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Megakaryocyte
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<p>A megakaryocyte (from <i> mega-</i> 'large' <i> karyo-</i> '<a href="/facts/Cell_nucleus/D7sFRa3c">cell nucleus</a>' and <i> -cyte</i> '<a href="/facts/Cell_(biology)/bLM9UQvy">cell</a>') is a large <a href="/facts/Bone_marrow/4dfudk0H">bone marrow</a> cell with a <a href="/facts/Lobation/8NQq2P1t">lobated</a> nucleus that produces blood <a href="/facts/Platelet/I0xrDVGa">platelets</a> (thrombocytes), which are necessary for normal <a href="/facts/Blood_coagulation/vnfEevM0">clotting</a>. In humans, megakaryocytes usually account for 1 out of 10,000 <a href="/facts/Bone_marrow/4dfudk0H">bone marrow</a> cells, but can increase in number nearly 10-fold during the course of certain diseases. Owing to variations in <a href="/facts/Neoclassical_compound/9zVyEVVL">combining forms</a> and spelling, synonyms include megalokaryocyte and megacaryocyte. </p>