Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
AMY2B
open-in-new
<h2 id="function">Function</h2> <p><a href="/facts/Amylase/H1MPNNVL">Amylases</a> are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and <a href="/facts/Glycogen/kWa8fPFE">glycogen</a>. The human genome has a cluster of several amylase genes that are expressed at high levels in either <a href="/facts/Salivary_gland/VtteDtH0">salivary gland</a> or <a href="/facts/Pancreas/r0WPGjAq">pancreas</a>. This gene encodes an amylase isoenzyme produced by the pancreas.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p> <h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=AMY2B"><i>AMY2B</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=AMY2B"><i>AMY2B</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Kaczmarek MJ, Rosenmund H (August 1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen". <i>Clinica Chimica Acta; International Journal of Clinical Chemistry</i>. 79 (1): 69–73. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0009-8981%2877%2990462-4">10.1016/0009-8981(77)90462-4</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/890964">890964</a>.</li> <li>Groot PC, Mager WH, Henriquez NV, Pronk JC, Arwert F, Planta RJ, Eriksson AW, Frants RR (September 1990). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". <i>Genomics</i>. 8 (1): 97–105. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0888-7543%2890%2990230-R">10.1016/0888-7543(90)90230-R</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2081604">2081604</a>.</li> <li>Yokouchi H, Horii A, Emi M, Tomita N, Doi S, Ogawa M, Mori T, Matsubara K (June 1990). "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B". <i>Gene</i>. 90 (2): 281–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2890%2990191-S">10.1016/0378-1119(90)90191-S</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2401405">2401405</a>.</li> <li>Gumucio DL, Wiebauer K, Caldwell RM, Samuelson LC, Meisler MH (March 1988). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC363264">"Concerted evolution of human amylase genes"</a>. <i>Molecular and Cellular Biology</i>. 8 (3): 1197–205. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.8.3.1197">10.1128/mcb.8.3.1197</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC363264">363264</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2452973">2452973</a>.</li> <li>Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (September 1988). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC338557">"Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene"</a>. <i>Nucleic Acids Research</i>. 16 (17): 8261–76. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F16.17.8261">10.1093/nar/16.17.8261</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC338557">338557</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2458567">2458567</a>.</li> <li>Tomita N, Horii A, Doi S, Yokouchi H, Shiosaki K, Higashiyama M, Matsuura N, Ogawa M, Mori T, Matsubara K (March 1989). "A novel type of human alpha-amylase produced in lung carcinoid tumor". <i>Gene</i>. 76 (1): 11–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2889%2990003-6">10.1016/0378-1119(89)90003-6</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2701942">2701942</a>.</li> <li>Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (July 1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". <i>Genomics</i>. 5 (1): 29–42. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0888-7543%2889%2990083-9">10.1016/0888-7543(89)90083-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2788608">2788608</a>.</li> <li>Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (May 1988). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC336663">"Human pancreatic amylase is encoded by two different genes"</a>. <i>Nucleic Acids Research</i>. 16 (10): 4724. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F16.10.4724">10.1093/nar/16.10.4724</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC336663">336663</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/3260028">3260028</a>.</li> <li>Tricoli JV, Shows TB (March 1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". <i>Somatic Cell and Molecular Genetics</i>. 10 (2): 205–10. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2FBF01534909">10.1007/BF01534909</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/6608795">6608795</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:21230969">21230969</a>.</li> <li>Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). <a href="https://doi.org/10.1093%2Fdnares%2F8.2.85">"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"</a>. <i>DNA Research</i>. 8 (2): 85–95. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F8.2.85">10.1093/dnares/8.2.85</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11347906">11347906</a>.</li> <li>Aughsteen AA (May 2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". <i>Saudi Medical Journal</i>. 22 (5): 410–5. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11376382">11376382</a>.</li> <li>Koyama I, Komine S, Iino N, Hokari S, Igarashi S, Alpers DH, Komoda T (July 2001). "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues". <i>Clinica Chimica Acta; International Journal of Clinical Chemistry</i>. 309 (1): 73–83. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0009-8981%2801%2900501-0">10.1016/S0009-8981(01)00501-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11408008">11408008</a>.</li> <li>Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C (September 2004). <a href="https://doi.org/10.1038%2Fng1416">"Detection of large-scale variation in the human genome"</a>. <i>Nature Genetics</i>. 36 (9): 949–51. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng1416">10.1038/ng1416</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15286789">15286789</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Omichi K, Hase S (December 1993). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1203 (2): 224–9. doi:10.1016/0167-4838(93)90087-8. PMID 8268204. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> </ol>