Discovery and development of bisphosphonates

<p><a href="/facts/Bisphosphonate/s6po5jLd">Bisphosphonates</a> are an important class of drugs originally commercialised in the mid to late 20th century. They are used for the treatment of <a href="/facts/Osteoporosis/xa1W00Tj">osteoporosis</a> and other bone disorders that cause bone fragility and diseases where <a href="/facts/Bone_resorption/cMx23mGW">bone resorption</a> is excessive. Osteoporosis is common in <a href="/facts/Menopause/b3Fz6NHb">post-menopausal</a> women and patients in <a href="/facts/Corticosteroid/jeL2QeIL">corticosteroid</a> treatment where biphosphonates have been proven a valuable treatment and also used successfully against <a href="/facts/Paget%2527s_disease_of_bone/5KetYpfm">Paget's disease</a>, <a href="/facts/Multiple_myeloma/Pp9Tt33l">myeloma</a>, bone <a href="/facts/Metastasis/4dadbm6z">metastases</a> and <a href="/facts/Hypercalcaemia/kdEeLaVd">hypercalcemia</a>. Bisphosphonates reduce breakdown of bones by inhibiting <a href="/facts/Osteoclast/jHHtEQru">osteoclasts</a>, they have a long history of use and today there are a few different types of bisphosphonate drugs on the market around the world.
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Discovery and development of bisphosphonates open-in-new

Discovery and development of bisphosphonates