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Protein-truncating variants
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<p>Protein-truncating variants (PTVs) are <a href="/facts/Mutation/Ee4NnWbY">genetic variants</a> predicted to shorten the <a href="/facts/Gene_coding/eSR9aIKr">coding sequence of genes</a>, through ways like a <a href="/facts/Nonsense_mutation/Sqxnqwvv">stop-gain mutation</a>. PTV is sometime categorized under the umbrella term frameshift or truncating variants (FTVs), which includes both PTVs and DNA variants caused by <a href="/facts/Frameshift_mutation/ncWrMHqm">frameshift mutation</a>. </p>