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Reference.org
Glutathione peroxidase 3
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<p>Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> that in humans is encoded by the <i>GPX3</i> <a href="/facts/Gene/e1swwPY6">gene</a>. </p><p>GPx-3 belongs to the <a href="/facts/Glutathione_peroxidase/Y7AQpAub">glutathione peroxidase</a> family, which functions in the detoxification of hydrogen peroxide. It contains a <a href="/facts/Selenocysteine/9ovfzrXW">selenocysteine</a> (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. </p>