium.<a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a> </p> <h2 id="clinical-significance">Clinical significance</h2> <h3>Pathology</h3> <p>No diseases have been shown to be directly linked to TEX9, but some correlations have been found regarding <a href="/facts/Estrogen_receptor/dEGaNney">estrogen receptor</a> knockdown and increased TEX9 expression<a class="footnote-ref" id="fnref:35" href="#fn:35"><sup>35</sup></a> as well as <a href="/facts/Colorectal_cancer/nV592sW7">colorectal cancer</a> cells with decreased TEX9 expression.<a class="footnote-ref" id="fnref:36" href="#fn:36"><sup>36</sup></a> </p> <h3>Disease Association</h3> <p>Reduced expression of <i>TEX9</i> has been shown to boost tumor growth in <a href="/facts/Immunocompetence/9dHaIBb7">immunocompetent</a> mice but not in <a href="/facts/Immunocompromised/CIEujXmc">immunocompromised</a> mice.<a class="footnote-ref" id="fnref:37" href="#fn:37"><sup>37</sup></a> This result suggested that TEX9 may function as a <a href="/facts/Tumor_antigen/o0Kkwe8U">tumor antigen</a> in some tumors. Mutations of the TEX9 protein have been found in 1-2% of tumors taken from certain cancers, including <a href="/facts/Endometrial_cancer/rh605tHh">endometrial</a>, <a href="/facts/Head_and_neck_cancer/v8T8bNs7">head and neck</a>, <a href="/facts/Colorectal_cancer/nV592sW7">colorectal</a>, and squamous <a href="/facts/Lung_cancer/LHLdR454">lung</a>.<a class="footnote-ref" id="fnref:38" href="#fn:38"><sup>38</sup></a> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2019-02-25. <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi#899148579" target="_blank">https://blast.ncbi.nlm.nih.gov/Blast.cgi#899148579</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>"User Sequence vs Genomic". genome.ucsc.edu. Retrieved 2019-02-25. <a href="http://genome.ucsc.edu/cgi-bin/hgc?o=56365572&g=htcUserAli&i=../trash/hgSs/hgSs_genome_42ff_434f30.pslx+../trash/hgSs/hgSs_genome_42ff_434f30.fa+Hsa_TEX9&c=chr15&l=56365572&r=56428441&db=hg38&hgsid=713211977_iC49eQ7BReAxjfPlVDIwZWACTDjZ" target="_blank">http://genome.ucsc.edu/cgi-bin/hgc?o=56365572&g=htcUserAli&i=../trash/hgSs/hgSs_genome_42ff_434f30.pslx+../trash/hgSs/hgSs_genome_42ff_434f30.fa+Hsa_TEX9&c=chr15&l=56365572&r=56428441&db=hg38&hgsid=713211977_iC49eQ7BReAxjfPlVDIwZWACTDjZ</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>"Human BLAT Search". genome.ucsc.edu. Retrieved 2019-04-21. <a href="https://genome.ucsc.edu/cgi-bin/hgBlat" target="_blank">https://genome.ucsc.edu/cgi-bin/hgBlat</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>"Genomatix: Login Page". www.genomatix.de. Retrieved 2019-05-05. <a href="http://www.genomatix.de/cgi-bin/sessions/login.pl?s=692b50cf896e42c54ccd6e36c5b751c9" target="_blank">http://www.genomatix.de/cgi-bin/sessions/login.pl?s=692b50cf896e42c54ccd6e36c5b751c9</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>"Phyre 2 alignment of TEX9_____ with c1ciiA_". www.sbg.bio.ic.ac.uk. Retrieved 2019-05-05. <a href="http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/b223294f03c7d863/aligs/c1ciiA_.1.alig.html" target="_blank">http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/b223294f03c7d863/aligs/c1ciiA_.1.alig.html</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>"Sequence Utilities". www.bioline.com. Retrieved 2019-05-05. <a href="http://www.bioline.com/media/calculator/01_12.html" target="_blank">http://www.bioline.com/media/calculator/01_12.html</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>"testis-expressed protein 9 isoform 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/protein/NP_940926.1" target="_blank">https://www.ncbi.nlm.nih.gov/protein/NP_940926.1</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>"TEX9 - Testis-expressed protein 9 - Homo sapiens (Human) - TEX9 gene & protein". www.uniprot.org. Retrieved 2019-02-08. <a href="https://www.uniprot.org/uniprot/Q8N6V9" target="_blank">https://www.uniprot.org/uniprot/Q8N6V9</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>"TEX9 - Antibodies - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2019-05-05. <a href="https://www.proteinatlas.org/ENSG00000151575-TEX9/antibody#immunohistochemistry" target="_blank">https://www.proteinatlas.org/ENSG00000151575-TEX9/antibody#immunohistochemistry</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>"COILS Server". embnet.vital-it.ch. Archived from the original on 2019-07-12. Retrieved 2019-04-21. <a href="https://web.archive.org/web/20190712063634/https://embnet.vital-it.ch/software/COILS_form.html" target="_blank">https://web.archive.org/web/20190712063634/https://embnet.vital-it.ch/software/COILS_form.html</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>"SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2019-04-21. <a href="https://www.ebi.ac.uk/Tools/seqstats/saps/" target="_blank">https://www.ebi.ac.uk/Tools/seqstats/saps/</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>"SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2019-04-21. <a href="https://www.ebi.ac.uk/Tools/seqstats/saps/" target="_blank">https://www.ebi.ac.uk/Tools/seqstats/saps/</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>"testis-expressed protein 9 isoform 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/protein/NP_940926.1" target="_blank">https://www.ncbi.nlm.nih.gov/protein/NP_940926.1</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>"NetPhos 3.1 Server". www.cbs.dtu.dk. Retrieved 2019-05-05. <a href="http://www.cbs.dtu.dk/services/NetPhos/" target="_blank">http://www.cbs.dtu.dk/services/NetPhos/</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> <li id="fn:21"><p>"YinOYang 1.2 Server". www.cbs.dtu.dk. Retrieved 2019-05-05. <a href="http://www.cbs.dtu.dk/services/YinOYang/" target="_blank">http://www.cbs.dtu.dk/services/YinOYang/</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></p></li> <li id="fn:22"><p>"NetGlycate 1.0 Server". www.cbs.dtu.dk. Retrieved 2019-05-05. <a href="http://www.cbs.dtu.dk/services/NetGlycate/" target="_blank">http://www.cbs.dtu.dk/services/NetGlycate/</a> <a href="#fnref:22" class="footnote-back-ref">↩</a></p></li> <li id="fn:23"><p>"SUMOplot™ Analysis Program | Abgent". www.abgent.com. Archived from the original on 2005-01-03. Retrieved 2019-05-05. <a href="https://web.archive.org/web/20050103221931/http://www.abgent.com/sumoplot" target="_blank">https://web.archive.org/web/20050103221931/http://www.abgent.com/sumoplot</a> <a href="#fnref:23" class="footnote-back-ref">↩</a></p></li> <li id="fn:24"><p>"Phyre 2 alignment of TEX9_____ with c1ciiA_". www.sbg.bio.ic.ac.uk. Retrieved 2019-05-05. <a href="http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/b223294f03c7d863/aligs/c1ciiA_.1.alig.html" target="_blank">http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/b223294f03c7d863/aligs/c1ciiA_.1.alig.html</a> <a href="#fnref:24" class="footnote-back-ref">↩</a></p></li> <li id="fn:25"><p>"TEX9 protein (human) - STRING interaction network". version-10-5.string-db.org. Retrieved 2019-02-08. <a href="https://version-10-5.string-db.org/cgi/network.pl?taskId=oGt0kWoasNou" target="_blank">https://version-10-5.string-db.org/cgi/network.pl?taskId=oGt0kWoasNou</a> <a href="#fnref:25" class="footnote-back-ref">↩</a></p></li> <li id="fn:26"><p>"TEX9 protein (human) - STRING interaction network". version-10-5.string-db.org. Retrieved 2019-02-08. <a href="https://version-10-5.string-db.org/cgi/network.pl?taskId=oGt0kWoasNou" target="_blank">https://version-10-5.string-db.org/cgi/network.pl?taskId=oGt0kWoasNou</a> <a href="#fnref:26" class="footnote-back-ref">↩</a></p></li> <li id="fn:27"><p>"TEX9 - Testis-expressed protein 9 - Homo sapiens (Human) - TEX9 gene & protein". www.uniprot.org. Retrieved 2019-02-08. <a href="https://www.uniprot.org/uniprot/Q8N6V9" target="_blank">https://www.uniprot.org/uniprot/Q8N6V9</a> <a href="#fnref:27" class="footnote-back-ref">↩</a></p></li> <li id="fn:28"><p>"SUMOplot™ Analysis Program | Abgent". www.abgent.com. Archived from the original on 2005-01-03. Retrieved 2019-05-05. <a href="https://web.archive.org/web/20050103221931/http://www.abgent.com/sumoplot" target="_blank">https://web.archive.org/web/20050103221931/http://www.abgent.com/sumoplot</a> <a href="#fnref:28" class="footnote-back-ref">↩</a></p></li> <li id="fn:29"><p>"SUMO Prediction". Archived from the original on 3 January 2005. Retrieved 20 April 2019. <a href="https://web.archive.org/web/20050103221931/http://www.abgent.com/sumoplot" target="_blank">https://web.archive.org/web/20050103221931/http://www.abgent.com/sumoplot</a> <a href="#fnref:29" class="footnote-back-ref">↩</a></p></li> <li id="fn:30"><p>"Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2019-04-21. <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastp&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome" target="_blank">https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastp&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome</a> <a href="#fnref:30" class="footnote-back-ref">↩</a></p></li> <li id="fn:31"><p>"TEX9 testis expressed 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-08. <a href="https://www.ncbi.nlm.nih.gov/gene/374618" target="_blank">https://www.ncbi.nlm.nih.gov/gene/374618</a> <a href="#fnref:31" class="footnote-back-ref">↩</a></p></li> <li id="fn:32"><p>"Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2019-04-21. <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastp&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome" target="_blank">https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastp&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome</a> <a href="#fnref:32" class="footnote-back-ref">↩</a></p></li> <li id="fn:33"><p>"TimeTree :: The Timescale of Life". timetree.org. Retrieved 2019-05-05. <a href="http://timetree.org/" target="_blank">http://timetree.org/</a> <a href="#fnref:33" class="footnote-back-ref">↩</a></p></li> <li id="fn:34"><p>"Bacteria and Humans Have Been Swapping DNA for Millennia". The Scientist Magazine®. Retrieved 2019-05-05. <a href="https://www.the-scientist.com/features/bacteria-and-humans-have-been-swapping-dna-for-millennia-32779" target="_blank">https://www.the-scientist.com/features/bacteria-and-humans-have-been-swapping-dna-for-millennia-32779</a> <a href="#fnref:34" class="footnote-back-ref">↩</a></p></li> <li id="fn:35"><p>"GDS4061 / 243198_at". www.ncbi.nlm.nih.gov. Retrieved 2019-04-21. <a href="https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS4061:243198_at" target="_blank">https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS4061:243198_at</a> <a href="#fnref:35" class="footnote-back-ref">↩</a></p></li> <li id="fn:36"><p>"GDS4511 / 243198_at". www.ncbi.nlm.nih.gov. Retrieved 2019-04-21. <a href="https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS4511:243198_at" target="_blank">https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS4511:243198_at</a> <a href="#fnref:36" class="footnote-back-ref">↩</a></p></li> <li id="fn:37"><p>Shuptrine CW, Ajina R, Fertig EJ, Jablonski SA, Kim Lyerly H, Hartman ZC, Weiner LM (December 2017). "An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection". Cancer Immunology, Immunotherapy. 66 (12): 1529–1544. doi:10.1007/s00262-017-2047-2. PMC 5854209. PMID 28770278. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854209" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854209</a> <a href="#fnref:37" class="footnote-back-ref">↩</a></p></li> <li id="fn:38"><p>"TEX9 (human)". www.phosphosite.org. Retrieved 2019-02-08. <a href="https://www.phosphosite.org/proteinAction?id=18371&showAllSites=true#appletMsg" target="_blank">https://www.phosphosite.org/proteinAction?id=18371&showAllSites=true#appletMsg</a> <a href="#fnref:38" class="footnote-back-ref">↩</a></p></li> </ol>