IRX4

<h2 id="function">Function</h2>
<p>IRX4 is a member of the <a href="/facts/Iroquois_homeobox_factor/vIxM6muo">Iroquois homeobox</a> gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a>
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<h2 id="further-reading">Further reading</h2>

<ul><li>Lewis MT, Ross S, Strickland PA, et al. (1999). <a href="https://escholarship.org/uc/item/6q61x39v">"Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast"</a>. <i>Cell Tissue Res</i>. 296 (3): 549–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs004410051316">10.1007/s004410051316</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10370142">10370142</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:37046813">37046813</a>.</li>
<li>Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). <a href="https://doi.org/10.1074%2Fjbc.M103716200">"Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression"</a>. <i>J. Biol. Chem</i>. 276 (31): 28835–41. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M103716200">10.1074/jbc.M103716200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11382777">11382777</a>.</li>
<li>Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". <i>Turk Kardiyol Dern Ars</i>. 36 (2): 90–5. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18497553">18497553</a>.</li>
<li>Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987367">"Common genetic variation and performance on standardized cognitive tests"</a>. <i>European Journal of Human Genetics</i>. 18 (7): 815–820. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fejhg.2010.2">10.1038/ejhg.2010.2</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987367">2987367</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20125193">20125193</a>.</li>
<li>Strausberg RL, Feingold EA, Grouse LH, et al. (2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li></ul>

<p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i>
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<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>"Entrez Gene: iroquois homeobox 4". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50805" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50805</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
<li id="fn:2"><p>Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552. <a href="https://doi.org/10.1006%2Fdbio.1999.9548" target="_blank">https://doi.org/10.1006%2Fdbio.1999.9548</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li>
<li id="fn:3"><p>"Entrez Gene: iroquois homeobox 4". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50805" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50805</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li>
</ol>

IRX4 open-in-new

IRX4