Clinical endpoint

Clinical endpoints or clinical outcomes are <a href="/facts/Outcome_measure/ennf2Ftk">outcome measures</a> referring to occurrence of <a href="/facts/Disease/55eeQlGL">disease</a>, <a href="/facts/Symptom/BzP6MrTN">symptom</a>, <a href="/facts/Medical_sign/BzP6MrTN">sign</a> or laboratory abnormality constituting a target outcome in <a href="/facts/Clinical_trial/q8LMr832">clinical research trials</a>. The term may also refer to any disease or sign that strongly motivates withdrawal of an individual or entity from the trial, then often termed a humane (clinical) endpoint.
The primary endpoint of a clinical trial is the endpoint for which the trial is <a href="/facts/Statistical_power/5KU54nW1">powered</a>. Secondary endpoints are additional endpoints, preferably also pre-specified, for which the trial may not be powered.
<a href="/facts/Surrogate_endpoint/qSWmMdt9">Surrogate endpoints</a> are trial endpoints that have outcomes that substitute for a clinical endpoint, often because studying the clinical endpoint is difficult, for example using an increase in blood pressure as a surrogate for death by cardiovascular disease, where strong evidence of a <a href="/facts/Causality/Swh496X7">causal</a> link exists.

Clinical endpoint open-in-new

Clinical endpoint