Eminem says that "Lose Yourself" was written on set, during breaks while filming 8 Mile. Taryn Manning, who played Jimmy's ex-girlfriend Janeane in 8 Mile, said in an interview with MTV, that during the filming of the movie, in any downtime, Eminem was writing and that "you could just see him formulating stuff in his head". According to studio engineer Steven King, who spoke to Rolling Stone magazine, Eminem recorded the song in a portable studio on the set while he was on a break from shooting, using only one take for each verse. The sheet on which he wrote the song appears in 8 Mile in a scene where his character is writing while riding the bus.
The official demo version of this song, titled "Lose Yourself (Demo Version)" with two different verses and a slightly different hook, was released on the album Shady XV November 24, 2014. A Drum & Bass remix has been made and was released on the mixtape Straight from the Lab as a European bonus track.
"Lose Yourself" is a mid-tempo hip hop track with an urgent narrative delivery. The song's lyrics explicitly sum up the background of Eminem's character in 8 Mile, B-Rabbit, with the first verse summing up much of the plot of the movie. The song incorporates several aggressive themes, largely dealing with the struggles dealt with by B-Rabbit, and how he eventually overcomes his many problems and obstacles to gain the respect of other rappers.
"Lose Yourself" received critical acclaim, with many praising the song's aggressive themes and describing it as Eminem's best work to date. Eminem's rapping ability, the lyrics and the production were praised as well. In many retrospective reviews and lists, critics have cited the song among Eminem's finest, as well as one of the greatest hip-hop songs of all time. AllMusic editor Stephen Thomas Erlewine praised the song's production: "The opening track and first single [from the 8 Mile soundtrack] "Lose Yourself" is easily equaled by the title song with its layered pianos" and he highlighted it.
In France, it is the 53rd-best-selling single of the 21st century, with 386,000 units sold as of August 2014[update]. By December 2016, it had sold more than 11,590,000 units worldwide.
It contains scenes focusing on both Rabbit's and the real-life Eminem's character; for example, the interpersonal difficulties he has to face while rapping, the insults and booing of crowds due to being a white rapper in a black-dominate scene, the domestic trouble he has to overcome due to his alcoholic mother and her deadbeat boyfriend, and dealing with the problems that arise from the people he associates with.
While not Eminem's best-selling single, "Lose Yourself" is considered by many to be his signature song. Upon its release, the track was a worldwide chart success, peaking at number one on 24 national charts worldwide. These included the US Billboard Hot 100, making it Eminem's first number-one hit in the United States. It had a 12-week run at No. 1 in the United States and Australia, and it topped the charts in many other countries, including United Kingdom, Ireland, New Zealand and Denmark. It debuted at number nine in Canada and moved up to #1 the following week. According to the Guinness Book of World Records, "Lose Yourself" became the "Longest-Running Single at Number One for a Rap Song", at 23 weeks. With over 19 million copies sold in the United States, it is Eminem's third-best-selling song, just behind "Love the Way You Lie" and "Not Afraid".
At No. 166, "Lose Yourself" is the highest-ranked of the three songs from the 21st century featured in the 2004 List of Rolling Stone's 500 Greatest Songs of All Time (joining "Stan" at No. 290 and Outkast's "Hey Ya!" at No. 180), although it was dropped from the 2010 update but later reinstated to 167 in the 2021 version. The magazine later ranked the song the twelfth-best of the 2000s decade. The song was the 51st best-selling single of the 2000s decade in the United Kingdom. The song was placed at number 104 by Pitchfork on their list of "The Top 500 Tracks of the 2000s".
The song continued to be prominent in 2020 and beyond. In an analysis of over 30,000 songs on Spotify, "Lose Yourself" was in the top 10 most popular songs on running playlists along with one of the most popular songs of the year in which the data was analyzed—"Blinding Lights" by the Weeknd—which also shares its tempo at 171 beats per minute. The song was also used by President Joe Biden for his 2020 presidential campaign. Mathers, who endorsed Biden in his election campaign, gave his consent for Biden to use it for a campaign ad. President Barack Obama rapped Eminem's Lose Yourself at Detroit rally in 2024 election rally.
Credits for "Lose Yourself" are adapted from the liner notes of the original soundtrack to the movie 8 Mile.
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