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5-HT1B receptor
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<h2 id="tissue-distribution-and-function">Tissue distribution and function</h2> <p>5-HT1B receptors are widely distributed throughout the <a href="/facts/Central_nervous_system/k8I6To97">central nervous system</a> with the highest concentrations found in the <a href="/facts/Frontal_cortex/RvokInmf">frontal cortex</a>, <a href="/facts/Basal_ganglia/d9mbF6p3">basal ganglia</a>, <a href="/facts/Striatum/MjNnTjSd">striatum</a>, and the <a href="/facts/Hippocampus/X7CqbP8X">hippocampus</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> The function of the 5-HT1B receptor differs depending upon its location. In the frontal cortex, it is believed to act as a terminal receptor inhibiting the release of <a href="/facts/Dopamine/5gNy8Xkd">dopamine</a>. In the basal ganglia and the striatum, evidence suggests 5-HT signaling acts on an <a href="/facts/Autoreceptor/m8FPWHcK">autoreceptor</a>, inhibiting the release of <a href="/facts/Serotonin/EzY58q4a">serotonin</a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> and decreasing glutamatergic transmission by reducing miniature <a href="/facts/Excitatory_postsynaptic_potential/fh6J3sUm">excitatory postsynaptic potential</a> (mEPSP) frequency,<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> respectively. In the hippocampus, a recent study has demonstrated that activation of postsynaptic 5-HT1B <a href="/facts/Heteroreceptor/lP8nCApa">heteroreceptors</a> produces a facilitation in excitatory synaptic transmission which is altered in depression.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> When the expression of 5-HT1B in human cortex was traced throughout life, significant changes during adolescence were observed, in a way that is strongly correlated with the expression of 5-HT1E.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p><p>Outside of the CNS, the 5-HT1B receptor is also expressed on the <a href="/facts/Endothelium/L4ENFVnw">endothelium</a> of blood vessels, particularly in the <a href="/facts/Meninges/IcxhShYH">meninges</a>.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> Activation of these receptors results in <a href="/facts/Vasoconstriction/9hdY0aR2">vasoconstriction</a>. The high distribution of vasoconstrictive 5-HT1B and <a href="/facts/5-HT1D_receptor/zzGzggdV">5-HT1D</a> receptors around the brain makes them a valuable drug target for the treatment of migraines.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> </p><p>Blocking 5-HT1B receptor signalling also increases the number of <a href="/facts/Osteoblast/N6mMDQvR">osteoblasts</a>, bone mass, and the bone formation rate.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> </p><p><a href="/facts/Knockout_mice/Aw50cobf">Knockout mice</a> lacking the 5-HT1B gene have been reported to have a higher preference for alcohol, although later studies failed to replicate such abnormalities in alcohol consumption.<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> These mice have also been reported to have a lower measure of anxiety (such as on the <a href="/facts/Elevated_plus_maze/1dLTsPRa">elevated plus maze test</a>) and a higher measure of aggression.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> </p><p>Under basal conditions, knockout mice present with a "normal" phenotype and exhibit a sucrose preference (lack of sucrose preference is considered a measure of anhedonia). However, after undergoing chronic unpredictable stress treatment to induce a "depression-like" phenotype these animals do not benefit from administration of <a href="/facts/Selective_serotonin_reuptake_inhibitor/L6jjcmEH">selective serotonin reuptake inhibitor</a> (SSRIs).<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> </p><p>Activation of the serotonin 5-HT1B receptor appears to mediate the <a href="/facts/Prosocial/kBLsbSLk">prosocial</a> effects of <a href="/facts/Entactogen/hxo3LqDS">entactogens</a> acting as <a href="/facts/Serotonin_releasing_agent/p19Sjpqx">serotonin releasing agents</a> like <a href="/facts/MDMA/WYDACxGN">MDMA</a> in animals.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a><a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a><a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a><a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> In addition, serotonin 5-HT1B receptor activation appears to mediate the <a href="/facts/Locomotor_hyperactivity/Mk7mADL7">locomotor hyperactivity</a> of these agents.<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a><a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a><a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a> The serotonin 5-HT1B receptor also appears to be required for the persisting <a href="/facts/Antidepressant/N62ND3Fa">antidepressant</a>- and <a href="/facts/Anxiolytic/uEWpGca9">anxiolytic</a>-like effects as well as acute <a href="/facts/Hypolocomotion/HPekWj74">hypolocomotion</a> of the <a href="/facts/Serotonergic_psychedelic/oyp10dgE">serotonergic psychedelic</a> and <a href="/facts/Binding_selectivity/RryTsdGv">non-selective</a> <a href="/facts/Serotonin_receptor_agonist/zqbpWcFg">serotonin receptor agonist</a> <a href="/facts/Psilocybin/0jGynLUX">psilocybin</a> in animals.<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a> </p> <h2 id="ligands">Ligands</h2> <h3>Agonists</h3> <ul><li><a href="/facts/2ZEDMA/FH54Ej4B">2ZEDMA</a> (also a 5-HT2A agonist)</li> <li><a href="/facts/5-Carboxamidotryptamine/L9eU5CKr">5-Carboxamidotryptamine</a> (5-CT)</li> <li><a href="/facts/Almotriptan/TTf4q1xC">Almotriptan</a></li> <li><a href="/facts/Anpirtoline/40Pw1che">Anpirtoline</a> (D-16949)</li> <li><a href="/facts/Avitriptan/EJdSBTnz">Avitriptan</a></li> <li><a href="/facts/Batoprazine/sclyj7tB">Batoprazine</a></li> <li><a href="/facts/CGS-12066A/IwW4wn4q">CGS-12066A</a></li> <li><a href="/facts/CP-93%2c129/AJmETxdN">CP-93,129</a> (peripherally acting)</li> <li><a href="/facts/CP-94%2c253/722LMFLx">CP-94,253</a></li> <li><a href="/facts/CP-122%2c288/b76dSqou">CP-122,288</a> (mixed 5-HT1B/1D agonist)</li> <li><a href="/facts/CP-135%2c807/u5Fbk3xk">CP-135,807</a> (mixed 5-HT1B/1D agonist)</li> <li><a href="/facts/Dihydroergotamine/Y3ELJ85t">Dihydroergotamine</a></li> <li><a href="/facts/Donitriptan/UgNfCJVX">Donitriptan</a></li> <li><a href="/facts/Eletriptan/eQwL3bSl">Eletriptan</a></li> <li><a href="/facts/Eltoprazine/53tj8BDX">Eltoprazine</a> (DU-28853)</li> <li>Emodin-8-glucoside</li> <li><a href="/facts/Ergotamine/o3mIe2ct">Ergotamine</a></li> <li><a href="/facts/Fluprazine/1ef6z1wC">Fluprazine</a></li> <li><a href="/facts/Frovatriptan/hM9pFXtb">Frovatriptan</a></li> <li>L-741,604</li> <li><a href="/facts/Lisuride/bJUPphfB">Lisuride</a></li> <li><a href="/facts/Meta-Chlorophenylpiperazine/m5fmVR1h">mCPP</a></li> <li><a href="/facts/Methylergometrine/ete7dx5D">Methylergometrine</a> (methylergonovine)</li> <li><a href="/facts/Methysergide/Hblg2Wh8">Methysergide</a></li> <li><a href="/facts/Naratriptan/5WXbsovo">Naratriptan</a></li> <li><a href="/facts/Oxymetazoline/74hVTwQz">Oxymetazoline</a></li> <li><a href="/facts/Pergolide/uuGLDCPI">Pergolide</a></li> <li>PZKKN-94 (also a 5-HT6 antagonist)<a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a></li> <li><a href="/facts/Rizatriptan/pLfRPX7p">Rizatriptan</a></li> <li><a href="/facts/RU-24969/1hjuMRyH">RU-24969</a> (mixed 5-HT1A/1B agonist)</li> <li>(S)-DCPT</li> <li><a href="/facts/Serotonin/EzY58q4a">Serotonin</a></li> <li><a href="/facts/Sumatriptan/fNXI5V1M">Sumatriptan</a></li> <li><a href="/facts/TFMPP/bddHfave">TFMPP</a></li> <li><a href="/facts/Substituted_tryptamine/rNKEIl5T">Tryptamine</a> <a href="/facts/Serotonergic_psychedelic/oyp10dgE">psychedelics</a> (e.g., <a href="/facts/5-MeO-DMT/loYNtULA">5-MeO-DMT</a>, <a href="/facts/Dipropyltryptamine/zJPF0gCY">DPT</a>, <a href="/facts/Psilocin/HEhEetVJ">psilocin</a>/<a href="/facts/Psilocybin/0jGynLUX">psilocybin</a>)</li> <li><a href="/facts/Zolmitriptan/hM71z0Qy">Zolmitriptan</a></li></ul> <h3>Partial agonists</h3> <ul><li><a href="/facts/Asenapine/QqBmPoyK">Asenapine</a></li> <li>AZ10419369</li> <li><a href="/facts/Bromocriptine/jtto1Pku">Bromocriptine</a></li> <li><a href="/facts/Metergoline/4CxHN6g6">Metergoline</a></li> <li><a href="/facts/Naphthylpiperazine/IzveDGqk">Naphthylpiperazine</a></li> <li><a href="/facts/Vortioxetine/ghj3RRpk">Vortioxetine</a></li> <li><a href="/facts/Ziprasidone/armf6BDh">Ziprasidone</a></li></ul> <h3>Antagonists and inverse agonists</h3> <ul><li><a href="/facts/Alprenolol/mh798Sfp">Alprenolol</a></li> <li>AOP-208 (LB-208)</li> <li><a href="/facts/AR-A000002/hospgnvM">AR-A000002</a> (AZD-8129)<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a></li> <li><a href="/facts/Aripiprazole/A6g2UwMz">Aripiprazole</a></li> <li>AZD-1134</li> <li>AZD-3783</li> <li>AZ12320927</li> <li><a href="/facts/Carteolol/tJF4geab">Carteolol</a></li> <li><a href="/facts/Elzasonan/MXPBuc4w">Elzasonan</a></li> <li><a href="/facts/GR-55562/slUAF9Tz">GR-55562</a></li> <li><a href="/facts/GR-127935/ITs7Thps">GR-127935</a></li> <li><a href="/facts/Isamoltane/TRxNS2jj">Isamoltane</a> (CGP-361A)</li> <li><a href="/facts/LY-393558/5r9llXK0">LY-393558</a></li> <li><a href="/facts/Metitepine/SA6y62kK">Metitepine</a> (methiothepin)</li> <li><a href="/facts/NAS-181/baqRlp9o">NAS-181</a> (MCOMM)</li> <li><a href="/facts/Oxprenolol/x6ojNJGY">Oxprenolol</a></li> <li><a href="/facts/Penbutolol/A1Vq8L9H">Penbutolol</a></li> <li><a href="/facts/Propranolol/QvH2XYt1">Propranolol</a></li> <li><a href="/facts/Risperidone/xpFEYzoF">Risperidone</a></li> <li><a href="/facts/SB-216%2c641/5tlkGKMc">SB-216,641</a></li> <li><a href="/facts/SB-224%2c289/mW0xeECw">SB-224,289</a> (inverse agonist)<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a></li> <li><a href="/facts/SB-236%2c057/hgolpTWH">SB-236,057</a> (inverse agonist)<a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a></li> <li><a href="/facts/SB-245%2c570/nFXlwwCa">SB-245,570</a></li> <li><a href="/facts/SB-649%2c915/zQEPSJB0">SB-649,915</a></li> <li><a href="/facts/Tertatolol/0d61RHcy">Tertatolol</a></li> <li><a href="/facts/Yohimbine/5HcoTsKu">Yohimbine</a></li></ul> <h3>Unknown</h3> <ul><li><a href="/facts/Dextromethorphan/Jq9UgD4M">Dextromethorphan</a><a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a></li></ul> <h2 id="genetics">Genetics</h2> <p>In humans the protein is coded by the gene <i>HTR1B</i>. </p><p>A genetic variant in the promoter region, <i>A-161T</i>, has been examined with respect to <a href="/facts/Personality_trait/Iun5UFdX">personality traits</a> and showed no major effect.<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/5-HT1_receptor/c2tVGHCw">5-HT1 receptor</a></li> <li><a href="/facts/5-HT_receptor/D6656QzQ">5-HT receptor</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Olivier B, van Oorschot R (Dec 2005). "5-HT1B receptors and aggression: a review". <i>European Journal of Pharmacology</i>. 526 (1–3): 207–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.ejphar.2005.09.066">10.1016/j.ejphar.2005.09.066</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16310769">16310769</a>.</li> <li>Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (Apr 1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity". <i>Biochemical and Biophysical Research Communications</i>. 184 (2): 752–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0006-291X%2892%2990654-4">10.1016/0006-291X(92)90654-4</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1315531">1315531</a>.</li> <li>Veldman SA, Bienkowski MJ (Sep 1992). "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype". <i>Molecular Pharmacology</i>. 42 (3): 439–44. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1328844">1328844</a>.</li> <li>Demchyshyn L, Sunahara RK, Miller K, Teitler M, Hoffman BJ, Kennedy JL, et al. (Jun 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49324">"A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 89 (12): 5522–6. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1992PNAS...89.5522D">1992PNAS...89.5522D</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.89.12.5522">10.1073/pnas.89.12.5522</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49324">49324</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1351684">1351684</a>.</li> <li>Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, Kaumann AJ, Birnbaumer L (Apr 1992). <a href="https://doi.org/10.1016%2FS0021-9258%2818%2942552-5">"Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype"</a>. <i>The Journal of Biological Chemistry</i>. 267 (11): 7553–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2818%2942552-5">10.1016/S0021-9258(18)42552-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1559993">1559993</a>.</li> <li>Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR (Apr 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48922">"Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 89 (8): 3630–4. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1992PNAS...89.3630W">1992PNAS...89.3630W</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.89.8.3630">10.1073/pnas.89.8.3630</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48922">48922</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1565658">1565658</a>.</li> <li>Mochizuki D, Yuyama Y, Tsujita R, Komaki H, Sagai H (Jun 1992). "Cloning and expression of the human 5-HT1B-type receptor gene". <i>Biochemical and Biophysical Research Communications</i>. 185 (2): 517–23. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0006-291X%2892%2991655-A">10.1016/0006-291X(92)91655-A</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1610347">1610347</a>.</li> <li>Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P (Dec 1994). "Identification of genetic variation in the human serotonin 1D beta receptor gene". <i>Biochemical and Biophysical Research Communications</i>. 205 (2): 1194–200. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.1994.2792">10.1006/bbrc.1994.2792</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7802650">7802650</a>.</li> <li>Ng GY, George SR, Zastawny RL, Caron M, Bouvier M, Dennis M, et al. (Nov 1993). "Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition". <i>Biochemistry</i>. 32 (43): 11727–33. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi00094a032">10.1021/bi00094a032</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8218242">8218242</a>.</li> <li>Bouchelet I, Cohen Z, Case B, Séguéla P, Hamel E (Aug 1996). "Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels". <i>Molecular Pharmacology</i>. 50 (2): 219–23. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8700126">8700126</a>.</li> <li>Varnäs K, Hall H, Bonaventure P, Sedvall G (Oct 2001). "Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743". <i>Brain Research</i>. 915 (1): 47–57. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0006-8993%2801%2902823-2">10.1016/S0006-8993(01)02823-2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11578619">11578619</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:43104381">43104381</a>.</li> <li>Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, et al. (May 2002). <a href="https://doi.org/10.1074%2Fjbc.M201539200">"Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation"</a>. <i>The Journal of Biological Chemistry</i>. 277 (18): 15482–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M201539200">10.1074/jbc.M201539200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11854302">11854302</a>.</li> <li>Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H (Apr 2002). "Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2". <i>Journal of Neural Transmission</i>. 109 (4): 513–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs007020200042">10.1007/s007020200042</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11956970">11956970</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:35750034">35750034</a>.</li> <li>Hawi Z, Dring M, Kirley A, Foley D, Kent L, Craddock N, et al. (2003). <a href="https://doi.org/10.1038%2Fsj.mp.4001048">"Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample"</a>. <i>Molecular Psychiatry</i>. 7 (7): 718–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.mp.4001048">10.1038/sj.mp.4001048</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12192616">12192616</a>.</li> <li>Huang YY, Oquendo MA, Friedman JM, Greenhill LL, Brodsky B, Malone KM, et al. (Jan 2003). <a href="https://doi.org/10.1038%2Fsj.npp.1300000">"Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism"</a>. <i>Neuropsychopharmacology</i>. 28 (1): 163–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.npp.1300000">10.1038/sj.npp.1300000</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12496953">12496953</a>.</li> <li>Quist JF, Barr CL, Schachar R, Roberts W, Malone M, Tannock R, et al. 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"Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism". <i>American Journal of Medical Genetics Part B</i>. 121B (1): 83–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fajmg.b.20064">10.1002/ajmg.b.20064</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12898580">12898580</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:33460360">33460360</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=2">"5-HT1B"</a>. <i>IUPHAR Database of Receptors and Ion Channels</i>. International Union of Basic and Clinical Pharmacology.</li> <li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=HTR1B"><i>HTR1B</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=HTR1B"><i>HTR1B</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/facts/Protein_Data_Bank/oUhq4ABD">PDB</a> for <a href="/facts/UniProt/lfDDHjAl">UniProt</a>: <i><a href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P28222">P28222</a></i> (5-hydroxytryptamine receptor 1B) at the <a href="/facts/PDBe-KB/p1WX7lPH">PDBe-KB</a>.</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, et al. 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