ICAM3 has an important function in the immune cell response, as it helps facilitate initial interactions between T cells and dendritic cells. Resting T cells show high levels of ICAM3 expression. ICAM3 on these T cells can bind to DC-SIGN, a transmembrane receptor present on dendritic cells, creating temporary contact between resting T cells and dendritic cells. This adhesion allows the T cell receptor (TCR) to interact with major histocompatibility complex (MHC) molecules on the surface of the dendritic cell, which, upon binding between the TCR, the MHC, and the peptide coupled to the MHC, facilitates T cell activation.
"ICAM3 intercellular adhesion molecule 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-03-10. https://www.ncbi.nlm.nih.gov/gene/3385
Xiao X, Mruk DD, Cheng CY (March 2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–186. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576004
Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J (December 2020). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. PMC 7764012. PMID 33322506. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764012
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127357
Gupta RK, Gupta GS (2012), Gupta GS (ed.), "Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family)", Animal Lectins: Form, Function and Clinical Applications, Vienna: Springer, pp. 749–771, doi:10.1007/978-3-7091-1065-2_35, ISBN 978-3-7091-1065-2, retrieved 2022-03-11 978-3-7091-1065-2
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
Numata Y, Hirayama D, Wagatsuma K, Iida T, Nakase H (2018), Turksen K (ed.), "Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration", Autophagy in Health and Disease: Potential Therapeutic Approaches, Stem Cell Biology and Regenerative Medicine, Cham: Springer International Publishing, pp. 87–100, doi:10.1007/978-3-319-98146-8_6, ISBN 978-3-319-98146-8, retrieved 2022-03-09 978-3-319-98146-8
Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09 978-1-60327-381-7
Xiao X, Mruk DD, Cheng CY (March 2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–186. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576004
Smith CW (February 2008). "3. Adhesion molecules and receptors". The Journal of Allergy and Clinical Immunology. 2008 Mini-Primer on Allergic and Immunologic Diseases. 121 (2 Suppl): S375-9, quiz S414. doi:10.1016/j.jaci.2007.07.030. PMID 18241685. https://doi.org/10.1016%2Fj.jaci.2007.07.030
Smith CW (February 2008). "3. Adhesion molecules and receptors". The Journal of Allergy and Clinical Immunology. 2008 Mini-Primer on Allergic and Immunologic Diseases. 121 (2 Suppl): S375-9, quiz S414. doi:10.1016/j.jaci.2007.07.030. PMID 18241685. https://doi.org/10.1016%2Fj.jaci.2007.07.030
Xiao X, Mruk DD, Cheng CY (March 2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–186. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576004
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127357
Gupta RK, Gupta GS (2012), Gupta GS (ed.), "Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family)", Animal Lectins: Form, Function and Clinical Applications, Vienna: Springer, pp. 749–771, doi:10.1007/978-3-7091-1065-2_35, ISBN 978-3-7091-1065-2, retrieved 2022-03-11 978-3-7091-1065-2
Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127357
Gupta RK, Gupta GS (2012), Gupta GS (ed.), "Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family)", Animal Lectins: Form, Function and Clinical Applications, Vienna: Springer, pp. 749–771, doi:10.1007/978-3-7091-1065-2_35, ISBN 978-3-7091-1065-2, retrieved 2022-03-11 978-3-7091-1065-2
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
Numata Y, Hirayama D, Wagatsuma K, Iida T, Nakase H (2018), Turksen K (ed.), "Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration", Autophagy in Health and Disease: Potential Therapeutic Approaches, Stem Cell Biology and Regenerative Medicine, Cham: Springer International Publishing, pp. 87–100, doi:10.1007/978-3-319-98146-8_6, ISBN 978-3-319-98146-8, retrieved 2022-03-09 978-3-319-98146-8
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
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Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09 978-1-60327-381-7
Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09 978-1-60327-381-7
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09 978-1-60327-381-7
Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J (December 2020). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. PMC 7764012. PMID 33322506. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764012
Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J (December 2020). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. PMC 7764012. PMID 33322506. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764012
Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J (December 2020). "The Art of Mast Cell Adhesion". Cells. 9 (12): 2664. doi:10.3390/cells9122664. PMC 7764012. PMID 33322506. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764012
Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127357
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
Rahimi N (2020-12-22). "C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors". Biology. 10 (1): 1. doi:10.3390/biology10010001. ISSN 2079-7737. PMC 7822156. PMID 33375175. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822156
Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity". Cellular Signalling. 22 (10): 1397–1405. doi:10.1016/j.cellsig.2010.03.018. PMC 7127357. PMID 20363321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127357
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
Rahimi N (2020-12-22). "C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors". Biology. 10 (1): 1. doi:10.3390/biology10010001. ISSN 2079-7737. PMC 7822156. PMID 33375175. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822156
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09 978-1-60327-381-7
Cockram TO, Dundee JM, Popescu AS, Brown GC (2021). "The Phagocytic Code Regulating Phagocytosis of Mammalian Cells". Frontiers in Immunology. 12: 629979. doi:10.3389/fimmu.2021.629979. ISSN 1664-3224. PMC 8220072. PMID 34177884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220072
Marek CJ, Erwig LP (2009), Dong Z, Yin XM (eds.), "Clearance of Apoptotic Cells – Mechanisms and Consequences", Essentials of Apoptosis: A Guide for Basic and Clinical Research, Totowa, NJ: Humana Press, pp. 261–282, doi:10.1007/978-1-60327-381-7_11, ISBN 978-1-60327-381-7, retrieved 2022-03-09 978-1-60327-381-7
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
van Kooyk Y, Geijtenbeek TB (August 2002). "A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions". Immunological Reviews. 186: 47–56. doi:10.1034/j.1600-065x.2002.18605.x. PMID 12234361. S2CID 23267228. /wiki/Doi_(identifier)
Smith CW (February 2008). "3. Adhesion molecules and receptors". The Journal of Allergy and Clinical Immunology. 2008 Mini-Primer on Allergic and Immunologic Diseases. 121 (2 Suppl): S375-9, quiz S414. doi:10.1016/j.jaci.2007.07.030. PMID 18241685. https://doi.org/10.1016%2Fj.jaci.2007.07.030
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