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Reference.org
Circe effect
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<p>The <a href="/facts/Circe/xmMprE5k">Circe</a> effect is a phenomenon proposed by <a href="/facts/William_Jencks/HGb42ITt">William Jencks</a> seen in <a href="/facts/Chemistry/SrNqkGVm">chemistry</a> and <a href="/facts/Biochemistry/fa2pWEBp">biochemistry</a> where in order to speed up a reaction, the ground state of the substrate is destabilized by an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a>. </p>